Incidental Mutation 'R7135:Sugct'
ID 553023
Institutional Source Beutler Lab
Gene Symbol Sugct
Ensembl Gene ENSMUSG00000055137
Gene Name succinyl-CoA glutarate-CoA transferase
Synonyms 5033411D12Rik
MMRRC Submission 045247-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.094) question?
Stock # R7135 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 17032057-17869380 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 17476594 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 297 (N297D)
Ref Sequence ENSEMBL: ENSMUSP00000070759 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068545]
AlphaFold Q7TNE1
Predicted Effect probably benign
Transcript: ENSMUST00000068545
AA Change: N297D

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000070759
Gene: ENSMUSG00000055137
AA Change: N297D

DomainStartEndE-ValueType
low complexity region 12 28 N/A INTRINSIC
Pfam:CoA_transf_3 39 406 3.4e-127 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (83/83)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 T A 17: 45,819,887 (GRCm39) Y221* probably null Het
AC166344.1 T A 14: 43,158,245 (GRCm39) F97I Het
Ankmy2 T C 12: 36,246,311 (GRCm39) S412P probably benign Het
Ap1s3 T C 1: 79,586,919 (GRCm39) T144A probably benign Het
Armh2 T C 13: 24,925,489 (GRCm39) S78P probably benign Het
Asb3 T A 11: 30,948,501 (GRCm39) L59* probably null Het
Asxl3 G T 18: 22,650,758 (GRCm39) G916* probably null Het
Asxl3 G C 18: 22,650,759 (GRCm39) G916A probably damaging Het
Birc2 A C 9: 7,818,762 (GRCm39) F610V probably damaging Het
Camk4 G A 18: 33,240,996 (GRCm39) probably null Het
Ccdc162 A G 10: 41,549,855 (GRCm39) S343P probably benign Het
Ccnk T A 12: 108,152,734 (GRCm39) L17Q probably damaging Het
Cd59b G A 2: 103,914,792 (GRCm39) W63* probably null Het
Chrm3 C T 13: 9,927,837 (GRCm39) V400I probably benign Het
Crb1 C A 1: 139,171,105 (GRCm39) V762F probably damaging Het
Cspp1 C T 1: 10,159,161 (GRCm39) T529I possibly damaging Het
Cttnbp2 A G 6: 18,448,446 (GRCm39) I71T possibly damaging Het
Cyb561 C A 11: 105,826,393 (GRCm39) G90V probably damaging Het
Cyld T A 8: 89,471,520 (GRCm39) D804E possibly damaging Het
Ddx31 G A 2: 28,738,318 (GRCm39) V160I probably benign Het
Dgkg T C 16: 22,319,132 (GRCm39) D643G probably damaging Het
Dnah12 G A 14: 26,500,869 (GRCm39) probably null Het
Dnah12 T G 14: 26,523,370 (GRCm39) I1953S probably damaging Het
Dnah7b T C 1: 46,178,870 (GRCm39) W848R probably damaging Het
Dnah7c C T 1: 46,572,368 (GRCm39) T947M probably damaging Het
Dnmt3c C A 2: 153,556,872 (GRCm39) probably null Het
Dsp A T 13: 38,363,049 (GRCm39) Y443F probably damaging Het
Espl1 T A 15: 102,227,959 (GRCm39) C1603* probably null Het
Faiml G T 9: 99,116,496 (GRCm39) R65S probably benign Het
Gfpt2 T C 11: 49,695,782 (GRCm39) I4T probably damaging Het
Gm10376 T A 14: 42,867,950 (GRCm39) M179L probably benign Het
Gm4302 T A 10: 100,177,589 (GRCm39) M291K unknown Het
Gnb1l T A 16: 18,363,918 (GRCm39) D154E probably benign Het
Igkv10-94 T C 6: 68,681,727 (GRCm39) R38G possibly damaging Het
Inmt A T 6: 55,148,013 (GRCm39) Y205* probably null Het
Krba1 A G 6: 48,393,233 (GRCm39) Q1049R probably benign Het
Lpxn T A 19: 12,810,683 (GRCm39) C376S probably damaging Het
Lrrc52 T A 1: 167,294,019 (GRCm39) I89F probably damaging Het
Map9 A T 3: 82,270,765 (GRCm39) T110S probably benign Het
Mccc1 T C 3: 36,049,967 (GRCm39) Y75C probably damaging Het
Mff T A 1: 82,724,812 (GRCm39) L203* probably null Het
Micall1 C A 15: 78,993,624 (GRCm39) D47E unknown Het
Mink1 T C 11: 70,494,329 (GRCm39) F243S probably damaging Het
Mlycd C T 8: 120,129,216 (GRCm39) R228W probably damaging Het
Msr1 A T 8: 40,042,465 (GRCm39) V370E possibly damaging Het
Naip6 T C 13: 100,436,927 (GRCm39) E532G probably damaging Het
Nepn G A 10: 52,267,815 (GRCm39) C27Y probably damaging Het
Ninl T C 2: 150,797,524 (GRCm39) H592R probably benign Het
Nr4a2 A G 2: 57,002,261 (GRCm39) M64T possibly damaging Het
Oprm1 A T 10: 6,780,203 (GRCm39) I171F possibly damaging Het
Or4g16 T A 2: 111,137,365 (GRCm39) F272I probably benign Het
Or5p60 T C 7: 107,723,781 (GRCm39) K230E probably damaging Het
Pcbp1 A T 6: 86,502,488 (GRCm39) M137K possibly damaging Het
Pcf11 A T 7: 92,306,524 (GRCm39) S1215T probably benign Het
Pdlim5 A T 3: 142,017,683 (GRCm39) probably null Het
Pecam1 T C 11: 106,579,857 (GRCm39) I402V probably damaging Het
Pex12 T C 11: 83,188,468 (GRCm39) T176A probably benign Het
Phf3 T C 1: 30,870,190 (GRCm39) K286R possibly damaging Het
Pik3ap1 T A 19: 41,320,760 (GRCm39) D153V probably damaging Het
Pkhd1l1 T A 15: 44,448,374 (GRCm39) probably null Het
Plekhn1 A G 4: 156,307,792 (GRCm39) V378A probably benign Het
Pramel26 A T 4: 143,537,233 (GRCm39) L366Q probably damaging Het
Ptprm A T 17: 67,251,283 (GRCm39) D531E possibly damaging Het
Pum2 A T 12: 8,778,952 (GRCm39) Q508L possibly damaging Het
Rad54l A G 4: 115,963,027 (GRCm39) S324P probably damaging Het
Recql5 C T 11: 115,821,498 (GRCm39) probably null Het
Reln A T 5: 22,181,594 (GRCm39) V1763D possibly damaging Het
Rp1 T C 1: 4,418,391 (GRCm39) N907S possibly damaging Het
Scaf11 T A 15: 96,318,209 (GRCm39) N452Y possibly damaging Het
Scgb2b3 T A 7: 31,059,639 (GRCm39) H45L possibly damaging Het
Sim1 A G 10: 50,772,023 (GRCm39) T11A probably damaging Het
Slc5a12 T A 2: 110,447,059 (GRCm39) M189K possibly damaging Het
Slco2b1 C T 7: 99,344,270 (GRCm39) G10S probably null Het
Speer1j C T 5: 11,555,198 (GRCm39) P83S probably damaging Het
Stxbp3 A G 3: 108,708,071 (GRCm39) L410P probably damaging Het
Syne1 A G 10: 5,183,409 (GRCm39) I4132T probably benign Het
Teddm1b A T 1: 153,750,912 (GRCm39) L240F probably damaging Het
Tlr5 C A 1: 182,803,088 (GRCm39) D797E possibly damaging Het
Tmprss13 G T 9: 45,249,643 (GRCm39) G327C probably damaging Het
Tnrc18 G T 5: 142,773,572 (GRCm39) A419D Het
Ttc28 T C 5: 111,427,873 (GRCm39) Y1790H probably damaging Het
Vmn1r125 T G 7: 21,006,327 (GRCm39) M75R probably damaging Het
Vwa3a T A 7: 120,372,253 (GRCm39) D276E possibly damaging Het
Wdfy3 C T 5: 102,063,303 (GRCm39) V1322M probably damaging Het
Wdr11 T C 7: 129,229,830 (GRCm39) S872P possibly damaging Het
Zc3h13 T C 14: 75,559,161 (GRCm39) S357P unknown Het
Other mutations in Sugct
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00725:Sugct APN 13 17,837,357 (GRCm39) missense probably damaging 1.00
IGL00917:Sugct APN 13 17,032,503 (GRCm39) nonsense probably null
IGL02118:Sugct APN 13 17,627,105 (GRCm39) nonsense probably null
IGL02267:Sugct APN 13 17,819,450 (GRCm39) missense possibly damaging 0.94
IGL02285:Sugct APN 13 17,847,181 (GRCm39) missense possibly damaging 0.51
IGL02412:Sugct APN 13 17,837,386 (GRCm39) missense probably damaging 1.00
IGL02420:Sugct APN 13 17,627,053 (GRCm39) missense probably damaging 1.00
IGL02703:Sugct APN 13 17,627,125 (GRCm39) missense possibly damaging 0.94
IGL03098:Sugct UTSW 13 17,846,321 (GRCm39) missense probably damaging 1.00
R0024:Sugct UTSW 13 17,032,454 (GRCm39) missense probably benign 0.01
R0024:Sugct UTSW 13 17,032,454 (GRCm39) missense probably benign 0.01
R0058:Sugct UTSW 13 17,847,166 (GRCm39) missense probably damaging 1.00
R1472:Sugct UTSW 13 17,627,131 (GRCm39) missense probably benign 0.26
R1709:Sugct UTSW 13 17,847,151 (GRCm39) missense probably damaging 0.99
R1780:Sugct UTSW 13 17,627,039 (GRCm39) splice site probably null
R2189:Sugct UTSW 13 17,836,851 (GRCm39) missense probably benign 0.09
R4420:Sugct UTSW 13 17,627,130 (GRCm39) missense probably damaging 1.00
R4763:Sugct UTSW 13 17,837,372 (GRCm39) missense probably damaging 1.00
R5197:Sugct UTSW 13 17,497,861 (GRCm39) missense probably damaging 0.99
R5310:Sugct UTSW 13 17,427,145 (GRCm39) nonsense probably null
R5401:Sugct UTSW 13 17,032,455 (GRCm39) missense probably damaging 1.00
R6695:Sugct UTSW 13 17,497,815 (GRCm39) missense possibly damaging 0.94
R6962:Sugct UTSW 13 17,032,606 (GRCm39) splice site probably null
R6991:Sugct UTSW 13 17,728,965 (GRCm39) missense probably benign 0.23
R7141:Sugct UTSW 13 17,819,372 (GRCm39) missense possibly damaging 0.76
R7367:Sugct UTSW 13 17,819,399 (GRCm39) missense probably damaging 0.97
R7753:Sugct UTSW 13 17,752,104 (GRCm39) missense possibly damaging 0.79
R8053:Sugct UTSW 13 17,476,554 (GRCm39) missense probably damaging 1.00
R8234:Sugct UTSW 13 17,032,459 (GRCm39) missense probably benign 0.01
R8336:Sugct UTSW 13 17,032,504 (GRCm39) missense probably benign 0.30
R8351:Sugct UTSW 13 17,427,143 (GRCm39) missense probably damaging 1.00
R8451:Sugct UTSW 13 17,427,143 (GRCm39) missense probably damaging 1.00
R8826:Sugct UTSW 13 17,427,180 (GRCm39) critical splice acceptor site probably null
R9102:Sugct UTSW 13 17,497,833 (GRCm39) missense probably benign 0.15
R9231:Sugct UTSW 13 17,627,071 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTTCAAAATGCAGGAAGGC -3'
(R):5'- TGCCCTTAAGATATATGTTGGCCG -3'

Sequencing Primer
(F):5'- AGGCATACATAGGTCTCTGACTG -3'
(R):5'- AGGTACTCTCATATAACTGACAAGAG -3'
Posted On 2019-05-15