Mutagenetix > Incidental Mutation

Incidental Mutation 'PIT4366001:Dock10'

554732

Institutional Source

Beutler Lab

Gene Symbol

Dock10

Ensembl Gene

ENSMUSG00000038608

Gene Name

dedicator of cytokinesis 10

Synonyms

Zizimin3, A630054M16Rik, Jr5, ZIZ3, Jr4, 9330153B10Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.487) question?

Stock #

PIT4366001 (G1)

Quality Score

190.009

Status

Not validated

Chromosome

Chromosomal Location

80478790-80736244 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 80573438 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 239 (N239D)

Ref Sequence

ENSEMBL: ENSMUSP00000140085 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077946] [ENSMUST00000186087] [ENSMUST00000187774] [ENSMUST00000190595] [ENSMUST00000190983] [ENSMUST00000191449]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000077946
AA Change: N251D

PolyPhen 2 Score 0.290 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000077099
Gene: ENSMUSG00000038608
AA Change: N251D

Domain	Start	End	E-Value	Type
low complexity region	25	42	N/A	INTRINSIC
Pfam:DUF3398	61	153	1.7e-36	PFAM
PH	182	292	8.5e-17	SMART
Blast:PH	350	458	7e-18	BLAST
Pfam:DOCK-C2	668	859	1e-50	PFAM
low complexity region	1269	1279	N/A	INTRINSIC
low complexity region	1284	1295	N/A	INTRINSIC
Pfam:DHR-2	1592	2143	1.3e-216	PFAM
low complexity region	2174	2187	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000186087
AA Change: N264D

PolyPhen 2 Score 0.577 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000140102
Gene: ENSMUSG00000038608
AA Change: N264D

Domain	Start	End	E-Value	Type
Pfam:DUF3398	71	166	1.5e-29	PFAM
PH	195	305	3.9e-19	SMART
Blast:PH	363	475	3e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000187774
AA Change: N239D

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000140085
Gene: ENSMUSG00000038608
AA Change: N239D

Domain	Start	End	E-Value	Type
Pfam:DUF3398	46	141	9e-29	PFAM
PH	170	280	3.9e-19	SMART
Blast:PH	338	446	7e-18	BLAST
Pfam:DOCK-C2	655	848	1.5e-54	PFAM
low complexity region	1257	1267	N/A	INTRINSIC
low complexity region	1272	1283	N/A	INTRINSIC
low complexity region	1870	1890	N/A	INTRINSIC
Pfam:Ded_cyto	1954	2131	3.4e-65	PFAM
low complexity region	2162	2175	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190595

SMART Domains

Protein: ENSMUSP00000139567
Gene: ENSMUSG00000038608

Domain	Start	End	E-Value	Type
Blast:PH	3	111	5e-18	BLAST
Pfam:DOCK-C2	320	513	1.2e-54	PFAM
low complexity region	922	932	N/A	INTRINSIC
low complexity region	937	948	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
Pfam:Ded_cyto	1588	1765	2.7e-65	PFAM
low complexity region	1783	1795	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190983
AA Change: N238D

PolyPhen 2 Score 0.187 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000140719
Gene: ENSMUSG00000038608
AA Change: N238D

Domain	Start	End	E-Value	Type
Pfam:DUF3398	45	140	8.9e-29	PFAM
PH	169	279	3.9e-19	SMART
Blast:PH	337	445	7e-18	BLAST
Pfam:DOCK-C2	654	847	1.5e-54	PFAM
low complexity region	1256	1266	N/A	INTRINSIC
low complexity region	1271	1282	N/A	INTRINSIC
low complexity region	1869	1889	N/A	INTRINSIC
Pfam:Ded_cyto	1953	2130	3.4e-65	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000191449
AA Change: N233D

PolyPhen 2 Score 0.717 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000140513
Gene: ENSMUSG00000038608
AA Change: N233D

Domain	Start	End	E-Value	Type
Pfam:DUF3398	40	135	1.1e-32	PFAM
PH	164	274	8.5e-17	SMART

Coding Region Coverage

1x: 93.0%
3x: 90.7%
10x: 85.5%
20x: 73.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatk	C	A	11: 119,901,786 (GRCm39)	S870I	possibly damaging	Het
Abca13	T	C	11: 9,244,962 (GRCm39)	V2275A	probably benign	Het
Abcb5	T	C	12: 118,899,833 (GRCm39)	K278R	probably damaging	Het
Adcy2	TA	TAA	13: 68,858,109 (GRCm39)		probably benign	Het
Add3	C	T	19: 53,205,298 (GRCm39)	P16L	unknown	Het
Akap9	T	A	5: 4,096,221 (GRCm39)	D2365E	probably benign	Het
Asah1	A	G	8: 41,796,783 (GRCm39)	S300P	possibly damaging	Het
Astn1	A	T	1: 158,424,779 (GRCm39)	H655L	probably benign	Het
Astn1	A	T	1: 158,424,781 (GRCm39)	I656F	probably benign	Het
Bmpr1b	T	A	3: 141,586,224 (GRCm39)	T13S	probably benign	Het
Camsap2	A	G	1: 136,208,055 (GRCm39)	F478L		Het
Card10	G	A	15: 78,671,631 (GRCm39)	S611L	probably benign	Het
Cep68	T	C	11: 20,190,007 (GRCm39)	N335S	probably benign	Het
Chac1	T	C	2: 119,181,986 (GRCm39)	W35R	probably damaging	Het
Cntn6	T	C	6: 104,809,498 (GRCm39)	V511A	probably benign	Het
Cpne9	G	T	6: 113,271,707 (GRCm39)	G356W	probably damaging	Het
Dnah10	C	A	5: 124,852,588 (GRCm39)	T1939K	possibly damaging	Het
Dock5	T	C	14: 68,062,123 (GRCm39)	K415R	possibly damaging	Het
Dtd2	C	A	12: 52,046,582 (GRCm39)	D86Y	probably damaging	Het
Efcab9	A	G	11: 32,473,608 (GRCm39)	F127S	probably damaging	Het
Ermp1	T	C	19: 29,606,189 (GRCm39)	H375R	probably benign	Het
Frem2	A	T	3: 53,560,622 (GRCm39)	M1295K	probably damaging	Het
Gbp7	T	G	3: 142,248,712 (GRCm39)	I325R	probably benign	Het
Gpr179	T	C	11: 97,227,677 (GRCm39)	K1493E	probably benign	Het
Gucy2g	T	A	19: 55,226,214 (GRCm39)	E234V	probably null	Het
Itpr1	T	A	6: 108,470,718 (GRCm39)	C2215*	probably null	Het
Ltn1	G	A	16: 87,177,728 (GRCm39)	R1634*	probably null	Het
Lynx1	A	T	15: 74,623,258 (GRCm39)	M58K	possibly damaging	Het
Macc1	T	C	12: 119,410,684 (GRCm39)	V484A	probably benign	Het
Map3k9	C	T	12: 81,819,535 (GRCm39)	V240M	possibly damaging	Het
Mars1	A	G	10: 127,135,267 (GRCm39)	M608T	possibly damaging	Het
Mc2r	T	C	18: 68,540,826 (GRCm39)	M156V	probably benign	Het
Mchr1	G	T	15: 81,121,417 (GRCm39)	V56L	probably benign	Het
Mlxip	C	T	5: 123,533,173 (GRCm39)	P61S	probably benign	Het
Mtarc1	A	G	1: 184,539,383 (GRCm39)	F96S	probably benign	Het
Muc4	A	G	16: 32,575,542 (GRCm39)	T1557A	unknown	Het
Myt1	T	C	2: 181,467,731 (GRCm39)	V1135A	probably damaging	Het
Ndufaf6	A	T	4: 11,073,215 (GRCm39)	S76T	probably benign	Het
Ntrk2	A	G	13: 59,208,149 (GRCm39)	Y665C	probably damaging	Het
Oaz3	T	G	3: 94,340,901 (GRCm39)	R215S	unknown	Het
Or10x1	T	C	1: 174,196,656 (GRCm39)	Y58H	probably damaging	Het
Or5m10b	T	C	2: 85,699,226 (GRCm39)	C97R	probably damaging	Het
Or5m8	A	T	2: 85,822,385 (GRCm39)	N75Y	probably damaging	Het
Or5w1b	C	T	2: 87,475,534 (GRCm39)	W311*	probably null	Het
Perm1	G	T	4: 156,303,192 (GRCm39)	V579L	probably benign	Het
Phyhipl	A	G	10: 70,404,788 (GRCm39)	V140A	probably benign	Het
Pip5k1c	T	A	10: 81,144,842 (GRCm39)	S228T	probably damaging	Het
Plekhn1	T	G	4: 156,309,268 (GRCm39)	T213P	probably damaging	Het
Pomt2	A	T	12: 87,163,303 (GRCm39)		probably null	Het
Ptcd1	A	G	5: 145,088,145 (GRCm39)	V622A	probably benign	Het
Ptn	T	A	6: 36,718,284 (GRCm39)	H127L	probably benign	Het
Ptprk	A	T	10: 28,462,015 (GRCm39)	M1193L	probably benign	Het
Ptpru	G	A	4: 131,527,023 (GRCm39)	P650S	probably benign	Het
Pum2	T	A	12: 8,783,390 (GRCm39)	L613Q	probably damaging	Het
Rapgef6	A	G	11: 54,582,446 (GRCm39)	T1458A	probably damaging	Het
Sap130	C	T	18: 31,810,462 (GRCm39)	A470V	probably benign	Het
Sertad2	C	A	11: 20,598,116 (GRCm39)	P104Q	probably benign	Het
Sfrp4	A	T	13: 19,814,414 (GRCm39)	M324L	unknown	Het
Sh3bp4	A	G	1: 89,073,156 (GRCm39)	N668S	probably benign	Het
Snx30	C	A	4: 59,894,653 (GRCm39)	D410E	probably benign	Het
Spata31	C	A	13: 65,069,319 (GRCm39)	S489*	probably null	Het
Taok3	T	A	5: 117,366,050 (GRCm39)	M367K	probably benign	Het
Tfap2a	T	C	13: 40,874,850 (GRCm39)	N254D	possibly damaging	Het
Tgtp1	T	G	11: 48,877,867 (GRCm39)	L279F	possibly damaging	Het
Tmpo	A	G	10: 90,999,172 (GRCm39)	F205S	probably damaging	Het
Tmprss5	A	T	9: 49,023,517 (GRCm39)	I218L	probably benign	Het
Tti2	A	G	8: 31,641,224 (GRCm39)	E116G	probably benign	Het
Vmn2r59	A	T	7: 41,695,205 (GRCm39)	N402K	possibly damaging	Het

Other mutations in Dock10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00569:Dock10	APN	1	80,562,729 (GRCm39)	missense	probably damaging	1.00
IGL00783:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00784:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00858:Dock10	APN	1	80,545,720 (GRCm39)	missense	possibly damaging	0.48
IGL01298:Dock10	APN	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
IGL01351:Dock10	APN	1	80,570,876 (GRCm39)	missense	probably damaging	1.00
IGL01356:Dock10	APN	1	80,501,459 (GRCm39)	missense	probably damaging	1.00
IGL01584:Dock10	APN	1	80,511,567 (GRCm39)	missense	probably damaging	0.99
IGL01619:Dock10	APN	1	80,612,015 (GRCm39)	splice site	probably benign
IGL01678:Dock10	APN	1	80,521,069 (GRCm39)	missense	probably damaging	1.00
IGL01759:Dock10	APN	1	80,503,990 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dock10	APN	1	80,511,510 (GRCm39)	missense	probably damaging	0.99
IGL02352:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02359:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dock10	APN	1	80,562,711 (GRCm39)	critical splice donor site	probably null
IGL02433:Dock10	APN	1	80,507,905 (GRCm39)	missense	probably damaging	1.00
IGL02471:Dock10	APN	1	80,493,339 (GRCm39)	missense	probably damaging	0.99
IGL02645:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02646:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02648:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02649:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02650:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02652:Dock10	APN	1	80,570,561 (GRCm39)	splice site	probably null
IGL02718:Dock10	APN	1	80,501,535 (GRCm39)	missense	probably benign	0.00
IGL02998:Dock10	APN	1	80,551,259 (GRCm39)	missense	probably damaging	1.00
IGL03057:Dock10	APN	1	80,545,088 (GRCm39)	missense	probably damaging	1.00
IGL03066:Dock10	APN	1	80,562,758 (GRCm39)	missense	probably benign	0.00
IGL03106:Dock10	APN	1	80,546,551 (GRCm39)	missense	probably damaging	0.98
IGL03148:Dock10	APN	1	80,518,075 (GRCm39)	missense	probably benign	0.01
IGL03271:Dock10	APN	1	80,483,126 (GRCm39)	missense	probably damaging	1.00
IGL03352:Dock10	APN	1	80,584,013 (GRCm39)	splice site	probably benign
LCD18:Dock10	UTSW	1	80,716,623 (GRCm38)	intron	probably benign
PIT4581001:Dock10	UTSW	1	80,483,163 (GRCm39)	missense	probably damaging	1.00
R0019:Dock10	UTSW	1	80,583,642 (GRCm39)	missense	probably damaging	1.00
R0081:Dock10	UTSW	1	80,584,295 (GRCm39)	missense	probably damaging	0.99
R0095:Dock10	UTSW	1	80,501,788 (GRCm39)	missense	probably benign	0.00
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0255:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R0267:Dock10	UTSW	1	80,490,171 (GRCm39)	missense	probably damaging	1.00
R0299:Dock10	UTSW	1	80,514,646 (GRCm39)	missense	probably damaging	0.99
R0365:Dock10	UTSW	1	80,573,400 (GRCm39)	missense	probably damaging	1.00
R0387:Dock10	UTSW	1	80,517,993 (GRCm39)	missense	probably damaging	1.00
R0403:Dock10	UTSW	1	80,501,787 (GRCm39)	missense	possibly damaging	0.94
R0408:Dock10	UTSW	1	80,518,193 (GRCm39)	missense	probably benign	0.03
R0414:Dock10	UTSW	1	80,513,650 (GRCm39)	missense	possibly damaging	0.93
R0591:Dock10	UTSW	1	80,518,936 (GRCm39)	splice site	probably benign
R0698:Dock10	UTSW	1	80,507,895 (GRCm39)	missense	probably damaging	1.00
R0711:Dock10	UTSW	1	80,501,692 (GRCm39)	missense	probably damaging	1.00
R0925:Dock10	UTSW	1	80,514,657 (GRCm39)	missense	probably benign	0.20
R1162:Dock10	UTSW	1	80,546,559 (GRCm39)	missense	possibly damaging	0.58
R1370:Dock10	UTSW	1	80,518,060 (GRCm39)	missense	probably damaging	1.00
R1440:Dock10	UTSW	1	80,526,853 (GRCm39)	missense	probably benign	0.03
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1525:Dock10	UTSW	1	80,583,881 (GRCm39)	critical splice donor site	probably null
R1544:Dock10	UTSW	1	80,570,352 (GRCm39)	missense	probably benign	0.00
R1601:Dock10	UTSW	1	80,527,519 (GRCm39)	missense	probably benign	0.00
R1757:Dock10	UTSW	1	80,511,586 (GRCm39)	missense	probably damaging	1.00
R1765:Dock10	UTSW	1	80,583,540 (GRCm39)	missense	probably damaging	1.00
R1783:Dock10	UTSW	1	80,551,897 (GRCm39)	missense	probably benign	0.17
R1823:Dock10	UTSW	1	80,520,814 (GRCm39)	splice site	probably null
R1827:Dock10	UTSW	1	80,508,009 (GRCm39)	missense	probably benign	0.07
R1844:Dock10	UTSW	1	80,520,918 (GRCm39)	missense	probably damaging	0.99
R1856:Dock10	UTSW	1	80,584,285 (GRCm39)	missense	possibly damaging	0.46
R1974:Dock10	UTSW	1	80,488,143 (GRCm39)	missense	possibly damaging	0.50
R2006:Dock10	UTSW	1	80,527,506 (GRCm39)	missense	possibly damaging	0.95
R2112:Dock10	UTSW	1	80,483,360 (GRCm39)	missense	probably damaging	0.99
R2112:Dock10	UTSW	1	80,483,359 (GRCm39)	missense	probably damaging	1.00
R2113:Dock10	UTSW	1	80,584,280 (GRCm39)	missense	probably damaging	1.00
R2439:Dock10	UTSW	1	80,510,149 (GRCm39)	missense	probably damaging	1.00
R2566:Dock10	UTSW	1	80,517,970 (GRCm39)	missense	possibly damaging	0.88
R3086:Dock10	UTSW	1	80,510,074 (GRCm39)	missense	possibly damaging	0.91
R3766:Dock10	UTSW	1	80,514,643 (GRCm39)	missense	probably damaging	0.99
R3768:Dock10	UTSW	1	80,510,085 (GRCm39)	missense	probably damaging	1.00
R4009:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R4016:Dock10	UTSW	1	80,584,286 (GRCm39)	missense	probably damaging	1.00
R4179:Dock10	UTSW	1	80,488,134 (GRCm39)	missense	probably benign	0.00
R4243:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4244:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4245:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4674:Dock10	UTSW	1	80,584,337 (GRCm39)	missense	possibly damaging	0.79
R4696:Dock10	UTSW	1	80,493,330 (GRCm39)	missense	possibly damaging	0.95
R4789:Dock10	UTSW	1	80,518,998 (GRCm39)	missense	probably damaging	1.00
R4851:Dock10	UTSW	1	80,526,874 (GRCm39)	missense	probably benign	0.33
R4911:Dock10	UTSW	1	80,583,953 (GRCm39)	missense	probably damaging	1.00
R4976:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5086:Dock10	UTSW	1	80,529,189 (GRCm39)	missense	possibly damaging	0.89
R5119:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5301:Dock10	UTSW	1	80,625,973 (GRCm39)	missense	probably benign	0.41
R5404:Dock10	UTSW	1	80,481,630 (GRCm39)	intron	probably benign
R5457:Dock10	UTSW	1	80,501,781 (GRCm39)	missense	probably damaging	1.00
R5790:Dock10	UTSW	1	80,482,887 (GRCm39)	missense	probably benign	0.00
R5845:Dock10	UTSW	1	80,483,459 (GRCm39)	intron	probably benign
R5871:Dock10	UTSW	1	80,519,057 (GRCm39)	critical splice acceptor site	probably null
R5873:Dock10	UTSW	1	80,551,855 (GRCm39)	missense	probably damaging	1.00
R5881:Dock10	UTSW	1	80,538,640 (GRCm39)	missense	probably benign	0.19
R5895:Dock10	UTSW	1	80,514,676 (GRCm39)	missense	probably benign
R5935:Dock10	UTSW	1	80,483,304 (GRCm39)	intron	probably benign
R5965:Dock10	UTSW	1	80,546,461 (GRCm39)	splice site	probably null
R5966:Dock10	UTSW	1	80,546,225 (GRCm39)	missense	possibly damaging	0.84
R6008:Dock10	UTSW	1	80,583,890 (GRCm39)	missense	probably damaging	0.98
R6029:Dock10	UTSW	1	80,514,663 (GRCm39)	missense	possibly damaging	0.68
R6083:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R6145:Dock10	UTSW	1	80,553,621 (GRCm39)	nonsense	probably null
R6257:Dock10	UTSW	1	80,481,413 (GRCm39)	intron	probably benign
R6274:Dock10	UTSW	1	80,516,540 (GRCm39)	missense	probably damaging	1.00
R6324:Dock10	UTSW	1	80,482,893 (GRCm39)	missense	probably benign	0.03
R6346:Dock10	UTSW	1	80,553,573 (GRCm39)	splice site	probably null
R6476:Dock10	UTSW	1	80,518,959 (GRCm39)	nonsense	probably null
R6516:Dock10	UTSW	1	80,518,178 (GRCm39)	missense	probably damaging	1.00
R6526:Dock10	UTSW	1	80,564,068 (GRCm39)	missense	probably damaging	0.97
R6534:Dock10	UTSW	1	80,481,388 (GRCm39)	missense	probably benign	0.01
R6620:Dock10	UTSW	1	80,570,355 (GRCm39)	missense	probably benign	0.01
R6640:Dock10	UTSW	1	80,511,555 (GRCm39)	nonsense	probably null
R6669:Dock10	UTSW	1	80,570,572 (GRCm39)	missense	probably damaging	1.00
R6672:Dock10	UTSW	1	80,490,248 (GRCm39)	missense	probably benign	0.00
R6679:Dock10	UTSW	1	80,544,514 (GRCm39)	missense	probably benign	0.11
R6682:Dock10	UTSW	1	80,490,338 (GRCm39)	missense	probably damaging	1.00
R6712:Dock10	UTSW	1	80,514,583 (GRCm39)	missense	probably benign	0.00
R6726:Dock10	UTSW	1	80,490,147 (GRCm39)	missense	probably damaging	1.00
R6788:Dock10	UTSW	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
R6805:Dock10	UTSW	1	80,564,407 (GRCm39)	missense	probably benign
R6815:Dock10	UTSW	1	80,516,576 (GRCm39)	missense	possibly damaging	0.94
R6818:Dock10	UTSW	1	80,593,082 (GRCm39)	missense	possibly damaging	0.95
R6867:Dock10	UTSW	1	80,508,976 (GRCm39)	missense	probably damaging	1.00
R6964:Dock10	UTSW	1	80,481,365 (GRCm39)	intron	probably benign
R7026:Dock10	UTSW	1	80,479,504 (GRCm39)	missense	probably benign	0.40
R7084:Dock10	UTSW	1	80,481,573 (GRCm39)	missense
R7087:Dock10	UTSW	1	80,570,543 (GRCm39)	missense	probably benign
R7158:Dock10	UTSW	1	80,564,589 (GRCm39)	critical splice acceptor site	probably null
R7191:Dock10	UTSW	1	80,518,048 (GRCm39)	missense	possibly damaging	0.93
R7214:Dock10	UTSW	1	80,546,246 (GRCm39)	missense	probably benign	0.01
R7255:Dock10	UTSW	1	80,520,816 (GRCm39)	critical splice donor site	probably null
R7320:Dock10	UTSW	1	80,527,421 (GRCm39)	critical splice donor site	probably null
R7359:Dock10	UTSW	1	80,687,065 (GRCm39)	missense	probably benign	0.01
R7423:Dock10	UTSW	1	80,501,497 (GRCm39)	missense	possibly damaging	0.67
R7464:Dock10	UTSW	1	80,518,032 (GRCm39)	missense	probably damaging	0.99
R7483:Dock10	UTSW	1	80,493,283 (GRCm39)	missense	probably benign	0.01
R7487:Dock10	UTSW	1	80,562,765 (GRCm39)	missense	probably benign	0.00
R7789:Dock10	UTSW	1	80,536,930 (GRCm39)	missense	possibly damaging	0.82
R7943:Dock10	UTSW	1	80,626,006 (GRCm39)	missense	probably damaging	0.98
R7962:Dock10	UTSW	1	80,564,085 (GRCm39)	missense	possibly damaging	0.88
R8079:Dock10	UTSW	1	80,556,421 (GRCm39)	missense	probably benign	0.00
R8086:Dock10	UTSW	1	80,481,707 (GRCm39)	missense	probably benign	0.17
R8184:Dock10	UTSW	1	80,530,469 (GRCm39)	missense	probably damaging	1.00
R8220:Dock10	UTSW	1	80,506,366 (GRCm39)	missense	probably null	1.00
R8225:Dock10	UTSW	1	80,481,447 (GRCm39)	nonsense	probably null
R8267:Dock10	UTSW	1	80,518,045 (GRCm39)	missense	probably benign	0.00
R8276:Dock10	UTSW	1	80,505,998 (GRCm39)	missense	probably benign
R8294:Dock10	UTSW	1	80,488,079 (GRCm39)	missense	possibly damaging	0.88
R8298:Dock10	UTSW	1	80,514,654 (GRCm39)	missense	probably benign	0.00
R8326:Dock10	UTSW	1	80,583,892 (GRCm39)	missense	possibly damaging	0.77
R8724:Dock10	UTSW	1	80,570,344 (GRCm39)	missense	probably benign	0.00
R8828:Dock10	UTSW	1	80,521,134 (GRCm39)	missense	probably damaging	1.00
R8846:Dock10	UTSW	1	80,545,786 (GRCm39)	missense	possibly damaging	0.93
R8919:Dock10	UTSW	1	80,483,147 (GRCm39)	missense	probably benign	0.00
R8950:Dock10	UTSW	1	80,519,016 (GRCm39)	missense	probably benign
R8993:Dock10	UTSW	1	80,551,888 (GRCm39)	missense	probably benign	0.21
R9028:Dock10	UTSW	1	80,584,012 (GRCm39)	splice site	probably benign
R9115:Dock10	UTSW	1	80,490,156 (GRCm39)	missense	probably damaging	1.00
R9327:Dock10	UTSW	1	80,510,184 (GRCm39)	missense	probably damaging	1.00
R9342:Dock10	UTSW	1	80,570,360 (GRCm39)	missense	probably benign
R9421:Dock10	UTSW	1	80,501,509 (GRCm39)	missense	probably damaging	1.00
R9431:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R9486:Dock10	UTSW	1	80,479,452 (GRCm39)	missense	unknown
R9521:Dock10	UTSW	1	80,501,763 (GRCm39)	missense	probably damaging	1.00
R9598:Dock10	UTSW	1	80,625,939 (GRCm39)	missense	probably benign	0.15
R9629:Dock10	UTSW	1	80,481,389 (GRCm39)	missense
R9703:Dock10	UTSW	1	80,517,540 (GRCm39)	missense	probably damaging	0.98
RF021:Dock10	UTSW	1	80,542,290 (GRCm39)	critical splice acceptor site	probably null
X0025:Dock10	UTSW	1	80,514,637 (GRCm39)	missense	probably damaging	0.98
X0065:Dock10	UTSW	1	80,518,977 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock10	UTSW	1	80,510,064 (GRCm39)	missense	probably damaging	1.00
Z1176:Dock10	UTSW	1	80,538,671 (GRCm39)	missense	probably benign
Z1177:Dock10	UTSW	1	80,536,917 (GRCm39)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- AGATGATTGCCTGAGCCCCTAC -3'
(R):5'- ATTGAGCCAAAATGCCATCC -3'

Sequencing Primer
(F):5'- TGAGCCCCTACCTAGCCC -3'
(R):5'- CCTAGACCGCTTCAATGT -3'

Posted On

2019-06-07