Mutagenetix > Incidental Mutations

Incidental Mutation 'R7140:Olfr1362'

553420

Institutional Source

Beutler Lab

Gene Symbol

Olfr1362

Ensembl Gene

ENSMUSG00000051258

Gene Name

olfactory receptor 1362

Synonyms

GA_x6K02T2QHY8-11628399-11628868, GA_x6K02T2QHY8-11617756-11618682, MOR256-8, Olfr1363-ps1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.134) question?

Stock #

R7140 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

21610978-21614022 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 21611127 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 281 (V281M)

Ref Sequence

ENSEMBL: ENSMUSP00000061660 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051874]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000051874
AA Change: V281M

PolyPhen 2 Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000061660
Gene: ENSMUSG00000051258
AA Change: V281M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	307	3.5e-51	PFAM
Pfam:7tm_1	41	290	9e-24	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

99% (70/71)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra2	T	C	8: 27,120,901		probably null	Het
Ap2a2	G	A	7: 141,598,864	A148T	probably benign	Het
Arhgef3	A	T	14: 27,401,707	N442Y	probably damaging	Het
B3gat3	A	G	19: 8,925,852	Y191C	probably damaging	Het
B430306N03Rik	A	T	17: 48,322,455	K203*	probably null	Het
C1qtnf6	T	A	15: 78,525,083	Y188F	probably benign	Het
Capn10	T	C	1: 92,945,271	V573A	possibly damaging	Het
Cbx4	T	C	11: 119,081,928	Y207C	probably damaging	Het
Ccdc43	G	T	11: 102,688,869		probably null	Het
Ccng2	C	A	5: 93,268,755	P45Q	probably benign	Het
Cd86	T	C	16: 36,620,901	H68R	probably benign	Het
Cmtm4	A	G	8: 104,355,195	Y187H	probably damaging	Het
Cst11	T	C	2: 148,768,729	N134S	probably benign	Het
Cyp3a25	A	T	5: 146,003,045	F51I	probably benign	Het
Dnhd1	A	G	7: 105,693,766	E1439G	probably benign	Het
Dock4	T	C	12: 40,636,159	V131A	probably benign	Het
Dpysl2	A	G	14: 66,862,533	S85P	probably benign	Het
Dync1i2	A	G	2: 71,247,939	H324R	probably benign	Het
Elf1	A	G	14: 79,567,270	D162G	probably benign	Het
Eri3	G	A	4: 117,649,407		probably null	Het
Fbxl21	T	C	13: 56,532,332	S203P	probably damaging	Het
Foxi1	G	A	11: 34,205,758	R291C	probably damaging	Het
Gm13089	T	G	4: 143,698,432	H147P	probably benign	Het
Gprin3	C	T	6: 59,355,143	A60T	possibly damaging	Het
Hecw1	A	G	13: 14,316,533	C212R	probably benign	Het
Hivep3	T	C	4: 120,097,121	L878P	probably damaging	Het
Hs6st3	A	T	14: 119,139,102	N230Y	probably damaging	Het
Htr3b	A	G	9: 48,937,141	V268A	possibly damaging	Het
Ip6k3	T	C	17: 27,144,995	T360A	probably damaging	Het
Izumo1	A	G	7: 45,626,112	T282A	probably benign	Het
Kidins220	T	A	12: 25,036,624	I1019N	probably damaging	Het
Med13l	T	C	5: 118,741,972	V1043A	probably benign	Het
Mon2	C	T	10: 123,035,453	V420I	probably benign	Het
Naip6	T	A	13: 100,300,200	Y605F	possibly damaging	Het
Nek7	A	G	1: 138,487,055	I285T	probably benign	Het
Notch3	A	G	17: 32,156,377	V357A	possibly damaging	Het
Nrxn1	G	A	17: 91,088,764		probably benign	Het
Nutm1	G	A	2: 112,250,056	R505C	probably damaging	Het
Olfr1009	T	A	2: 85,721,474	L23Q	probably damaging	Het
Olfr1200	G	A	2: 88,767,964	A117V	probably damaging	Het
Olfr821	T	G	10: 130,034,214	M196R	possibly damaging	Het
Ostm1	C	T	10: 42,683,272	A176V	probably null	Het
Pabpc6	C	A	17: 9,668,428	S398I	possibly damaging	Het
Pcdhac2	C	A	18: 37,144,186	P73H	possibly damaging	Het
Pcdhga9	A	G	18: 37,739,131	D671G	possibly damaging	Het
Peg10	GC	GCTCC	6: 4,756,452		probably benign	Het
Pigu	A	C	2: 155,301,240	L248R	possibly damaging	Het
Pinx1	C	A	14: 63,860,385		probably null	Het
Pon3	T	C	6: 5,221,664	N322S	possibly damaging	Het
Rnft1	A	G	11: 86,491,760	I270V	probably benign	Het
Scgb2b11	A	G	7: 32,210,581	F27L	probably damaging	Het
Slc5a4b	C	T	10: 76,075,109	V298I	probably damaging	Het
Slco1a6	T	A	6: 142,103,019	H345L	probably benign	Het
Sox1	C	T	8: 12,397,405	P349S	possibly damaging	Het
Spata31	A	G	13: 64,921,099	N354D	probably benign	Het
Speg	T	C	1: 75,406,770		probably null	Het
Stpg1	T	C	4: 135,533,722	I281T	probably benign	Het
Sult3a1	T	C	10: 33,877,287	L193P	probably damaging	Het
Tenm3	A	T	8: 48,292,236	C1097S	probably damaging	Het
Tfap2a	A	G	13: 40,730,047	S7P	probably benign	Het
Tlr1	T	C	5: 64,925,678	I519V	probably benign	Het
Tmem238	A	G	7: 4,789,073	V157A	possibly damaging	Het
Tmem45b	A	T	9: 31,434,484		probably null	Het
Togaram2	A	T	17: 71,714,766	H742L	probably benign	Het
Trpc7	A	T	13: 56,789,674	Y656*	probably null	Het
Wdr35	T	A	12: 9,022,785	Y920N	probably damaging	Het
Xab2	G	A	8: 3,618,117	R154C	possibly damaging	Het
Zfp759	A	T	13: 67,140,113	H576L	possibly damaging	Het
Zfp958	G	T	8: 4,628,481	A169S	probably benign	Het

Other mutations in Olfr1362

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00949:Olfr1362	APN	13	21611351	missense	probably damaging	0.99
R0070:Olfr1362	UTSW	13	21611261	missense	possibly damaging	0.60
R0070:Olfr1362	UTSW	13	21611261	missense	possibly damaging	0.60
R1458:Olfr1362	UTSW	13	21611822	missense	probably benign	0.37
R1587:Olfr1362	UTSW	13	21611913	missense	probably benign	0.01
R1588:Olfr1362	UTSW	13	21611913	missense	probably benign	0.01
R1607:Olfr1362	UTSW	13	21611764	missense	probably benign	0.04
R1708:Olfr1362	UTSW	13	21611070	missense	probably damaging	0.98
R4633:Olfr1362	UTSW	13	21611228	missense	probably damaging	0.99
R6223:Olfr1362	UTSW	13	21611366	missense	probably benign
R6229:Olfr1362	UTSW	13	21611649	missense	probably benign
R8385:Olfr1362	UTSW	13	21611352	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- ACCAAAAGAGTACTTCAGTGTGTC -3'
(R):5'- GGTGGAAATGTTGTCCTTCAC -3'

Sequencing Primer
(F):5'- CTTCAGTGTGTCTAATACATTAGCTG -3'
(R):5'- CTATGGTTACATTGCTGCAGC -3'

Posted On

2019-05-15