Mutagenetix > Incidental Mutation

Incidental Mutation 'R7145:Olfr167'

553740

Institutional Source

Beutler Lab

Gene Symbol

Olfr167

Ensembl Gene

ENSMUSG00000045341

Gene Name

olfactory receptor 167

Synonyms

MOR272-1, GA_x54KRFPKG5P-15963726-15962788

MMRRC Submission

045223-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.252) question?

Stock #

R7145 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19509558-19522266 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to G at 19514899 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 246 (V246L)

Ref Sequence

ENSEMBL: ENSMUSP00000150102 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054606] [ENSMUST00000214315]

AlphaFold

Q8VGJ5

Predicted Effect

probably damaging
Transcript: ENSMUST00000054606
AA Change: V246L

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000055344
Gene: ENSMUSG00000045341
AA Change: V246L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	306	4.8e-46	PFAM
Pfam:7TM_GPCR_Srsx	33	295	1.2e-6	PFAM
Pfam:7tm_1	40	289	1.8e-26	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214315
AA Change: V246L

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	T	C	3: 138,070,059 (GRCm38)	Y1670H	probably damaging	Het
Abca12	T	C	1: 71,307,053 (GRCm38)	K886R	possibly damaging	Het
Adcy3	G	A	12: 4,200,992 (GRCm38)	E584K	probably benign	Het
Ano3	A	T	2: 110,862,860 (GRCm38)	V131D	probably benign	Het
Arhgdig	C	T	17: 26,199,363 (GRCm38)	W215*	probably null	Het
Cad	G	T	5: 31,067,612 (GRCm38)	W953L	possibly damaging	Het
Calhm2	T	C	19: 47,135,641 (GRCm38)	Y88C	probably benign	Het
Cdk5rap2	A	T	4: 70,238,231 (GRCm38)	D1681E	probably benign	Het
Cenpl	T	A	1: 161,082,912 (GRCm38)	L143H	possibly damaging	Het
Cherp	T	C	8: 72,468,386 (GRCm38)	K270E		Het
Cmss1	A	G	16: 57,311,355 (GRCm38)	I136T	probably benign	Het
Col23a1	T	C	11: 51,565,223 (GRCm38)		probably null	Het
Crnn	C	A	3: 93,148,382 (GRCm38)	D158E	probably damaging	Het
Dnmt3a	A	T	12: 3,872,844 (GRCm38)	Q149L	probably benign	Het
Dst	T	A	1: 34,189,882 (GRCm38)	N2185K	probably benign	Het
Elp2	T	A	18: 24,604,069 (GRCm38)	N25K	probably benign	Het
Ephb4	A	T	5: 137,372,046 (GRCm38)	D845V	probably damaging	Het
Esyt3	T	C	9: 99,319,574 (GRCm38)	T561A	probably damaging	Het
F3	G	T	3: 121,731,586 (GRCm38)	V159L	probably damaging	Het
Fam81a	A	T	9: 70,110,278 (GRCm38)	D128E	probably damaging	Het
Flot1	T	G	17: 35,824,943 (GRCm38)	H155Q	probably benign	Het
Fut9	T	A	4: 25,620,507 (GRCm38)	K102N	probably damaging	Het
Gm16368	G	T	12: 88,083,827 (GRCm38)	C44F	probably benign	Het
Gm6309	T	C	5: 146,170,290 (GRCm38)	Q82R	possibly damaging	Het
H13	A	G	2: 152,681,072 (GRCm38)	N102D	probably damaging	Het
Lamc2	C	G	1: 153,130,772 (GRCm38)	A878P	possibly damaging	Het
Lepr	C	T	4: 101,752,197 (GRCm38)	T327I	probably benign	Het
Lrp2	A	G	2: 69,454,808 (GRCm38)		probably null	Het
Ly86	A	G	13: 37,377,010 (GRCm38)	K116E	probably damaging	Het
Mapk8ip2	T	A	15: 89,458,998 (GRCm38)	F648I	possibly damaging	Het
Muc16	G	A	9: 18,655,580 (GRCm38)	T1881I	unknown	Het
Myh13	T	G	11: 67,354,740 (GRCm38)	S1069A	probably benign	Het
Myh4	T	A	11: 67,260,228 (GRCm38)	I1903N	possibly damaging	Het
Myo18b	A	T	5: 112,817,679 (GRCm38)	L1341*	probably null	Het
Naa25	G	T	5: 121,417,489 (GRCm38)		probably null	Het
Nbeal1	G	C	1: 60,237,151 (GRCm38)	V684L	probably benign	Het
Ncapg	C	T	5: 45,670,030 (GRCm38)	A3V	possibly damaging	Het
Ncln	T	C	10: 81,488,252 (GRCm38)	H481R	probably benign	Het
Nek4	C	A	14: 30,982,348 (GRCm38)	Q607K	probably damaging	Het
Neo1	T	C	9: 58,889,179 (GRCm38)	Y1182C	probably damaging	Het
Npnt	T	C	3: 132,909,931 (GRCm38)	N165S	probably benign	Het
Olfr1076	T	C	2: 86,508,528 (GRCm38)	L23P	probably damaging	Het
Olfr1184	C	T	2: 88,487,377 (GRCm38)	S215L	probably damaging	Het
Olfr145	A	G	9: 37,897,563 (GRCm38)	H53R	probably benign	Het
Otulin	T	C	15: 27,608,770 (GRCm38)	Y229C	probably damaging	Het
Palld	A	T	8: 61,532,017 (GRCm38)	D1071E	unknown	Het
Pcdhb20	T	C	18: 37,505,089 (GRCm38)	S223P	probably damaging	Het
Pcdhga6	T	A	18: 37,707,728 (GRCm38)	I167N	probably damaging	Het
Pcdhgb4	A	G	18: 37,721,790 (GRCm38)	N413D	probably benign	Het
Pcdhgb8	T	A	18: 37,762,997 (GRCm38)	Y373*	probably null	Het
Plxna2	G	T	1: 194,649,522 (GRCm38)	V419L	probably benign	Het
Rpgrip1l	A	T	8: 91,232,806 (GRCm38)		probably null	Het
Rsrc2	A	G	5: 123,739,567 (GRCm38)		probably benign	Het
Scaper	C	T	9: 55,912,111 (GRCm38)	D107N	unknown	Het
Scgb2b3	T	A	7: 31,360,148 (GRCm38)	Y67F	probably benign	Het
Scn5a	G	A	9: 119,486,371 (GRCm38)	T1757I	probably damaging	Het
Sgo2b	G	A	8: 63,928,184 (GRCm38)	P538L	probably damaging	Het
Slc9a3	A	G	13: 74,150,678 (GRCm38)	K72R	probably damaging	Het
Smchd1	T	A	17: 71,378,207 (GRCm38)	T1409S	probably benign	Het
Stab1	A	T	14: 31,145,073 (GRCm38)		probably null	Het
Sult2b1	T	C	7: 45,733,632 (GRCm38)	E242G	probably damaging	Het
Tcaf1	A	T	6: 42,686,753 (GRCm38)	H64Q	probably damaging	Het
Tle6	T	C	10: 81,600,076 (GRCm38)	T2A	possibly damaging	Het
Tmem115	T	C	9: 107,535,086 (GRCm38)	V203A	probably benign	Het
Tmem45b	G	A	9: 31,429,041 (GRCm38)	T108I	probably damaging	Het
Tmf1	A	T	6: 97,176,118 (GRCm38)	D331E	probably damaging	Het
Txndc9	T	C	1: 37,990,296 (GRCm38)	Y157C	probably damaging	Het
Vmn2r111	T	C	17: 22,559,051 (GRCm38)	N549S	possibly damaging	Het
Vmn2r27	C	A	6: 124,191,752 (GRCm38)	R806S	probably benign	Het
Vmn2r59	G	A	7: 42,045,764 (GRCm38)	A408V	probably damaging	Het
Ythdc1	T	C	5: 86,816,608 (GRCm38)	V92A	probably benign	Het

Other mutations in Olfr167

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01535:Olfr167	APN	16	19,515,478 (GRCm38)	missense	probably benign	0.01
IGL02115:Olfr167	APN	16	19,515,103 (GRCm38)	missense	probably damaging	1.00
IGL02562:Olfr167	APN	16	19,514,964 (GRCm38)	missense	possibly damaging	0.74
BB008:Olfr167	UTSW	16	19,515,508 (GRCm38)	missense	possibly damaging	0.94
BB018:Olfr167	UTSW	16	19,515,508 (GRCm38)	missense	possibly damaging	0.94
R0366:Olfr167	UTSW	16	19,514,848 (GRCm38)	missense	probably benign	0.13
R0673:Olfr167	UTSW	16	19,515,396 (GRCm38)	missense	probably damaging	1.00
R1187:Olfr167	UTSW	16	19,515,046 (GRCm38)	missense	probably benign	0.01
R1237:Olfr167	UTSW	16	19,515,625 (GRCm38)	missense	probably benign	0.01
R1975:Olfr167	UTSW	16	19,514,836 (GRCm38)	missense	probably damaging	0.99
R1977:Olfr167	UTSW	16	19,514,836 (GRCm38)	missense	probably damaging	0.99
R1997:Olfr167	UTSW	16	19,515,042 (GRCm38)	missense	probably damaging	1.00
R2225:Olfr167	UTSW	16	19,515,246 (GRCm38)	missense	probably benign	0.05
R2226:Olfr167	UTSW	16	19,515,246 (GRCm38)	missense	probably benign	0.05
R4078:Olfr167	UTSW	16	19,515,232 (GRCm38)	missense	possibly damaging	0.76
R5019:Olfr167	UTSW	16	19,515,535 (GRCm38)	missense	probably damaging	0.99
R5071:Olfr167	UTSW	16	19,515,027 (GRCm38)	missense	probably benign	0.00
R5278:Olfr167	UTSW	16	19,515,378 (GRCm38)	nonsense	probably null
R5415:Olfr167	UTSW	16	19,515,246 (GRCm38)	missense	possibly damaging	0.94
R5744:Olfr167	UTSW	16	19,515,336 (GRCm38)	missense	probably benign	0.00
R5991:Olfr167	UTSW	16	19,514,757 (GRCm38)	missense	probably damaging	0.99
R6151:Olfr167	UTSW	16	19,515,531 (GRCm38)	missense	probably damaging	1.00
R6540:Olfr167	UTSW	16	19,514,821 (GRCm38)	missense	probably benign
R7014:Olfr167	UTSW	16	19,515,456 (GRCm38)	missense	probably benign	0.20
R7535:Olfr167	UTSW	16	19,514,794 (GRCm38)	missense	probably damaging	1.00
R7677:Olfr167	UTSW	16	19,514,928 (GRCm38)	missense	probably benign	0.42
R7715:Olfr167	UTSW	16	19,514,730 (GRCm38)	missense	probably benign	0.00
R7931:Olfr167	UTSW	16	19,515,508 (GRCm38)	missense	possibly damaging	0.94
R8137:Olfr167	UTSW	16	19,515,096 (GRCm38)	missense	possibly damaging	0.89
R8671:Olfr167	UTSW	16	19,515,054 (GRCm38)	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- TGGATTCACGGAAGCAACTTGTC -3'
(R):5'- CTTGCACAGACACATGGGTC -3'

Sequencing Primer
(F):5'- GCAAAGCAAATTCTGTGAGTCATCC -3'
(R):5'- CACATGGGTCTATGAGTATACAGTG -3'

Posted On

2019-05-15