|Institutional Source||Beutler Lab|
|Gene Name||taste receptor, type 2, member 108|
|Synonyms||mGR08, T2R108, T2r8, mt2r8, T2R8|
|Is this an essential gene?||Probably non essential (E-score: 0.073)|
|Stock #||PIT4418001 (G1)|
|Chromosomal Location||40493529-40494541 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 40493680 bp|
|Amino Acid Change||Isoleucine to Lysine at position 30 (I30K)|
|Ref Sequence||ENSEMBL: ENSMUSP00000044089 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000038750] [ENSMUST00000064932]|
|Predicted Effect||probably damaging
AA Change: I30K
PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
AA Change: I30K
|Predicted Effect||probably benign
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tas2r108||
(F):5'- GCTGCCTCTTAGACCAGAAATG -3'
(R):5'- TTTGCATCCAGAAACTTCCAAC -3'
(F):5'- CTCTTAGACCAGAAATGGTGTTTGCC -3'
(R):5'- GCATCCAGAAACTTCCAACACAATAG -3'