Incidental Mutation 'PIT4468001:Vmn2r83'
ID 555650
Institutional Source Beutler Lab
Gene Symbol Vmn2r83
Ensembl Gene ENSMUSG00000091381
Gene Name vomeronasal 2, receptor 83
Synonyms EG625029
Accession Numbers
Essential gene? Probably non essential (E-score: 0.141) question?
Stock # PIT4468001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 79304792-79327988 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 79313884 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 164 (L164R)
Ref Sequence ENSEMBL: ENSMUSP00000131426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167976]
AlphaFold E9Q0G7
Predicted Effect probably damaging
Transcript: ENSMUST00000167976
AA Change: L164R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131426
Gene: ENSMUSG00000091381
AA Change: L164R

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 79 473 1.5e-33 PFAM
Pfam:NCD3G 516 569 6.2e-22 PFAM
Pfam:7tm_3 602 837 8.1e-52 PFAM
Coding Region Coverage
  • 1x: 93.0%
  • 3x: 90.7%
  • 10x: 85.2%
  • 20x: 72.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610042L04Rik C T 14: 4,348,940 (GRCm38) L34F probably damaging Het
Alms1 T C 6: 85,601,701 (GRCm39) probably null Het
Arhgap15 C A 2: 44,133,143 (GRCm39) Q350K probably damaging Het
Bbs1 T A 19: 4,956,190 (GRCm39) H35L probably benign Het
Cep85 T C 4: 133,876,008 (GRCm39) N468S probably damaging Het
Chd8 T C 14: 52,455,338 (GRCm39) I1050V possibly damaging Het
Chd8 A C 14: 52,445,453 (GRCm39) D1709E probably benign Het
Clec9a G A 6: 129,396,597 (GRCm39) probably null Het
Cyp2c70 T A 19: 40,153,806 (GRCm39) D261V probably damaging Het
Deup1 T C 9: 15,475,301 (GRCm39) N420D possibly damaging Het
Dpys T A 15: 39,720,601 (GRCm39) D53V probably damaging Het
Edem1 A G 6: 108,821,828 (GRCm39) E295G probably damaging Het
Farp2 G T 1: 93,456,499 (GRCm39) E61* probably null Het
Fat3 T G 9: 15,907,647 (GRCm39) D2785A probably benign Het
Fbxo30 T A 10: 11,166,700 (GRCm39) M474K possibly damaging Het
Gm13090 C A 4: 151,175,539 (GRCm39) P93Q unknown Het
Gm21976 A T 13: 98,443,535 (GRCm39) R229* probably null Het
Gpr108 A T 17: 57,554,563 (GRCm39) L25Q probably null Het
Hdac9 C A 12: 34,145,933 (GRCm39) V920F unknown Het
Ighv13-2 T C 12: 114,321,593 (GRCm39) S49G probably benign Het
Krt6a T C 15: 101,602,352 (GRCm39) Y111C probably damaging Het
Mib1 T C 18: 10,798,463 (GRCm39) S775P possibly damaging Het
Mki67 A G 7: 135,300,876 (GRCm39) I1386T probably benign Het
Mroh2b A G 15: 4,942,294 (GRCm39) E352G probably damaging Het
Nfya A G 17: 48,702,805 (GRCm39) M61T unknown Het
Ntn4 A G 10: 93,480,587 (GRCm39) T104A probably damaging Het
Numb G A 12: 83,854,921 (GRCm39) T135I probably damaging Het
Or4b12 C A 2: 90,096,564 (GRCm39) C70F probably benign Het
Or52ab4 A C 7: 102,987,807 (GRCm39) E182A probably damaging Het
Or5m5 A T 2: 85,814,792 (GRCm39) T203S probably benign Het
Parpbp A C 10: 87,979,935 (GRCm39) L7R probably benign Het
Pcdhb8 T C 18: 37,489,686 (GRCm39) Y455H probably damaging Het
Pcdhga10 T A 18: 37,880,936 (GRCm39) D232E probably damaging Het
Pcdhga9 T A 18: 37,872,527 (GRCm39) C785* probably null Het
Pkd1l3 A G 8: 110,391,131 (GRCm39) Y1913C possibly damaging Het
Pld4 T G 12: 112,734,256 (GRCm39) L374R probably damaging Het
Ppp1r13b A T 12: 111,805,136 (GRCm39) I350N probably benign Het
Rc3h2 C A 2: 37,289,651 (GRCm39) G387V probably damaging Het
Rfwd3 T C 8: 112,009,352 (GRCm39) H408R probably benign Het
Rpl3l A G 17: 24,954,457 (GRCm39) T173A probably benign Het
Sdad1 T C 5: 92,439,777 (GRCm39) D416G probably damaging Het
Srp72 C A 5: 77,142,053 (GRCm39) T430K probably benign Het
Steap1 C A 5: 5,786,642 (GRCm39) G265V probably damaging Het
Sulf2 A T 2: 165,922,720 (GRCm39) I670N probably benign Het
Tcf7l2 A T 19: 55,730,820 (GRCm39) D16V probably damaging Het
Tmem100 T A 11: 89,926,187 (GRCm39) S5T probably benign Het
Tnc C A 4: 63,882,904 (GRCm39) D1906Y probably damaging Het
Trak1 T C 9: 121,282,398 (GRCm39) S436P probably benign Het
Ttyh1 T C 7: 4,122,771 (GRCm39) Y40H possibly damaging Het
Ubxn8 T A 8: 34,111,569 (GRCm39) S275C probably benign Het
Umodl1 A G 17: 31,178,252 (GRCm39) Y76C probably damaging Het
Upk3b C T 5: 136,071,861 (GRCm39) T222M probably benign Het
Usp42 T A 5: 143,700,399 (GRCm39) K1208M probably damaging Het
Vmn2r25 A T 6: 123,816,557 (GRCm39) D341E probably benign Het
Vwa8 G T 14: 79,420,501 (GRCm39) R1734L probably damaging Het
Zfand2b G T 1: 75,146,476 (GRCm39) R117L probably benign Het
Other mutations in Vmn2r83
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Vmn2r83 APN 10 79,314,805 (GRCm39) missense probably damaging 1.00
IGL01096:Vmn2r83 APN 10 79,313,662 (GRCm39) missense probably damaging 1.00
IGL01542:Vmn2r83 APN 10 79,314,846 (GRCm39) missense probably benign 0.30
IGL01803:Vmn2r83 APN 10 79,304,894 (GRCm39) missense probably benign 0.01
IGL02110:Vmn2r83 APN 10 79,327,534 (GRCm39) missense possibly damaging 0.82
IGL02347:Vmn2r83 APN 10 79,316,067 (GRCm39) missense possibly damaging 0.75
IGL02417:Vmn2r83 APN 10 79,314,881 (GRCm39) missense probably benign 0.00
IGL02544:Vmn2r83 APN 10 79,317,293 (GRCm39) splice site probably benign
IGL02683:Vmn2r83 APN 10 79,327,115 (GRCm39) missense probably benign
IGL02976:Vmn2r83 APN 10 79,304,832 (GRCm39) missense probably benign 0.00
PIT4378001:Vmn2r83 UTSW 10 79,304,849 (GRCm39) missense probably benign 0.00
R0092:Vmn2r83 UTSW 10 79,327,798 (GRCm39) missense probably damaging 1.00
R1391:Vmn2r83 UTSW 10 79,314,931 (GRCm39) missense probably damaging 0.96
R1539:Vmn2r83 UTSW 10 79,327,759 (GRCm39) missense probably damaging 1.00
R1575:Vmn2r83 UTSW 10 79,314,956 (GRCm39) missense probably damaging 0.98
R2033:Vmn2r83 UTSW 10 79,327,653 (GRCm39) missense probably benign 0.03
R3916:Vmn2r83 UTSW 10 79,314,744 (GRCm39) missense probably benign 0.01
R3967:Vmn2r83 UTSW 10 79,327,154 (GRCm39) missense probably benign 0.00
R4840:Vmn2r83 UTSW 10 79,313,682 (GRCm39) missense possibly damaging 0.73
R5063:Vmn2r83 UTSW 10 79,314,921 (GRCm39) missense probably benign 0.04
R5630:Vmn2r83 UTSW 10 79,327,785 (GRCm39) missense possibly damaging 0.94
R5707:Vmn2r83 UTSW 10 79,327,183 (GRCm39) missense possibly damaging 0.53
R5980:Vmn2r83 UTSW 10 79,314,626 (GRCm39) missense probably benign 0.04
R6294:Vmn2r83 UTSW 10 79,313,688 (GRCm39) missense probably damaging 0.99
R6302:Vmn2r83 UTSW 10 79,304,837 (GRCm39) missense possibly damaging 0.95
R6769:Vmn2r83 UTSW 10 79,313,856 (GRCm39) missense probably damaging 1.00
R6986:Vmn2r83 UTSW 10 79,316,093 (GRCm39) missense probably benign
R7221:Vmn2r83 UTSW 10 79,316,001 (GRCm39) missense probably benign 0.02
R7376:Vmn2r83 UTSW 10 79,314,790 (GRCm39) missense probably benign 0.00
R7431:Vmn2r83 UTSW 10 79,327,306 (GRCm39) missense probably damaging 0.99
R7501:Vmn2r83 UTSW 10 79,327,771 (GRCm39) missense probably damaging 0.98
R7526:Vmn2r83 UTSW 10 79,327,392 (GRCm39) missense probably damaging 1.00
R7663:Vmn2r83 UTSW 10 79,314,956 (GRCm39) missense probably damaging 0.98
R7881:Vmn2r83 UTSW 10 79,314,261 (GRCm39) missense probably benign 0.01
R7939:Vmn2r83 UTSW 10 79,314,651 (GRCm39) missense probably damaging 1.00
R8314:Vmn2r83 UTSW 10 79,317,313 (GRCm39) missense possibly damaging 0.76
R8364:Vmn2r83 UTSW 10 79,316,037 (GRCm39) missense probably benign 0.12
R8802:Vmn2r83 UTSW 10 79,314,261 (GRCm39) missense probably benign 0.01
R8947:Vmn2r83 UTSW 10 79,304,873 (GRCm39) missense probably benign 0.00
R8969:Vmn2r83 UTSW 10 79,313,853 (GRCm39) missense probably benign 0.15
R8983:Vmn2r83 UTSW 10 79,327,360 (GRCm39) missense probably damaging 1.00
R9018:Vmn2r83 UTSW 10 79,316,020 (GRCm39) missense probably damaging 1.00
R9082:Vmn2r83 UTSW 10 79,304,894 (GRCm39) missense probably benign 0.00
R9390:Vmn2r83 UTSW 10 79,317,322 (GRCm39) nonsense probably null
X0026:Vmn2r83 UTSW 10 79,314,486 (GRCm39) missense probably benign
X0026:Vmn2r83 UTSW 10 79,304,849 (GRCm39) missense probably benign 0.00
Z1176:Vmn2r83 UTSW 10 79,314,756 (GRCm39) missense possibly damaging 0.74
Predicted Primers PCR Primer
(F):5'- ACCAAACACTTCTCTGGGTCTTG -3'
(R):5'- TGATCATGATCAAAAGGCCCAAAAG -3'

Sequencing Primer
(F):5'- CTGGGTCTTGAGATTTATAATGTGCC -3'
(R):5'- AGTGATAAAGTTGAAACTCTTCTCC -3'
Posted On 2019-06-07