Incidental Mutation 'R7148:Vmn2r23'
| ID |
553940 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r23
|
| Ensembl Gene |
ENSMUSG00000091620 |
| Gene Name |
vomeronasal 2, receptor 23 |
| Synonyms |
EG435916 |
| MMRRC Submission |
045225-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R7148 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
123702821-123742291 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 123713022 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 286
(F286I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126682
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172391]
|
| AlphaFold |
E9PXI5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172391
AA Change: F286I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: F286I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
79 |
461 |
1.7e-31 |
PFAM |
|
Pfam:NCD3G
|
513 |
566 |
1.2e-23 |
PFAM |
|
Pfam:7tm_3
|
596 |
834 |
1.5e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700024G13Rik |
T |
A |
14: 32,388,312 (GRCm38) |
Y14F |
probably damaging |
Het |
| 2410131K14Rik |
A |
G |
5: 118,255,694 (GRCm38) |
N46D |
probably benign |
Het |
| 4930563D23Rik |
T |
C |
16: 92,320,987 (GRCm38) |
K138E |
probably benign |
Het |
| Acly |
A |
G |
11: 100,483,782 (GRCm38) |
V805A |
possibly damaging |
Het |
| AF366264 |
T |
A |
8: 13,837,996 (GRCm38) |
I32L |
probably benign |
Het |
| Apcdd1 |
T |
C |
18: 62,951,845 (GRCm38) |
V371A |
probably damaging |
Het |
| Cacna1g |
A |
T |
11: 94,465,930 (GRCm38) |
F127I |
probably benign |
Het |
| Ccdc129 |
T |
C |
6: 55,897,686 (GRCm38) |
I207T |
probably damaging |
Het |
| Ccdc138 |
T |
C |
10: 58,538,280 (GRCm38) |
L374P |
probably damaging |
Het |
| Ces2b |
A |
G |
8: 104,838,296 (GRCm38) |
Y504C |
probably damaging |
Het |
| Ces5a |
C |
T |
8: 93,502,322 (GRCm38) |
G427S |
probably damaging |
Het |
| Chd1l |
C |
T |
3: 97,591,316 (GRCm38) |
V256M |
probably damaging |
Het |
| Col24a1 |
C |
T |
3: 145,315,299 (GRCm38) |
T477M |
probably damaging |
Het |
| Dmbt1 |
T |
A |
7: 131,066,734 (GRCm38) |
C573* |
probably null |
Het |
| Emcn |
A |
T |
3: 137,417,094 (GRCm38) |
Y188F |
possibly damaging |
Het |
| Eva1a |
T |
G |
6: 82,071,144 (GRCm38) |
M1R |
probably null |
Het |
| Fam83h |
C |
A |
15: 76,005,167 (GRCm38) |
D194Y |
probably damaging |
Het |
| Flywch1 |
T |
C |
17: 23,755,675 (GRCm38) |
K664E |
probably benign |
Het |
| Fzd9 |
A |
G |
5: 135,249,690 (GRCm38) |
V447A |
probably benign |
Het |
| Gm21964 |
G |
T |
8: 110,109,416 (GRCm38) |
R119I |
probably benign |
Het |
| Heatr5b |
T |
C |
17: 78,831,434 (GRCm38) |
D93G |
probably damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,686,854 (GRCm38) |
I2318V |
probably benign |
Het |
| Hyal5 |
T |
A |
6: 24,876,902 (GRCm38) |
L258Q |
probably damaging |
Het |
| Kmo |
T |
A |
1: 175,651,602 (GRCm38) |
C235S |
probably damaging |
Het |
| Lamc2 |
G |
A |
1: 153,185,984 (GRCm38) |
P2S |
probably benign |
Het |
| Lman2 |
G |
A |
13: 55,352,949 (GRCm38) |
P146S |
probably benign |
Het |
| Mars2 |
T |
C |
1: 55,237,514 (GRCm38) |
I92T |
probably damaging |
Het |
| Msh3 |
A |
G |
13: 92,354,822 (GRCm38) |
F27L |
probably benign |
Het |
| Myom2 |
T |
C |
8: 15,084,577 (GRCm38) |
V460A |
possibly damaging |
Het |
| Nicn1 |
T |
A |
9: 108,295,107 (GRCm38) |
*214R |
probably null |
Het |
| Nsd2 |
T |
C |
5: 33,885,511 (GRCm38) |
F1040L |
possibly damaging |
Het |
| Olfr374 |
T |
A |
8: 72,110,157 (GRCm38) |
I197N |
possibly damaging |
Het |
| Osm |
T |
A |
11: 4,239,936 (GRCm38) |
I240N |
probably benign |
Het |
| Pard3b |
T |
A |
1: 62,440,032 (GRCm38) |
D884E |
probably benign |
Het |
| Pex5 |
T |
G |
6: 124,405,272 (GRCm38) |
D150A |
probably benign |
Het |
| Pfkfb4 |
T |
C |
9: 109,027,608 (GRCm38) |
V394A |
probably damaging |
Het |
| Pjvk |
A |
G |
2: 76,658,487 (GRCm38) |
K334R |
possibly damaging |
Het |
| Pkd1l2 |
T |
C |
8: 117,080,786 (GRCm38) |
D171G |
probably benign |
Het |
| Prpf4b |
T |
G |
13: 34,894,472 (GRCm38) |
N688K |
probably benign |
Het |
| R3hcc1 |
T |
C |
14: 69,705,552 (GRCm38) |
E192G |
possibly damaging |
Het |
| Rad54l2 |
C |
A |
9: 106,719,119 (GRCm38) |
G207* |
probably null |
Het |
| Rhobtb3 |
G |
T |
13: 75,910,887 (GRCm38) |
T264K |
probably benign |
Het |
| Rpl27 |
A |
G |
11: 101,442,406 (GRCm38) |
|
probably benign |
Het |
| Rxfp3 |
C |
T |
15: 11,036,777 (GRCm38) |
V170I |
possibly damaging |
Het |
| Samd4 |
T |
A |
14: 47,016,683 (GRCm38) |
S201R |
probably benign |
Het |
| Sell |
A |
G |
1: 164,065,607 (GRCm38) |
I131V |
possibly damaging |
Het |
| Sirpb1c |
A |
T |
3: 15,833,059 (GRCm38) |
Y205* |
probably null |
Het |
| Smc3 |
A |
T |
19: 53,641,895 (GRCm38) |
E1111V |
possibly damaging |
Het |
| Sowaha |
C |
A |
11: 53,479,355 (GRCm38) |
V185L |
probably benign |
Het |
| Spata4 |
A |
C |
8: 54,602,550 (GRCm38) |
I159L |
probably benign |
Het |
| Tekt2 |
A |
G |
4: 126,322,381 (GRCm38) |
I373T |
probably benign |
Het |
| Tomm20l |
T |
C |
12: 71,117,539 (GRCm38) |
V65A |
probably benign |
Het |
| Trabd2b |
A |
G |
4: 114,409,350 (GRCm38) |
D187G |
probably damaging |
Het |
| Trrap |
A |
G |
5: 144,821,803 (GRCm38) |
I2147V |
possibly damaging |
Het |
| Tsc22d2 |
T |
A |
3: 58,417,008 (GRCm38) |
C440* |
probably null |
Het |
| Ube3b |
A |
C |
5: 114,406,252 (GRCm38) |
N570T |
probably damaging |
Het |
| Uevld |
A |
G |
7: 46,950,976 (GRCm38) |
I70T |
probably damaging |
Het |
| Usp10 |
C |
T |
8: 119,936,550 (GRCm38) |
T37I |
possibly damaging |
Het |
| Vmn2r62 |
A |
G |
7: 42,765,216 (GRCm38) |
V601A |
probably benign |
Het |
| Wdr81 |
G |
C |
11: 75,446,002 (GRCm38) |
N401K |
|
Het |
| Ythdc2 |
G |
T |
18: 44,833,122 (GRCm38) |
V142F |
probably benign |
Het |
| Zfp346 |
T |
C |
13: 55,105,450 (GRCm38) |
F36S |
possibly damaging |
Het |
| Zfp748 |
C |
T |
13: 67,542,239 (GRCm38) |
V301M |
possibly damaging |
Het |
| Zim1 |
T |
C |
7: 6,678,221 (GRCm38) |
K148E |
possibly damaging |
Het |
|
| Other mutations in Vmn2r23 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00324:Vmn2r23
|
APN |
6 |
123,729,725 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
IGL01012:Vmn2r23
|
APN |
6 |
123,729,596 (GRCm38) |
missense |
probably benign |
|
|
IGL01073:Vmn2r23
|
APN |
6 |
123,712,800 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
IGL01547:Vmn2r23
|
APN |
6 |
123,704,424 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL01571:Vmn2r23
|
APN |
6 |
123,704,407 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01950:Vmn2r23
|
APN |
6 |
123,741,886 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
IGL02028:Vmn2r23
|
APN |
6 |
123,741,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02248:Vmn2r23
|
APN |
6 |
123,741,744 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02318:Vmn2r23
|
APN |
6 |
123,741,836 (GRCm38) |
missense |
probably benign |
0.10 |
|
IGL02649:Vmn2r23
|
APN |
6 |
123,704,478 (GRCm38) |
missense |
probably benign |
|
|
IGL02831:Vmn2r23
|
APN |
6 |
123,704,385 (GRCm38) |
missense |
probably benign |
0.22 |
|
IGL02832:Vmn2r23
|
APN |
6 |
123,704,396 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02865:Vmn2r23
|
APN |
6 |
123,741,619 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02964:Vmn2r23
|
APN |
6 |
123,741,782 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL03347:Vmn2r23
|
APN |
6 |
123,704,374 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL03396:Vmn2r23
|
APN |
6 |
123,729,626 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4472001:Vmn2r23
|
UTSW |
6 |
123,712,977 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R0597:Vmn2r23
|
UTSW |
6 |
123,729,721 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0677:Vmn2r23
|
UTSW |
6 |
123,713,451 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0904:Vmn2r23
|
UTSW |
6 |
123,742,135 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1330:Vmn2r23
|
UTSW |
6 |
123,742,004 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1424:Vmn2r23
|
UTSW |
6 |
123,713,270 (GRCm38) |
nonsense |
probably null |
|
|
R1629:Vmn2r23
|
UTSW |
6 |
123,713,427 (GRCm38) |
missense |
probably benign |
0.05 |
|
R1842:Vmn2r23
|
UTSW |
6 |
123,729,690 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R1867:Vmn2r23
|
UTSW |
6 |
123,702,915 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1919:Vmn2r23
|
UTSW |
6 |
123,713,010 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R2087:Vmn2r23
|
UTSW |
6 |
123,741,499 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2338:Vmn2r23
|
UTSW |
6 |
123,704,425 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R2568:Vmn2r23
|
UTSW |
6 |
123,742,188 (GRCm38) |
nonsense |
probably null |
|
|
R2867:Vmn2r23
|
UTSW |
6 |
123,713,164 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R2867:Vmn2r23
|
UTSW |
6 |
123,713,164 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R3500:Vmn2r23
|
UTSW |
6 |
123,713,170 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R3789:Vmn2r23
|
UTSW |
6 |
123,741,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4164:Vmn2r23
|
UTSW |
6 |
123,729,738 (GRCm38) |
missense |
probably benign |
|
|
R4506:Vmn2r23
|
UTSW |
6 |
123,702,925 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4652:Vmn2r23
|
UTSW |
6 |
123,741,730 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4697:Vmn2r23
|
UTSW |
6 |
123,741,826 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4840:Vmn2r23
|
UTSW |
6 |
123,713,074 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4983:Vmn2r23
|
UTSW |
6 |
123,733,349 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5276:Vmn2r23
|
UTSW |
6 |
123,712,977 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R5392:Vmn2r23
|
UTSW |
6 |
123,704,364 (GRCm38) |
missense |
probably benign |
0.36 |
|
R5528:Vmn2r23
|
UTSW |
6 |
123,713,002 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5529:Vmn2r23
|
UTSW |
6 |
123,713,451 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5664:Vmn2r23
|
UTSW |
6 |
123,713,074 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5749:Vmn2r23
|
UTSW |
6 |
123,733,273 (GRCm38) |
missense |
probably benign |
|
|
R5761:Vmn2r23
|
UTSW |
6 |
123,712,759 (GRCm38) |
missense |
probably benign |
0.39 |
|
R5762:Vmn2r23
|
UTSW |
6 |
123,733,393 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5868:Vmn2r23
|
UTSW |
6 |
123,712,942 (GRCm38) |
missense |
probably benign |
0.12 |
|
R5935:Vmn2r23
|
UTSW |
6 |
123,741,895 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6242:Vmn2r23
|
UTSW |
6 |
123,704,400 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R6416:Vmn2r23
|
UTSW |
6 |
123,712,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6524:Vmn2r23
|
UTSW |
6 |
123,713,425 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r23
|
UTSW |
6 |
123,733,273 (GRCm38) |
missense |
probably benign |
|
|
R6925:Vmn2r23
|
UTSW |
6 |
123,704,553 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7215:Vmn2r23
|
UTSW |
6 |
123,704,364 (GRCm38) |
missense |
probably benign |
0.36 |
|
R7252:Vmn2r23
|
UTSW |
6 |
123,741,581 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7403:Vmn2r23
|
UTSW |
6 |
123,704,579 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8015:Vmn2r23
|
UTSW |
6 |
123,704,541 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8143:Vmn2r23
|
UTSW |
6 |
123,741,353 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8474:Vmn2r23
|
UTSW |
6 |
123,704,640 (GRCm38) |
missense |
probably benign |
0.36 |
|
R8520:Vmn2r23
|
UTSW |
6 |
123,741,656 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8679:Vmn2r23
|
UTSW |
6 |
123,713,472 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8713:Vmn2r23
|
UTSW |
6 |
123,703,032 (GRCm38) |
missense |
|
|
|
R8966:Vmn2r23
|
UTSW |
6 |
123,742,120 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9124:Vmn2r23
|
UTSW |
6 |
123,742,079 (GRCm38) |
missense |
possibly damaging |
0.57 |
|
R9163:Vmn2r23
|
UTSW |
6 |
123,741,823 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9189:Vmn2r23
|
UTSW |
6 |
123,704,364 (GRCm38) |
missense |
probably benign |
0.36 |
|
R9451:Vmn2r23
|
UTSW |
6 |
123,733,393 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9495:Vmn2r23
|
UTSW |
6 |
123,712,713 (GRCm38) |
missense |
probably benign |
0.30 |
|
R9514:Vmn2r23
|
UTSW |
6 |
123,712,713 (GRCm38) |
missense |
probably benign |
0.30 |
|
RF018:Vmn2r23
|
UTSW |
6 |
123,713,116 (GRCm38) |
missense |
probably benign |
0.00 |
|
T0975:Vmn2r23
|
UTSW |
6 |
123,713,161 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1088:Vmn2r23
|
UTSW |
6 |
123,742,108 (GRCm38) |
missense |
probably damaging |
0.98 |
|
Z1177:Vmn2r23
|
UTSW |
6 |
123,729,725 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCTTAGGGACATCACAGAGG -3'
(R):5'- AGATGGACCACACATCCTGG -3'
Sequencing Primer
(F):5'- GAGATGACGAACCATGGACTTTGTG -3'
(R):5'- GGTTGAACGTCTCTGAGAAAATCC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation