|Institutional Source||Beutler Lab|
|Is this an essential gene?||Probably non essential (E-score: 0.134)|
|Stock #||PIT4519001 (G1)|
|Chromosomal Location||88970252-88991613 bp(+) (GRCm38)|
|Type of Mutation||start gained|
|DNA Base Change (assembly)||C to T at 88972726 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000103530 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000036649] [ENSMUST00000107898]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
PHENOTYPE: Animals homozygous for a mutation in this gene show reduced viability on inbred backgrounds. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Coil||
(F):5'- TGCAGATATCCAATTGAAACCAGC -3'
(R):5'- AGGCCTTCAAAGACATCTCCTG -3'
(F):5'- CCTTTCCTGTCAGGGTCAGAGAAAC -3'
(R):5'- AAGACATCTCCTGTTCTGAAGGC -3'