Mutagenetix > Incidental Mutation

Incidental Mutation 'R7143:Akap6'

553565

Institutional Source

Beutler Lab

Gene Symbol

Akap6

Ensembl Gene

ENSMUSG00000061603

Gene Name

A kinase (PRKA) anchor protein 6

Synonyms

MMRRC Submission

045222-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.868) question?

Stock #

R7143 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

52699383-53155599 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 52887364 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 546 (D546E)

Ref Sequence

ENSEMBL: ENSMUSP00000093406 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095737] [ENSMUST00000219786]

AlphaFold

E9Q9K8

Predicted Effect

probably benign
Transcript: ENSMUST00000095737
AA Change: D546E

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000093406
Gene: ENSMUSG00000061603
AA Change: D546E

Domain	Start	End	E-Value	Type
low complexity region	34	51	N/A	INTRINSIC
Blast:SPEC	66	168	2e-50	BLAST
low complexity region	441	455	N/A	INTRINSIC
low complexity region	544	555	N/A	INTRINSIC
low complexity region	569	587	N/A	INTRINSIC
low complexity region	640	651	N/A	INTRINSIC
low complexity region	694	708	N/A	INTRINSIC
SPEC	779	880	1.06e-1	SMART
SPEC	959	1057	1.45e0	SMART
SPEC	1078	1185	2.56e-2	SMART
low complexity region	1316	1332	N/A	INTRINSIC
low complexity region	1555	1568	N/A	INTRINSIC
low complexity region	1610	1622	N/A	INTRINSIC
low complexity region	1683	1698	N/A	INTRINSIC
low complexity region	1737	1781	N/A	INTRINSIC
low complexity region	1899	1910	N/A	INTRINSIC
low complexity region	2019	2031	N/A	INTRINSIC
low complexity region	2104	2115	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000219786
AA Change: D546E

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted disruption of this gene results in partial embryonic lethality; surviving homozygotes display a decreased body weight, craniofacial defects and reduced viability. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930516K23Rik	C	T	7: 104,059,215 (GRCm38)	C129Y	probably damaging	Het
Agbl4	A	G	4: 111,617,136 (GRCm38)	N374S	probably damaging	Het
Agl	A	G	3: 116,792,021 (GRCm38)	S153P	probably damaging	Het
Ankrd17	C	A	5: 90,285,961 (GRCm38)	A650S	possibly damaging	Het
Ankrd53	A	G	6: 83,762,911 (GRCm38)	R16G	possibly damaging	Het
Apba2	T	C	7: 64,744,417 (GRCm38)	L570P	probably damaging	Het
Asap1	A	G	15: 64,191,528 (GRCm38)	F101L	probably damaging	Het
Cadm4	T	A	7: 24,499,567 (GRCm38)	I89N	possibly damaging	Het
Cadps	C	T	14: 12,491,838 (GRCm38)	V771I	probably benign	Het
Cenph	A	G	13: 100,761,777 (GRCm38)	V206A	possibly damaging	Het
Cenpn	A	G	8: 116,937,227 (GRCm38)	T253A	probably benign	Het
Cep120	C	T	18: 53,683,385 (GRCm38)	G939R	probably benign	Het
Cfap57	G	A	4: 118,620,709 (GRCm38)		probably benign	Het
Clip1	T	C	5: 123,653,610 (GRCm38)	I166V	probably benign	Het
Cstf3	T	A	2: 104,646,616 (GRCm38)	V144E	probably benign	Het
Cyp21a1	T	A	17: 34,802,326 (GRCm38)	H357L	probably damaging	Het
Cyth3	T	A	5: 143,684,396 (GRCm38)	V12E	unknown	Het
Dgat2	T	C	7: 99,157,124 (GRCm38)	I289V	probably benign	Het
Dip2a	A	G	10: 76,297,791 (GRCm38)	C527R	probably damaging	Het
Dnah17	A	C	11: 118,086,130 (GRCm38)	W1879G	probably damaging	Het
Dnai2	A	G	11: 114,754,250 (GRCm38)	T504A	possibly damaging	Het
Efl1	C	T	7: 82,762,680 (GRCm38)	P759L	probably damaging	Het
Egfr	A	C	11: 16,871,627 (GRCm38)	I351L	probably benign	Het
Ercc6	G	A	14: 32,570,305 (GRCm38)	E1209K	probably damaging	Het
Fam135b	A	T	15: 71,479,151 (GRCm38)	M292K	probably benign	Het
Fbxl7	C	A	15: 26,543,158 (GRCm38)	V468L	probably benign	Het
Fhl2	G	T	1: 43,141,851 (GRCm38)	H60N	probably damaging	Het
G6pc1	G	T	11: 101,370,723 (GRCm38)	R83L	probably damaging	Het
Gata4	C	A	14: 63,204,617 (GRCm38)	R252L	probably damaging	Het
Glt8d1	T	A	14: 31,006,645 (GRCm38)	I10N	probably damaging	Het
Gm10803	T	A	2: 93,563,959 (GRCm38)	Y25*	probably null	Het
Gm19345	T	C	7: 19,857,834 (GRCm38)	F108S	unknown	Het
Gm4952	A	G	19: 12,618,407 (GRCm38)	T54A	possibly damaging	Het
Gprc6a	C	T	10: 51,614,890 (GRCm38)	R921H	probably benign	Het
Hc	A	T	2: 35,050,438 (GRCm38)	H129Q	probably benign	Het
Heatr5a	T	C	12: 51,961,468 (GRCm38)	R31G	probably benign	Het
Hephl1	T	C	9: 15,060,810 (GRCm38)	K945E	possibly damaging	Het
Ik	G	T	18: 36,751,177 (GRCm38)	M237I	probably damaging	Het
Izumo1	T	A	7: 45,627,095 (GRCm38)	S361T	probably benign	Het
Kcnq4	A	G	4: 120,711,239 (GRCm38)	F427L	probably benign	Het
Kifap3	T	A	1: 163,856,040 (GRCm38)	M430K	possibly damaging	Het
Kifap3	A	T	1: 163,825,859 (GRCm38)	N338I	possibly damaging	Het
Lamb3	A	G	1: 193,304,565 (GRCm38)	E53G	probably damaging	Het
Lrp1b	A	T	2: 41,312,643 (GRCm38)	I1266K		Het
Nat8	A	T	6: 85,830,503 (GRCm38)	I216K	probably benign	Het
Ncapd2	T	C	6: 125,179,561 (GRCm38)	I454V	probably benign	Het
Nlrp4f	G	C	13: 65,199,352 (GRCm38)	Q9E	possibly damaging	Het
Nlrp4f	A	T	13: 65,195,306 (GRCm38)	V153E	probably damaging	Het
Npy2r	A	T	3: 82,540,943 (GRCm38)	I175N	probably benign	Het
Nutm1	G	A	2: 112,250,056 (GRCm38)	R505C	probably damaging	Het
Olfr364-ps1	A	G	2: 37,146,874 (GRCm38)	T221A	probably benign	Het
Or4a74	T	C	2: 89,610,019 (GRCm38)	M28V	probably benign	Het
Or52n3	C	T	7: 104,881,186 (GRCm38)	P160S	probably damaging	Het
Pcdh9	T	C	14: 93,888,272 (GRCm38)	N154S	probably damaging	Het
Pcdhb2	A	T	18: 37,295,881 (GRCm38)	E302D	probably benign	Het
Pclo	T	A	5: 14,858,822 (GRCm38)	V5048E	unknown	Het
Pcnt	A	G	10: 76,389,060 (GRCm38)	L1870S	possibly damaging	Het
Pigc	T	C	1: 161,970,592 (GRCm38)	Y48H	probably damaging	Het
Pisd	C	T	5: 32,738,502 (GRCm38)	V241I	possibly damaging	Het
Pkhd1l1	A	T	15: 44,573,637 (GRCm38)	M3464L	possibly damaging	Het
Pofut2	T	A	10: 77,259,426 (GRCm38)	I35N	probably benign	Het
Prss27	A	G	17: 24,045,658 (GRCm38)	Y265C	probably damaging	Het
Prss56	T	A	1: 87,188,153 (GRCm38)	I583K	probably benign	Het
Rnpep	T	C	1: 135,283,749 (GRCm38)	E87G	probably benign	Het
Shtn1	T	C	19: 59,018,906 (GRCm38)	H304R	probably damaging	Het
Slc23a4	A	T	6: 34,978,913 (GRCm38)	I62N	probably damaging	Het
Slc35e2	A	T	4: 155,618,594 (GRCm38)	I355F	probably benign	Het
Snx25	T	C	8: 46,035,715 (GRCm38)	I868V	possibly damaging	Het
Spatc1l	T	A	10: 76,569,931 (GRCm38)	L323Q	probably damaging	Het
Speer4a2	T	A	5: 26,085,676 (GRCm38)	I166F	probably benign	Het
Taok1	A	G	11: 77,537,988 (GRCm38)	V962A	probably benign	Het
Tas2r140	A	G	6: 133,055,519 (GRCm38)	I92T	probably benign	Het
Trim17	C	A	11: 58,965,184 (GRCm38)	Y22*	probably null	Het
Tti1	T	A	2: 158,007,676 (GRCm38)	M548L	probably benign	Het
Unc93b1	T	C	19: 3,935,204 (GRCm38)	V4A	unknown	Het
Utp3	G	C	5: 88,554,517 (GRCm38)		probably benign	Het
Vmn1r225	A	T	17: 20,502,384 (GRCm38)	Y29F	probably benign	Het
Vmn1r34	A	T	6: 66,637,664 (GRCm38)	I30N	probably benign	Het
Vmn2r67	T	A	7: 85,152,638 (GRCm38)	M152L	probably benign	Het
Wdr20rt	T	G	12: 65,225,918 (GRCm38)	F52V	probably benign	Het
Zfp869	G	T	8: 69,706,656 (GRCm38)	H422Q	probably damaging	Het

Other mutations in Akap6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Akap6	APN	12	53,140,980 (GRCm38)	missense	possibly damaging	0.79
IGL00505:Akap6	APN	12	52,887,102 (GRCm38)	missense	possibly damaging	0.92
IGL01134:Akap6	APN	12	52,937,217 (GRCm38)	missense	probably damaging	0.96
IGL01458:Akap6	APN	12	52,886,818 (GRCm38)	nonsense	probably null
IGL01589:Akap6	APN	12	53,139,664 (GRCm38)	missense	probably damaging	1.00
IGL01592:Akap6	APN	12	53,142,142 (GRCm38)	missense	probably damaging	1.00
IGL01738:Akap6	APN	12	52,886,817 (GRCm38)	missense	probably damaging	0.99
IGL01867:Akap6	APN	12	52,888,008 (GRCm38)	missense	probably damaging	1.00
IGL02025:Akap6	APN	12	53,140,335 (GRCm38)	missense	probably benign
IGL02041:Akap6	APN	12	53,140,653 (GRCm38)	missense	probably damaging	1.00
IGL02058:Akap6	APN	12	53,140,555 (GRCm38)	missense	probably damaging	1.00
IGL02194:Akap6	APN	12	52,886,823 (GRCm38)	missense	probably benign	0.00
IGL02226:Akap6	APN	12	53,010,467 (GRCm38)	splice site	probably benign
IGL02323:Akap6	APN	12	53,140,429 (GRCm38)	missense	probably benign	0.00
IGL02449:Akap6	APN	12	53,140,188 (GRCm38)	missense	probably damaging	1.00
IGL02475:Akap6	APN	12	53,139,494 (GRCm38)	missense	probably benign	0.03
IGL02546:Akap6	APN	12	52,880,738 (GRCm38)	missense	probably damaging	1.00
IGL02547:Akap6	APN	12	53,140,696 (GRCm38)	missense	probably damaging	1.00
IGL02588:Akap6	APN	12	52,886,499 (GRCm38)	nonsense	probably null
IGL02608:Akap6	APN	12	53,010,606 (GRCm38)	missense	probably benign	0.39
IGL02884:Akap6	APN	12	52,886,622 (GRCm38)	missense	probably benign	0.00
IGL02945:Akap6	APN	12	52,880,837 (GRCm38)	missense	probably damaging	1.00
IGL03029:Akap6	APN	12	52,886,412 (GRCm38)	missense	probably damaging	1.00
IGL03129:Akap6	APN	12	53,140,306 (GRCm38)	missense	probably damaging	1.00
R0133:Akap6	UTSW	12	53,139,471 (GRCm38)	nonsense	probably null
R0166:Akap6	UTSW	12	53,140,924 (GRCm38)	missense	probably benign	0.04
R0189:Akap6	UTSW	12	53,141,254 (GRCm38)	missense	probably benign	0.41
R0532:Akap6	UTSW	12	52,887,983 (GRCm38)	missense	probably benign	0.00
R0632:Akap6	UTSW	12	52,937,148 (GRCm38)	missense	probably damaging	1.00
R0666:Akap6	UTSW	12	52,911,808 (GRCm38)	missense	probably damaging	1.00
R0723:Akap6	UTSW	12	53,141,902 (GRCm38)	missense	probably damaging	1.00
R0763:Akap6	UTSW	12	53,142,214 (GRCm38)	missense	possibly damaging	0.93
R0785:Akap6	UTSW	12	52,886,622 (GRCm38)	missense	probably benign	0.00
R0879:Akap6	UTSW	12	52,880,799 (GRCm38)	missense	probably damaging	1.00
R0880:Akap6	UTSW	12	53,139,508 (GRCm38)	missense	possibly damaging	0.93
R1033:Akap6	UTSW	12	53,069,222 (GRCm38)	missense	probably damaging	0.97
R1055:Akap6	UTSW	12	52,880,672 (GRCm38)	nonsense	probably null
R1199:Akap6	UTSW	12	52,796,190 (GRCm38)	missense	probably damaging	1.00
R1295:Akap6	UTSW	12	52,887,029 (GRCm38)	missense	probably damaging	1.00
R1389:Akap6	UTSW	12	53,139,520 (GRCm38)	missense	probably benign	0.15
R1471:Akap6	UTSW	12	53,141,496 (GRCm38)	missense	probably benign	0.05
R1483:Akap6	UTSW	12	52,796,087 (GRCm38)	missense	probably damaging	1.00
R1512:Akap6	UTSW	12	52,937,154 (GRCm38)	missense	probably damaging	1.00
R1648:Akap6	UTSW	12	53,142,006 (GRCm38)	nonsense	probably null
R1791:Akap6	UTSW	12	53,069,125 (GRCm38)	missense	probably damaging	1.00
R1888:Akap6	UTSW	12	53,142,175 (GRCm38)	missense	possibly damaging	0.88
R1888:Akap6	UTSW	12	53,142,175 (GRCm38)	missense	possibly damaging	0.88
R1891:Akap6	UTSW	12	53,142,175 (GRCm38)	missense	possibly damaging	0.88
R1899:Akap6	UTSW	12	53,141,852 (GRCm38)	missense	possibly damaging	0.95
R1917:Akap6	UTSW	12	53,104,612 (GRCm38)	missense	probably benign	0.13
R1970:Akap6	UTSW	12	52,938,475 (GRCm38)	missense	probably damaging	0.96
R1987:Akap6	UTSW	12	53,140,795 (GRCm38)	missense	possibly damaging	0.78
R1988:Akap6	UTSW	12	53,140,795 (GRCm38)	missense	possibly damaging	0.78
R2153:Akap6	UTSW	12	53,141,404 (GRCm38)	missense	probably benign	0.03
R2567:Akap6	UTSW	12	52,938,373 (GRCm38)	missense	probably damaging	1.00
R2568:Akap6	UTSW	12	52,887,278 (GRCm38)	missense	possibly damaging	0.77
R3025:Akap6	UTSW	12	53,140,143 (GRCm38)	missense	probably benign
R3051:Akap6	UTSW	12	52,887,033 (GRCm38)	missense	probably damaging	1.00
R3195:Akap6	UTSW	12	53,072,457 (GRCm38)	nonsense	probably null
R3196:Akap6	UTSW	12	53,072,457 (GRCm38)	nonsense	probably null
R3426:Akap6	UTSW	12	52,888,034 (GRCm38)	missense	probably damaging	1.00
R3783:Akap6	UTSW	12	52,880,769 (GRCm38)	missense	probably damaging	1.00
R3934:Akap6	UTSW	12	53,140,444 (GRCm38)	missense	possibly damaging	0.92
R3936:Akap6	UTSW	12	53,140,444 (GRCm38)	missense	possibly damaging	0.92
R3967:Akap6	UTSW	12	53,141,453 (GRCm38)	missense	probably damaging	1.00
R3970:Akap6	UTSW	12	53,141,453 (GRCm38)	missense	probably damaging	1.00
R4042:Akap6	UTSW	12	53,139,379 (GRCm38)	critical splice acceptor site	probably null
R4095:Akap6	UTSW	12	53,139,462 (GRCm38)	missense	probably damaging	1.00
R4152:Akap6	UTSW	12	53,140,407 (GRCm38)	missense	probably benign	0.45
R4231:Akap6	UTSW	12	53,141,038 (GRCm38)	missense	probably damaging	1.00
R4232:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4233:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4234:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4235:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4236:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4475:Akap6	UTSW	12	53,141,643 (GRCm38)	missense	probably benign	0.00
R4513:Akap6	UTSW	12	52,796,004 (GRCm38)	missense	probably benign	0.03
R4686:Akap6	UTSW	12	52,887,623 (GRCm38)	frame shift	probably null
R4724:Akap6	UTSW	12	52,795,885 (GRCm38)	missense	possibly damaging	0.80
R4782:Akap6	UTSW	12	52,887,623 (GRCm38)	frame shift	probably null
R4852:Akap6	UTSW	12	53,104,675 (GRCm38)	missense	probably damaging	1.00
R5024:Akap6	UTSW	12	53,142,562 (GRCm38)	missense	probably benign	0.01
R5116:Akap6	UTSW	12	53,141,515 (GRCm38)	missense	probably benign	0.01
R5164:Akap6	UTSW	12	53,142,466 (GRCm38)	missense	probably benign
R5225:Akap6	UTSW	12	52,886,546 (GRCm38)	missense	probably damaging	1.00
R5269:Akap6	UTSW	12	53,139,843 (GRCm38)	missense	probably damaging	0.99
R5352:Akap6	UTSW	12	52,796,097 (GRCm38)	missense	probably damaging	1.00
R5496:Akap6	UTSW	12	53,140,653 (GRCm38)	missense	possibly damaging	0.87
R5551:Akap6	UTSW	12	52,795,964 (GRCm38)	missense	probably damaging	1.00
R5997:Akap6	UTSW	12	52,937,233 (GRCm38)	critical splice donor site	probably null
R6137:Akap6	UTSW	12	53,140,354 (GRCm38)	missense	probably damaging	1.00
R6151:Akap6	UTSW	12	53,025,792 (GRCm38)	missense	probably damaging	1.00
R6169:Akap6	UTSW	12	53,142,358 (GRCm38)	missense	probably benign
R6307:Akap6	UTSW	12	53,141,568 (GRCm38)	missense	possibly damaging	0.85
R6351:Akap6	UTSW	12	53,142,025 (GRCm38)	missense	probably damaging	0.98
R6479:Akap6	UTSW	12	53,141,169 (GRCm38)	missense	probably damaging	1.00
R6502:Akap6	UTSW	12	53,140,215 (GRCm38)	missense	probably damaging	1.00
R6760:Akap6	UTSW	12	53,139,778 (GRCm38)	missense	probably damaging	1.00
R6778:Akap6	UTSW	12	53,025,816 (GRCm38)	missense	probably damaging	1.00
R6837:Akap6	UTSW	12	53,141,262 (GRCm38)	missense	probably damaging	1.00
R6896:Akap6	UTSW	12	52,887,494 (GRCm38)	missense	probably benign	0.06
R6917:Akap6	UTSW	12	53,069,168 (GRCm38)	missense	probably null	0.97
R6983:Akap6	UTSW	12	52,887,653 (GRCm38)	missense	probably damaging	1.00
R7142:Akap6	UTSW	12	52,887,364 (GRCm38)	missense	probably benign	0.02
R7216:Akap6	UTSW	12	53,140,457 (GRCm38)	missense	probably benign	0.02
R7297:Akap6	UTSW	12	52,887,364 (GRCm38)	missense	probably benign	0.02
R7356:Akap6	UTSW	12	52,911,864 (GRCm38)	missense	probably damaging	1.00
R7378:Akap6	UTSW	12	53,142,574 (GRCm38)	missense	probably benign	0.00
R7382:Akap6	UTSW	12	53,142,171 (GRCm38)	missense	probably benign	0.00
R7498:Akap6	UTSW	12	53,142,705 (GRCm38)	nonsense	probably null
R7542:Akap6	UTSW	12	53,069,234 (GRCm38)	missense	probably damaging	1.00
R7589:Akap6	UTSW	12	53,142,063 (GRCm38)	nonsense	probably null
R7676:Akap6	UTSW	12	52,886,850 (GRCm38)	missense	possibly damaging	0.94
R7814:Akap6	UTSW	12	53,140,961 (GRCm38)	missense	probably benign	0.28
R7971:Akap6	UTSW	12	53,139,795 (GRCm38)	missense	probably damaging	1.00
R8039:Akap6	UTSW	12	53,141,676 (GRCm38)	missense	probably benign	0.00
R8425:Akap6	UTSW	12	52,886,621 (GRCm38)	missense	probably benign	0.00
R8747:Akap6	UTSW	12	53,142,216 (GRCm38)	missense	probably benign	0.01
R8885:Akap6	UTSW	12	53,141,536 (GRCm38)	missense	probably benign
R8956:Akap6	UTSW	12	53,140,344 (GRCm38)	missense	probably benign	0.00
R8989:Akap6	UTSW	12	52,880,871 (GRCm38)	missense	probably damaging	1.00
R9014:Akap6	UTSW	12	53,139,620 (GRCm38)	missense	possibly damaging	0.60
R9031:Akap6	UTSW	12	53,142,048 (GRCm38)	missense	probably benign	0.36
R9216:Akap6	UTSW	12	52,880,885 (GRCm38)	missense	probably benign	0.05
R9220:Akap6	UTSW	12	53,140,449 (GRCm38)	missense	possibly damaging	0.49
R9243:Akap6	UTSW	12	53,141,252 (GRCm38)	missense	probably benign	0.08
R9286:Akap6	UTSW	12	53,072,471 (GRCm38)	missense	possibly damaging	0.90
R9347:Akap6	UTSW	12	53,069,111 (GRCm38)	missense	probably damaging	1.00
R9475:Akap6	UTSW	12	53,010,552 (GRCm38)	missense	probably damaging	1.00
R9509:Akap6	UTSW	12	53,142,238 (GRCm38)	missense	probably damaging	0.99
R9523:Akap6	UTSW	12	52,795,889 (GRCm38)	missense	probably benign	0.02
R9600:Akap6	UTSW	12	52,886,558 (GRCm38)	missense	probably benign	0.04
R9612:Akap6	UTSW	12	52,911,907 (GRCm38)	missense	probably damaging	1.00
R9627:Akap6	UTSW	12	53,104,630 (GRCm38)	missense
R9666:Akap6	UTSW	12	53,141,535 (GRCm38)	missense	probably benign
R9784:Akap6	UTSW	12	53,141,070 (GRCm38)	missense	probably damaging	1.00
X0062:Akap6	UTSW	12	53,142,361 (GRCm38)	missense	probably benign	0.43
Z1176:Akap6	UTSW	12	53,140,444 (GRCm38)	missense	possibly damaging	0.92

Predicted Primers

PCR Primer
(F):5'- TGCCATAAAGAGAAACCGCG -3'
(R):5'- ATTCATCAGAGCCGTACCAG -3'

Sequencing Primer
(F):5'- GACTGAAAAAGCCTCACAAGACCTTG -3'
(R):5'- CACCTGACCGTTCTGTGTGG -3'

Posted On

2019-05-15