|Institutional Source||Beutler Lab|
|Gene Name||gastric inhibitory polypeptide receptor|
|Synonyms||LOC232937, glucose-dependent insulinotropic polypeptide receptor, LOC381853|
|Is this an essential gene?||Probably non essential (E-score: 0.111)|
|Stock #||PIT4480001 (G1)|
|Chromosomal Location||19156061-19166127 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 19162934 bp|
|Amino Acid Change||Tyrosine to Cysteine at position 137 (Y137C)|
|Ref Sequence||ENSEMBL: ENSMUSP00000092384 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000094790] [ENSMUST00000206971]|
|Predicted Effect||probably damaging
AA Change: Y137C
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: Y137C
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous inactivation of this gene results in mild glucose intolerance due to impaired glucose-stimulated insulin secretion. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gipr||
(F):5'- AATTACGAGTGCAGTGCAGC -3'
(R):5'- CGCCTGTTTGGAGAGAAGGAAC -3'
(F):5'- TGAAAAGCTGTCCTCAGGC -3'
(R):5'- CATTTTTCCCAGAAGAGACCGGG -3'