Incidental Mutation 'R7133:Trip11'
| ID |
552845 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
045218-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7133 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 101850329 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Leucine
at position 1245
(Q1245L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021605
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000021605
AA Change: Q1245L
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: Q1245L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177183
AA Change: Q960L
PolyPhen 2
Score 0.551 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: Q960L
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0652 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
98% (91/93) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610008E11Rik |
T |
A |
10: 78,902,473 (GRCm39) |
K614N |
probably benign |
Het |
| 2610008E11Rik |
T |
G |
10: 78,902,474 (GRCm39) |
K614T |
probably benign |
Het |
| Ahsa1 |
T |
A |
12: 87,317,116 (GRCm39) |
S120R |
probably benign |
Het |
| Anapc16 |
G |
A |
10: 59,832,302 (GRCm39) |
T37I |
possibly damaging |
Het |
| Arid2 |
C |
A |
15: 96,276,756 (GRCm39) |
P1606H |
probably damaging |
Het |
| Ash1l |
TATCTCCTTTTCCAAAAA |
TA |
3: 88,890,764 (GRCm39) |
|
probably null |
Het |
| Asic1 |
T |
A |
15: 99,569,968 (GRCm39) |
N96K |
probably damaging |
Het |
| Asph |
A |
T |
4: 9,484,575 (GRCm39) |
D582E |
probably benign |
Het |
| Astn1 |
A |
G |
1: 158,400,557 (GRCm39) |
D528G |
probably damaging |
Het |
| Atp9b |
A |
G |
18: 80,952,871 (GRCm39) |
V164A |
|
Het |
| Cbx6 |
C |
T |
15: 79,712,866 (GRCm39) |
G187D |
possibly damaging |
Het |
| Cct7 |
A |
G |
6: 85,443,627 (GRCm39) |
T332A |
probably benign |
Het |
| Clca4a |
A |
T |
3: 144,667,651 (GRCm39) |
L440* |
probably null |
Het |
| Crybg2 |
A |
T |
4: 133,792,754 (GRCm39) |
I130F |
probably benign |
Het |
| Crybg3 |
T |
C |
16: 59,357,167 (GRCm39) |
E798G |
probably damaging |
Het |
| Ctnnd2 |
A |
G |
15: 30,480,995 (GRCm39) |
E81G |
possibly damaging |
Het |
| Cwc22 |
C |
T |
2: 77,759,822 (GRCm39) |
R75H |
possibly damaging |
Het |
| Cym |
T |
G |
3: 107,121,530 (GRCm39) |
D254A |
probably damaging |
Het |
| Dcaf11 |
T |
A |
14: 55,806,383 (GRCm39) |
|
probably null |
Het |
| Dctn1 |
A |
T |
6: 83,157,026 (GRCm39) |
|
probably null |
Het |
| Dennd5a |
C |
T |
7: 109,495,449 (GRCm39) |
|
probably null |
Het |
| Dmpk |
T |
A |
7: 18,821,232 (GRCm39) |
C217S |
probably damaging |
Het |
| Dnah1 |
C |
A |
14: 31,008,033 (GRCm39) |
V2125L |
probably benign |
Het |
| Exoc4 |
G |
A |
6: 33,415,408 (GRCm39) |
A427T |
probably benign |
Het |
| Farp2 |
G |
T |
1: 93,548,956 (GRCm39) |
V1021F |
probably damaging |
Het |
| Flg2 |
T |
C |
3: 93,127,069 (GRCm39) |
S1994P |
unknown |
Het |
| Fmnl1 |
T |
C |
11: 103,072,610 (GRCm39) |
|
probably null |
Het |
| Frem2 |
T |
A |
3: 53,479,760 (GRCm39) |
I1978F |
possibly damaging |
Het |
| Gan |
T |
A |
8: 117,913,969 (GRCm39) |
C122* |
probably null |
Het |
| Gpr25 |
T |
A |
1: 136,188,559 (GRCm39) |
Y18F |
probably damaging |
Het |
| Hoxa7 |
C |
T |
6: 52,192,720 (GRCm39) |
E223K |
probably benign |
Het |
| Hypk |
A |
G |
2: 121,283,961 (GRCm39) |
|
probably null |
Het |
| Ibsp |
A |
T |
5: 104,450,172 (GRCm39) |
K27* |
probably null |
Het |
| Ighv6-5 |
T |
A |
12: 114,380,395 (GRCm39) |
T41S |
probably benign |
Het |
| Ighv9-4 |
T |
C |
12: 114,263,757 (GRCm39) |
M59V |
probably benign |
Het |
| Il17rb |
T |
C |
14: 29,718,828 (GRCm39) |
D418G |
probably damaging |
Het |
| Ints5 |
T |
A |
19: 8,872,923 (GRCm39) |
V294E |
probably damaging |
Het |
| Irx6 |
G |
A |
8: 93,405,041 (GRCm39) |
C303Y |
probably damaging |
Het |
| Itih3 |
T |
A |
14: 30,639,655 (GRCm39) |
I389F |
probably damaging |
Het |
| Lama1 |
C |
T |
17: 68,089,141 (GRCm39) |
T1604I |
|
Het |
| Lama3 |
C |
A |
18: 12,672,843 (GRCm39) |
Q873K |
probably benign |
Het |
| Lhx1 |
T |
G |
11: 84,410,746 (GRCm39) |
S284R |
probably benign |
Het |
| Lrba |
T |
A |
3: 86,302,238 (GRCm39) |
|
probably null |
Het |
| Lrg1 |
C |
T |
17: 56,427,592 (GRCm39) |
G127R |
possibly damaging |
Het |
| Macir |
G |
A |
1: 97,573,645 (GRCm39) |
P140L |
probably benign |
Het |
| Mapre1 |
T |
A |
2: 153,606,883 (GRCm39) |
L205H |
probably benign |
Het |
| Meltf |
A |
G |
16: 31,711,617 (GRCm39) |
N581S |
probably damaging |
Het |
| Mgat5 |
A |
C |
1: 127,292,926 (GRCm39) |
M149L |
probably benign |
Het |
| Myh1 |
A |
G |
11: 67,093,412 (GRCm39) |
T168A |
probably benign |
Het |
| Naalad2 |
C |
T |
9: 18,238,673 (GRCm39) |
V681I |
probably benign |
Het |
| Or51e2 |
A |
G |
7: 102,391,524 (GRCm39) |
S229P |
probably damaging |
Het |
| Or52r1c |
T |
A |
7: 102,735,205 (GRCm39) |
L155Q |
probably damaging |
Het |
| Pcnx2 |
T |
C |
8: 126,528,243 (GRCm39) |
T1326A |
probably benign |
Het |
| Peg3 |
A |
T |
7: 6,711,944 (GRCm39) |
C1093S |
probably damaging |
Het |
| Pidd1 |
T |
C |
7: 141,019,813 (GRCm39) |
S650G |
probably benign |
Het |
| Pik3c2b |
T |
C |
1: 133,017,972 (GRCm39) |
S945P |
possibly damaging |
Het |
| Plec |
T |
C |
15: 76,060,227 (GRCm39) |
T3237A |
possibly damaging |
Het |
| Prpf3 |
A |
T |
3: 95,741,052 (GRCm39) |
|
probably null |
Het |
| Prpf4b |
C |
A |
13: 35,085,477 (GRCm39) |
H974Q |
probably benign |
Het |
| Ptpn3 |
T |
C |
4: 57,225,863 (GRCm39) |
T451A |
probably benign |
Het |
| Ptprs |
A |
G |
17: 56,724,429 (GRCm39) |
Y1577H |
probably damaging |
Het |
| Rgr |
C |
T |
14: 36,770,882 (GRCm39) |
M1I |
probably null |
Het |
| Rxrg |
A |
T |
1: 167,458,678 (GRCm39) |
N257I |
probably benign |
Het |
| Sbno2 |
T |
C |
10: 79,922,146 (GRCm39) |
D9G |
probably damaging |
Het |
| Scd1 |
T |
C |
19: 44,395,034 (GRCm39) |
K64E |
probably damaging |
Het |
| Serpinb1a |
T |
A |
13: 33,034,308 (GRCm39) |
I28F |
possibly damaging |
Het |
| Sfmbt2 |
A |
T |
2: 10,406,818 (GRCm39) |
E39V |
probably damaging |
Het |
| Slc29a1 |
A |
G |
17: 45,900,897 (GRCm39) |
M89T |
possibly damaging |
Het |
| Slco4a1 |
T |
A |
2: 180,113,856 (GRCm39) |
V431E |
possibly damaging |
Het |
| Smg1 |
C |
T |
7: 117,752,131 (GRCm39) |
C2698Y |
unknown |
Het |
| Sptlc2 |
C |
T |
12: 87,397,151 (GRCm39) |
D212N |
probably benign |
Het |
| St6galnac1 |
T |
C |
11: 116,657,899 (GRCm39) |
T334A |
possibly damaging |
Het |
| Stim2 |
A |
T |
5: 54,156,263 (GRCm39) |
D13V |
possibly damaging |
Het |
| Syne1 |
A |
G |
10: 5,181,592 (GRCm39) |
W4248R |
probably damaging |
Het |
| Tanc1 |
T |
C |
2: 59,627,953 (GRCm39) |
Y584H |
probably benign |
Het |
| Thoc6 |
C |
A |
17: 23,892,634 (GRCm39) |
|
probably null |
Het |
| Trim30a |
T |
A |
7: 104,078,533 (GRCm39) |
N181I |
possibly damaging |
Het |
| Tshz3 |
A |
G |
7: 36,469,994 (GRCm39) |
D661G |
probably benign |
Het |
| Ttll8 |
C |
A |
15: 88,799,630 (GRCm39) |
V604L |
probably damaging |
Het |
| Ubtfl1 |
A |
G |
9: 18,320,931 (GRCm39) |
D153G |
probably damaging |
Het |
| Ufsp2 |
C |
A |
8: 46,436,661 (GRCm39) |
N137K |
probably benign |
Het |
| Ugt2a3 |
A |
G |
5: 87,473,393 (GRCm39) |
I508T |
possibly damaging |
Het |
| Uso1 |
G |
A |
5: 92,306,324 (GRCm39) |
E94K |
probably benign |
Het |
| Usp54 |
A |
G |
14: 20,611,310 (GRCm39) |
S1169P |
probably benign |
Het |
| Vmn1r235 |
C |
T |
17: 21,482,292 (GRCm39) |
P206S |
probably benign |
Het |
| Vmn1r69 |
T |
C |
7: 10,314,995 (GRCm39) |
|
probably benign |
Het |
| Zfp263 |
T |
A |
16: 3,567,255 (GRCm39) |
C523* |
probably null |
Het |
| Zfp799 |
G |
T |
17: 33,039,210 (GRCm39) |
T352K |
probably benign |
Het |
| Zfr |
T |
A |
15: 12,180,724 (GRCm39) |
V951E |
probably damaging |
Het |
| Zfyve26 |
T |
C |
12: 79,330,926 (GRCm39) |
D431G |
probably benign |
Het |
| Zswim9 |
C |
A |
7: 12,993,664 (GRCm39) |
A831S |
probably damaging |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTTTTCCTAAAAGAAGGTCCTTGG -3'
(R):5'- ACTGAGTCAGAAGTGCCAGAC -3'
Sequencing Primer
(F):5'- GGTATTACAAAGCTGCCCTATGC -3'
(R):5'- AGACCCTGCTGACAGTCTTG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation