Incidental Mutation 'PIT4445001:Vmn2r15'
ID 555395
Institutional Source Beutler Lab
Gene Symbol Vmn2r15
Ensembl Gene ENSMUSG00000091375
Gene Name vomeronasal 2, receptor 15
Synonyms EG211223
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # PIT4445001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 109434135-109445422 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 109435008 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 565 (D565E)
Ref Sequence ENSEMBL: ENSMUSP00000128333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167133]
AlphaFold L7N2A0
Predicted Effect probably damaging
Transcript: ENSMUST00000167133
AA Change: D565E

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: D565E

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 472 1e-29 PFAM
Pfam:NCD3G 514 568 5.8e-18 PFAM
Pfam:7tm_3 601 836 9.1e-55 PFAM
Coding Region Coverage
  • 1x: 93.5%
  • 3x: 90.8%
  • 10x: 84.5%
  • 20x: 70.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T C 11: 109,966,377 (GRCm39) K419E probably damaging Het
Adam7 T A 14: 68,747,197 (GRCm39) K587N possibly damaging Het
Agl T C 3: 116,565,109 (GRCm39) M382V Het
Agpat3 A T 10: 78,109,927 (GRCm39) F341I possibly damaging Het
Ampd2 A T 3: 107,982,328 (GRCm39) L767Q probably damaging Het
Arhgap28 A T 17: 68,203,230 (GRCm39) D124E possibly damaging Het
Arhgap32 T C 9: 32,172,152 (GRCm39) L1644P probably damaging Het
Asic4 T C 1: 75,427,771 (GRCm39) V99A probably benign Het
Asns T A 6: 7,689,277 (GRCm39) N75I probably damaging Het
Atp10a A G 7: 58,453,215 (GRCm39) D798G probably damaging Het
Atp8a1 A G 5: 67,780,003 (GRCm39) V1145A Het
Ccdc171 A G 4: 83,579,984 (GRCm39) Q577R probably damaging Het
Cd247 T A 1: 165,688,605 (GRCm39) D154E probably damaging Het
Ceacam1 A T 7: 25,175,881 (GRCm39) N104K probably damaging Het
Chfr A G 5: 110,299,543 (GRCm39) D312G possibly damaging Het
Ddb1 C A 19: 10,603,334 (GRCm39) L881I probably damaging Het
Dgkh A T 14: 78,813,382 (GRCm39) I1032N possibly damaging Het
Efcab6 A T 15: 83,788,468 (GRCm39) V942D probably benign Het
Fmo5 A G 3: 97,558,844 (GRCm39) T435A probably benign Het
Fpr1 T C 17: 18,097,155 (GRCm39) Q278R probably benign Het
Fzr1 C T 10: 81,205,228 (GRCm39) W256* probably null Het
Gabrb1 T C 5: 72,266,125 (GRCm39) S261P probably damaging Het
Galr2 G T 11: 116,172,474 (GRCm39) A55S probably benign Het
Gbp2 A T 3: 142,343,227 (GRCm39) K581N probably benign Het
Gria1 A T 11: 57,076,664 (GRCm39) Y89F probably damaging Het
Ibsp T A 5: 104,450,170 (GRCm39) I26N possibly damaging Het
Igf1r T C 7: 67,857,211 (GRCm39) F1058L probably damaging Het
Ighv1-16 A C 12: 114,629,680 (GRCm39) C36G probably benign Het
Igll1 T C 16: 16,678,783 (GRCm39) T176A probably benign Het
Ilkap T C 1: 91,313,067 (GRCm39) T143A probably benign Het
Kdm3b A T 18: 34,926,168 (GRCm39) K103* probably null Het
Mphosph9 A G 5: 124,436,853 (GRCm39) I497T possibly damaging Het
Mrgpra3 G A 7: 47,239,908 (GRCm39) T6I possibly damaging Het
Mrpl38 T C 11: 116,023,384 (GRCm39) probably null Het
Myo3a A T 2: 22,434,457 (GRCm39) E813V possibly damaging Het
Myo7b T C 18: 32,095,405 (GRCm39) K1851R probably damaging Het
Myo7b G T 18: 32,092,519 (GRCm39) Q2093K possibly damaging Het
P3h2 T A 16: 25,803,749 (GRCm39) D339V probably benign Het
Pcdhb6 C A 18: 37,468,300 (GRCm39) P407Q possibly damaging Het
Plch2 C A 4: 155,093,483 (GRCm39) R153L probably damaging Het
Plppr4 G A 3: 117,153,957 (GRCm39) probably benign Het
Ppp1r3a A G 6: 14,717,776 (GRCm39) F1046S probably damaging Het
Pramel41 T G 5: 94,596,366 (GRCm39) W468G probably benign Het
Prkacb A T 3: 146,461,446 (GRCm39) L107M probably benign Het
Ranbp17 A G 11: 33,431,020 (GRCm39) probably null Het
Rasl11b C A 5: 74,357,994 (GRCm39) P88Q probably damaging Het
Rcc2 A G 4: 140,448,460 (GRCm39) E503G possibly damaging Het
Rnf216 T A 5: 143,071,758 (GRCm39) K407N probably damaging Het
Rusf1 A G 7: 127,875,706 (GRCm39) V243A probably benign Het
Scrn3 G A 2: 73,148,673 (GRCm39) M81I possibly damaging Het
Scube2 T C 7: 109,408,387 (GRCm39) T687A probably benign Het
Serpinb10 T A 1: 107,463,728 (GRCm39) F3L probably benign Het
Sgcb C T 5: 73,797,155 (GRCm39) V202I probably damaging Het
Sgce A G 6: 4,689,654 (GRCm39) V429A possibly damaging Het
Sh3rf2 T C 18: 42,286,229 (GRCm39) V574A probably benign Het
Sncaip T C 18: 53,002,016 (GRCm39) L179S probably damaging Het
Sntg2 A T 12: 30,362,571 (GRCm39) D58E probably damaging Het
Taar3 T C 10: 23,825,586 (GRCm39) I44T possibly damaging Het
Tmem87b G A 2: 128,673,391 (GRCm39) V227I probably benign Het
Tnfsf9 T C 17: 57,412,517 (GRCm39) L29P possibly damaging Het
Tnip2 T C 5: 34,654,215 (GRCm39) H391R probably benign Het
Traf5 A G 1: 191,729,768 (GRCm39) Y125H Het
Ttc23 T G 7: 67,316,961 (GRCm39) I77M probably damaging Het
Ube2l3 T C 16: 16,978,036 (GRCm39) N43S probably benign Het
Vars2 A T 17: 35,977,103 (GRCm39) C142* probably null Het
Vmn2r56 C T 7: 12,449,153 (GRCm39) probably null Het
Vmn2r79 A T 7: 86,651,408 (GRCm39) D269V possibly damaging Het
Vmn2r85 A T 10: 130,261,572 (GRCm39) M255K probably benign Het
Wfdc6a T A 2: 164,421,746 (GRCm39) *137C probably null Het
Wipi2 T C 5: 142,652,639 (GRCm39) V417A probably benign Het
Xirp2 G T 2: 67,340,116 (GRCm39) V786L possibly damaging Het
Zdhhc13 G A 7: 48,445,697 (GRCm39) G26S probably benign Het
Zscan25 T A 5: 145,227,422 (GRCm39) V362D probably damaging Het
Other mutations in Vmn2r15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Vmn2r15 APN 5 109,434,602 (GRCm39) missense possibly damaging 0.70
IGL01367:Vmn2r15 APN 5 109,441,075 (GRCm39) missense probably damaging 0.99
IGL01844:Vmn2r15 APN 5 109,434,135 (GRCm39) makesense probably null
IGL02190:Vmn2r15 APN 5 109,441,240 (GRCm39) missense probably damaging 1.00
IGL02754:Vmn2r15 APN 5 109,441,134 (GRCm39) nonsense probably null
IGL02797:Vmn2r15 APN 5 109,445,250 (GRCm39) missense probably benign 0.18
IGL03301:Vmn2r15 APN 5 109,445,221 (GRCm39) critical splice donor site probably null
IGL03407:Vmn2r15 APN 5 109,434,185 (GRCm39) nonsense probably null
BB001:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
BB011:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
PIT4520001:Vmn2r15 UTSW 5 109,434,871 (GRCm39) missense probably damaging 1.00
R0038:Vmn2r15 UTSW 5 109,441,010 (GRCm39) missense possibly damaging 0.46
R0111:Vmn2r15 UTSW 5 109,435,022 (GRCm39) missense possibly damaging 0.56
R0379:Vmn2r15 UTSW 5 109,434,344 (GRCm39) missense probably damaging 1.00
R0427:Vmn2r15 UTSW 5 109,434,953 (GRCm39) missense probably damaging 1.00
R0639:Vmn2r15 UTSW 5 109,440,881 (GRCm39) missense probably benign 0.22
R0964:Vmn2r15 UTSW 5 109,445,401 (GRCm39) missense probably benign 0.34
R1147:Vmn2r15 UTSW 5 109,441,072 (GRCm39) missense probably damaging 1.00
R1147:Vmn2r15 UTSW 5 109,441,072 (GRCm39) missense probably damaging 1.00
R1232:Vmn2r15 UTSW 5 109,441,168 (GRCm39) missense probably benign 0.39
R1241:Vmn2r15 UTSW 5 109,440,770 (GRCm39) missense probably damaging 1.00
R1244:Vmn2r15 UTSW 5 109,441,092 (GRCm39) nonsense probably null
R1394:Vmn2r15 UTSW 5 109,442,014 (GRCm39) missense probably benign 0.44
R1395:Vmn2r15 UTSW 5 109,442,014 (GRCm39) missense probably benign 0.44
R1423:Vmn2r15 UTSW 5 109,441,093 (GRCm39) missense probably damaging 1.00
R1439:Vmn2r15 UTSW 5 109,441,953 (GRCm39) missense probably damaging 1.00
R1513:Vmn2r15 UTSW 5 109,441,195 (GRCm39) missense probably damaging 1.00
R1777:Vmn2r15 UTSW 5 109,442,136 (GRCm39) missense possibly damaging 0.79
R1844:Vmn2r15 UTSW 5 109,434,860 (GRCm39) nonsense probably null
R2072:Vmn2r15 UTSW 5 109,434,619 (GRCm39) missense possibly damaging 0.65
R2074:Vmn2r15 UTSW 5 109,434,619 (GRCm39) missense possibly damaging 0.65
R2122:Vmn2r15 UTSW 5 109,434,322 (GRCm39) missense probably damaging 1.00
R2208:Vmn2r15 UTSW 5 109,445,309 (GRCm39) missense possibly damaging 0.64
R2268:Vmn2r15 UTSW 5 109,441,073 (GRCm39) missense probably benign 0.31
R2831:Vmn2r15 UTSW 5 109,434,458 (GRCm39) missense probably damaging 1.00
R3848:Vmn2r15 UTSW 5 109,445,312 (GRCm39) missense probably benign 0.00
R4058:Vmn2r15 UTSW 5 109,441,312 (GRCm39) missense probably damaging 0.99
R4615:Vmn2r15 UTSW 5 109,441,348 (GRCm39) missense possibly damaging 0.91
R4663:Vmn2r15 UTSW 5 109,441,940 (GRCm39) missense probably benign
R4681:Vmn2r15 UTSW 5 109,434,488 (GRCm39) missense probably damaging 0.97
R4751:Vmn2r15 UTSW 5 109,434,620 (GRCm39) missense probably benign 0.01
R5095:Vmn2r15 UTSW 5 109,436,317 (GRCm39) critical splice acceptor site probably null
R5300:Vmn2r15 UTSW 5 109,441,974 (GRCm39) missense probably damaging 0.99
R5309:Vmn2r15 UTSW 5 109,440,956 (GRCm39) missense probably damaging 0.99
R5335:Vmn2r15 UTSW 5 109,434,673 (GRCm39) missense probably damaging 0.99
R5421:Vmn2r15 UTSW 5 109,434,401 (GRCm39) missense probably damaging 1.00
R5805:Vmn2r15 UTSW 5 109,434,806 (GRCm39) missense possibly damaging 0.88
R6280:Vmn2r15 UTSW 5 109,441,291 (GRCm39) missense possibly damaging 0.65
R6324:Vmn2r15 UTSW 5 109,434,137 (GRCm39) makesense probably null
R6383:Vmn2r15 UTSW 5 109,441,092 (GRCm39) nonsense probably null
R6772:Vmn2r15 UTSW 5 109,434,238 (GRCm39) missense probably damaging 0.99
R6991:Vmn2r15 UTSW 5 109,441,180 (GRCm39) missense probably damaging 1.00
R7194:Vmn2r15 UTSW 5 109,440,649 (GRCm39) missense probably damaging 1.00
R7365:Vmn2r15 UTSW 5 109,445,388 (GRCm39) missense probably benign 0.15
R7365:Vmn2r15 UTSW 5 109,441,105 (GRCm39) missense probably benign 0.19
R7423:Vmn2r15 UTSW 5 109,445,394 (GRCm39) missense probably benign 0.00
R7552:Vmn2r15 UTSW 5 109,440,774 (GRCm39) nonsense probably null
R7619:Vmn2r15 UTSW 5 109,436,190 (GRCm39) critical splice donor site probably null
R7892:Vmn2r15 UTSW 5 109,434,217 (GRCm39) missense probably damaging 1.00
R7924:Vmn2r15 UTSW 5 109,434,254 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r15 UTSW 5 109,440,956 (GRCm39) missense probably damaging 0.99
R8099:Vmn2r15 UTSW 5 109,441,185 (GRCm39) missense possibly damaging 0.58
R8189:Vmn2r15 UTSW 5 109,434,713 (GRCm39) missense probably benign 0.02
R8275:Vmn2r15 UTSW 5 109,434,150 (GRCm39) missense probably benign 0.08
R8277:Vmn2r15 UTSW 5 109,441,310 (GRCm39) missense probably damaging 1.00
R8277:Vmn2r15 UTSW 5 109,440,970 (GRCm39) missense probably benign 0.00
R8465:Vmn2r15 UTSW 5 109,445,302 (GRCm39) missense probably damaging 1.00
R8679:Vmn2r15 UTSW 5 109,434,779 (GRCm39) missense probably benign 0.31
R8682:Vmn2r15 UTSW 5 109,441,938 (GRCm39) missense probably damaging 0.98
R8809:Vmn2r15 UTSW 5 109,434,874 (GRCm39) missense probably benign 0.22
R9016:Vmn2r15 UTSW 5 109,442,109 (GRCm39) missense probably benign 0.01
R9372:Vmn2r15 UTSW 5 109,441,953 (GRCm39) missense possibly damaging 0.60
R9596:Vmn2r15 UTSW 5 109,440,791 (GRCm39) missense probably benign 0.01
R9619:Vmn2r15 UTSW 5 109,440,622 (GRCm39) missense possibly damaging 0.58
R9685:Vmn2r15 UTSW 5 109,440,598 (GRCm39) missense probably benign 0.05
R9716:Vmn2r15 UTSW 5 109,445,224 (GRCm39) missense possibly damaging 0.88
R9772:Vmn2r15 UTSW 5 109,434,923 (GRCm39) missense probably damaging 1.00
X0065:Vmn2r15 UTSW 5 109,441,174 (GRCm39) missense probably damaging 1.00
Z1187:Vmn2r15 UTSW 5 109,434,529 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGGTTATTGGCCTTCACAATAG -3'
(R):5'- CCCTATGATAGTGTTATCACAAAGC -3'

Sequencing Primer
(F):5'- GGCCTTCACAATAGGTGTATCCTTG -3'
(R):5'- GAAATCTTGAGTCAGTGGTTTCTAC -3'
Posted On 2019-06-07