Incidental Mutation 'PIT4468001:Vmn2r25'
ID 555638
Institutional Source Beutler Lab
Gene Symbol Vmn2r25
Ensembl Gene ENSMUSG00000094672
Gene Name vomeronasal 2, receptor 25
Synonyms EG545874
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # PIT4468001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 123799773-123830149 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 123816557 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 341 (D341E)
Ref Sequence ENSEMBL: ENSMUSP00000124342 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162046]
AlphaFold W4VSP2
Predicted Effect probably benign
Transcript: ENSMUST00000162046
AA Change: D341E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000124342
Gene: ENSMUSG00000094672
AA Change: D341E

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 82 473 6e-31 PFAM
Pfam:NCD3G 519 572 5.8e-25 PFAM
Pfam:7tm_3 603 840 4.8e-55 PFAM
Coding Region Coverage
  • 1x: 93.0%
  • 3x: 90.7%
  • 10x: 85.2%
  • 20x: 72.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610042L04Rik C T 14: 4,348,940 (GRCm38) L34F probably damaging Het
Alms1 T C 6: 85,601,701 (GRCm39) probably null Het
Arhgap15 C A 2: 44,133,143 (GRCm39) Q350K probably damaging Het
Bbs1 T A 19: 4,956,190 (GRCm39) H35L probably benign Het
Cep85 T C 4: 133,876,008 (GRCm39) N468S probably damaging Het
Chd8 T C 14: 52,455,338 (GRCm39) I1050V possibly damaging Het
Chd8 A C 14: 52,445,453 (GRCm39) D1709E probably benign Het
Clec9a G A 6: 129,396,597 (GRCm39) probably null Het
Cyp2c70 T A 19: 40,153,806 (GRCm39) D261V probably damaging Het
Deup1 T C 9: 15,475,301 (GRCm39) N420D possibly damaging Het
Dpys T A 15: 39,720,601 (GRCm39) D53V probably damaging Het
Edem1 A G 6: 108,821,828 (GRCm39) E295G probably damaging Het
Farp2 G T 1: 93,456,499 (GRCm39) E61* probably null Het
Fat3 T G 9: 15,907,647 (GRCm39) D2785A probably benign Het
Fbxo30 T A 10: 11,166,700 (GRCm39) M474K possibly damaging Het
Gm13090 C A 4: 151,175,539 (GRCm39) P93Q unknown Het
Gm21976 A T 13: 98,443,535 (GRCm39) R229* probably null Het
Gpr108 A T 17: 57,554,563 (GRCm39) L25Q probably null Het
Hdac9 C A 12: 34,145,933 (GRCm39) V920F unknown Het
Ighv13-2 T C 12: 114,321,593 (GRCm39) S49G probably benign Het
Krt6a T C 15: 101,602,352 (GRCm39) Y111C probably damaging Het
Mib1 T C 18: 10,798,463 (GRCm39) S775P possibly damaging Het
Mki67 A G 7: 135,300,876 (GRCm39) I1386T probably benign Het
Mroh2b A G 15: 4,942,294 (GRCm39) E352G probably damaging Het
Nfya A G 17: 48,702,805 (GRCm39) M61T unknown Het
Ntn4 A G 10: 93,480,587 (GRCm39) T104A probably damaging Het
Numb G A 12: 83,854,921 (GRCm39) T135I probably damaging Het
Or4b12 C A 2: 90,096,564 (GRCm39) C70F probably benign Het
Or52ab4 A C 7: 102,987,807 (GRCm39) E182A probably damaging Het
Or5m5 A T 2: 85,814,792 (GRCm39) T203S probably benign Het
Parpbp A C 10: 87,979,935 (GRCm39) L7R probably benign Het
Pcdhb8 T C 18: 37,489,686 (GRCm39) Y455H probably damaging Het
Pcdhga10 T A 18: 37,880,936 (GRCm39) D232E probably damaging Het
Pcdhga9 T A 18: 37,872,527 (GRCm39) C785* probably null Het
Pkd1l3 A G 8: 110,391,131 (GRCm39) Y1913C possibly damaging Het
Pld4 T G 12: 112,734,256 (GRCm39) L374R probably damaging Het
Ppp1r13b A T 12: 111,805,136 (GRCm39) I350N probably benign Het
Rc3h2 C A 2: 37,289,651 (GRCm39) G387V probably damaging Het
Rfwd3 T C 8: 112,009,352 (GRCm39) H408R probably benign Het
Rpl3l A G 17: 24,954,457 (GRCm39) T173A probably benign Het
Sdad1 T C 5: 92,439,777 (GRCm39) D416G probably damaging Het
Srp72 C A 5: 77,142,053 (GRCm39) T430K probably benign Het
Steap1 C A 5: 5,786,642 (GRCm39) G265V probably damaging Het
Sulf2 A T 2: 165,922,720 (GRCm39) I670N probably benign Het
Tcf7l2 A T 19: 55,730,820 (GRCm39) D16V probably damaging Het
Tmem100 T A 11: 89,926,187 (GRCm39) S5T probably benign Het
Tnc C A 4: 63,882,904 (GRCm39) D1906Y probably damaging Het
Trak1 T C 9: 121,282,398 (GRCm39) S436P probably benign Het
Ttyh1 T C 7: 4,122,771 (GRCm39) Y40H possibly damaging Het
Ubxn8 T A 8: 34,111,569 (GRCm39) S275C probably benign Het
Umodl1 A G 17: 31,178,252 (GRCm39) Y76C probably damaging Het
Upk3b C T 5: 136,071,861 (GRCm39) T222M probably benign Het
Usp42 T A 5: 143,700,399 (GRCm39) K1208M probably damaging Het
Vmn2r83 T G 10: 79,313,884 (GRCm39) L164R probably damaging Het
Vwa8 G T 14: 79,420,501 (GRCm39) R1734L probably damaging Het
Zfand2b G T 1: 75,146,476 (GRCm39) R117L probably benign Het
Other mutations in Vmn2r25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Vmn2r25 APN 6 123,830,130 (GRCm39) missense probably benign 0.25
IGL01781:Vmn2r25 APN 6 123,816,324 (GRCm39) missense possibly damaging 0.48
IGL01843:Vmn2r25 APN 6 123,829,962 (GRCm39) missense possibly damaging 0.67
IGL02023:Vmn2r25 APN 6 123,816,388 (GRCm39) missense probably damaging 0.96
IGL02502:Vmn2r25 APN 6 123,816,392 (GRCm39) missense probably damaging 0.96
IGL02709:Vmn2r25 APN 6 123,816,723 (GRCm39) missense possibly damaging 0.50
IGL03053:Vmn2r25 APN 6 123,800,077 (GRCm39) missense probably damaging 1.00
PIT4812001:Vmn2r25 UTSW 6 123,800,447 (GRCm39) missense probably damaging 1.00
R0054:Vmn2r25 UTSW 6 123,829,984 (GRCm39) missense probably benign 0.00
R0312:Vmn2r25 UTSW 6 123,805,539 (GRCm39) splice site probably benign
R0366:Vmn2r25 UTSW 6 123,800,581 (GRCm39) nonsense probably null
R0390:Vmn2r25 UTSW 6 123,800,140 (GRCm39) missense probably damaging 1.00
R0466:Vmn2r25 UTSW 6 123,829,008 (GRCm39) missense probably benign 0.16
R0541:Vmn2r25 UTSW 6 123,816,786 (GRCm39) missense probably damaging 0.97
R0612:Vmn2r25 UTSW 6 123,816,481 (GRCm39) missense probably damaging 1.00
R0865:Vmn2r25 UTSW 6 123,829,976 (GRCm39) missense probably benign 0.09
R1219:Vmn2r25 UTSW 6 123,816,282 (GRCm39) missense probably benign 0.00
R1240:Vmn2r25 UTSW 6 123,828,864 (GRCm39) missense probably damaging 0.98
R1701:Vmn2r25 UTSW 6 123,828,754 (GRCm39) splice site probably null
R1780:Vmn2r25 UTSW 6 123,805,424 (GRCm39) missense probably damaging 1.00
R1809:Vmn2r25 UTSW 6 123,802,337 (GRCm39) missense probably benign 0.00
R1833:Vmn2r25 UTSW 6 123,816,643 (GRCm39) missense probably benign 0.01
R1964:Vmn2r25 UTSW 6 123,800,254 (GRCm39) missense possibly damaging 0.94
R2154:Vmn2r25 UTSW 6 123,816,805 (GRCm39) missense probably benign 0.01
R2164:Vmn2r25 UTSW 6 123,816,518 (GRCm39) missense possibly damaging 0.96
R3799:Vmn2r25 UTSW 6 123,830,143 (GRCm39) missense probably benign 0.12
R3836:Vmn2r25 UTSW 6 123,830,044 (GRCm39) missense probably damaging 1.00
R3946:Vmn2r25 UTSW 6 123,817,057 (GRCm39) missense probably damaging 0.97
R4282:Vmn2r25 UTSW 6 123,800,606 (GRCm39) missense probably damaging 1.00
R4367:Vmn2r25 UTSW 6 123,805,496 (GRCm39) missense probably damaging 1.00
R4438:Vmn2r25 UTSW 6 123,816,756 (GRCm39) missense probably benign 0.03
R4488:Vmn2r25 UTSW 6 123,799,819 (GRCm39) missense probably damaging 1.00
R4580:Vmn2r25 UTSW 6 123,799,982 (GRCm39) missense possibly damaging 0.46
R4631:Vmn2r25 UTSW 6 123,829,962 (GRCm39) missense possibly damaging 0.94
R4765:Vmn2r25 UTSW 6 123,800,182 (GRCm39) missense probably damaging 1.00
R4908:Vmn2r25 UTSW 6 123,805,406 (GRCm39) missense probably benign
R5207:Vmn2r25 UTSW 6 123,817,062 (GRCm39) missense probably damaging 1.00
R5254:Vmn2r25 UTSW 6 123,802,277 (GRCm39) missense probably damaging 1.00
R5444:Vmn2r25 UTSW 6 123,805,451 (GRCm39) missense probably benign 0.00
R5586:Vmn2r25 UTSW 6 123,802,255 (GRCm39) missense probably damaging 1.00
R5607:Vmn2r25 UTSW 6 123,805,318 (GRCm39) missense possibly damaging 0.49
R5985:Vmn2r25 UTSW 6 123,800,587 (GRCm39) missense probably benign
R6046:Vmn2r25 UTSW 6 123,799,876 (GRCm39) missense probably damaging 1.00
R6057:Vmn2r25 UTSW 6 123,799,900 (GRCm39) missense possibly damaging 0.69
R6569:Vmn2r25 UTSW 6 123,828,941 (GRCm39) missense probably benign 0.01
R6826:Vmn2r25 UTSW 6 123,800,071 (GRCm39) missense probably damaging 1.00
R7054:Vmn2r25 UTSW 6 123,800,569 (GRCm39) missense probably damaging 1.00
R7120:Vmn2r25 UTSW 6 123,805,394 (GRCm39) missense possibly damaging 0.51
R7177:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7287:Vmn2r25 UTSW 6 123,829,040 (GRCm39) missense possibly damaging 0.49
R7397:Vmn2r25 UTSW 6 123,800,498 (GRCm39) missense probably damaging 0.96
R7486:Vmn2r25 UTSW 6 123,800,101 (GRCm39) missense probably damaging 1.00
R7699:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7700:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7759:Vmn2r25 UTSW 6 123,800,339 (GRCm39) missense probably damaging 0.99
R7802:Vmn2r25 UTSW 6 123,828,791 (GRCm39) missense possibly damaging 0.88
R7850:Vmn2r25 UTSW 6 123,805,431 (GRCm39) missense probably damaging 1.00
R8064:Vmn2r25 UTSW 6 123,800,581 (GRCm39) nonsense probably null
R8170:Vmn2r25 UTSW 6 123,829,976 (GRCm39) missense probably benign 0.09
R8340:Vmn2r25 UTSW 6 123,829,972 (GRCm39) missense probably benign 0.01
R8346:Vmn2r25 UTSW 6 123,802,350 (GRCm39) missense probably benign 0.00
R8395:Vmn2r25 UTSW 6 123,799,982 (GRCm39) missense possibly damaging 0.81
R8889:Vmn2r25 UTSW 6 123,800,569 (GRCm39) missense probably damaging 1.00
R9094:Vmn2r25 UTSW 6 123,805,391 (GRCm39) missense probably benign 0.44
R9204:Vmn2r25 UTSW 6 123,830,092 (GRCm39) missense probably benign 0.00
R9253:Vmn2r25 UTSW 6 123,816,960 (GRCm39) missense probably damaging 0.98
R9392:Vmn2r25 UTSW 6 123,816,937 (GRCm39) missense probably benign
R9520:Vmn2r25 UTSW 6 123,830,066 (GRCm39) nonsense probably null
R9525:Vmn2r25 UTSW 6 123,800,164 (GRCm39) missense probably damaging 1.00
R9622:Vmn2r25 UTSW 6 123,816,579 (GRCm39) missense probably damaging 0.99
X0020:Vmn2r25 UTSW 6 123,816,359 (GRCm39) missense possibly damaging 0.95
Z1176:Vmn2r25 UTSW 6 123,799,856 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACACAGCAGCATGGACTTTG -3'
(R):5'- TTTGGAGACACACATTCTCTTCTG -3'

Sequencing Primer
(F):5'- CAGCAGCATGGACTTTGTAGCTC -3'
(R):5'- AGACACACATTCTCTTCTGCGAATTG -3'
Posted On 2019-06-07