Incidental Mutation 'R7137:Slc22a2'
ID 553152
Institutional Source Beutler Lab
Gene Symbol Slc22a2
Ensembl Gene ENSMUSG00000040966
Gene Name solute carrier family 22 (organic cation transporter), member 2
Synonyms Oct2, Orct2
MMRRC Submission 045248-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7137 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 12803076-12847376 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12803228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 21 (T21A)
Ref Sequence ENSEMBL: ENSMUSP00000041186 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046959]
AlphaFold O70577
Predicted Effect probably benign
Transcript: ENSMUST00000046959
AA Change: T21A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000041186
Gene: ENSMUSG00000040966
AA Change: T21A

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Pfam:Sugar_tr 80 528 7.6e-37 PFAM
Pfam:MFS_1 134 398 3.5e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knockout allele are viable and fertile and display no obvious phenotypic abnormalities. No significant defects in the renal secretion of a model organic cation are observed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,654,944 (GRCm39) S1423P possibly damaging Het
Acvr1c A G 2: 58,173,399 (GRCm39) probably null Het
Adgrf5 A G 17: 43,761,788 (GRCm39) K1161R probably damaging Het
Aoc1l3 A G 6: 48,967,083 (GRCm39) Y677C probably damaging Het
Arhgap32 T G 9: 32,063,232 (GRCm39) D80E probably benign Het
Aspg T C 12: 112,078,632 (GRCm39) V30A possibly damaging Het
Bcl2a1d T C 9: 88,613,531 (GRCm39) D81G probably damaging Het
Cep170b T C 12: 112,701,601 (GRCm39) V160A probably benign Het
Ces1c T C 8: 93,857,470 (GRCm39) Y37C probably benign Het
Cntnap5a T C 1: 116,017,106 (GRCm39) L233P probably damaging Het
Crem C A 18: 3,273,459 (GRCm39) A245S possibly damaging Het
Cyp2d12 C T 15: 82,442,022 (GRCm39) A280V probably benign Het
Dnah2 C T 11: 69,382,381 (GRCm39) G1243D probably damaging Het
Eif1ad19 A T 12: 87,740,316 (GRCm39) L81Q possibly damaging Het
Emcn T G 3: 137,109,752 (GRCm39) N131K probably damaging Het
Fat3 A T 9: 15,908,444 (GRCm39) D2519E probably damaging Het
Fibin T A 2: 110,193,001 (GRCm39) D47V probably damaging Het
Fsd1 G A 17: 56,300,876 (GRCm39) R245H probably damaging Het
Gimap8 C A 6: 48,627,187 (GRCm39) L54I probably damaging Het
Gm20481 A G 17: 35,189,071 (GRCm39) Y27C unknown Het
Grin1 T G 2: 25,203,550 (GRCm39) M154L probably benign Het
Ighv8-13 A G 12: 115,729,197 (GRCm39) L20P probably damaging Het
Insc G A 7: 114,410,850 (GRCm39) V236I probably benign Het
Lrrk1 A G 7: 65,935,027 (GRCm39) F1031L probably benign Het
Man2a2 C A 7: 80,009,499 (GRCm39) R785L probably benign Het
Mcur1 C A 13: 43,697,931 (GRCm39) probably null Het
Med12l A C 3: 59,165,675 (GRCm39) R1464S probably damaging Het
Mycbp2 A T 14: 103,520,115 (GRCm39) M767K possibly damaging Het
Naalad2 T C 9: 18,234,783 (GRCm39) I762V probably benign Het
Nfkbid A G 7: 30,125,681 (GRCm39) T357A possibly damaging Het
Pcdh17 A G 14: 84,770,989 (GRCm39) R1156G possibly damaging Het
Pcdhb1 T C 18: 37,400,445 (GRCm39) S799P possibly damaging Het
Pde3a A T 6: 141,444,472 (GRCm39) E1093D probably benign Het
Plcg1 T C 2: 160,595,846 (GRCm39) Y572H possibly damaging Het
Plxna4 A G 6: 32,494,199 (GRCm39) L139P probably damaging Het
Psma1 A G 7: 113,873,683 (GRCm39) Y6H probably damaging Het
Psmd2 A G 16: 20,471,377 (GRCm39) E76G probably benign Het
Ptk2 G A 15: 73,093,658 (GRCm39) P854S possibly damaging Het
Pyy T G 11: 101,998,099 (GRCm39) D27A possibly damaging Het
Slc25a2 T C 18: 37,771,200 (GRCm39) I110V probably benign Het
Sult1c2 A C 17: 54,145,422 (GRCm39) W85G probably damaging Het
Syt12 C T 19: 4,503,978 (GRCm39) D218N probably damaging Het
Tln1 C T 4: 43,540,616 (GRCm39) V1462M probably damaging Het
Tor1aip2 T A 1: 155,927,722 (GRCm39) N33K possibly damaging Het
Usp17lb C A 7: 104,490,798 (GRCm39) W43L probably benign Het
Vmn1r76 A G 7: 11,664,612 (GRCm39) Y201H possibly damaging Het
Wnk1 C A 6: 120,015,173 (GRCm39) probably benign Het
Wrnip1 A G 13: 32,986,732 (GRCm39) D171G probably benign Het
Zar1 T A 5: 72,738,159 (GRCm39) N81I probably damaging Het
Zbtb45 T C 7: 12,741,083 (GRCm39) T392A probably benign Het
Zfp445 T C 9: 122,683,843 (GRCm39) E272G probably damaging Het
Other mutations in Slc22a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Slc22a2 APN 17 12,827,305 (GRCm39) missense possibly damaging 0.79
IGL00658:Slc22a2 APN 17 12,834,202 (GRCm39) missense probably benign 0.37
IGL01073:Slc22a2 APN 17 12,803,236 (GRCm39) missense probably benign 0.00
IGL01573:Slc22a2 APN 17 12,824,848 (GRCm39) missense probably damaging 0.99
IGL02000:Slc22a2 APN 17 12,803,270 (GRCm39) missense possibly damaging 0.77
IGL02943:Slc22a2 APN 17 12,828,948 (GRCm39) missense probably damaging 1.00
IGL03301:Slc22a2 APN 17 12,824,926 (GRCm39) missense probably damaging 1.00
R0492:Slc22a2 UTSW 17 12,834,159 (GRCm39) missense probably benign 0.00
R0835:Slc22a2 UTSW 17 12,831,318 (GRCm39) missense probably benign 0.01
R1330:Slc22a2 UTSW 17 12,805,699 (GRCm39) missense possibly damaging 0.94
R1432:Slc22a2 UTSW 17 12,803,195 (GRCm39) missense possibly damaging 0.89
R1559:Slc22a2 UTSW 17 12,803,298 (GRCm39) missense probably damaging 1.00
R1855:Slc22a2 UTSW 17 12,805,699 (GRCm39) missense probably damaging 0.99
R1884:Slc22a2 UTSW 17 12,833,713 (GRCm39) splice site probably benign
R2042:Slc22a2 UTSW 17 12,818,012 (GRCm39) missense probably benign 0.01
R2197:Slc22a2 UTSW 17 12,817,949 (GRCm39) missense probably damaging 1.00
R2255:Slc22a2 UTSW 17 12,818,062 (GRCm39) missense probably damaging 1.00
R2271:Slc22a2 UTSW 17 12,805,692 (GRCm39) missense probably benign
R4003:Slc22a2 UTSW 17 12,831,337 (GRCm39) missense probably benign 0.01
R4021:Slc22a2 UTSW 17 12,803,376 (GRCm39) missense probably damaging 1.00
R4093:Slc22a2 UTSW 17 12,831,281 (GRCm39) missense probably damaging 1.00
R4404:Slc22a2 UTSW 17 12,833,651 (GRCm39) missense probably damaging 1.00
R4419:Slc22a2 UTSW 17 12,831,473 (GRCm39) nonsense probably null
R4564:Slc22a2 UTSW 17 12,828,943 (GRCm39) missense probably benign 0.08
R4866:Slc22a2 UTSW 17 12,803,316 (GRCm39) missense probably damaging 1.00
R4877:Slc22a2 UTSW 17 12,833,702 (GRCm39) missense possibly damaging 0.53
R5224:Slc22a2 UTSW 17 12,805,719 (GRCm39) missense probably damaging 0.97
R5668:Slc22a2 UTSW 17 12,827,296 (GRCm39) missense probably benign
R6326:Slc22a2 UTSW 17 12,831,297 (GRCm39) nonsense probably null
R7211:Slc22a2 UTSW 17 12,805,770 (GRCm39) critical splice donor site probably null
R7378:Slc22a2 UTSW 17 12,831,278 (GRCm39) missense probably damaging 1.00
R7521:Slc22a2 UTSW 17 12,805,710 (GRCm39) missense probably benign 0.14
R7524:Slc22a2 UTSW 17 12,824,944 (GRCm39) missense possibly damaging 0.87
R7735:Slc22a2 UTSW 17 12,828,917 (GRCm39) missense probably damaging 0.99
R8136:Slc22a2 UTSW 17 12,824,917 (GRCm39) missense probably damaging 1.00
R8671:Slc22a2 UTSW 17 12,824,863 (GRCm39) nonsense probably null
R8799:Slc22a2 UTSW 17 12,831,425 (GRCm39) missense probably benign 0.14
R8874:Slc22a2 UTSW 17 12,828,866 (GRCm39) missense probably benign 0.37
R9046:Slc22a2 UTSW 17 12,834,234 (GRCm39) missense probably null 0.15
R9220:Slc22a2 UTSW 17 12,838,757 (GRCm39) missense probably benign 0.03
R9367:Slc22a2 UTSW 17 12,824,837 (GRCm39) missense probably benign 0.19
R9410:Slc22a2 UTSW 17 12,805,732 (GRCm39) missense probably damaging 0.99
R9511:Slc22a2 UTSW 17 12,828,916 (GRCm39) missense probably damaging 0.98
R9580:Slc22a2 UTSW 17 12,803,177 (GRCm39) missense probably benign 0.00
Z1088:Slc22a2 UTSW 17 12,833,663 (GRCm39) missense probably benign 0.36
Z1176:Slc22a2 UTSW 17 12,803,512 (GRCm39) missense possibly damaging 0.79
Z1177:Slc22a2 UTSW 17 12,824,897 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGCTGGTCCCTCTCTAAATAAG -3'
(R):5'- CATACCTCATGCACTGGCTG -3'

Sequencing Primer
(F):5'- GGTCCCTCTCTAAATAAGCTAATGC -3'
(R):5'- CTCATGCACTGGCTGAGGAAG -3'
Posted On 2019-05-15