Incidental Mutation 'IGL00339:Oas1g'
ID 5546
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oas1g
Ensembl Gene ENSMUSG00000066861
Gene Name 2'-5' oligoadenylate synthetase 1G
Synonyms Oias-1, L2, Mmu-L2, Oias1, Oas1a, Mmu-L
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL00339
Quality Score
Status
Chromosome 5
Chromosomal Location 121014205-121025676 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 121024109 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 67 (K67*)
Ref Sequence ENSEMBL: ENSMUSP00000124597 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086368] [ENSMUST00000162096]
AlphaFold Q8K469
Predicted Effect probably null
Transcript: ENSMUST00000086368
AA Change: K67*
SMART Domains Protein: ENSMUSP00000083555
Gene: ENSMUSG00000066861
AA Change: K67*

DomainStartEndE-ValueType
Pfam:NTP_transf_2 38 139 1.6e-13 PFAM
Pfam:OAS1_C 164 349 6.9e-87 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000162096
AA Change: K67*
SMART Domains Protein: ENSMUSP00000124597
Gene: ENSMUSG00000066861
AA Change: K67*

DomainStartEndE-ValueType
Pfam:NTP_transf_2 42 138 1.1e-9 PFAM
Pfam:OAS1_C 163 231 1.4e-24 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5. These proteins are believed to function in antiviral immunity through binding to viral dsRNA and subsequent synthesis of 2'-5'-oligoadenylates. The expression of this gene has been shown to be induced by interferon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A G 12: 71,213,893 (GRCm39) M707V probably benign Het
Amz2 A T 11: 109,324,847 (GRCm39) I244F probably damaging Het
Atp4a T C 7: 30,412,629 (GRCm39) C112R possibly damaging Het
Axin2 A G 11: 108,814,816 (GRCm39) T235A probably benign Het
Barhl2 C T 5: 106,603,365 (GRCm39) A265T possibly damaging Het
Brd8 C A 18: 34,742,936 (GRCm39) G310* probably null Het
Capn11 A T 17: 45,954,693 (GRCm39) I148N probably damaging Het
Caskin2 A G 11: 115,694,425 (GRCm39) L392P probably benign Het
Cep72 C T 13: 74,210,387 (GRCm39) probably benign Het
Chst11 A G 10: 83,027,467 (GRCm39) Y298C possibly damaging Het
Cyp21a1 C T 17: 35,023,108 (GRCm39) probably null Het
F830045P16Rik T C 2: 129,302,449 (GRCm39) D381G probably damaging Het
Fnip2 T G 3: 79,422,462 (GRCm39) H106P probably benign Het
Fosl1 T A 19: 5,500,330 (GRCm39) I83K probably damaging Het
Foxk2 C T 11: 121,190,560 (GRCm39) T567M probably damaging Het
Frmd4a A G 2: 4,599,525 (GRCm39) N208S probably benign Het
Gm4553 T C 7: 141,718,964 (GRCm39) S155G unknown Het
Heatr5a A T 12: 51,935,684 (GRCm39) I1634N probably damaging Het
Hspg2 C T 4: 137,266,506 (GRCm39) T1889M probably damaging Het
Kcnh6 C T 11: 105,909,845 (GRCm39) P457S probably damaging Het
Kcnk18 G T 19: 59,223,502 (GRCm39) A216S probably benign Het
Klhl42 A G 6: 147,003,231 (GRCm39) Y335C probably damaging Het
Lrguk C T 6: 34,020,364 (GRCm39) P36L probably damaging Het
Mmp1b T A 9: 7,368,304 (GRCm39) R443S probably benign Het
Ncapd3 T C 9: 26,963,649 (GRCm39) S501P probably benign Het
Neurl4 C T 11: 69,795,413 (GRCm39) R422W probably damaging Het
Nol4 T C 18: 22,956,469 (GRCm39) S311G probably benign Het
Oaf T C 9: 43,135,313 (GRCm39) D155G probably damaging Het
Or1l4 T C 2: 37,091,609 (GRCm39) S119P probably damaging Het
Or2a20 T G 6: 43,194,782 (GRCm39) L312V probably benign Het
Rims2 C A 15: 39,323,011 (GRCm39) T735K probably benign Het
Sema4f T C 6: 82,914,155 (GRCm39) T68A probably benign Het
Snx19 T G 9: 30,340,380 (GRCm39) V506G possibly damaging Het
Sp140 T A 1: 85,569,543 (GRCm39) C107* probably null Het
Sspo G A 6: 48,460,680 (GRCm39) probably benign Het
Syce1l T G 8: 114,376,134 (GRCm39) L28R probably damaging Het
Tgm3 G A 2: 129,880,333 (GRCm39) V380M probably damaging Het
Unc5a T A 13: 55,143,628 (GRCm39) V104D possibly damaging Het
Other mutations in Oas1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0389:Oas1g UTSW 5 121,025,592 (GRCm39) missense probably benign 0.01
R1433:Oas1g UTSW 5 121,020,012 (GRCm39) missense probably damaging 1.00
R1468:Oas1g UTSW 5 121,020,069 (GRCm39) missense probably benign 0.02
R1468:Oas1g UTSW 5 121,020,069 (GRCm39) missense probably benign 0.02
R1926:Oas1g UTSW 5 121,017,205 (GRCm39) missense probably benign 0.00
R2062:Oas1g UTSW 5 121,023,946 (GRCm39) missense probably damaging 1.00
R2063:Oas1g UTSW 5 121,023,946 (GRCm39) missense probably damaging 1.00
R2064:Oas1g UTSW 5 121,023,946 (GRCm39) missense probably damaging 1.00
R2067:Oas1g UTSW 5 121,023,946 (GRCm39) missense probably damaging 1.00
R2932:Oas1g UTSW 5 121,017,206 (GRCm39) missense probably benign 0.00
R4296:Oas1g UTSW 5 121,017,230 (GRCm39) missense probably damaging 1.00
R4808:Oas1g UTSW 5 121,017,385 (GRCm39) missense possibly damaging 0.45
R5874:Oas1g UTSW 5 121,015,081 (GRCm39) missense probably benign
R6842:Oas1g UTSW 5 121,025,621 (GRCm39) missense probably benign 0.01
R7314:Oas1g UTSW 5 121,016,526 (GRCm39) missense probably damaging 1.00
R7729:Oas1g UTSW 5 121,024,063 (GRCm39) missense probably damaging 1.00
R9353:Oas1g UTSW 5 121,023,986 (GRCm39) missense possibly damaging 0.78
Z1177:Oas1g UTSW 5 121,016,393 (GRCm39) missense probably damaging 1.00
Posted On 2012-04-20