Incidental Mutation 'PIT4280001:Psg19'
ID554411
Institutional Source Beutler Lab
Gene Symbol Psg19
Ensembl Gene ENSMUSG00000004542
Gene Namepregnancy specific glycoprotein 19
SynonymsCGM7, Cea-4, Cea4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #PIT4280001 (G1)
Quality Score225.009
Status Not validated
Chromosome7
Chromosomal Location18789567-18798520 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 18796906 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 108 (I108V)
Ref Sequence ENSEMBL: ENSMUSP00000004657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004657] [ENSMUST00000182853]
Predicted Effect probably damaging
Transcript: ENSMUST00000004657
AA Change: I108V

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000004657
Gene: ENSMUSG00000004542
AA Change: I108V

DomainStartEndE-ValueType
IG 40 141 9.2e-3 SMART
IG 160 261 4.5e0 SMART
IG 280 381 4.67e-4 SMART
IGc2 397 461 1.58e-10 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000182853
AA Change: I108V

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000138621
Gene: ENSMUSG00000004542
AA Change: I108V

DomainStartEndE-ValueType
IG 40 141 9.2e-3 SMART
IG 160 261 4.67e-4 SMART
IGc2 277 341 1.58e-10 SMART
Coding Region Coverage
  • 1x: 93.1%
  • 3x: 90.9%
  • 10x: 85.5%
  • 20x: 73.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020L24Rik A G 11: 83,440,834 D161G probably damaging Het
2810474O19Rik T G 6: 149,325,525 I23S probably benign Het
Acer2 C T 4: 86,887,083 L95F probably damaging Het
Adam15 C T 3: 89,343,978 probably null Het
Bmi1 T A 2: 18,683,009 Y98* probably null Het
Cdon T C 9: 35,486,935 C983R probably damaging Het
Col12a1 T C 9: 79,678,105 R1297G probably damaging Het
Cpd A T 11: 76,791,024 M1132K probably benign Het
Dnah17 T A 11: 118,098,582 R1267W possibly damaging Het
Dnah9 G A 11: 66,005,013 A2512V probably benign Het
Eri3 G A 4: 117,582,634 G175D probably damaging Het
Fbxo9 C A 9: 78,087,511 W244L probably damaging Het
Fgfr3 A T 5: 33,732,232 H343L probably benign Het
Fmnl2 G A 2: 53,118,196 A803T unknown Het
Fmnl3 A G 15: 99,321,253 probably null Het
Fth1 C A 19: 9,984,609 A104E probably damaging Het
Gcm1 T C 9: 78,059,633 Y45H probably damaging Het
Gm5157 C G 7: 21,185,082 G179R probably damaging Het
Gpr179 A G 11: 97,344,115 I463T probably damaging Het
Gpr35 T C 1: 92,982,634 Y23H probably damaging Het
Inpp4b C T 8: 82,034,417 H647Y probably benign Het
Kif6 A T 17: 49,755,120 K436M probably benign Het
Lacc1 T A 14: 77,035,077 Q93L probably damaging Het
Lamc1 T C 1: 153,243,471 R801G probably damaging Het
Lrp2bp T G 8: 46,023,011 V263G probably damaging Het
Maats1 C T 16: 38,332,773 V160I probably benign Het
Magi3 T A 3: 104,054,352 K453N probably damaging Het
Mfsd6 T A 1: 52,660,880 Y703F probably benign Het
Mms22l A G 4: 24,581,149 T820A probably benign Het
Ndufa12 T C 10: 94,199,132 probably null Het
Nlrp12 A T 7: 3,241,433 C150S possibly damaging Het
Noc4l G A 5: 110,651,439 T159I probably benign Het
Olfml2b T A 1: 170,647,736 C77S probably damaging Het
Olfr1259 A T 2: 89,943,743 I124N probably damaging Het
Olfr460 C A 6: 40,571,716 T110K probably damaging Het
Pdzd2 A G 15: 12,399,288 V784A probably damaging Het
Pip5kl1 A T 2: 32,583,458 Y369F probably benign Het
Pkdrej A T 15: 85,819,935 I600N probably benign Het
Pxdn G A 12: 29,995,328 V539M probably damaging Het
Rsbn1l T A 5: 20,919,655 H383L probably damaging Het
Scamp2 A T 9: 57,580,793 N118I probably damaging Het
Scn2a T C 2: 65,715,730 V879A probably damaging Het
Scn8a G A 15: 100,957,489 E172K probably damaging Het
Slc16a6 C T 11: 109,458,593 C214Y possibly damaging Het
Stag1 A G 9: 100,942,716 T922A possibly damaging Het
Svs1 A T 6: 48,987,120 M21L probably benign Het
Tarbp1 T C 8: 126,430,847 H1307R probably damaging Het
Tut1 T G 19: 8,959,262 V150G probably benign Het
Ubr2 G A 17: 46,944,863 R1371W probably damaging Het
Vmn2r124 A G 17: 18,063,225 N394D probably benign Het
Vmn2r63 T C 7: 42,903,985 T616A probably damaging Het
Zp3 G A 5: 135,984,464 V217M possibly damaging Het
Other mutations in Psg19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Psg19 APN 7 18794046 nonsense probably null
IGL01864:Psg19 APN 7 18794152 missense probably benign 0.03
IGL01996:Psg19 APN 7 18790061 missense possibly damaging 0.45
IGL02603:Psg19 APN 7 18792768 missense probably benign 0.04
R0139:Psg19 UTSW 7 18797017 missense possibly damaging 0.65
R0894:Psg19 UTSW 7 18794062 missense probably benign 0.14
R1394:Psg19 UTSW 7 18797058 missense probably damaging 0.99
R1911:Psg19 UTSW 7 18794268 missense probably damaging 0.96
R2116:Psg19 UTSW 7 18794255 missense probably damaging 0.99
R2165:Psg19 UTSW 7 18796986 missense possibly damaging 0.70
R4791:Psg19 UTSW 7 18794146 missense probably damaging 1.00
R5093:Psg19 UTSW 7 18796969 missense probably benign 0.00
R6290:Psg19 UTSW 7 18794089 missense probably benign 0.00
R7255:Psg19 UTSW 7 18794048 missense probably benign 0.17
R7718:Psg19 UTSW 7 18792443 missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- CCAACATGGAGACTCAATGCAG -3'
(R):5'- CGTACCACCCAAATTGGTCG -3'

Sequencing Primer
(F):5'- GAGACACAAGCCAGGCCTG -3'
(R):5'- TACCACCCAAATTGGTCGAAGGAG -3'
Posted On2019-06-07