Mutagenetix > Incidental Mutations

Incidental Mutation 'R7142:Olfr1156'

553449

Institutional Source

Beutler Lab

Gene Symbol

Olfr1156

Ensembl Gene

ENSMUSG00000075144

Gene Name

olfactory receptor 1156

Synonyms

MOR174-3, GA_x6K02T2Q125-49433499-49432537

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R7142 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87947053-87953100 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 87949712 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 174 (I174V)

Ref Sequence

ENSEMBL: ENSMUSP00000149665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099842] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]

Predicted Effect

probably benign
Transcript: ENSMUST00000099842
AA Change: I174V

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000097430
Gene: ENSMUSG00000075144
AA Change: I174V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.2e-47	PFAM
Pfam:7tm_1	41	290	1.4e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215903

Predicted Effect

probably benign
Transcript: ENSMUST00000216191
AA Change: I174V

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)

Predicted Effect

probably benign
Transcript: ENSMUST00000216726
AA Change: I174V

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)

Meta Mutation Damage Score

0.2492

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

98% (63/64)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610008E11Rik	T	A	10: 79,067,612	H290L	probably damaging	Het
Abca1	T	A	4: 53,082,050	S737C	probably damaging	Het
Abca14	G	C	7: 120,251,183	V753L	possibly damaging	Het
Adgrl1	C	T	8: 83,937,200	H1099Y	probably benign	Het
Akap6	T	G	12: 52,887,364	D546E	probably benign	Het
Aldh1l1	G	A	6: 90,563,416	D228N	probably damaging	Het
Cacna1e	G	T	1: 154,412,484	Q1883K	probably damaging	Het
Caskin2	A	G	11: 115,806,736	Y125H	probably benign	Het
Ccdc85a	A	T	11: 28,577,192	Y139N	probably damaging	Het
Cd93	C	T	2: 148,441,805	W540*	probably null	Het
Cdh3	G	A	8: 106,545,228		probably null	Het
Chmp2b	G	A	16: 65,546,908	Q88*	probably null	Het
Cpt1a	T	C	19: 3,375,100	M489T	probably benign	Het
Ctsk	G	A	3: 95,506,948	V274M	possibly damaging	Het
Cyp3a44	A	G	5: 145,777,961	V460A	probably benign	Het
Cypt4	C	T	9: 24,625,444	R77*	probably null	Het
D6Ertd527e	C	G	6: 87,111,524	T223S	unknown	Het
Dnah7a	A	T	1: 53,413,768	Y3850*	probably null	Het
Drosha	A	T	15: 12,924,146	T1205S	possibly damaging	Het
Eif3j2	T	C	18: 43,477,400	E116G	probably damaging	Het
Ercc5	A	G	1: 44,174,214	E790G	probably damaging	Het
Fam163b	C	T	2: 27,113,555	R29Q	probably damaging	Het
Fbxo44	C	T	4: 148,158,812	G50E	unknown	Het
Foxo3	T	C	10: 42,274,595		probably null	Het
Gm9992	G	A	17: 7,376,622	T96I	probably damaging	Het
Gnal	C	T	18: 67,218,528	P386L	probably damaging	Het
Gpc5	T	A	14: 115,417,203	H478Q	probably benign	Het
Grhl2	A	T	15: 37,279,582	D178V	probably benign	Het
Gtf2i	C	A	5: 134,244,851	V755L	possibly damaging	Het
Hal	T	C	10: 93,500,651	V414A	possibly damaging	Het
Hmx2	T	C	7: 131,555,736	V193A	probably damaging	Het
Il17a	T	A	1: 20,732,103	M12K	probably benign	Het
Invs	T	A	4: 48,407,696	I557N	probably damaging	Het
Kng1	T	A	16: 23,079,420	H523Q	probably benign	Het
Lrp4	T	A	2: 91,494,994	I1388N	probably damaging	Het
Mboat4	A	G	8: 34,120,137	I63V	probably benign	Het
Mcoln2	G	A	3: 146,183,569		probably null	Het
Mgat5	A	T	1: 127,412,187	D435V	probably damaging	Het
Mri1	C	A	8: 84,257,124	R46L	probably damaging	Het
Mxra8	A	T	4: 155,843,062	Y409F	probably benign	Het
Nlrp1b	T	A	11: 71,172,075	R720*	probably null	Het
Ofcc1	T	C	13: 40,004,062	I887V	probably benign	Het
Otud4	T	A	8: 79,672,762		probably null	Het
P3h1	T	A	4: 119,247,161	D626E	probably benign	Het
Pde2a	A	T	7: 101,504,650	D485V	probably damaging	Het
Phldb2	G	A	16: 45,757,176	R1129*	probably null	Het
Pkn1	T	C	8: 83,693,967	E10G	possibly damaging	Het
Psd2	A	G	18: 35,980,044	D264G	possibly damaging	Het
Psg29	A	G	7: 17,210,621	D352G	probably damaging	Het
Rgs14	T	C	13: 55,379,604	S218P	probably damaging	Het
Sec14l2	T	C	11: 4,098,379	T380A	probably benign	Het
Sept12	T	C	16: 4,988,362	T312A	unknown	Het
Skint5	A	T	4: 113,571,594	V1075E	unknown	Het
Ston2	A	G	12: 91,647,235	S800P	probably damaging	Het
Tmem106b	A	G	6: 13,081,565	N157S	probably damaging	Het
Tmem132b	G	A	5: 125,622,673	G133S	probably damaging	Het
Tmie	A	T	9: 110,870,681	M55K	possibly damaging	Het
Trpc6	A	T	9: 8,653,016	R608*	probably null	Het
Usp35	A	G	7: 97,311,547	S891P	probably damaging	Het
Vmn1r178	A	G	7: 23,893,610	T28A	probably damaging	Het
Wnk1	T	A	6: 119,949,279	M1324L	probably benign	Het
Wrnip1	C	A	13: 32,802,633	S132R	possibly damaging	Het
Wsb1	T	C	11: 79,250,988	K68E	probably benign	Het
Zfp433	A	T	10: 81,720,206	K181*	probably null	Het

Other mutations in Olfr1156

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01396:Olfr1156	APN	2	87949863	missense	probably damaging	0.99
IGL02831:Olfr1156	APN	2	87949676	splice site	probably null
IGL03214:Olfr1156	APN	2	87950071	missense	probably benign	0.16
R0285:Olfr1156	UTSW	2	87950131	missense	probably damaging	0.98
R0926:Olfr1156	UTSW	2	87949922	missense	probably damaging	1.00
R0987:Olfr1156	UTSW	2	87949547	missense	probably benign	0.12
R1422:Olfr1156	UTSW	2	87950095	missense	probably benign	0.00
R1958:Olfr1156	UTSW	2	87949465	missense	probably damaging	1.00
R2239:Olfr1156	UTSW	2	87949397	missense	probably damaging	1.00
R2380:Olfr1156	UTSW	2	87949397	missense	probably damaging	1.00
R3872:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R3873:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R3874:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R4526:Olfr1156	UTSW	2	87949409	missense	probably benign	0.09
R5116:Olfr1156	UTSW	2	87949529	missense	probably benign	0.03
R5985:Olfr1156	UTSW	2	87949321	missense	probably benign	0.02
R5999:Olfr1156	UTSW	2	87949801	splice site	probably null
R6127:Olfr1156	UTSW	2	87949361	missense	probably damaging	1.00
R6259:Olfr1156	UTSW	2	87949435	missense	probably benign	0.20
R6544:Olfr1156	UTSW	2	87949991	missense	probably benign	0.35
R6556:Olfr1156	UTSW	2	87949976	missense	probably benign	0.00
R6715:Olfr1156	UTSW	2	87949991	missense	probably benign	0.35
R6951:Olfr1156	UTSW	2	87949979	missense	possibly damaging	0.79
R7062:Olfr1156	UTSW	2	87950224	missense	probably benign	0.01
R7749:Olfr1156	UTSW	2	87949478	missense	probably damaging	1.00
R7887:Olfr1156	UTSW	2	87949880	missense	probably damaging	1.00
R8222:Olfr1156	UTSW	2	87949444	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GACCATGATGACTGTGAGATGG -3'
(R):5'- AATGGCCTATGACCGCTTC -3'

Sequencing Primer
(F):5'- AGAAAAGGCTTTGCGTCTCC -3'
(R):5'- GACCGCTTCGTGGCCATTTG -3'

Posted On

2019-05-15