Incidental Mutation 'R7146:Ano1'
| ID |
553794 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ano1
|
| Ensembl Gene |
ENSMUSG00000031075 |
| Gene Name |
anoctamin 1, calcium activated chloride channel |
| Synonyms |
Tmem16a |
| MMRRC Submission |
045251-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7146 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
144142286-144305711 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 144209393 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 269
(H269R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112616
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033393]
[ENSMUST00000118556]
[ENSMUST00000121758]
[ENSMUST00000131731]
[ENSMUST00000155175]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000033393
AA Change: H212R
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000033393
Gene: ENSMUSG00000031075
AA Change: H212R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
129 |
147 |
N/A |
INTRINSIC |
|
Pfam:Anoctamin
|
320 |
898 |
1.3e-149 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118556
AA Change: H270R
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000113899
Gene: ENSMUSG00000031075
AA Change: H270R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Anoct_dimer
|
112 |
375 |
5.5e-83 |
PFAM |
|
Pfam:Anoctamin
|
378 |
955 |
6.7e-140 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121758
AA Change: H269R
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000112616
Gene: ENSMUSG00000031075
AA Change: H269R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Anoct_dimer
|
54 |
317 |
7.1e-83 |
PFAM |
|
Pfam:Anoctamin
|
320 |
901 |
2.2e-139 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131731
AA Change: H212R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000118206
Gene: ENSMUSG00000031075
AA Change: H212R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
129 |
147 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000119653
Gene: ENSMUSG00000031075
AA Change: H77R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Anoct_dimer
|
2 |
205 |
4.4e-64 |
PFAM |
|
Pfam:Anoctamin
|
208 |
335 |
3e-36 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155175
AA Change: H236R
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000120306
Gene: ENSMUSG00000031075
AA Change: H236R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
153 |
171 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
95% (99/104) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knockout allele exhibit postnatal death associated with aerophagia, slow postnatal weight gain, cyanosis, and abnormal tracheal morphology. Mice homozygous for a different knock-out allele exhibit proteinuria and intracellular endosomal vesicles in PTE cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca14 |
A |
T |
7: 119,854,520 (GRCm39) |
I895F |
probably benign |
Het |
| Abca16 |
A |
G |
7: 120,126,974 (GRCm39) |
N1222D |
possibly damaging |
Het |
| Abcc4 |
A |
T |
14: 118,852,593 (GRCm39) |
Y499N |
probably damaging |
Het |
| Adgrg7 |
A |
C |
16: 56,550,605 (GRCm39) |
C702W |
probably damaging |
Het |
| Adk |
C |
A |
14: 21,376,682 (GRCm39) |
P27H |
|
Het |
| Ankrd13a |
T |
C |
5: 114,913,293 (GRCm39) |
S2P |
probably damaging |
Het |
| Aox3 |
T |
A |
1: 58,197,688 (GRCm39) |
|
probably null |
Het |
| Asl |
G |
A |
5: 130,053,290 (GRCm39) |
|
probably benign |
Het |
| Asxl2 |
A |
T |
12: 3,507,066 (GRCm39) |
D86V |
probably damaging |
Het |
| Ate1 |
A |
T |
7: 130,083,508 (GRCm39) |
|
probably null |
Het |
| Bach2 |
A |
G |
4: 32,562,670 (GRCm39) |
D379G |
probably damaging |
Het |
| Bdkrb1 |
T |
A |
12: 105,571,142 (GRCm39) |
L236Q |
probably damaging |
Het |
| Cacna2d3 |
T |
C |
14: 29,443,654 (GRCm39) |
Y24C |
unknown |
Het |
| Cage1 |
G |
T |
13: 38,207,025 (GRCm39) |
N273K |
probably benign |
Het |
| Ccdc51 |
T |
A |
9: 108,920,848 (GRCm39) |
I245N |
probably damaging |
Het |
| Cep152 |
T |
C |
2: 125,456,325 (GRCm39) |
I229V |
probably benign |
Het |
| Chst4 |
T |
A |
8: 110,757,363 (GRCm39) |
S167C |
probably damaging |
Het |
| Cntnap4 |
A |
T |
8: 113,537,268 (GRCm39) |
Y713F |
probably damaging |
Het |
| Cntnap5b |
G |
A |
1: 99,978,519 (GRCm39) |
|
probably null |
Het |
| Cog8 |
G |
T |
8: 107,779,005 (GRCm39) |
T424K |
possibly damaging |
Het |
| Cop1 |
T |
G |
1: 159,071,922 (GRCm39) |
|
probably null |
Het |
| Cyp2j6 |
A |
G |
4: 96,434,019 (GRCm39) |
I97T |
probably damaging |
Het |
| D430041D05Rik |
T |
C |
2: 104,088,698 (GRCm39) |
T131A |
probably benign |
Het |
| Dnah17 |
T |
C |
11: 117,972,936 (GRCm39) |
D1999G |
probably damaging |
Het |
| Dnah8 |
A |
G |
17: 30,863,591 (GRCm39) |
D250G |
probably benign |
Het |
| Dnah8 |
T |
C |
17: 30,988,618 (GRCm39) |
V3196A |
possibly damaging |
Het |
| Dscam |
A |
T |
16: 96,631,117 (GRCm39) |
Y299* |
probably null |
Het |
| Efcab3 |
A |
G |
11: 104,858,578 (GRCm39) |
N3879S |
unknown |
Het |
| Efcab3 |
A |
C |
11: 104,913,764 (GRCm39) |
D4594A |
probably benign |
Het |
| Ephb1 |
A |
G |
9: 101,841,157 (GRCm39) |
S774P |
probably damaging |
Het |
| Fat1 |
G |
A |
8: 45,403,962 (GRCm39) |
V238I |
probably benign |
Het |
| Fermt1 |
C |
T |
2: 132,776,785 (GRCm39) |
M234I |
probably benign |
Het |
| Fmnl2 |
C |
T |
2: 52,958,552 (GRCm39) |
S212L |
|
Het |
| Frem1 |
T |
C |
4: 82,840,532 (GRCm39) |
N1798S |
possibly damaging |
Het |
| Gabrd |
T |
A |
4: 155,469,863 (GRCm39) |
M449L |
probably benign |
Het |
| Gad1 |
T |
C |
2: 70,417,706 (GRCm39) |
F302L |
probably benign |
Het |
| Gm10800 |
A |
AC |
2: 98,497,378 (GRCm39) |
|
probably null |
Het |
| Gm21886 |
GGGCCTGCAGACAGTAGGTGCTCACTAGGGCCTGTAAATAGTAGGTGCTCACTGAGGCCTGTAGACAGTAGGTGCTCA |
GGGCCTGTAGACAGTAGGTGCTCA |
18: 80,132,697 (GRCm39) |
|
probably benign |
Het |
| Gnb3 |
C |
T |
6: 124,813,887 (GRCm39) |
|
probably null |
Het |
| Gtf3c1 |
A |
T |
7: 125,271,993 (GRCm39) |
M642K |
possibly damaging |
Het |
| Hps3 |
A |
T |
3: 20,063,050 (GRCm39) |
W838R |
probably damaging |
Het |
| Ide |
A |
T |
19: 37,273,343 (GRCm39) |
W527R |
|
Het |
| Ighe |
A |
T |
12: 113,235,975 (GRCm39) |
I117N |
|
Het |
| Ighv1-50 |
T |
C |
12: 115,083,396 (GRCm39) |
E108G |
probably benign |
Het |
| Ivl |
G |
A |
3: 92,479,538 (GRCm39) |
P176S |
probably damaging |
Het |
| Lamb2 |
T |
A |
9: 108,361,283 (GRCm39) |
L605Q |
possibly damaging |
Het |
| Lgi3 |
G |
A |
14: 70,770,832 (GRCm39) |
R157H |
probably damaging |
Het |
| Lrp1b |
G |
T |
2: 41,266,006 (GRCm39) |
C1053* |
probably null |
Het |
| Mcpt9 |
A |
T |
14: 56,264,445 (GRCm39) |
S217T |
probably damaging |
Het |
| Mgat4c |
T |
G |
10: 102,224,357 (GRCm39) |
N190K |
probably damaging |
Het |
| Mknk1 |
T |
A |
4: 115,721,789 (GRCm39) |
V111D |
probably damaging |
Het |
| Mmp11 |
T |
C |
10: 75,764,280 (GRCm39) |
T62A |
probably benign |
Het |
| Mmp1b |
C |
A |
9: 7,385,014 (GRCm39) |
V212F |
probably damaging |
Het |
| Mmp7 |
A |
G |
9: 7,697,587 (GRCm39) |
|
probably null |
Het |
| Muc5b |
C |
T |
7: 141,417,704 (GRCm39) |
T3550M |
possibly damaging |
Het |
| Nbeal1 |
G |
C |
1: 60,276,310 (GRCm39) |
V684L |
probably benign |
Het |
| Nphp3 |
A |
T |
9: 103,882,036 (GRCm39) |
K169* |
probably null |
Het |
| Npy6r |
G |
T |
18: 44,408,788 (GRCm39) |
V70F |
probably benign |
Het |
| Nsun2 |
T |
A |
13: 69,774,672 (GRCm39) |
|
probably null |
Het |
| Oplah |
T |
A |
15: 76,186,860 (GRCm39) |
I652F |
probably benign |
Het |
| Pcdh18 |
T |
C |
3: 49,710,271 (GRCm39) |
N348S |
probably damaging |
Het |
| Pcdhb5 |
T |
A |
18: 37,454,409 (GRCm39) |
V263D |
probably damaging |
Het |
| Pcdhga1 |
C |
A |
18: 37,795,164 (GRCm39) |
T56N |
probably benign |
Het |
| Pdk4 |
A |
G |
6: 5,491,068 (GRCm39) |
|
probably null |
Het |
| Pfkp |
C |
A |
13: 6,652,817 (GRCm39) |
V434F |
probably benign |
Het |
| Phospho1 |
G |
A |
11: 95,721,732 (GRCm39) |
R134H |
probably damaging |
Het |
| Polg2 |
G |
T |
11: 106,663,572 (GRCm39) |
Q374K |
probably benign |
Het |
| Ptpra |
T |
C |
2: 130,379,571 (GRCm39) |
|
probably null |
Het |
| Rassf3 |
C |
T |
10: 121,252,052 (GRCm39) |
E120K |
probably benign |
Het |
| Reln |
A |
T |
5: 22,311,095 (GRCm39) |
S273T |
probably damaging |
Het |
| Scarb1 |
C |
T |
5: 125,361,089 (GRCm39) |
A133T |
probably benign |
Het |
| Scn3a |
T |
A |
2: 65,313,486 (GRCm39) |
K1142N |
probably damaging |
Het |
| Sema3c |
G |
A |
5: 17,899,701 (GRCm39) |
V398I |
probably benign |
Het |
| Serpine1 |
C |
A |
5: 137,099,918 (GRCm39) |
Q80H |
probably damaging |
Het |
| Sh3gl1 |
G |
A |
17: 56,324,646 (GRCm39) |
T334M |
probably damaging |
Het |
| Smg7 |
T |
C |
1: 152,737,576 (GRCm39) |
N122D |
probably benign |
Het |
| Speer4b |
T |
C |
5: 27,703,708 (GRCm39) |
I144V |
probably benign |
Het |
| Spire2 |
T |
A |
8: 124,095,989 (GRCm39) |
D671E |
probably benign |
Het |
| Sspo |
A |
T |
6: 48,478,029 (GRCm39) |
H5144L |
probably benign |
Het |
| Sstr2 |
A |
T |
11: 113,516,179 (GRCm39) |
Q366L |
probably damaging |
Het |
| Ssu72 |
T |
C |
4: 155,815,850 (GRCm39) |
F98S |
probably damaging |
Het |
| Syde2 |
C |
T |
3: 145,712,870 (GRCm39) |
Q1003* |
probably null |
Het |
| Tapbp |
G |
A |
17: 34,144,461 (GRCm39) |
A186T |
possibly damaging |
Het |
| Tcf12 |
T |
A |
9: 71,790,385 (GRCm39) |
|
probably null |
Het |
| Tnfrsf22 |
A |
T |
7: 143,194,556 (GRCm39) |
C124S |
probably damaging |
Het |
| Txlnb |
A |
T |
10: 17,703,546 (GRCm39) |
T235S |
possibly damaging |
Het |
| Uaca |
T |
C |
9: 60,777,695 (GRCm39) |
L694P |
probably damaging |
Het |
| Unc13a |
T |
A |
8: 72,083,197 (GRCm39) |
N1620Y |
probably damaging |
Het |
| Vmn2r10 |
C |
T |
5: 109,151,200 (GRCm39) |
C138Y |
probably damaging |
Het |
| Vmn2r111 |
T |
C |
17: 22,778,032 (GRCm39) |
N549S |
possibly damaging |
Het |
| Vmn2r28 |
T |
A |
7: 5,484,495 (GRCm39) |
E568D |
probably benign |
Het |
| Vmn2r57 |
A |
T |
7: 41,097,895 (GRCm39) |
H57Q |
possibly damaging |
Het |
| Vwa5b1 |
A |
G |
4: 138,308,923 (GRCm39) |
S756P |
probably benign |
Het |
| Washc5 |
C |
A |
15: 59,224,350 (GRCm39) |
E470* |
probably null |
Het |
| Xpot |
A |
T |
10: 121,442,678 (GRCm39) |
V508D |
probably damaging |
Het |
| Zfp616 |
A |
T |
11: 73,976,087 (GRCm39) |
K785N |
possibly damaging |
Het |
| Zfp653 |
T |
C |
9: 21,977,195 (GRCm39) |
N119D |
probably damaging |
Het |
| Zfp729b |
A |
G |
13: 67,741,495 (GRCm39) |
S257P |
probably damaging |
Het |
| Zfp82 |
T |
A |
7: 29,755,592 (GRCm39) |
T497S |
probably benign |
Het |
| Znrf4 |
T |
G |
17: 56,819,305 (GRCm39) |
M1L |
probably benign |
Het |
|
| Other mutations in Ano1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00595:Ano1
|
APN |
7 |
144,192,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00754:Ano1
|
APN |
7 |
144,150,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00780:Ano1
|
APN |
7 |
144,209,367 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00918:Ano1
|
APN |
7 |
144,198,489 (GRCm39) |
splice site |
probably benign |
|
|
IGL01112:Ano1
|
APN |
7 |
144,190,882 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL01285:Ano1
|
APN |
7 |
144,198,479 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01285:Ano1
|
APN |
7 |
144,149,275 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01308:Ano1
|
APN |
7 |
144,149,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01407:Ano1
|
APN |
7 |
144,190,848 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01672:Ano1
|
APN |
7 |
144,209,412 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01920:Ano1
|
APN |
7 |
144,165,191 (GRCm39) |
splice site |
probably benign |
|
|
IGL01926:Ano1
|
APN |
7 |
144,164,612 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02164:Ano1
|
APN |
7 |
144,190,918 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02190:Ano1
|
APN |
7 |
144,172,620 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02214:Ano1
|
APN |
7 |
144,209,445 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02299:Ano1
|
APN |
7 |
144,143,812 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02567:Ano1
|
APN |
7 |
144,165,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03131:Ano1
|
APN |
7 |
144,157,322 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03291:Ano1
|
APN |
7 |
144,175,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03299:Ano1
|
APN |
7 |
144,207,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03394:Ano1
|
APN |
7 |
144,149,176 (GRCm39) |
splice site |
probably null |
|
|
PIT4434001:Ano1
|
UTSW |
7 |
144,164,632 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0502:Ano1
|
UTSW |
7 |
144,150,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0595:Ano1
|
UTSW |
7 |
144,143,890 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0732:Ano1
|
UTSW |
7 |
144,173,225 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0970:Ano1
|
UTSW |
7 |
144,149,308 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0988:Ano1
|
UTSW |
7 |
144,187,390 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1074:Ano1
|
UTSW |
7 |
144,165,417 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1301:Ano1
|
UTSW |
7 |
144,187,426 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1528:Ano1
|
UTSW |
7 |
144,149,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2018:Ano1
|
UTSW |
7 |
144,207,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2056:Ano1
|
UTSW |
7 |
144,201,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2057:Ano1
|
UTSW |
7 |
144,201,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2058:Ano1
|
UTSW |
7 |
144,201,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2059:Ano1
|
UTSW |
7 |
144,165,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Ano1
|
UTSW |
7 |
144,143,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2861:Ano1
|
UTSW |
7 |
144,143,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3770:Ano1
|
UTSW |
7 |
144,149,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3970:Ano1
|
UTSW |
7 |
144,161,700 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4179:Ano1
|
UTSW |
7 |
144,204,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4489:Ano1
|
UTSW |
7 |
144,165,479 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4678:Ano1
|
UTSW |
7 |
144,223,289 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4915:Ano1
|
UTSW |
7 |
144,165,112 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5114:Ano1
|
UTSW |
7 |
144,210,820 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5362:Ano1
|
UTSW |
7 |
144,202,337 (GRCm39) |
unclassified |
probably benign |
|
|
R5364:Ano1
|
UTSW |
7 |
144,190,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5366:Ano1
|
UTSW |
7 |
144,207,946 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5387:Ano1
|
UTSW |
7 |
144,202,356 (GRCm39) |
missense |
probably benign |
|
|
R5762:Ano1
|
UTSW |
7 |
144,201,774 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5857:Ano1
|
UTSW |
7 |
144,190,840 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6091:Ano1
|
UTSW |
7 |
144,223,171 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6093:Ano1
|
UTSW |
7 |
144,165,114 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6177:Ano1
|
UTSW |
7 |
144,232,478 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6246:Ano1
|
UTSW |
7 |
144,187,462 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6274:Ano1
|
UTSW |
7 |
144,172,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6323:Ano1
|
UTSW |
7 |
144,165,423 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6574:Ano1
|
UTSW |
7 |
144,161,653 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6782:Ano1
|
UTSW |
7 |
144,175,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6880:Ano1
|
UTSW |
7 |
144,198,479 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6909:Ano1
|
UTSW |
7 |
144,209,468 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7066:Ano1
|
UTSW |
7 |
144,190,823 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7073:Ano1
|
UTSW |
7 |
144,192,289 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7420:Ano1
|
UTSW |
7 |
144,209,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7874:Ano1
|
UTSW |
7 |
144,175,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8468:Ano1
|
UTSW |
7 |
144,209,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8867:Ano1
|
UTSW |
7 |
144,223,397 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8923:Ano1
|
UTSW |
7 |
144,204,288 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9215:Ano1
|
UTSW |
7 |
144,149,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9281:Ano1
|
UTSW |
7 |
144,149,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9572:Ano1
|
UTSW |
7 |
144,204,293 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9668:Ano1
|
UTSW |
7 |
144,164,579 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9681:Ano1
|
UTSW |
7 |
144,143,893 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R9756:Ano1
|
UTSW |
7 |
144,162,666 (GRCm39) |
missense |
probably benign |
0.45 |
|
R9780:Ano1
|
UTSW |
7 |
144,209,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9792:Ano1
|
UTSW |
7 |
144,175,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9793:Ano1
|
UTSW |
7 |
144,175,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9795:Ano1
|
UTSW |
7 |
144,175,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCAAAATTCTGCAATCCCTC -3'
(R):5'- TCTCGCCAGCCAAGAATAGG -3'
Sequencing Primer
(F):5'- GCAAAATTCTGCAATCCCTCTCTCC -3'
(R):5'- CCTCGCAGTTTATGGAGATACAGC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation