Incidental Mutation 'R0601:Megf8'
| ID |
55396 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Megf8
|
| Ensembl Gene |
ENSMUSG00000045039 |
| Gene Name |
multiple EGF-like-domains 8 |
| Synonyms |
m687Ddg, b2b1702Clo, Egfl4, b2b288Clo |
| MMRRC Submission |
038790-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.952)
|
| Stock # |
R0601 (G1)
|
| Quality Score |
186 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
25016589-25065342 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 25027965 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Proline
at position 205
(H205P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122192
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000128119]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000128119
AA Change: H205P
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000122192
Gene: ENSMUSG00000045039
AA Change: H205P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
CUB
|
33 |
140 |
1.24e-15 |
SMART |
|
EGF
|
141 |
170 |
4.26e0 |
SMART |
|
EGF
|
173 |
203 |
2.43e1 |
SMART |
|
Pfam:Kelch_4
|
227 |
277 |
1.3e-11 |
PFAM |
|
Pfam:Kelch_3
|
240 |
287 |
1.6e-7 |
PFAM |
|
low complexity region
|
320 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
531 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
738 |
N/A |
INTRINSIC |
|
PSI
|
847 |
899 |
1.37e0 |
SMART |
|
low complexity region
|
932 |
938 |
N/A |
INTRINSIC |
|
PSI
|
949 |
991 |
2.11e-2 |
SMART |
|
PSI
|
1005 |
1073 |
7.82e-1 |
SMART |
|
EGF_CA
|
1074 |
1115 |
2.62e-9 |
SMART |
|
EGF
|
1117 |
1160 |
5.4e-2 |
SMART |
|
EGF_like
|
1163 |
1208 |
4e-1 |
SMART |
|
EGF_Lam
|
1211 |
1259 |
1.03e-7 |
SMART |
|
Blast:CUB
|
1263 |
1401 |
1e-30 |
BLAST |
|
EGF_like
|
1406 |
1445 |
3.29e1 |
SMART |
|
Pfam:Kelch_4
|
1509 |
1564 |
6.5e-12 |
PFAM |
|
Pfam:Kelch_3
|
1520 |
1574 |
1.2e-10 |
PFAM |
|
PSI
|
1868 |
1923 |
2.75e-1 |
SMART |
|
PSI
|
2004 |
2062 |
1.6e0 |
SMART |
|
PSI
|
2064 |
2121 |
1.68e-5 |
SMART |
|
EGF
|
2125 |
2164 |
1.08e-1 |
SMART |
|
EGF
|
2166 |
2194 |
4.26e0 |
SMART |
|
EGF
|
2204 |
2244 |
2.2e1 |
SMART |
|
EGF_like
|
2248 |
2321 |
6.37e-1 |
SMART |
|
low complexity region
|
2493 |
2504 |
N/A |
INTRINSIC |
|
low complexity region
|
2530 |
2541 |
N/A |
INTRINSIC |
|
transmembrane domain
|
2592 |
2614 |
N/A |
INTRINSIC |
|
low complexity region
|
2649 |
2668 |
N/A |
INTRINSIC |
|
low complexity region
|
2674 |
2702 |
N/A |
INTRINSIC |
|
low complexity region
|
2759 |
2774 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1280 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.2%
|
| Validation Efficiency |
98% (119/122) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects. Mice homozygous for another ENU-induced mutation exhibit abnormal development and patterning of the peripheral nervous system. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 119 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930596D02Rik |
T |
G |
14: 35,532,146 (GRCm39) |
D143A |
probably damaging |
Het |
| Abca9 |
C |
T |
11: 110,007,884 (GRCm39) |
|
probably null |
Het |
| Abcc5 |
A |
G |
16: 20,223,309 (GRCm39) |
|
probably benign |
Het |
| Ablim3 |
T |
A |
18: 61,982,441 (GRCm39) |
D168V |
probably benign |
Het |
| Acsl3 |
C |
T |
1: 78,673,896 (GRCm39) |
S352F |
probably damaging |
Het |
| Adgrl4 |
A |
T |
3: 151,204,066 (GRCm39) |
|
probably benign |
Het |
| Arhgap29 |
A |
G |
3: 121,784,759 (GRCm39) |
K229E |
probably damaging |
Het |
| Atad3a |
A |
T |
4: 155,831,864 (GRCm39) |
V470D |
probably damaging |
Het |
| Atp8b1 |
A |
G |
18: 64,704,724 (GRCm39) |
|
probably null |
Het |
| Bcl2 |
G |
A |
1: 106,640,292 (GRCm39) |
R107C |
probably damaging |
Het |
| Bpifa5 |
A |
G |
2: 154,006,175 (GRCm39) |
N121S |
possibly damaging |
Het |
| Bpifb4 |
G |
A |
2: 153,789,203 (GRCm39) |
|
probably benign |
Het |
| Bptf |
T |
A |
11: 106,952,518 (GRCm39) |
T2112S |
probably benign |
Het |
| Btnl4 |
T |
C |
17: 34,688,285 (GRCm39) |
K498E |
probably benign |
Het |
| Calhm2 |
A |
G |
19: 47,129,469 (GRCm39) |
|
probably null |
Het |
| Capn3 |
A |
T |
2: 120,333,077 (GRCm39) |
|
probably null |
Het |
| Caps2 |
T |
C |
10: 112,031,695 (GRCm39) |
F265L |
possibly damaging |
Het |
| Casp3 |
G |
T |
8: 47,089,262 (GRCm39) |
C170F |
probably benign |
Het |
| Ccdc39 |
T |
C |
3: 33,873,988 (GRCm39) |
R615G |
probably damaging |
Het |
| Cd177 |
A |
G |
7: 24,451,738 (GRCm39) |
I426T |
probably benign |
Het |
| Cfap53 |
G |
A |
18: 74,433,221 (GRCm39) |
R102H |
possibly damaging |
Het |
| Cfhr3 |
G |
A |
1: 139,521,623 (GRCm39) |
|
noncoding transcript |
Het |
| Col7a1 |
T |
C |
9: 108,809,652 (GRCm39) |
|
probably benign |
Het |
| Cplx3 |
T |
C |
9: 57,513,357 (GRCm39) |
E24G |
possibly damaging |
Het |
| Dhx30 |
A |
G |
9: 109,915,782 (GRCm39) |
|
probably null |
Het |
| Dnah8 |
T |
A |
17: 30,927,332 (GRCm39) |
N1329K |
probably benign |
Het |
| Dnajc11 |
C |
G |
4: 152,054,393 (GRCm39) |
R200G |
probably damaging |
Het |
| Dok3 |
A |
T |
13: 55,672,076 (GRCm39) |
F201I |
probably benign |
Het |
| Dpf2 |
A |
T |
19: 5,952,240 (GRCm39) |
H303Q |
probably damaging |
Het |
| Dtnb |
A |
G |
12: 3,785,039 (GRCm39) |
|
probably benign |
Het |
| Dync2i1 |
T |
C |
12: 116,219,555 (GRCm39) |
D129G |
possibly damaging |
Het |
| Elk3 |
T |
C |
10: 93,101,343 (GRCm39) |
E136G |
probably damaging |
Het |
| Ephb1 |
T |
C |
9: 102,072,329 (GRCm39) |
D150G |
probably damaging |
Het |
| Erbb3 |
A |
G |
10: 128,412,881 (GRCm39) |
S570P |
probably benign |
Het |
| F2 |
A |
T |
2: 91,463,656 (GRCm39) |
|
probably null |
Het |
| Fanca |
A |
T |
8: 124,035,252 (GRCm39) |
M231K |
probably damaging |
Het |
| Fbxo34 |
T |
C |
14: 47,767,714 (GRCm39) |
V358A |
probably benign |
Het |
| Foxp1 |
C |
T |
6: 98,907,083 (GRCm39) |
E666K |
probably damaging |
Het |
| Fto |
A |
G |
8: 92,128,430 (GRCm39) |
|
probably null |
Het |
| Gbp2 |
C |
T |
3: 142,336,519 (GRCm39) |
R290C |
possibly damaging |
Het |
| Gm57859 |
T |
A |
11: 113,578,712 (GRCm39) |
S36T |
probably benign |
Het |
| Grik2 |
T |
G |
10: 49,298,693 (GRCm39) |
S343R |
probably damaging |
Het |
| Heatr5b |
A |
T |
17: 79,075,974 (GRCm39) |
M1448K |
probably benign |
Het |
| Hmgn3 |
A |
T |
9: 83,028,482 (GRCm39) |
|
probably null |
Het |
| Htt |
T |
C |
5: 35,003,347 (GRCm39) |
V1274A |
probably benign |
Het |
| Kcnh8 |
A |
G |
17: 53,201,033 (GRCm39) |
D489G |
probably damaging |
Het |
| Kcnip3 |
A |
T |
2: 127,300,317 (GRCm39) |
|
probably benign |
Het |
| Kdm5a |
A |
G |
6: 120,379,632 (GRCm39) |
T647A |
possibly damaging |
Het |
| Krt72 |
T |
C |
15: 101,694,491 (GRCm39) |
R135G |
probably damaging |
Het |
| Larp7 |
T |
A |
3: 127,337,858 (GRCm39) |
K400N |
probably damaging |
Het |
| Lifr |
T |
C |
15: 7,198,753 (GRCm39) |
|
probably null |
Het |
| Lima1 |
G |
A |
15: 99,678,353 (GRCm39) |
P696L |
probably damaging |
Het |
| Lrrc8e |
T |
G |
8: 4,285,239 (GRCm39) |
|
probably null |
Het |
| Map1a |
A |
G |
2: 121,129,083 (GRCm39) |
R116G |
probably damaging |
Het |
| Map3k13 |
A |
G |
16: 21,723,999 (GRCm39) |
E327G |
possibly damaging |
Het |
| Med13 |
A |
G |
11: 86,236,788 (GRCm39) |
V123A |
possibly damaging |
Het |
| Met |
G |
A |
6: 17,555,631 (GRCm39) |
|
probably null |
Het |
| Mfsd14b |
A |
C |
13: 65,234,964 (GRCm39) |
V71G |
possibly damaging |
Het |
| Mpl |
T |
A |
4: 118,300,733 (GRCm39) |
T599S |
probably benign |
Het |
| Myh15 |
A |
T |
16: 48,881,944 (GRCm39) |
D62V |
probably damaging |
Het |
| Myo5a |
A |
G |
9: 75,081,297 (GRCm39) |
T961A |
probably benign |
Het |
| Myrfl |
A |
G |
10: 116,612,665 (GRCm39) |
Y895H |
probably damaging |
Het |
| Nap1l1 |
T |
C |
10: 111,326,224 (GRCm39) |
|
probably benign |
Het |
| Ncapd3 |
T |
A |
9: 26,952,803 (GRCm39) |
Y111N |
probably benign |
Het |
| Nlrc3 |
A |
G |
16: 3,766,113 (GRCm39) |
|
probably benign |
Het |
| Nsun2 |
G |
T |
13: 69,781,361 (GRCm39) |
V657L |
probably benign |
Het |
| Or10g1b |
C |
A |
14: 52,627,283 (GRCm39) |
G316* |
probably null |
Het |
| Or4a74 |
T |
A |
2: 89,439,564 (GRCm39) |
N294I |
probably benign |
Het |
| Or4b13 |
T |
C |
2: 90,083,278 (GRCm39) |
D18G |
probably benign |
Het |
| Or52d1 |
A |
T |
7: 103,756,349 (GRCm39) |
I288F |
possibly damaging |
Het |
| Or52e19 |
T |
C |
7: 102,959,371 (GRCm39) |
S148P |
probably damaging |
Het |
| Or5k3 |
G |
A |
16: 58,970,117 (GRCm39) |
M301I |
probably benign |
Het |
| Or5m13b |
A |
T |
2: 85,753,722 (GRCm39) |
I37F |
probably benign |
Het |
| Or6c68 |
T |
A |
10: 129,157,885 (GRCm39) |
M131K |
possibly damaging |
Het |
| Osbpl3 |
A |
T |
6: 50,276,383 (GRCm39) |
V795D |
probably benign |
Het |
| Osbpl5 |
T |
C |
7: 143,263,286 (GRCm39) |
D155G |
probably damaging |
Het |
| Parm1 |
G |
A |
5: 91,742,123 (GRCm39) |
V164I |
probably benign |
Het |
| Pgd |
A |
T |
4: 149,241,267 (GRCm39) |
|
probably benign |
Het |
| Pkp1 |
G |
A |
1: 135,805,920 (GRCm39) |
R593W |
probably damaging |
Het |
| Polr2l |
A |
T |
7: 141,053,255 (GRCm39) |
V53E |
probably damaging |
Het |
| Ppp4c |
G |
T |
7: 126,386,460 (GRCm39) |
T29K |
probably benign |
Het |
| Ppp4r4 |
T |
A |
12: 103,566,779 (GRCm39) |
|
probably benign |
Het |
| Ptprd |
A |
G |
4: 76,018,711 (GRCm39) |
S688P |
probably benign |
Het |
| Rab3b |
A |
T |
4: 108,747,586 (GRCm39) |
I28F |
probably damaging |
Het |
| Rnase4 |
T |
C |
14: 51,342,552 (GRCm39) |
L92P |
probably benign |
Het |
| Rnpc3 |
T |
C |
3: 113,413,755 (GRCm39) |
E229G |
probably benign |
Het |
| Rtraf |
A |
T |
14: 19,866,274 (GRCm39) |
D147E |
possibly damaging |
Het |
| Rttn |
G |
A |
18: 89,061,090 (GRCm39) |
G1086D |
probably benign |
Het |
| Ryr2 |
A |
G |
13: 11,720,519 (GRCm39) |
|
probably null |
Het |
| Sft2d2 |
T |
C |
1: 165,011,430 (GRCm39) |
I126V |
probably benign |
Het |
| Skap1 |
G |
T |
11: 96,614,236 (GRCm39) |
|
probably benign |
Het |
| Slc14a2 |
A |
T |
18: 78,200,394 (GRCm39) |
L753* |
probably null |
Het |
| Slc25a5 |
G |
A |
X: 36,059,408 (GRCm39) |
A9T |
probably benign |
Het |
| Slc30a5 |
T |
C |
13: 100,951,278 (GRCm39) |
|
probably benign |
Het |
| Slc5a4b |
A |
C |
10: 75,899,870 (GRCm39) |
I456S |
possibly damaging |
Het |
| Slc9a4 |
A |
T |
1: 40,642,230 (GRCm39) |
S400C |
probably damaging |
Het |
| Slx1b |
T |
A |
7: 126,291,812 (GRCm39) |
H84L |
probably damaging |
Het |
| Sptbn1 |
T |
C |
11: 30,100,008 (GRCm39) |
Y190C |
probably damaging |
Het |
| Stk32b |
T |
C |
5: 37,688,910 (GRCm39) |
Q138R |
probably damaging |
Het |
| Syt6 |
C |
A |
3: 103,528,206 (GRCm39) |
D308E |
probably damaging |
Het |
| Sytl2 |
G |
A |
7: 90,044,374 (GRCm39) |
D572N |
probably damaging |
Het |
| Taok2 |
A |
T |
7: 126,478,605 (GRCm39) |
L109Q |
probably damaging |
Het |
| Tbl1xr1 |
T |
C |
3: 22,233,483 (GRCm39) |
|
probably benign |
Het |
| Tlk1 |
A |
G |
2: 70,544,502 (GRCm39) |
I711T |
probably benign |
Het |
| Trf |
A |
G |
9: 103,100,132 (GRCm39) |
|
probably null |
Het |
| Trpc2 |
A |
G |
7: 101,733,572 (GRCm39) |
T548A |
possibly damaging |
Het |
| Ttbk2 |
A |
T |
2: 120,655,777 (GRCm39) |
I29N |
possibly damaging |
Het |
| Tti1 |
A |
T |
2: 157,835,292 (GRCm39) |
C989S |
probably damaging |
Het |
| Txndc8 |
A |
G |
4: 58,000,256 (GRCm39) |
Y108H |
probably benign |
Het |
| Ugt2b1 |
A |
T |
5: 87,065,539 (GRCm39) |
V500D |
possibly damaging |
Het |
| Vmn1r34 |
A |
G |
6: 66,614,648 (GRCm39) |
I30T |
possibly damaging |
Het |
| Vmn2r115 |
A |
G |
17: 23,579,074 (GRCm39) |
K849R |
probably null |
Het |
| Vmn2r76 |
T |
A |
7: 85,875,323 (GRCm39) |
|
probably null |
Het |
| Vps13c |
T |
A |
9: 67,834,754 (GRCm39) |
S1694R |
probably benign |
Het |
| Wdfy3 |
G |
T |
5: 101,984,038 (GRCm39) |
P3509T |
probably benign |
Het |
| Wdr59 |
GGGTGGTG |
GGGTG |
8: 112,207,172 (GRCm39) |
|
probably benign |
Het |
| Wnt8b |
T |
A |
19: 44,482,106 (GRCm39) |
W40R |
probably benign |
Het |
| Xrra1 |
A |
G |
7: 99,560,175 (GRCm39) |
I384V |
possibly damaging |
Het |
| Zfp11 |
A |
T |
5: 129,734,971 (GRCm39) |
H163Q |
probably damaging |
Het |
|
| Other mutations in Megf8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00639:Megf8
|
APN |
7 |
25,043,109 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL00696:Megf8
|
APN |
7 |
25,041,817 (GRCm39) |
missense |
probably benign |
|
|
IGL01021:Megf8
|
APN |
7 |
25,037,799 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01290:Megf8
|
APN |
7 |
25,049,083 (GRCm39) |
nonsense |
probably null |
|
|
IGL01392:Megf8
|
APN |
7 |
25,063,174 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01410:Megf8
|
APN |
7 |
25,059,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01634:Megf8
|
APN |
7 |
25,058,206 (GRCm39) |
splice site |
probably benign |
|
|
IGL01648:Megf8
|
APN |
7 |
25,026,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01930:Megf8
|
APN |
7 |
25,034,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01954:Megf8
|
APN |
7 |
25,048,439 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02150:Megf8
|
APN |
7 |
25,045,842 (GRCm39) |
splice site |
probably null |
|
|
IGL02192:Megf8
|
APN |
7 |
25,053,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02250:Megf8
|
APN |
7 |
25,042,000 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02301:Megf8
|
APN |
7 |
25,037,325 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02317:Megf8
|
APN |
7 |
25,063,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02324:Megf8
|
APN |
7 |
25,039,873 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02503:Megf8
|
APN |
7 |
25,062,988 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02583:Megf8
|
APN |
7 |
25,055,218 (GRCm39) |
missense |
probably benign |
|
|
IGL02636:Megf8
|
APN |
7 |
25,057,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02704:Megf8
|
APN |
7 |
25,059,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02898:Megf8
|
APN |
7 |
25,045,933 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03082:Megf8
|
APN |
7 |
25,029,661 (GRCm39) |
missense |
probably benign |
|
|
IGL03182:Megf8
|
APN |
7 |
25,046,773 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
megatherium
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4810001:Megf8
|
UTSW |
7 |
25,041,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Megf8
|
UTSW |
7 |
25,053,383 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0217:Megf8
|
UTSW |
7 |
25,063,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0514:Megf8
|
UTSW |
7 |
25,063,728 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0561:Megf8
|
UTSW |
7 |
25,028,257 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0563:Megf8
|
UTSW |
7 |
25,041,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0879:Megf8
|
UTSW |
7 |
25,037,896 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1430:Megf8
|
UTSW |
7 |
25,063,768 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1445:Megf8
|
UTSW |
7 |
25,042,081 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1533:Megf8
|
UTSW |
7 |
25,034,280 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1606:Megf8
|
UTSW |
7 |
25,058,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1635:Megf8
|
UTSW |
7 |
25,046,172 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1654:Megf8
|
UTSW |
7 |
25,037,911 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1661:Megf8
|
UTSW |
7 |
25,063,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1880:Megf8
|
UTSW |
7 |
25,034,285 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1962:Megf8
|
UTSW |
7 |
25,062,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Megf8
|
UTSW |
7 |
25,053,163 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2127:Megf8
|
UTSW |
7 |
25,064,007 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2129:Megf8
|
UTSW |
7 |
25,030,140 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2199:Megf8
|
UTSW |
7 |
25,039,039 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2201:Megf8
|
UTSW |
7 |
25,040,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2205:Megf8
|
UTSW |
7 |
25,041,173 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2207:Megf8
|
UTSW |
7 |
25,049,222 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2361:Megf8
|
UTSW |
7 |
25,048,379 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2680:Megf8
|
UTSW |
7 |
25,016,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3085:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3086:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Megf8
|
UTSW |
7 |
25,059,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3939:Megf8
|
UTSW |
7 |
25,058,627 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4022:Megf8
|
UTSW |
7 |
25,037,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4214:Megf8
|
UTSW |
7 |
25,054,793 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4357:Megf8
|
UTSW |
7 |
25,055,174 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4521:Megf8
|
UTSW |
7 |
25,042,126 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4620:Megf8
|
UTSW |
7 |
25,054,523 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4700:Megf8
|
UTSW |
7 |
25,062,940 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4916:Megf8
|
UTSW |
7 |
25,039,089 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4940:Megf8
|
UTSW |
7 |
25,060,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Megf8
|
UTSW |
7 |
25,030,517 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5258:Megf8
|
UTSW |
7 |
25,047,751 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5271:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5390:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5391:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5708:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5752:Megf8
|
UTSW |
7 |
25,054,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5930:Megf8
|
UTSW |
7 |
25,025,866 (GRCm39) |
nonsense |
probably null |
|
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Megf8
|
UTSW |
7 |
25,046,796 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6210:Megf8
|
UTSW |
7 |
25,043,145 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6457:Megf8
|
UTSW |
7 |
25,049,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6659:Megf8
|
UTSW |
7 |
25,058,159 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6867:Megf8
|
UTSW |
7 |
25,030,460 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6896:Megf8
|
UTSW |
7 |
25,029,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6899:Megf8
|
UTSW |
7 |
25,060,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6905:Megf8
|
UTSW |
7 |
25,037,357 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7099:Megf8
|
UTSW |
7 |
25,045,945 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7172:Megf8
|
UTSW |
7 |
25,043,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7378:Megf8
|
UTSW |
7 |
25,048,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Megf8
|
UTSW |
7 |
25,037,796 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7492:Megf8
|
UTSW |
7 |
25,053,273 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7699:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7700:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7756:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7758:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7786:Megf8
|
UTSW |
7 |
25,017,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7797:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7881:Megf8
|
UTSW |
7 |
25,040,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8165:Megf8
|
UTSW |
7 |
25,053,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8258:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8259:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8328:Megf8
|
UTSW |
7 |
25,046,917 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8362:Megf8
|
UTSW |
7 |
25,039,943 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8680:Megf8
|
UTSW |
7 |
25,059,166 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9080:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9297:Megf8
|
UTSW |
7 |
25,030,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9314:Megf8
|
UTSW |
7 |
25,029,297 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9378:Megf8
|
UTSW |
7 |
25,039,840 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9530:Megf8
|
UTSW |
7 |
25,030,124 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9557:Megf8
|
UTSW |
7 |
25,058,511 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9592:Megf8
|
UTSW |
7 |
25,028,228 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9612:Megf8
|
UTSW |
7 |
25,054,488 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9629:Megf8
|
UTSW |
7 |
25,043,194 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9643:Megf8
|
UTSW |
7 |
25,046,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Megf8
|
UTSW |
7 |
25,030,166 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9745:Megf8
|
UTSW |
7 |
25,058,133 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
Z1088:Megf8
|
UTSW |
7 |
25,039,094 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1177:Megf8
|
UTSW |
7 |
25,046,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Megf8
|
UTSW |
7 |
25,045,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGAACATGAGCCTCTCTTCTGTC -3'
(R):5'- GGTGTCCAGATGCACTTATCCAGTC -3'
Sequencing Primer
(F):5'- GGGTCTGTCTGCTCTGCC -3'
(R):5'- ATGCACTTATCCAGTCTGGGG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation