Incidental Mutation 'R7145:Naa25'
ID 553703
Institutional Source Beutler Lab
Gene Symbol Naa25
Ensembl Gene ENSMUSG00000042719
Gene Name N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms C330023M02Rik, 4833422K13Rik
MMRRC Submission 045223-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7145 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 121535977-121580612 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to T at 121555552 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000038977 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042163] [ENSMUST00000151458] [ENSMUST00000173895]
AlphaFold Q8BWZ3
Predicted Effect probably null
Transcript: ENSMUST00000042163
SMART Domains Protein: ENSMUSP00000038977
Gene: ENSMUSG00000042719

DomainStartEndE-ValueType
low complexity region 35 45 N/A INTRINSIC
Pfam:NatB_MDM20 263 658 1.6e-121 PFAM
low complexity region 672 683 N/A INTRINSIC
low complexity region 687 700 N/A INTRINSIC
low complexity region 721 734 N/A INTRINSIC
low complexity region 915 935 N/A INTRINSIC
low complexity region 958 971 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000151458
SMART Domains Protein: ENSMUSP00000120970
Gene: ENSMUSG00000042719

DomainStartEndE-ValueType
SCOP:d1a17__ 21 94 1e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173895
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 137,775,820 (GRCm39) Y1670H probably damaging Het
Abca12 T C 1: 71,346,212 (GRCm39) K886R possibly damaging Het
Adcy3 G A 12: 4,250,992 (GRCm39) E584K probably benign Het
Ano3 A T 2: 110,693,205 (GRCm39) V131D probably benign Het
Arhgdig C T 17: 26,418,337 (GRCm39) W215* probably null Het
Cad G T 5: 31,224,956 (GRCm39) W953L possibly damaging Het
Calhm2 T C 19: 47,124,080 (GRCm39) Y88C probably benign Het
Cdk5rap2 A T 4: 70,156,468 (GRCm39) D1681E probably benign Het
Cenpl T A 1: 160,910,482 (GRCm39) L143H possibly damaging Het
Cherp T C 8: 73,222,230 (GRCm39) K270E Het
Cmss1 A G 16: 57,131,718 (GRCm39) I136T probably benign Het
Col23a1 T C 11: 51,456,050 (GRCm39) probably null Het
Crnn C A 3: 93,055,689 (GRCm39) D158E probably damaging Het
Dnmt3a A T 12: 3,922,844 (GRCm39) Q149L probably benign Het
Dst T A 1: 34,228,963 (GRCm39) N2185K probably benign Het
Eif1ad18 G T 12: 88,050,597 (GRCm39) C44F probably benign Het
Elp2 T A 18: 24,737,126 (GRCm39) N25K probably benign Het
Ephb4 A T 5: 137,370,308 (GRCm39) D845V probably damaging Het
Esyt3 T C 9: 99,201,627 (GRCm39) T561A probably damaging Het
F3 G T 3: 121,525,235 (GRCm39) V159L probably damaging Het
Fam81a A T 9: 70,017,560 (GRCm39) D128E probably damaging Het
Flot1 T G 17: 36,135,835 (GRCm39) H155Q probably benign Het
Fut9 T A 4: 25,620,507 (GRCm39) K102N probably damaging Het
Gm6309 T C 5: 146,107,100 (GRCm39) Q82R possibly damaging Het
H13 A G 2: 152,522,992 (GRCm39) N102D probably damaging Het
Lamc2 C G 1: 153,006,518 (GRCm39) A878P possibly damaging Het
Lepr C T 4: 101,609,394 (GRCm39) T327I probably benign Het
Lrp2 A G 2: 69,285,152 (GRCm39) probably null Het
Ly86 A G 13: 37,560,986 (GRCm39) K116E probably damaging Het
Mapk8ip2 T A 15: 89,343,201 (GRCm39) F648I possibly damaging Het
Muc16 G A 9: 18,566,876 (GRCm39) T1881I unknown Het
Myh13 T G 11: 67,245,566 (GRCm39) S1069A probably benign Het
Myh4 T A 11: 67,151,054 (GRCm39) I1903N possibly damaging Het
Myo18b A T 5: 112,965,545 (GRCm39) L1341* probably null Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Ncapg C T 5: 45,827,372 (GRCm39) A3V possibly damaging Het
Ncln T C 10: 81,324,086 (GRCm39) H481R probably benign Het
Nek4 C A 14: 30,704,305 (GRCm39) Q607K probably damaging Het
Neo1 T C 9: 58,796,462 (GRCm39) Y1182C probably damaging Het
Npnt T C 3: 132,615,692 (GRCm39) N165S probably benign Het
Or2l5 C G 16: 19,333,649 (GRCm39) V246L probably damaging Het
Or4p22 C T 2: 88,317,721 (GRCm39) S215L probably damaging Het
Or8b8 A G 9: 37,808,859 (GRCm39) H53R probably benign Het
Or8k30 T C 2: 86,338,872 (GRCm39) L23P probably damaging Het
Otulin T C 15: 27,608,856 (GRCm39) Y229C probably damaging Het
Palld A T 8: 61,985,051 (GRCm39) D1071E unknown Het
Pcdhb20 T C 18: 37,638,142 (GRCm39) S223P probably damaging Het
Pcdhga6 T A 18: 37,840,781 (GRCm39) I167N probably damaging Het
Pcdhgb4 A G 18: 37,854,843 (GRCm39) N413D probably benign Het
Pcdhgb8 T A 18: 37,896,050 (GRCm39) Y373* probably null Het
Plxna2 G T 1: 194,331,830 (GRCm39) V419L probably benign Het
Rpgrip1l A T 8: 91,959,434 (GRCm39) probably null Het
Rsrc2 A G 5: 123,877,630 (GRCm39) probably benign Het
Scaper C T 9: 55,819,395 (GRCm39) D107N unknown Het
Scgb2b3 T A 7: 31,059,573 (GRCm39) Y67F probably benign Het
Scn5a G A 9: 119,315,437 (GRCm39) T1757I probably damaging Het
Sgo2b G A 8: 64,381,218 (GRCm39) P538L probably damaging Het
Slc9a3 A G 13: 74,298,797 (GRCm39) K72R probably damaging Het
Smchd1 T A 17: 71,685,202 (GRCm39) T1409S probably benign Het
Stab1 A T 14: 30,867,030 (GRCm39) probably null Het
Sult2b1 T C 7: 45,383,056 (GRCm39) E242G probably damaging Het
Tcaf1 A T 6: 42,663,687 (GRCm39) H64Q probably damaging Het
Tle6 T C 10: 81,435,910 (GRCm39) T2A possibly damaging Het
Tmem115 T C 9: 107,412,285 (GRCm39) V203A probably benign Het
Tmem45b G A 9: 31,340,337 (GRCm39) T108I probably damaging Het
Tmf1 A T 6: 97,153,079 (GRCm39) D331E probably damaging Het
Txndc9 T C 1: 38,029,377 (GRCm39) Y157C probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vmn2r27 C A 6: 124,168,711 (GRCm39) R806S probably benign Het
Vmn2r59 G A 7: 41,695,188 (GRCm39) A408V probably damaging Het
Ythdc1 T C 5: 86,964,467 (GRCm39) V92A probably benign Het
Other mutations in Naa25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02025:Naa25 APN 5 121,577,928 (GRCm39) missense probably damaging 1.00
IGL02142:Naa25 APN 5 121,564,825 (GRCm39) missense possibly damaging 0.52
IGL02541:Naa25 APN 5 121,562,594 (GRCm39) missense possibly damaging 0.92
IGL02747:Naa25 APN 5 121,552,668 (GRCm39) splice site probably benign
IGL03074:Naa25 APN 5 121,546,400 (GRCm39) critical splice donor site probably null
IGL03119:Naa25 APN 5 121,573,041 (GRCm39) missense probably null 1.00
IGL03218:Naa25 APN 5 121,564,133 (GRCm39) missense probably damaging 1.00
R0003:Naa25 UTSW 5 121,545,247 (GRCm39) intron probably benign
R0022:Naa25 UTSW 5 121,556,039 (GRCm39) missense probably damaging 1.00
R0022:Naa25 UTSW 5 121,556,039 (GRCm39) missense probably damaging 1.00
R0102:Naa25 UTSW 5 121,573,632 (GRCm39) missense possibly damaging 0.69
R0102:Naa25 UTSW 5 121,573,632 (GRCm39) missense possibly damaging 0.69
R0399:Naa25 UTSW 5 121,573,553 (GRCm39) missense probably benign 0.00
R0973:Naa25 UTSW 5 121,576,779 (GRCm39) splice site probably benign
R1418:Naa25 UTSW 5 121,561,797 (GRCm39) missense probably damaging 1.00
R1582:Naa25 UTSW 5 121,572,892 (GRCm39) missense probably benign
R1793:Naa25 UTSW 5 121,558,656 (GRCm39) missense probably damaging 1.00
R1793:Naa25 UTSW 5 121,555,478 (GRCm39) missense possibly damaging 0.82
R1863:Naa25 UTSW 5 121,573,611 (GRCm39) missense probably benign 0.00
R3160:Naa25 UTSW 5 121,573,135 (GRCm39) splice site probably null
R3162:Naa25 UTSW 5 121,573,135 (GRCm39) splice site probably null
R3721:Naa25 UTSW 5 121,569,619 (GRCm39) missense probably benign
R3864:Naa25 UTSW 5 121,547,260 (GRCm39) missense probably damaging 0.96
R4852:Naa25 UTSW 5 121,568,755 (GRCm39) missense probably damaging 1.00
R5077:Naa25 UTSW 5 121,562,639 (GRCm39) missense probably benign 0.02
R5602:Naa25 UTSW 5 121,558,558 (GRCm39) missense probably benign 0.30
R5855:Naa25 UTSW 5 121,561,755 (GRCm39) missense possibly damaging 0.94
R6464:Naa25 UTSW 5 121,556,024 (GRCm39) missense probably damaging 1.00
R6734:Naa25 UTSW 5 121,576,888 (GRCm39) missense possibly damaging 0.65
R6750:Naa25 UTSW 5 121,546,372 (GRCm39) missense probably damaging 1.00
R6767:Naa25 UTSW 5 121,577,928 (GRCm39) missense probably damaging 1.00
R6856:Naa25 UTSW 5 121,576,867 (GRCm39) missense probably damaging 1.00
R7631:Naa25 UTSW 5 121,576,791 (GRCm39) missense possibly damaging 0.92
R7701:Naa25 UTSW 5 121,564,042 (GRCm39) missense probably benign
R7800:Naa25 UTSW 5 121,562,594 (GRCm39) missense possibly damaging 0.92
R7804:Naa25 UTSW 5 121,562,652 (GRCm39) missense probably benign 0.00
R7822:Naa25 UTSW 5 121,545,276 (GRCm39) missense probably damaging 1.00
R8707:Naa25 UTSW 5 121,552,875 (GRCm39) missense probably damaging 1.00
R8944:Naa25 UTSW 5 121,552,573 (GRCm39) missense probably benign 0.34
R9486:Naa25 UTSW 5 121,577,958 (GRCm39) missense probably damaging 1.00
X0004:Naa25 UTSW 5 121,551,144 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTAATGCGATGTTGTCTTTCCTACG -3'
(R):5'- GGTGGAGGCCAGTATGATAC -3'

Sequencing Primer
(F):5'- CGATGTTGTCTTTCCTACGATTGG -3'
(R):5'- GTATGATACGGTGCTCATCCTCAAG -3'
Posted On 2019-05-15