Incidental Mutation 'PIT4382001:Adgrl2'
| ID |
554671 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrl2
|
| Ensembl Gene |
ENSMUSG00000028184 |
| Gene Name |
adhesion G protein-coupled receptor L2 |
| Synonyms |
Lec1, Lphn2, Lphh1 |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
PIT4382001 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
148815583-148990555 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 148817298 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 430
(L430P)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106128]
[ENSMUST00000168352]
[ENSMUST00000195988]
[ENSMUST00000196526]
[ENSMUST00000197567]
[ENSMUST00000198779]
[ENSMUST00000199059]
[ENSMUST00000199238]
[ENSMUST00000199750]
[ENSMUST00000200154]
[ENSMUST00000200543]
|
| AlphaFold |
Q8JZZ7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106128
AA Change: L1447P
PolyPhen 2
Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000101734
Gene: ENSMUSG00000028184
AA Change: L1447P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
2.5e-26 |
PFAM |
|
OLF
|
142 |
398 |
5.22e-140 |
SMART |
|
HormR
|
469 |
534 |
3.14e-20 |
SMART |
|
Pfam:GAIN
|
537 |
764 |
1.3e-58 |
PFAM |
|
GPS
|
788 |
840 |
3.47e-25 |
SMART |
|
Pfam:7tm_2
|
848 |
1108 |
4.6e-69 |
PFAM |
|
Pfam:Latrophilin
|
1128 |
1487 |
6.4e-181 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168352
AA Change: L199P
PolyPhen 2
Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000132116
Gene: ENSMUSG00000028184
AA Change: L199P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Latrophilin
|
1 |
239 |
2.5e-122 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195988
AA Change: L1395P
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000143444
Gene: ENSMUSG00000028184
AA Change: L1395P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.3e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.1e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1189 |
2.2e-28 |
PFAM |
|
Pfam:Latrophilin
|
1184 |
1435 |
5.5e-123 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196526
|
| SMART Domains |
Protein: ENSMUSP00000143788
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
8.7e-24 |
PFAM |
|
OLF
|
138 |
394 |
3.4e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
Pfam:GAIN
|
533 |
747 |
1.1e-54 |
PFAM |
|
GPS
|
771 |
823 |
2.2e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
6.5e-68 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1158 |
9.9e-36 |
PFAM |
|
low complexity region
|
1163 |
1173 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197348
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197567
AA Change: L1447P
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000143626
Gene: ENSMUSG00000028184
AA Change: L1447P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
1.9e-26 |
PFAM |
|
OLF
|
142 |
398 |
5.22e-140 |
SMART |
|
HormR
|
469 |
534 |
3.14e-20 |
SMART |
|
Pfam:GAIN
|
537 |
764 |
1.1e-58 |
PFAM |
|
GPS
|
788 |
840 |
3.47e-25 |
SMART |
|
Pfam:7tm_2
|
848 |
1108 |
6.4e-69 |
PFAM |
|
Pfam:Latrophilin
|
1128 |
1487 |
2.8e-181 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197925
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198779
AA Change: L1412P
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000142347
Gene: ENSMUSG00000028184
AA Change: L1412P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1084 |
1.8e-66 |
PFAM |
|
Pfam:Latrophilin
|
1104 |
1452 |
7e-174 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199059
AA Change: L1427P
PolyPhen 2
Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000143150
Gene: ENSMUSG00000028184
AA Change: L1427P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.3e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1467 |
7.1e-174 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199238
AA Change: L1438P
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000142405
Gene: ENSMUSG00000028184
AA Change: L1438P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.4e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1478 |
1.6e-187 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199750
AA Change: L1301P
PolyPhen 2
Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000143320
Gene: ENSMUSG00000028184
AA Change: L1301P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.1e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
403 |
468 |
1.9e-22 |
SMART |
|
GPS
|
709 |
761 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
769 |
1005 |
1.6e-66 |
PFAM |
|
Pfam:Latrophilin
|
1025 |
1095 |
2e-28 |
PFAM |
|
Pfam:Latrophilin
|
1090 |
1341 |
4.9e-123 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200154
|
| SMART Domains |
Protein: ENSMUSP00000142865
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
2.5e-23 |
PFAM |
|
OLF
|
138 |
394 |
3.3e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
GPS
|
771 |
823 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
1.2e-66 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1123 |
2.2e-4 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200216
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200456
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200543
AA Change: L1363P
PolyPhen 2
Score 0.238 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000142336
Gene: ENSMUSG00000028184
AA Change: L1363P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.2e-23 |
PFAM |
|
OLF
|
138 |
394 |
3.3e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
GPS
|
771 |
823 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
1.7e-66 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1157 |
2.1e-28 |
PFAM |
|
Pfam:Latrophilin
|
1152 |
1403 |
5.3e-123 |
PFAM |
|
| Meta Mutation Damage Score |
0.4185 |
| Coding Region Coverage |
- 1x: 92.9%
- 3x: 90.5%
- 10x: 84.6%
- 20x: 72.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
PHENOTYPE: Homozygous null mice die prenatally at fetal stages. Heterozygous mice exhibit decreased locomotor activity in an open field test. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9430038I01Rik |
G |
T |
7: 137,376,982 (GRCm38) |
H144N |
unknown |
Het |
| Acsm4 |
C |
T |
7: 119,698,575 (GRCm38) |
T145M |
probably damaging |
Het |
| Adam10 |
T |
C |
9: 70,766,081 (GRCm38) |
L498P |
probably damaging |
Het |
| Alk |
T |
C |
17: 71,949,921 (GRCm38) |
M648V |
probably benign |
Het |
| Arhgap35 |
T |
C |
7: 16,563,869 (GRCm38) |
R424G |
possibly damaging |
Het |
| Baiap2l1 |
T |
C |
5: 144,278,670 (GRCm38) |
K342E |
possibly damaging |
Het |
| Ccdc54 |
C |
T |
16: 50,590,856 (GRCm38) |
V16M |
probably damaging |
Het |
| Chil3 |
T |
G |
3: 106,148,659 (GRCm38) |
D366A |
probably damaging |
Het |
| Chuk |
A |
G |
19: 44,098,607 (GRCm38) |
V151A |
probably damaging |
Het |
| Cpd |
T |
G |
11: 76,797,788 (GRCm38) |
H886P |
probably benign |
Het |
| Cped1 |
T |
A |
6: 22,222,450 (GRCm38) |
C736* |
probably null |
Het |
| Creb3l3 |
T |
C |
10: 81,084,912 (GRCm38) |
E428G |
probably benign |
Het |
| Csad |
G |
A |
15: 102,188,650 (GRCm38) |
L7F |
probably benign |
Het |
| Dnah1 |
C |
T |
14: 31,284,455 (GRCm38) |
D2255N |
probably damaging |
Het |
| Dnajb12 |
T |
C |
10: 59,892,686 (GRCm38) |
Y159H |
probably damaging |
Het |
| Dpysl4 |
T |
A |
7: 139,089,578 (GRCm38) |
Y57* |
probably null |
Het |
| F2rl1 |
T |
G |
13: 95,513,646 (GRCm38) |
N243H |
probably benign |
Het |
| Fhl4 |
T |
C |
10: 85,098,429 (GRCm38) |
K163E |
possibly damaging |
Het |
| Flot2 |
T |
C |
11: 78,053,367 (GRCm38) |
S46P |
possibly damaging |
Het |
| Fsip2 |
C |
A |
2: 82,990,852 (GRCm38) |
T5643K |
possibly damaging |
Het |
| Gm853 |
A |
T |
4: 130,219,161 (GRCm38) |
N147K |
possibly damaging |
Het |
| Gm8765 |
A |
T |
13: 50,700,971 (GRCm38) |
E215V |
probably damaging |
Het |
| Golga4 |
T |
A |
9: 118,553,453 (GRCm38) |
Y542N |
possibly damaging |
Het |
| Il17re |
A |
G |
6: 113,469,077 (GRCm38) |
T426A |
probably benign |
Het |
| Kdm2a |
T |
A |
19: 4,343,173 (GRCm38) |
M385L |
probably benign |
Het |
| Kdm3b |
T |
C |
18: 34,809,087 (GRCm38) |
S744P |
probably damaging |
Het |
| Krtap6-3 |
T |
A |
16: 89,084,160 (GRCm38) |
Y26* |
probably null |
Het |
| Lama2 |
T |
C |
10: 27,204,905 (GRCm38) |
D974G |
probably damaging |
Het |
| Lipo5 |
A |
T |
19: 33,465,939 (GRCm38) |
L159Q |
probably null |
Het |
| Mau2 |
C |
T |
8: 70,030,652 (GRCm38) |
E187K |
possibly damaging |
Het |
| Mrpl9 |
T |
C |
3: 94,447,829 (GRCm38) |
L236P |
probably benign |
Het |
| Mta1 |
A |
G |
12: 113,133,250 (GRCm38) |
T564A |
probably benign |
Het |
| Mylk |
C |
T |
16: 34,875,642 (GRCm38) |
S249L |
probably damaging |
Het |
| Ncor1 |
G |
T |
11: 62,344,663 (GRCm38) |
T331K |
probably damaging |
Het |
| Nsun3 |
T |
A |
16: 62,785,865 (GRCm38) |
K15N |
probably damaging |
Het |
| Nsun5 |
A |
G |
5: 135,371,501 (GRCm38) |
Y132C |
probably benign |
Het |
| Obsl1 |
T |
A |
1: 75,487,963 (GRCm38) |
T1605S |
probably benign |
Het |
| Olfr1463 |
T |
C |
19: 13,234,895 (GRCm38) |
I215T |
probably damaging |
Het |
| Olfr519 |
A |
G |
7: 108,894,102 (GRCm38) |
Y107H |
probably damaging |
Het |
| Olfr566 |
A |
G |
7: 102,856,602 (GRCm38) |
Y227H |
probably damaging |
Het |
| Olfr574 |
A |
T |
7: 102,949,449 (GRCm38) |
Y328F |
probably benign |
Het |
| Oraov1 |
T |
A |
7: 144,916,444 (GRCm38) |
Y37N |
probably damaging |
Het |
| P2rx1 |
A |
G |
11: 73,009,200 (GRCm38) |
N148D |
probably benign |
Het |
| Pogz |
T |
A |
3: 94,879,796 (GRCm38) |
S1232T |
probably damaging |
Het |
| Polr3b |
C |
A |
10: 84,684,185 (GRCm38) |
T655N |
probably damaging |
Het |
| Prss34 |
T |
C |
17: 25,298,908 (GRCm38) |
|
probably null |
Het |
| Rhpn2 |
A |
G |
7: 35,390,753 (GRCm38) |
|
probably null |
Het |
| Runx1 |
T |
A |
16: 92,613,760 (GRCm38) |
D256V |
probably damaging |
Het |
| Shc1 |
C |
A |
3: 89,427,408 (GRCm38) |
Q525K |
probably benign |
Het |
| Slc10a5 |
T |
C |
3: 10,335,447 (GRCm38) |
D51G |
probably benign |
Het |
| Slc6a3 |
A |
T |
13: 73,571,523 (GRCm38) |
N557I |
probably benign |
Het |
| Slmap |
C |
T |
14: 26,533,431 (GRCm38) |
R32H |
probably damaging |
Het |
| Spata31d1c |
T |
C |
13: 65,036,171 (GRCm38) |
I509T |
probably benign |
Het |
| Srr |
C |
A |
11: 74,910,308 (GRCm38) |
V138F |
probably benign |
Het |
| Tas2r118 |
G |
A |
6: 23,969,786 (GRCm38) |
T92I |
possibly damaging |
Het |
| Tcaf2 |
A |
T |
6: 42,624,366 (GRCm38) |
*920K |
probably null |
Het |
| Tenm2 |
T |
A |
11: 36,063,902 (GRCm38) |
Y1141F |
probably damaging |
Het |
| Thoc6 |
T |
C |
17: 23,668,867 (GRCm38) |
N322S |
probably benign |
Het |
| Tlcd2 |
A |
G |
11: 75,468,591 (GRCm38) |
I70V |
probably benign |
Het |
| Tmem214 |
A |
G |
5: 30,871,451 (GRCm38) |
D128G |
possibly damaging |
Het |
| Trav13-4-dv7 |
T |
C |
14: 53,757,781 (GRCm38) |
V64A |
probably benign |
Het |
| Tyro3 |
T |
C |
2: 119,802,364 (GRCm38) |
W122R |
probably damaging |
Het |
| Ugcg |
A |
G |
4: 59,213,246 (GRCm38) |
D144G |
possibly damaging |
Het |
| Uimc1 |
T |
C |
13: 55,031,015 (GRCm38) |
D627G |
probably benign |
Het |
| Utp6 |
T |
C |
11: 79,962,273 (GRCm38) |
I13V |
probably benign |
Het |
| Vmn2r99 |
A |
G |
17: 19,394,343 (GRCm38) |
K775R |
probably damaging |
Het |
| Wdfy3 |
CG |
C |
5: 101,882,961 (GRCm38) |
|
probably null |
Het |
| Zw10 |
C |
T |
9: 49,071,644 (GRCm38) |
T525I |
probably benign |
Het |
|
| Other mutations in Adgrl2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00426:Adgrl2
|
APN |
3 |
148,865,608 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL00572:Adgrl2
|
APN |
3 |
148,826,498 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01624:Adgrl2
|
APN |
3 |
148,836,527 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01796:Adgrl2
|
APN |
3 |
148,858,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02380:Adgrl2
|
APN |
3 |
148,828,489 (GRCm38) |
nonsense |
probably null |
|
|
IGL02468:Adgrl2
|
APN |
3 |
148,890,480 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02708:Adgrl2
|
APN |
3 |
148,826,525 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02869:Adgrl2
|
APN |
3 |
148,890,605 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03248:Adgrl2
|
APN |
3 |
148,817,400 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03343:Adgrl2
|
APN |
3 |
148,859,380 (GRCm38) |
missense |
probably damaging |
0.98 |
|
P0157:Adgrl2
|
UTSW |
3 |
148,859,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4544001:Adgrl2
|
UTSW |
3 |
148,890,521 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0165:Adgrl2
|
UTSW |
3 |
148,852,863 (GRCm38) |
splice site |
probably benign |
|
|
R0242:Adgrl2
|
UTSW |
3 |
148,839,185 (GRCm38) |
splice site |
probably null |
|
|
R0242:Adgrl2
|
UTSW |
3 |
148,839,185 (GRCm38) |
splice site |
probably null |
|
|
R0344:Adgrl2
|
UTSW |
3 |
148,865,595 (GRCm38) |
splice site |
probably null |
|
|
R0488:Adgrl2
|
UTSW |
3 |
148,846,905 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0542:Adgrl2
|
UTSW |
3 |
148,859,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0630:Adgrl2
|
UTSW |
3 |
148,839,244 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0674:Adgrl2
|
UTSW |
3 |
148,837,679 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1401:Adgrl2
|
UTSW |
3 |
148,822,981 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1543:Adgrl2
|
UTSW |
3 |
148,859,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1575:Adgrl2
|
UTSW |
3 |
148,852,762 (GRCm38) |
missense |
probably benign |
0.17 |
|
R1645:Adgrl2
|
UTSW |
3 |
148,865,608 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1780:Adgrl2
|
UTSW |
3 |
148,852,593 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1992:Adgrl2
|
UTSW |
3 |
148,817,244 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R2014:Adgrl2
|
UTSW |
3 |
148,826,475 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2130:Adgrl2
|
UTSW |
3 |
148,890,488 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2131:Adgrl2
|
UTSW |
3 |
148,890,488 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2400:Adgrl2
|
UTSW |
3 |
148,851,934 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2997:Adgrl2
|
UTSW |
3 |
148,817,649 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3161:Adgrl2
|
UTSW |
3 |
148,817,551 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3416:Adgrl2
|
UTSW |
3 |
148,859,329 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3417:Adgrl2
|
UTSW |
3 |
148,859,329 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3551:Adgrl2
|
UTSW |
3 |
148,858,963 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3760:Adgrl2
|
UTSW |
3 |
148,817,235 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4355:Adgrl2
|
UTSW |
3 |
148,839,152 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4850:Adgrl2
|
UTSW |
3 |
148,859,020 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4911:Adgrl2
|
UTSW |
3 |
148,890,463 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4945:Adgrl2
|
UTSW |
3 |
148,823,036 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5313:Adgrl2
|
UTSW |
3 |
148,823,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5339:Adgrl2
|
UTSW |
3 |
148,817,844 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5540:Adgrl2
|
UTSW |
3 |
148,837,562 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5583:Adgrl2
|
UTSW |
3 |
148,859,164 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5890:Adgrl2
|
UTSW |
3 |
148,859,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6170:Adgrl2
|
UTSW |
3 |
148,823,009 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6197:Adgrl2
|
UTSW |
3 |
148,858,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6284:Adgrl2
|
UTSW |
3 |
148,826,507 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6877:Adgrl2
|
UTSW |
3 |
148,817,286 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7048:Adgrl2
|
UTSW |
3 |
148,846,929 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7205:Adgrl2
|
UTSW |
3 |
148,858,949 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7326:Adgrl2
|
UTSW |
3 |
148,846,870 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7348:Adgrl2
|
UTSW |
3 |
148,817,766 (GRCm38) |
missense |
|
|
|
R7382:Adgrl2
|
UTSW |
3 |
148,817,283 (GRCm38) |
missense |
|
|
|
R7486:Adgrl2
|
UTSW |
3 |
148,817,694 (GRCm38) |
missense |
|
|
|
R7498:Adgrl2
|
UTSW |
3 |
148,859,216 (GRCm38) |
nonsense |
probably null |
|
|
R7644:Adgrl2
|
UTSW |
3 |
148,839,153 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7690:Adgrl2
|
UTSW |
3 |
148,817,298 (GRCm38) |
missense |
|
|
|
R7742:Adgrl2
|
UTSW |
3 |
148,836,428 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7745:Adgrl2
|
UTSW |
3 |
148,836,458 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8291:Adgrl2
|
UTSW |
3 |
148,850,918 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R8326:Adgrl2
|
UTSW |
3 |
148,827,554 (GRCm38) |
missense |
|
|
|
R8343:Adgrl2
|
UTSW |
3 |
148,846,906 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8344:Adgrl2
|
UTSW |
3 |
148,859,525 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8487:Adgrl2
|
UTSW |
3 |
148,859,486 (GRCm38) |
missense |
probably benign |
0.06 |
|
R8748:Adgrl2
|
UTSW |
3 |
148,826,390 (GRCm38) |
missense |
|
|
|
R8769:Adgrl2
|
UTSW |
3 |
148,817,281 (GRCm38) |
missense |
|
|
|
R8804:Adgrl2
|
UTSW |
3 |
148,847,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8911:Adgrl2
|
UTSW |
3 |
148,852,527 (GRCm38) |
intron |
probably benign |
|
|
R8943:Adgrl2
|
UTSW |
3 |
148,828,483 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8977:Adgrl2
|
UTSW |
3 |
148,954,587 (GRCm38) |
missense |
probably null |
|
|
R9030:Adgrl2
|
UTSW |
3 |
148,839,125 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R9105:Adgrl2
|
UTSW |
3 |
148,837,653 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9427:Adgrl2
|
UTSW |
3 |
148,820,432 (GRCm38) |
missense |
|
|
|
R9471:Adgrl2
|
UTSW |
3 |
148,852,729 (GRCm38) |
missense |
probably benign |
|
|
R9646:Adgrl2
|
UTSW |
3 |
148,839,290 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9742:Adgrl2
|
UTSW |
3 |
148,836,350 (GRCm38) |
critical splice donor site |
probably null |
|
|
RF007:Adgrl2
|
UTSW |
3 |
148,839,248 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0009:Adgrl2
|
UTSW |
3 |
148,852,654 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0019:Adgrl2
|
UTSW |
3 |
148,865,594 (GRCm38) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGCGTCTCTATCAATTAATACTTGC -3'
(R):5'- AGGCAACAGACAGCTACGTC -3'
Sequencing Primer
(F):5'- AATACTTGCATGTGGCCCTAG -3'
(R):5'- AGCTACGTCTCCCAGCTGAC -3'
|
| Posted On |
2019-06-07 |
Incidental Mutation