Incidental Mutation 'PIT4280001:Vmn2r63'
ID 554413
Institutional Source Beutler Lab
Gene Symbol Vmn2r63
Ensembl Gene ENSMUSG00000090751
Gene Name vomeronasal 2, receptor 63
Synonyms EG435975
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # PIT4280001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 42552675-42583213 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42553409 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 616 (T616A)
Ref Sequence ENSEMBL: ENSMUSP00000129089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163803]
AlphaFold E9Q0K5
Predicted Effect probably damaging
Transcript: ENSMUST00000163803
AA Change: T616A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000129089
Gene: ENSMUSG00000090751
AA Change: T616A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 3.5e-43 PFAM
Pfam:NCD3G 514 567 5.1e-23 PFAM
Pfam:7tm_3 600 835 3.5e-51 PFAM
Coding Region Coverage
  • 1x: 93.1%
  • 3x: 90.9%
  • 10x: 85.5%
  • 20x: 73.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020L24Rik A G 11: 83,331,660 (GRCm39) D161G probably damaging Het
Acer2 C T 4: 86,805,320 (GRCm39) L95F probably damaging Het
Adam15 C T 3: 89,251,285 (GRCm39) probably null Het
Aoc1l3 A T 6: 48,964,054 (GRCm39) M21L probably benign Het
Bmi1 T A 2: 18,687,820 (GRCm39) Y98* probably null Het
Cdon T C 9: 35,398,231 (GRCm39) C983R probably damaging Het
Cfap91 C T 16: 38,153,135 (GRCm39) V160I probably benign Het
Col12a1 T C 9: 79,585,387 (GRCm39) R1297G probably damaging Het
Cpd A T 11: 76,681,850 (GRCm39) M1132K probably benign Het
Dnah17 T A 11: 117,989,408 (GRCm39) R1267W possibly damaging Het
Dnah9 G A 11: 65,895,839 (GRCm39) A2512V probably benign Het
Eri3 G A 4: 117,439,831 (GRCm39) G175D probably damaging Het
Fbxo9 C A 9: 77,994,793 (GRCm39) W244L probably damaging Het
Fgfr3 A T 5: 33,889,576 (GRCm39) H343L probably benign Het
Fmnl2 G A 2: 53,008,208 (GRCm39) A803T unknown Het
Fmnl3 A G 15: 99,219,134 (GRCm39) probably null Het
Fth1 C A 19: 9,961,973 (GRCm39) A104E probably damaging Het
Gcm1 T C 9: 77,966,915 (GRCm39) Y45H probably damaging Het
Gm5157 C G 7: 20,919,007 (GRCm39) G179R probably damaging Het
Gpr179 A G 11: 97,234,941 (GRCm39) I463T probably damaging Het
Gpr35 T C 1: 92,910,356 (GRCm39) Y23H probably damaging Het
Inpp4b C T 8: 82,761,046 (GRCm39) H647Y probably benign Het
Kif6 A T 17: 50,062,148 (GRCm39) K436M probably benign Het
Lacc1 T A 14: 77,272,517 (GRCm39) Q93L probably damaging Het
Lamc1 T C 1: 153,119,217 (GRCm39) R801G probably damaging Het
Lrp2bp T G 8: 46,476,048 (GRCm39) V263G probably damaging Het
Magi3 T A 3: 103,961,668 (GRCm39) K453N probably damaging Het
Mfsd6 T A 1: 52,700,039 (GRCm39) Y703F probably benign Het
Mms22l A G 4: 24,581,149 (GRCm39) T820A probably benign Het
Ndufa12 T C 10: 94,034,994 (GRCm39) probably null Het
Nlrp12 A T 7: 3,290,063 (GRCm39) C150S possibly damaging Het
Noc4l G A 5: 110,799,305 (GRCm39) T159I probably benign Het
Olfml2b T A 1: 170,475,305 (GRCm39) C77S probably damaging Het
Or4c12 A T 2: 89,774,087 (GRCm39) I124N probably damaging Het
Or9a4 C A 6: 40,548,650 (GRCm39) T110K probably damaging Het
Pdzd2 A G 15: 12,399,374 (GRCm39) V784A probably damaging Het
Pip5kl1 A T 2: 32,473,470 (GRCm39) Y369F probably benign Het
Pkdrej A T 15: 85,704,136 (GRCm39) I600N probably benign Het
Psg19 T C 7: 18,530,831 (GRCm39) I108V probably damaging Het
Pxdn G A 12: 30,045,327 (GRCm39) V539M probably damaging Het
Resf1 T G 6: 149,227,023 (GRCm39) I23S probably benign Het
Rsbn1l T A 5: 21,124,653 (GRCm39) H383L probably damaging Het
Scamp2 A T 9: 57,488,076 (GRCm39) N118I probably damaging Het
Scn2a T C 2: 65,546,074 (GRCm39) V879A probably damaging Het
Scn8a G A 15: 100,855,370 (GRCm39) E172K probably damaging Het
Slc16a6 C T 11: 109,349,419 (GRCm39) C214Y possibly damaging Het
Stag1 A G 9: 100,824,769 (GRCm39) T922A possibly damaging Het
Tarbp1 T C 8: 127,157,586 (GRCm39) H1307R probably damaging Het
Tut1 T G 19: 8,936,626 (GRCm39) V150G probably benign Het
Ubr2 G A 17: 47,255,789 (GRCm39) R1371W probably damaging Het
Vmn2r124 A G 17: 18,283,487 (GRCm39) N394D probably benign Het
Zp3 G A 5: 136,013,318 (GRCm39) V217M possibly damaging Het
Other mutations in Vmn2r63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01399:Vmn2r63 APN 7 42,553,543 (GRCm39) missense probably damaging 0.99
IGL01765:Vmn2r63 APN 7 42,552,788 (GRCm39) missense probably benign
IGL02203:Vmn2r63 APN 7 42,553,432 (GRCm39) missense probably benign 0.01
IGL02825:Vmn2r63 APN 7 42,576,274 (GRCm39) critical splice donor site probably null
IGL03155:Vmn2r63 APN 7 42,552,878 (GRCm39) missense probably damaging 1.00
IGL03260:Vmn2r63 APN 7 42,578,616 (GRCm39) missense probably damaging 1.00
IGL03411:Vmn2r63 APN 7 42,577,368 (GRCm39) missense probably benign 0.42
R0066:Vmn2r63 UTSW 7 42,576,514 (GRCm39) splice site probably benign
R0328:Vmn2r63 UTSW 7 42,552,699 (GRCm39) missense probably benign 0.09
R0344:Vmn2r63 UTSW 7 42,553,042 (GRCm39) missense probably damaging 0.98
R0554:Vmn2r63 UTSW 7 42,583,129 (GRCm39) nonsense probably null
R0555:Vmn2r63 UTSW 7 42,577,952 (GRCm39) nonsense probably null
R0685:Vmn2r63 UTSW 7 42,577,434 (GRCm39) missense probably benign 0.13
R0751:Vmn2r63 UTSW 7 42,577,459 (GRCm39) missense probably damaging 1.00
R1349:Vmn2r63 UTSW 7 42,578,642 (GRCm39) missense possibly damaging 0.95
R1372:Vmn2r63 UTSW 7 42,578,642 (GRCm39) missense possibly damaging 0.95
R1416:Vmn2r63 UTSW 7 42,577,339 (GRCm39) missense probably benign 0.00
R1502:Vmn2r63 UTSW 7 42,578,015 (GRCm39) missense possibly damaging 0.62
R1563:Vmn2r63 UTSW 7 42,553,550 (GRCm39) missense probably benign 0.00
R1652:Vmn2r63 UTSW 7 42,577,635 (GRCm39) missense probably benign 0.32
R1693:Vmn2r63 UTSW 7 42,577,743 (GRCm39) missense probably benign
R1698:Vmn2r63 UTSW 7 42,583,038 (GRCm39) missense probably benign
R1753:Vmn2r63 UTSW 7 42,577,669 (GRCm39) nonsense probably null
R2136:Vmn2r63 UTSW 7 42,576,297 (GRCm39) missense probably damaging 0.99
R2175:Vmn2r63 UTSW 7 42,583,004 (GRCm39) critical splice donor site probably null
R2261:Vmn2r63 UTSW 7 42,578,031 (GRCm39) missense probably benign 0.02
R2262:Vmn2r63 UTSW 7 42,578,031 (GRCm39) missense probably benign 0.02
R2263:Vmn2r63 UTSW 7 42,578,031 (GRCm39) missense probably benign 0.02
R3413:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R3426:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R3427:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R3802:Vmn2r63 UTSW 7 42,552,829 (GRCm39) missense probably damaging 0.99
R4319:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R4321:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R4323:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R4346:Vmn2r63 UTSW 7 42,577,537 (GRCm39) missense possibly damaging 0.67
R4568:Vmn2r63 UTSW 7 42,583,250 (GRCm39) splice site probably null
R4649:Vmn2r63 UTSW 7 42,553,114 (GRCm39) missense possibly damaging 0.79
R4653:Vmn2r63 UTSW 7 42,553,114 (GRCm39) missense possibly damaging 0.79
R4679:Vmn2r63 UTSW 7 42,577,544 (GRCm39) missense probably benign 0.00
R4734:Vmn2r63 UTSW 7 42,577,544 (GRCm39) missense probably benign 0.00
R4741:Vmn2r63 UTSW 7 42,577,544 (GRCm39) missense probably benign 0.00
R4748:Vmn2r63 UTSW 7 42,577,544 (GRCm39) missense probably benign 0.00
R4806:Vmn2r63 UTSW 7 42,576,314 (GRCm39) missense probably benign 0.34
R4933:Vmn2r63 UTSW 7 42,553,402 (GRCm39) missense probably damaging 1.00
R5198:Vmn2r63 UTSW 7 42,553,169 (GRCm39) missense probably benign 0.01
R5399:Vmn2r63 UTSW 7 42,577,701 (GRCm39) missense probably benign
R5400:Vmn2r63 UTSW 7 42,577,635 (GRCm39) missense probably benign 0.32
R6158:Vmn2r63 UTSW 7 42,583,104 (GRCm39) missense probably damaging 1.00
R6185:Vmn2r63 UTSW 7 42,578,435 (GRCm39) missense probably damaging 0.98
R6267:Vmn2r63 UTSW 7 42,578,059 (GRCm39) splice site probably null
R6362:Vmn2r63 UTSW 7 42,552,721 (GRCm39) missense probably benign
R6706:Vmn2r63 UTSW 7 42,578,001 (GRCm39) missense probably damaging 1.00
R6764:Vmn2r63 UTSW 7 42,552,695 (GRCm39) missense probably damaging 0.97
R7104:Vmn2r63 UTSW 7 42,577,959 (GRCm39) missense possibly damaging 0.67
R7503:Vmn2r63 UTSW 7 42,583,014 (GRCm39) missense probably benign 0.02
R7506:Vmn2r63 UTSW 7 42,576,391 (GRCm39) missense probably damaging 1.00
R7525:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense possibly damaging 0.52
R7658:Vmn2r63 UTSW 7 42,574,693 (GRCm39) missense probably damaging 1.00
R7663:Vmn2r63 UTSW 7 42,576,466 (GRCm39) missense probably benign 0.00
R7702:Vmn2r63 UTSW 7 42,577,553 (GRCm39) missense possibly damaging 0.46
R7918:Vmn2r63 UTSW 7 42,552,955 (GRCm39) missense probably damaging 1.00
R8826:Vmn2r63 UTSW 7 42,576,441 (GRCm39) missense probably benign 0.38
R8973:Vmn2r63 UTSW 7 42,577,919 (GRCm39) missense probably benign 0.19
R9024:Vmn2r63 UTSW 7 42,577,874 (GRCm39) missense probably benign 0.14
R9154:Vmn2r63 UTSW 7 42,576,413 (GRCm39) missense probably damaging 0.96
R9731:Vmn2r63 UTSW 7 42,553,361 (GRCm39) missense probably benign 0.32
Z1088:Vmn2r63 UTSW 7 42,577,983 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- ACCATTCTAGCTGGAGAGGTG -3'
(R):5'- GTGTGCAGTGTCCAGAAAGTC -3'

Sequencing Primer
(F):5'- GTGACCTTGAATGCAGTAACC -3'
(R):5'- TGCAGTGTCCAGAAAGTCACTATG -3'
Posted On 2019-06-07