Incidental Mutation 'PIT4354001:Or4c10b'
| ID |
554806 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or4c10b
|
| Ensembl Gene |
ENSMUSG00000049057 |
| Gene Name |
olfactory receptor family 4 subfamily C member 10B |
| Synonyms |
MOR232-1, Olfr1257, GA_x6K02T2Q125-51319458-51320387 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
PIT4354001 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
89709708-89712147 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 89711852 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 227
(S227R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107144
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060795]
[ENSMUST00000111519]
|
| AlphaFold |
Q8VGP0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060795
AA Change: S227R
PolyPhen 2
Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000056439
Gene: ENSMUSG00000049057
AA Change: S227R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
39 |
285 |
2.6e-31 |
PFAM |
|
Pfam:7tm_4
|
137 |
278 |
8e-42 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111519
AA Change: S227R
PolyPhen 2
Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000107144
Gene: ENSMUSG00000049057
AA Change: S227R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
29 |
303 |
1.5e-49 |
PFAM |
|
Pfam:7tm_1
|
39 |
285 |
3.9e-18 |
PFAM |
|
| Coding Region Coverage |
- 1x: 92.5%
- 3x: 90.1%
- 10x: 83.2%
- 20x: 69.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arap2 |
A |
T |
5: 62,811,392 (GRCm39) |
Y1140N |
probably damaging |
Het |
| Ccdc83 |
A |
T |
7: 89,873,182 (GRCm39) |
M391K |
probably benign |
Het |
| Cntnap1 |
A |
T |
11: 101,072,123 (GRCm39) |
I459F |
probably damaging |
Het |
| Cr2 |
T |
A |
1: 194,848,617 (GRCm39) |
Y302F |
probably damaging |
Het |
| Ctu2 |
A |
T |
8: 123,205,714 (GRCm39) |
D179V |
probably damaging |
Het |
| Cubn |
G |
A |
2: 13,473,663 (GRCm39) |
Q427* |
probably null |
Het |
| Depdc7 |
A |
G |
2: 104,558,533 (GRCm39) |
S163P |
probably benign |
Het |
| Eif2s3y |
C |
T |
Y: 1,020,126 (GRCm39) |
R385C |
probably benign |
Het |
| Gigyf1 |
A |
G |
5: 137,522,366 (GRCm39) |
K728R |
unknown |
Het |
| Gm1587 |
G |
A |
14: 78,034,473 (GRCm39) |
R32* |
probably null |
Het |
| Hjv |
T |
C |
3: 96,435,761 (GRCm39) |
C340R |
probably damaging |
Het |
| Isy1 |
A |
G |
6: 87,810,653 (GRCm39) |
I53T |
possibly damaging |
Het |
| Myh8 |
A |
T |
11: 67,180,456 (GRCm39) |
N564I |
probably benign |
Het |
| Neb |
A |
T |
2: 52,135,330 (GRCm39) |
I3260N |
probably damaging |
Het |
| Npc1 |
C |
T |
18: 12,344,592 (GRCm39) |
G426E |
probably benign |
Het |
| Nrdc |
G |
A |
4: 108,911,222 (GRCm39) |
|
probably null |
Het |
| Or2v1 |
G |
A |
11: 49,025,132 (GRCm39) |
V38M |
probably damaging |
Het |
| Or4c116 |
C |
A |
2: 88,942,830 (GRCm39) |
E9* |
probably null |
Het |
| Pate8 |
T |
A |
9: 36,492,597 (GRCm39) |
S103C |
possibly damaging |
Het |
| Prss51 |
T |
A |
14: 64,334,546 (GRCm39) |
V91D |
probably damaging |
Het |
| Qpct |
A |
C |
17: 79,389,188 (GRCm39) |
Y280S |
probably benign |
Het |
| Rbpms |
A |
G |
8: 34,296,866 (GRCm39) |
V137A |
possibly damaging |
Het |
| Rgl2 |
T |
A |
17: 34,152,914 (GRCm39) |
M441K |
possibly damaging |
Het |
| Sdhaf3 |
A |
T |
6: 6,956,072 (GRCm39) |
I16F |
possibly damaging |
Het |
| Slc38a3 |
T |
G |
9: 107,534,848 (GRCm39) |
N176H |
probably benign |
Het |
| Sos1 |
T |
C |
17: 80,756,785 (GRCm39) |
S256G |
possibly damaging |
Het |
| Spg11 |
A |
T |
2: 121,918,666 (GRCm39) |
C988S |
probably damaging |
Het |
| Sync |
A |
T |
4: 129,200,447 (GRCm39) |
Q451L |
possibly damaging |
Het |
| Tbc1d31 |
A |
G |
15: 57,831,329 (GRCm39) |
Y929C |
probably benign |
Het |
| Thbs2 |
G |
A |
17: 14,910,230 (GRCm39) |
T123I |
probably damaging |
Het |
| Thsd7a |
A |
C |
6: 12,331,926 (GRCm39) |
|
probably null |
Het |
| Tnfrsf11a |
T |
C |
1: 105,749,242 (GRCm39) |
L220P |
probably damaging |
Het |
| Trbv13-2 |
G |
A |
6: 41,098,752 (GRCm39) |
C109Y |
probably damaging |
Het |
| Ugt3a1 |
G |
A |
15: 9,306,446 (GRCm39) |
W198* |
probably null |
Het |
| Usp14 |
G |
A |
18: 9,996,189 (GRCm39) |
R464W |
probably damaging |
Het |
| Vmn1r2 |
C |
T |
4: 3,172,162 (GRCm39) |
S27L |
probably benign |
Het |
| Vmn1r68 |
T |
A |
7: 10,261,958 (GRCm39) |
N47Y |
probably benign |
Het |
| Zfc3h1 |
T |
A |
10: 115,262,944 (GRCm39) |
Y1719* |
probably null |
Het |
|
| Other mutations in Or4c10b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01600:Or4c10b
|
APN |
2 |
89,712,006 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01641:Or4c10b
|
APN |
2 |
89,711,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01668:Or4c10b
|
APN |
2 |
89,711,443 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01901:Or4c10b
|
APN |
2 |
89,711,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02401:Or4c10b
|
APN |
2 |
89,711,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Or4c10b
|
APN |
2 |
89,711,755 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL02631:Or4c10b
|
APN |
2 |
89,711,599 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0552:Or4c10b
|
UTSW |
2 |
89,711,235 (GRCm39) |
nonsense |
probably null |
|
|
R0616:Or4c10b
|
UTSW |
2 |
89,711,935 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0943:Or4c10b
|
UTSW |
2 |
89,711,305 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1146:Or4c10b
|
UTSW |
2 |
89,711,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1146:Or4c10b
|
UTSW |
2 |
89,711,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1314:Or4c10b
|
UTSW |
2 |
89,711,221 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1641:Or4c10b
|
UTSW |
2 |
89,711,745 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1763:Or4c10b
|
UTSW |
2 |
89,711,473 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1836:Or4c10b
|
UTSW |
2 |
89,711,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Or4c10b
|
UTSW |
2 |
89,711,982 (GRCm39) |
missense |
probably benign |
|
|
R4322:Or4c10b
|
UTSW |
2 |
89,712,078 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4897:Or4c10b
|
UTSW |
2 |
89,711,476 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5446:Or4c10b
|
UTSW |
2 |
89,711,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5456:Or4c10b
|
UTSW |
2 |
89,711,602 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6415:Or4c10b
|
UTSW |
2 |
89,711,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6905:Or4c10b
|
UTSW |
2 |
89,712,052 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7170:Or4c10b
|
UTSW |
2 |
89,711,397 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7170:Or4c10b
|
UTSW |
2 |
89,711,185 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7411:Or4c10b
|
UTSW |
2 |
89,711,605 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8171:Or4c10b
|
UTSW |
2 |
89,711,409 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8490:Or4c10b
|
UTSW |
2 |
89,711,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Or4c10b
|
UTSW |
2 |
89,711,515 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9204:Or4c10b
|
UTSW |
2 |
89,711,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9751:Or4c10b
|
UTSW |
2 |
89,711,956 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCTGTGGCCCTAACATCATAG -3'
(R):5'- AGTGCTACCCAATTTCTTAATGGC -3'
Sequencing Primer
(F):5'- TGCACCGATACTCACACT -3'
(R):5'- TTAATGGCATCTTTCATCTGAGC -3'
|
| Posted On |
2019-06-07 |
Incidental Mutation