Incidental Mutation 'R7144:Pik3c2g'
| ID |
553631 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pik3c2g
|
| Ensembl Gene |
ENSMUSG00000030228 |
| Gene Name |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma |
| Synonyms |
|
| MMRRC Submission |
045328-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
R7144 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
139591070-139915010 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 139606868 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Glutamine
at position 305
(P305Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141141
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032353]
[ENSMUST00000185968]
[ENSMUST00000187618]
[ENSMUST00000190962]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032353
AA Change: P305Q
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000032353
Gene: ENSMUSG00000030228
AA Change: P305Q
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000185968
AA Change: P305Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140368
Gene: ENSMUSG00000030228
AA Change: P305Q
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
371 |
2e-42 |
SMART |
|
Blast:PI3K_rbd
|
272 |
371 |
2e-64 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000187618
AA Change: P305Q
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000141025
Gene: ENSMUSG00000030228
AA Change: P305Q
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000190962
AA Change: P305Q
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000141141
Gene: ENSMUSG00000030228
AA Change: P305Q
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
99% (95/96) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
PHENOTYPE: Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
A |
T |
7: 120,032,796 (GRCm39) |
I272F |
possibly damaging |
Het |
| Adcy10 |
G |
T |
1: 165,337,939 (GRCm39) |
M184I |
probably benign |
Het |
| Aldoa |
G |
T |
7: 126,396,034 (GRCm39) |
T124N |
possibly damaging |
Het |
| Ap4e1 |
T |
A |
2: 126,853,727 (GRCm39) |
I55N |
probably damaging |
Het |
| Arhgap21 |
T |
C |
2: 20,870,198 (GRCm39) |
T913A |
probably benign |
Het |
| Atrnl1 |
G |
A |
19: 58,030,784 (GRCm39) |
E1309K |
probably damaging |
Het |
| BC034090 |
A |
T |
1: 155,117,777 (GRCm39) |
C114S |
probably damaging |
Het |
| Brinp2 |
A |
G |
1: 158,122,994 (GRCm39) |
|
probably null |
Het |
| Ccn4 |
T |
A |
15: 66,784,879 (GRCm39) |
V184E |
probably damaging |
Het |
| Ccna1 |
G |
T |
3: 54,953,120 (GRCm39) |
H408Q |
probably benign |
Het |
| Cd209g |
T |
G |
8: 4,185,189 (GRCm39) |
|
probably benign |
Het |
| Cdc20b |
A |
G |
13: 113,219,905 (GRCm39) |
I433V |
probably benign |
Het |
| Cdk2ap1 |
G |
A |
5: 124,492,421 (GRCm39) |
P5L |
probably damaging |
Het |
| Cep128 |
T |
C |
12: 91,260,933 (GRCm39) |
E310G |
probably damaging |
Het |
| Cflar |
G |
T |
1: 58,793,007 (GRCm39) |
V458F |
|
Het |
| Clec4b2 |
A |
G |
6: 123,158,343 (GRCm39) |
T70A |
probably benign |
Het |
| Cntnap5c |
A |
G |
17: 58,593,883 (GRCm39) |
T741A |
probably benign |
Het |
| Csf3r |
A |
T |
4: 125,937,515 (GRCm39) |
T800S |
probably benign |
Het |
| Csnk1g2 |
T |
C |
10: 80,473,733 (GRCm39) |
Y67H |
probably damaging |
Het |
| Cyp2c67 |
A |
T |
19: 39,604,138 (GRCm39) |
V406E |
probably benign |
Het |
| Dnah10 |
A |
G |
5: 124,900,006 (GRCm39) |
D3868G |
probably damaging |
Het |
| Dnah7a |
A |
T |
1: 53,737,867 (GRCm39) |
|
probably null |
Het |
| Dst |
A |
G |
1: 34,191,324 (GRCm39) |
N208S |
probably damaging |
Het |
| Echdc3 |
A |
G |
2: 6,211,224 (GRCm39) |
|
probably null |
Het |
| Edrf1 |
T |
C |
7: 133,239,578 (GRCm39) |
S13P |
probably benign |
Het |
| Ephb1 |
T |
C |
9: 101,841,276 (GRCm39) |
Y734C |
probably damaging |
Het |
| Eps8l1 |
A |
G |
7: 4,475,184 (GRCm39) |
Y325C |
probably damaging |
Het |
| Evc2 |
A |
G |
5: 37,544,183 (GRCm39) |
D644G |
probably damaging |
Het |
| Eya4 |
A |
C |
10: 23,048,943 (GRCm39) |
D54E |
probably benign |
Het |
| Filip1 |
T |
C |
9: 79,727,495 (GRCm39) |
S375G |
possibly damaging |
Het |
| Fmo9 |
A |
G |
1: 166,505,189 (GRCm39) |
M68T |
probably benign |
Het |
| Gemin5 |
G |
C |
11: 58,032,489 (GRCm39) |
P772A |
probably benign |
Het |
| Gle1 |
T |
G |
2: 29,833,805 (GRCm39) |
C401G |
probably damaging |
Het |
| Gm7298 |
A |
T |
6: 121,738,546 (GRCm39) |
I376F |
probably damaging |
Het |
| Gpr35 |
A |
C |
1: 92,910,353 (GRCm39) |
I22L |
probably benign |
Het |
| Grin2b |
T |
G |
6: 135,710,474 (GRCm39) |
D1024A |
possibly damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,539,624 (GRCm39) |
N2956D |
probably damaging |
Het |
| Htt |
T |
C |
5: 35,003,350 (GRCm39) |
L1275P |
probably damaging |
Het |
| Ibtk |
T |
C |
9: 85,625,744 (GRCm39) |
D2G |
probably benign |
Het |
| Il16 |
T |
A |
7: 83,295,659 (GRCm39) |
D1170V |
probably damaging |
Het |
| Iqgap3 |
T |
A |
3: 88,024,217 (GRCm39) |
I1513N |
probably damaging |
Het |
| Kiz |
T |
G |
2: 146,792,430 (GRCm39) |
|
probably null |
Het |
| Krt12 |
A |
T |
11: 99,306,839 (GRCm39) |
*488K |
probably null |
Het |
| Lap3 |
A |
T |
5: 45,654,290 (GRCm39) |
T83S |
probably benign |
Het |
| Lars2 |
T |
A |
9: 123,261,058 (GRCm39) |
S410T |
probably damaging |
Het |
| Limch1 |
A |
G |
5: 67,175,001 (GRCm39) |
T518A |
probably benign |
Het |
| Lrrc49 |
A |
T |
9: 60,522,439 (GRCm39) |
S381T |
probably damaging |
Het |
| Lrrk2 |
A |
G |
15: 91,618,258 (GRCm39) |
D919G |
possibly damaging |
Het |
| Mmp1a |
A |
T |
9: 7,475,319 (GRCm39) |
S363C |
probably damaging |
Het |
| Mrps22 |
A |
C |
9: 98,483,524 (GRCm39) |
|
probably null |
Het |
| Mybpc3 |
T |
C |
2: 90,964,949 (GRCm39) |
I1066T |
probably benign |
Het |
| Myo10 |
A |
T |
15: 25,724,011 (GRCm39) |
N215I |
probably damaging |
Het |
| Myocd |
A |
C |
11: 65,109,474 (GRCm39) |
L99R |
probably damaging |
Het |
| Nadk |
T |
G |
4: 155,673,793 (GRCm39) |
I394S |
probably damaging |
Het |
| Nadsyn1 |
T |
C |
7: 143,364,952 (GRCm39) |
N251S |
probably damaging |
Het |
| Nbeal1 |
G |
C |
1: 60,276,310 (GRCm39) |
V684L |
probably benign |
Het |
| Ncapd2 |
G |
A |
6: 125,153,633 (GRCm39) |
P694L |
probably benign |
Het |
| Or2ag1 |
T |
A |
7: 106,473,075 (GRCm39) |
I126F |
probably damaging |
Het |
| Or2w3b |
A |
C |
11: 58,623,571 (GRCm39) |
L140R |
probably damaging |
Het |
| Or4a71 |
T |
C |
2: 89,357,901 (GRCm39) |
I284M |
probably damaging |
Het |
| Or5t16 |
G |
T |
2: 86,819,164 (GRCm39) |
R119S |
probably damaging |
Het |
| Pcdhb13 |
T |
A |
18: 37,576,309 (GRCm39) |
I229K |
probably damaging |
Het |
| Pgbd5 |
A |
T |
8: 125,101,056 (GRCm39) |
M400K |
possibly damaging |
Het |
| Phactr3 |
A |
G |
2: 177,944,529 (GRCm39) |
N409S |
probably damaging |
Het |
| Pik3r4 |
G |
A |
9: 105,527,783 (GRCm39) |
V379M |
probably damaging |
Het |
| Pira12 |
A |
G |
7: 3,900,615 (GRCm39) |
V45A |
probably damaging |
Het |
| Pkd1l2 |
A |
T |
8: 117,802,870 (GRCm39) |
C250* |
probably null |
Het |
| Pramel14 |
A |
C |
4: 143,718,103 (GRCm39) |
S447A |
probably benign |
Het |
| Rapgef6 |
A |
C |
11: 54,548,191 (GRCm39) |
T792P |
possibly damaging |
Het |
| Rexo5 |
A |
G |
7: 119,404,414 (GRCm39) |
D170G |
probably damaging |
Het |
| Rnf17 |
G |
A |
14: 56,749,789 (GRCm39) |
|
probably null |
Het |
| Septin11 |
A |
G |
5: 93,304,725 (GRCm39) |
I181V |
probably benign |
Het |
| Serpina1e |
T |
G |
12: 103,913,277 (GRCm39) |
*414C |
probably null |
Het |
| Serpine1 |
C |
A |
5: 137,099,918 (GRCm39) |
Q80H |
probably damaging |
Het |
| Sh3bp2 |
A |
G |
5: 34,718,975 (GRCm39) |
N560S |
probably benign |
Het |
| Slc25a25 |
A |
G |
2: 32,309,178 (GRCm39) |
F221S |
probably damaging |
Het |
| Spag17 |
G |
T |
3: 99,934,717 (GRCm39) |
|
probably null |
Het |
| Sspn |
T |
C |
6: 145,906,881 (GRCm39) |
L104P |
probably damaging |
Het |
| St18 |
A |
C |
1: 6,903,818 (GRCm39) |
E693A |
probably damaging |
Het |
| St6galnac3 |
T |
C |
3: 153,117,169 (GRCm39) |
I185V |
possibly damaging |
Het |
| St8sia1 |
T |
C |
6: 142,822,395 (GRCm39) |
D156G |
probably damaging |
Het |
| Syne2 |
C |
A |
12: 76,052,152 (GRCm39) |
S4092R |
probably benign |
Het |
| Tll1 |
T |
A |
8: 64,577,979 (GRCm39) |
D76V |
possibly damaging |
Het |
| Tmco1 |
C |
T |
1: 167,136,022 (GRCm39) |
|
probably benign |
Het |
| Tnfaip3 |
T |
A |
10: 18,883,029 (GRCm39) |
T179S |
probably benign |
Het |
| Trav16 |
T |
C |
14: 53,981,096 (GRCm39) |
I95T |
possibly damaging |
Het |
| Trip12 |
A |
T |
1: 84,771,435 (GRCm39) |
S280T |
probably damaging |
Het |
| Unc79 |
A |
G |
12: 103,108,885 (GRCm39) |
M2166V |
probably benign |
Het |
| Vmn2r1 |
A |
G |
3: 63,997,362 (GRCm39) |
I339M |
probably damaging |
Het |
| Vwa5b1 |
A |
G |
4: 138,332,742 (GRCm39) |
|
probably null |
Het |
| Washc4 |
A |
T |
10: 83,409,638 (GRCm39) |
|
probably null |
Het |
| Wiz |
A |
G |
17: 32,576,602 (GRCm39) |
S642P |
possibly damaging |
Het |
| Zeb2 |
T |
A |
2: 45,000,053 (GRCm39) |
K60N |
possibly damaging |
Het |
| Zfat |
T |
A |
15: 68,050,631 (GRCm39) |
T797S |
probably benign |
Het |
| Zfp74 |
T |
C |
7: 29,634,590 (GRCm39) |
K373E |
probably damaging |
Het |
| Zswim5 |
T |
C |
4: 116,833,173 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Pik3c2g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Pik3c2g
|
APN |
6 |
139,841,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01355:Pik3c2g
|
APN |
6 |
139,798,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01579:Pik3c2g
|
APN |
6 |
139,700,467 (GRCm39) |
nonsense |
probably null |
|
|
IGL01580:Pik3c2g
|
APN |
6 |
139,599,514 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01587:Pik3c2g
|
APN |
6 |
139,700,467 (GRCm39) |
nonsense |
probably null |
|
|
IGL01813:Pik3c2g
|
APN |
6 |
139,599,407 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02218:Pik3c2g
|
APN |
6 |
139,806,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02479:Pik3c2g
|
APN |
6 |
139,863,730 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02480:Pik3c2g
|
APN |
6 |
139,798,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02721:Pik3c2g
|
APN |
6 |
139,682,699 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02967:Pik3c2g
|
APN |
6 |
139,913,554 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03221:Pik3c2g
|
APN |
6 |
139,718,133 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
FR4304:Pik3c2g
|
UTSW |
6 |
139,612,654 (GRCm39) |
frame shift |
probably null |
|
|
FR4340:Pik3c2g
|
UTSW |
6 |
139,612,654 (GRCm39) |
frame shift |
probably null |
|
|
FR4976:Pik3c2g
|
UTSW |
6 |
139,612,652 (GRCm39) |
frame shift |
probably null |
|
|
IGL02837:Pik3c2g
|
UTSW |
6 |
139,603,562 (GRCm39) |
nonsense |
probably null |
|
|
PIT4531001:Pik3c2g
|
UTSW |
6 |
139,805,096 (GRCm39) |
missense |
|
|
|
R0002:Pik3c2g
|
UTSW |
6 |
139,714,471 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0081:Pik3c2g
|
UTSW |
6 |
139,903,519 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0098:Pik3c2g
|
UTSW |
6 |
139,639,441 (GRCm39) |
missense |
unknown |
|
|
R0719:Pik3c2g
|
UTSW |
6 |
139,606,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0740:Pik3c2g
|
UTSW |
6 |
139,610,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0837:Pik3c2g
|
UTSW |
6 |
139,903,425 (GRCm39) |
splice site |
probably benign |
|
|
R0840:Pik3c2g
|
UTSW |
6 |
139,841,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1306:Pik3c2g
|
UTSW |
6 |
139,718,154 (GRCm39) |
missense |
probably benign |
|
|
R1501:Pik3c2g
|
UTSW |
6 |
139,789,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1591:Pik3c2g
|
UTSW |
6 |
139,693,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1666:Pik3c2g
|
UTSW |
6 |
139,612,634 (GRCm39) |
intron |
probably benign |
|
|
R1907:Pik3c2g
|
UTSW |
6 |
139,789,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Pik3c2g
|
UTSW |
6 |
139,846,112 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1982:Pik3c2g
|
UTSW |
6 |
139,599,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2171:Pik3c2g
|
UTSW |
6 |
139,801,012 (GRCm39) |
nonsense |
probably null |
|
|
R2188:Pik3c2g
|
UTSW |
6 |
139,798,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3777:Pik3c2g
|
UTSW |
6 |
139,599,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3778:Pik3c2g
|
UTSW |
6 |
139,599,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3965:Pik3c2g
|
UTSW |
6 |
139,801,018 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4076:Pik3c2g
|
UTSW |
6 |
139,798,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4078:Pik3c2g
|
UTSW |
6 |
139,612,608 (GRCm39) |
intron |
probably benign |
|
|
R4108:Pik3c2g
|
UTSW |
6 |
139,676,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4461:Pik3c2g
|
UTSW |
6 |
139,787,407 (GRCm39) |
intron |
probably benign |
|
|
R4474:Pik3c2g
|
UTSW |
6 |
139,610,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4509:Pik3c2g
|
UTSW |
6 |
139,665,732 (GRCm39) |
missense |
probably benign |
0.25 |
|
R4646:Pik3c2g
|
UTSW |
6 |
139,665,744 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4732:Pik3c2g
|
UTSW |
6 |
139,881,711 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4733:Pik3c2g
|
UTSW |
6 |
139,881,711 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4854:Pik3c2g
|
UTSW |
6 |
139,714,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4928:Pik3c2g
|
UTSW |
6 |
139,913,528 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4959:Pik3c2g
|
UTSW |
6 |
139,789,657 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4973:Pik3c2g
|
UTSW |
6 |
139,789,657 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5032:Pik3c2g
|
UTSW |
6 |
139,841,928 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5071:Pik3c2g
|
UTSW |
6 |
139,665,873 (GRCm39) |
missense |
probably null |
0.00 |
|
R5072:Pik3c2g
|
UTSW |
6 |
139,665,873 (GRCm39) |
missense |
probably null |
0.00 |
|
R5073:Pik3c2g
|
UTSW |
6 |
139,665,873 (GRCm39) |
missense |
probably null |
0.00 |
|
R5074:Pik3c2g
|
UTSW |
6 |
139,665,873 (GRCm39) |
missense |
probably null |
0.00 |
|
R5107:Pik3c2g
|
UTSW |
6 |
139,612,623 (GRCm39) |
intron |
probably benign |
|
|
R5186:Pik3c2g
|
UTSW |
6 |
139,599,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5253:Pik3c2g
|
UTSW |
6 |
139,841,983 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5359:Pik3c2g
|
UTSW |
6 |
139,599,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Pik3c2g
|
UTSW |
6 |
139,665,808 (GRCm39) |
missense |
probably benign |
|
|
R5417:Pik3c2g
|
UTSW |
6 |
139,682,669 (GRCm39) |
missense |
probably benign |
|
|
R5435:Pik3c2g
|
UTSW |
6 |
139,661,581 (GRCm39) |
splice site |
probably null |
|
|
R5580:Pik3c2g
|
UTSW |
6 |
139,603,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5664:Pik3c2g
|
UTSW |
6 |
139,682,733 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5908:Pik3c2g
|
UTSW |
6 |
139,714,436 (GRCm39) |
missense |
|
|
|
R5914:Pik3c2g
|
UTSW |
6 |
139,599,477 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,842,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,599,137 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6298:Pik3c2g
|
UTSW |
6 |
139,603,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6382:Pik3c2g
|
UTSW |
6 |
139,665,724 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6480:Pik3c2g
|
UTSW |
6 |
139,676,195 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6917:Pik3c2g
|
UTSW |
6 |
139,841,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6929:Pik3c2g
|
UTSW |
6 |
139,903,502 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7022:Pik3c2g
|
UTSW |
6 |
139,599,061 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7213:Pik3c2g
|
UTSW |
6 |
139,805,990 (GRCm39) |
missense |
|
|
|
R7215:Pik3c2g
|
UTSW |
6 |
139,700,589 (GRCm39) |
missense |
|
|
|
R7332:Pik3c2g
|
UTSW |
6 |
139,841,981 (GRCm39) |
missense |
|
|
|
R7357:Pik3c2g
|
UTSW |
6 |
139,610,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7359:Pik3c2g
|
UTSW |
6 |
139,913,620 (GRCm39) |
missense |
unknown |
|
|
R7385:Pik3c2g
|
UTSW |
6 |
139,801,079 (GRCm39) |
missense |
|
|
|
R7455:Pik3c2g
|
UTSW |
6 |
139,913,643 (GRCm39) |
missense |
unknown |
|
|
R7651:Pik3c2g
|
UTSW |
6 |
139,599,070 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7888:Pik3c2g
|
UTSW |
6 |
139,842,470 (GRCm39) |
missense |
|
|
|
R7923:Pik3c2g
|
UTSW |
6 |
139,610,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7964:Pik3c2g
|
UTSW |
6 |
139,827,786 (GRCm39) |
missense |
|
|
|
R8005:Pik3c2g
|
UTSW |
6 |
139,599,067 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8371:Pik3c2g
|
UTSW |
6 |
139,881,782 (GRCm39) |
missense |
unknown |
|
|
R8724:Pik3c2g
|
UTSW |
6 |
139,913,619 (GRCm39) |
missense |
unknown |
|
|
R8733:Pik3c2g
|
UTSW |
6 |
139,714,426 (GRCm39) |
nonsense |
probably null |
|
|
R8809:Pik3c2g
|
UTSW |
6 |
139,714,436 (GRCm39) |
missense |
|
|
|
R8888:Pik3c2g
|
UTSW |
6 |
139,676,092 (GRCm39) |
nonsense |
probably null |
|
|
R8931:Pik3c2g
|
UTSW |
6 |
139,821,093 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9188:Pik3c2g
|
UTSW |
6 |
139,599,401 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9336:Pik3c2g
|
UTSW |
6 |
139,821,161 (GRCm39) |
missense |
|
|
|
R9383:Pik3c2g
|
UTSW |
6 |
139,827,742 (GRCm39) |
nonsense |
probably null |
|
|
R9524:Pik3c2g
|
UTSW |
6 |
139,606,768 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9531:Pik3c2g
|
UTSW |
6 |
139,841,926 (GRCm39) |
missense |
|
|
|
R9630:Pik3c2g
|
UTSW |
6 |
139,599,237 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9697:Pik3c2g
|
UTSW |
6 |
139,913,517 (GRCm39) |
missense |
unknown |
|
|
R9708:Pik3c2g
|
UTSW |
6 |
139,606,865 (GRCm39) |
missense |
probably benign |
|
|
R9717:Pik3c2g
|
UTSW |
6 |
139,841,910 (GRCm39) |
missense |
|
|
|
RF015:Pik3c2g
|
UTSW |
6 |
139,700,497 (GRCm39) |
missense |
|
|
|
RF032:Pik3c2g
|
UTSW |
6 |
139,612,656 (GRCm39) |
frame shift |
probably null |
|
|
X0024:Pik3c2g
|
UTSW |
6 |
139,805,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGCCTTCCTTAATGGTGG -3'
(R):5'- AGCTCTGTGAAGGAAGATCATG -3'
Sequencing Primer
(F):5'- GAATGATGCAGATCAGTTTCTAAGC -3'
(R):5'- GTGAAGGAAGATCATGTTTCCCCC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation