Incidental Mutation 'R7135:Or4g16'
ID 552977
Institutional Source Beutler Lab
Gene Symbol Or4g16
Ensembl Gene ENSMUSG00000109813
Gene Name olfactory receptor family 4 subfamily G member 16
Synonyms Olfr1279, MOR245-12, GA_x6K02T2Q125-72357646-72358581
MMRRC Submission 045247-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.165) question?
Stock # R7135 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 111136546-111137487 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 111137365 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 272 (F272I)
Ref Sequence ENSEMBL: ENSMUSP00000149972 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090329] [ENSMUST00000213823] [ENSMUST00000216697]
AlphaFold Q8VF38
Predicted Effect probably benign
Transcript: ENSMUST00000090329
AA Change: F274I

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000087801
Gene: ENSMUSG00000109813
AA Change: F274I

DomainStartEndE-ValueType
Pfam:7tm_4 33 306 1.7e-44 PFAM
Pfam:7TM_GPCR_Srsx 36 300 3.2e-5 PFAM
Pfam:7tm_1 43 289 7.4e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213823
AA Change: F272I

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000216697
AA Change: F272I

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (83/83)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 T A 17: 45,819,887 (GRCm39) Y221* probably null Het
AC166344.1 T A 14: 43,158,245 (GRCm39) F97I Het
Ankmy2 T C 12: 36,246,311 (GRCm39) S412P probably benign Het
Ap1s3 T C 1: 79,586,919 (GRCm39) T144A probably benign Het
Armh2 T C 13: 24,925,489 (GRCm39) S78P probably benign Het
Asb3 T A 11: 30,948,501 (GRCm39) L59* probably null Het
Asxl3 G T 18: 22,650,758 (GRCm39) G916* probably null Het
Asxl3 G C 18: 22,650,759 (GRCm39) G916A probably damaging Het
Birc2 A C 9: 7,818,762 (GRCm39) F610V probably damaging Het
Camk4 G A 18: 33,240,996 (GRCm39) probably null Het
Ccdc162 A G 10: 41,549,855 (GRCm39) S343P probably benign Het
Ccnk T A 12: 108,152,734 (GRCm39) L17Q probably damaging Het
Cd59b G A 2: 103,914,792 (GRCm39) W63* probably null Het
Chrm3 C T 13: 9,927,837 (GRCm39) V400I probably benign Het
Crb1 C A 1: 139,171,105 (GRCm39) V762F probably damaging Het
Cspp1 C T 1: 10,159,161 (GRCm39) T529I possibly damaging Het
Cttnbp2 A G 6: 18,448,446 (GRCm39) I71T possibly damaging Het
Cyb561 C A 11: 105,826,393 (GRCm39) G90V probably damaging Het
Cyld T A 8: 89,471,520 (GRCm39) D804E possibly damaging Het
Ddx31 G A 2: 28,738,318 (GRCm39) V160I probably benign Het
Dgkg T C 16: 22,319,132 (GRCm39) D643G probably damaging Het
Dnah12 G A 14: 26,500,869 (GRCm39) probably null Het
Dnah12 T G 14: 26,523,370 (GRCm39) I1953S probably damaging Het
Dnah7b T C 1: 46,178,870 (GRCm39) W848R probably damaging Het
Dnah7c C T 1: 46,572,368 (GRCm39) T947M probably damaging Het
Dnmt3c C A 2: 153,556,872 (GRCm39) probably null Het
Dsp A T 13: 38,363,049 (GRCm39) Y443F probably damaging Het
Espl1 T A 15: 102,227,959 (GRCm39) C1603* probably null Het
Faiml G T 9: 99,116,496 (GRCm39) R65S probably benign Het
Gfpt2 T C 11: 49,695,782 (GRCm39) I4T probably damaging Het
Gm10376 T A 14: 42,867,950 (GRCm39) M179L probably benign Het
Gm4302 T A 10: 100,177,589 (GRCm39) M291K unknown Het
Gnb1l T A 16: 18,363,918 (GRCm39) D154E probably benign Het
Igkv10-94 T C 6: 68,681,727 (GRCm39) R38G possibly damaging Het
Inmt A T 6: 55,148,013 (GRCm39) Y205* probably null Het
Krba1 A G 6: 48,393,233 (GRCm39) Q1049R probably benign Het
Lpxn T A 19: 12,810,683 (GRCm39) C376S probably damaging Het
Lrrc52 T A 1: 167,294,019 (GRCm39) I89F probably damaging Het
Map9 A T 3: 82,270,765 (GRCm39) T110S probably benign Het
Mccc1 T C 3: 36,049,967 (GRCm39) Y75C probably damaging Het
Mff T A 1: 82,724,812 (GRCm39) L203* probably null Het
Micall1 C A 15: 78,993,624 (GRCm39) D47E unknown Het
Mink1 T C 11: 70,494,329 (GRCm39) F243S probably damaging Het
Mlycd C T 8: 120,129,216 (GRCm39) R228W probably damaging Het
Msr1 A T 8: 40,042,465 (GRCm39) V370E possibly damaging Het
Naip6 T C 13: 100,436,927 (GRCm39) E532G probably damaging Het
Nepn G A 10: 52,267,815 (GRCm39) C27Y probably damaging Het
Ninl T C 2: 150,797,524 (GRCm39) H592R probably benign Het
Nr4a2 A G 2: 57,002,261 (GRCm39) M64T possibly damaging Het
Oprm1 A T 10: 6,780,203 (GRCm39) I171F possibly damaging Het
Or5p60 T C 7: 107,723,781 (GRCm39) K230E probably damaging Het
Pcbp1 A T 6: 86,502,488 (GRCm39) M137K possibly damaging Het
Pcf11 A T 7: 92,306,524 (GRCm39) S1215T probably benign Het
Pdlim5 A T 3: 142,017,683 (GRCm39) probably null Het
Pecam1 T C 11: 106,579,857 (GRCm39) I402V probably damaging Het
Pex12 T C 11: 83,188,468 (GRCm39) T176A probably benign Het
Phf3 T C 1: 30,870,190 (GRCm39) K286R possibly damaging Het
Pik3ap1 T A 19: 41,320,760 (GRCm39) D153V probably damaging Het
Pkhd1l1 T A 15: 44,448,374 (GRCm39) probably null Het
Plekhn1 A G 4: 156,307,792 (GRCm39) V378A probably benign Het
Pramel26 A T 4: 143,537,233 (GRCm39) L366Q probably damaging Het
Ptprm A T 17: 67,251,283 (GRCm39) D531E possibly damaging Het
Pum2 A T 12: 8,778,952 (GRCm39) Q508L possibly damaging Het
Rad54l A G 4: 115,963,027 (GRCm39) S324P probably damaging Het
Recql5 C T 11: 115,821,498 (GRCm39) probably null Het
Reln A T 5: 22,181,594 (GRCm39) V1763D possibly damaging Het
Rp1 T C 1: 4,418,391 (GRCm39) N907S possibly damaging Het
Scaf11 T A 15: 96,318,209 (GRCm39) N452Y possibly damaging Het
Scgb2b3 T A 7: 31,059,639 (GRCm39) H45L possibly damaging Het
Sim1 A G 10: 50,772,023 (GRCm39) T11A probably damaging Het
Slc5a12 T A 2: 110,447,059 (GRCm39) M189K possibly damaging Het
Slco2b1 C T 7: 99,344,270 (GRCm39) G10S probably null Het
Speer1j C T 5: 11,555,198 (GRCm39) P83S probably damaging Het
Stxbp3 A G 3: 108,708,071 (GRCm39) L410P probably damaging Het
Sugct T C 13: 17,476,594 (GRCm39) N297D probably benign Het
Syne1 A G 10: 5,183,409 (GRCm39) I4132T probably benign Het
Teddm1b A T 1: 153,750,912 (GRCm39) L240F probably damaging Het
Tlr5 C A 1: 182,803,088 (GRCm39) D797E possibly damaging Het
Tmprss13 G T 9: 45,249,643 (GRCm39) G327C probably damaging Het
Tnrc18 G T 5: 142,773,572 (GRCm39) A419D Het
Ttc28 T C 5: 111,427,873 (GRCm39) Y1790H probably damaging Het
Vmn1r125 T G 7: 21,006,327 (GRCm39) M75R probably damaging Het
Vwa3a T A 7: 120,372,253 (GRCm39) D276E possibly damaging Het
Wdfy3 C T 5: 102,063,303 (GRCm39) V1322M probably damaging Het
Wdr11 T C 7: 129,229,830 (GRCm39) S872P possibly damaging Het
Zc3h13 T C 14: 75,559,161 (GRCm39) S357P unknown Het
Other mutations in Or4g16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01095:Or4g16 APN 2 111,136,966 (GRCm39) missense probably benign 0.19
IGL01355:Or4g16 APN 2 111,137,438 (GRCm39) missense probably benign 0.00
IGL01864:Or4g16 APN 2 111,137,400 (GRCm39) missense probably damaging 1.00
IGL02160:Or4g16 APN 2 111,137,143 (GRCm39) missense probably benign 0.02
IGL02183:Or4g16 APN 2 111,136,763 (GRCm39) missense probably damaging 0.98
PIT4377001:Or4g16 UTSW 2 111,137,225 (GRCm39) missense probably damaging 1.00
R0280:Or4g16 UTSW 2 111,137,417 (GRCm39) missense possibly damaging 0.48
R0636:Or4g16 UTSW 2 111,136,757 (GRCm39) missense probably benign 0.06
R0732:Or4g16 UTSW 2 111,137,325 (GRCm39) nonsense probably null
R1661:Or4g16 UTSW 2 111,137,116 (GRCm39) missense probably damaging 1.00
R1665:Or4g16 UTSW 2 111,137,116 (GRCm39) missense probably damaging 1.00
R2251:Or4g16 UTSW 2 111,136,655 (GRCm39) missense probably damaging 1.00
R2252:Or4g16 UTSW 2 111,136,655 (GRCm39) missense probably damaging 1.00
R2253:Or4g16 UTSW 2 111,136,655 (GRCm39) missense probably damaging 1.00
R2473:Or4g16 UTSW 2 111,137,236 (GRCm39) missense probably damaging 1.00
R3408:Or4g16 UTSW 2 111,136,850 (GRCm39) missense probably damaging 1.00
R5020:Or4g16 UTSW 2 111,136,637 (GRCm39) missense probably benign 0.01
R5634:Or4g16 UTSW 2 111,137,437 (GRCm39) missense probably benign
R5647:Or4g16 UTSW 2 111,137,392 (GRCm39) missense possibly damaging 0.67
R6782:Or4g16 UTSW 2 111,137,090 (GRCm39) missense probably damaging 1.00
R6911:Or4g16 UTSW 2 111,136,618 (GRCm39) missense probably benign 0.00
R7167:Or4g16 UTSW 2 111,136,793 (GRCm39) missense probably benign 0.10
R7452:Or4g16 UTSW 2 111,137,266 (GRCm39) missense probably damaging 1.00
R7563:Or4g16 UTSW 2 111,137,134 (GRCm39) missense probably benign 0.00
R7582:Or4g16 UTSW 2 111,136,793 (GRCm39) missense probably damaging 0.97
R8949:Or4g16 UTSW 2 111,137,379 (GRCm39) missense probably damaging 1.00
X0021:Or4g16 UTSW 2 111,136,933 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACAACTGGCGTGCACTGATG -3'
(R):5'- TGTGTCTCAGTGGAACCTTC -3'

Sequencing Primer
(F):5'- TGGCGTGCACTGATGGAGAC -3'
(R):5'- TGTCTCAGTGGAACCTTCTAATATAC -3'
Posted On 2019-05-15