Incidental Mutation 'PIT4466001:Ccdc27'
ID 555772
Institutional Source Beutler Lab
Gene Symbol Ccdc27
Ensembl Gene ENSMUSG00000039492
Gene Name coiled-coil domain containing 27
Synonyms LOC381580
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # PIT4466001 (G1)
Quality Score 174.009
Status Not validated
Chromosome 4
Chromosomal Location 154111096-154127134 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 154126184 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 102 (M102V)
Ref Sequence ENSEMBL: ENSMUSP00000039642 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047207]
AlphaFold Q3V036
Predicted Effect unknown
Transcript: ENSMUST00000047207
AA Change: M102V
SMART Domains Protein: ENSMUSP00000039642
Gene: ENSMUSG00000039492
AA Change: M102V

DomainStartEndE-ValueType
low complexity region 39 53 N/A INTRINSIC
coiled coil region 203 243 N/A INTRINSIC
low complexity region 305 320 N/A INTRINSIC
low complexity region 329 358 N/A INTRINSIC
coiled coil region 390 575 N/A INTRINSIC
Coding Region Coverage
  • 1x: 93.5%
  • 3x: 90.9%
  • 10x: 85.1%
  • 20x: 72.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt C A 9: 99,502,613 (GRCm39) P258T probably damaging Het
Adamts1 C A 16: 85,593,579 (GRCm39) G719* probably null Het
Ano5 G T 7: 51,194,599 (GRCm39) D111Y probably damaging Het
Arvcf T C 16: 18,221,699 (GRCm39) V714A possibly damaging Het
AU021092 T A 16: 5,038,253 (GRCm39) S85C probably damaging Het
Capn5 T C 7: 97,773,195 (GRCm39) D603G probably benign Het
Cbr1 T A 16: 93,406,692 (GRCm39) V136E probably damaging Het
Ccr1 T C 9: 123,763,765 (GRCm39) Y255C probably damaging Het
Cdr1 AAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCC AAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCC X: 60,228,130 (GRCm39) probably benign Het
Cep112 A G 11: 108,410,722 (GRCm39) T553A probably benign Het
Chd7 C T 4: 8,753,101 (GRCm39) L533F unknown Het
Cntnap1 T C 11: 101,068,131 (GRCm39) F48L probably benign Het
Cyb5r3 T C 15: 83,046,064 (GRCm39) D84G probably damaging Het
Ddx47 T C 6: 134,992,803 (GRCm39) I154T probably benign Het
Dennd2b G A 7: 109,130,337 (GRCm39) A888V probably damaging Het
Dnah6 A G 6: 73,185,624 (GRCm39) L99P probably benign Het
Dzank1 A G 2: 144,325,293 (GRCm39) I558T probably benign Het
Fbn1 T C 2: 125,148,421 (GRCm39) D2609G possibly damaging Het
Fhl5 C A 4: 25,211,194 (GRCm39) C166F probably damaging Het
Fndc1 A G 17: 7,969,206 (GRCm39) L1553P probably damaging Het
Frem1 G A 4: 82,890,374 (GRCm39) T1035I probably benign Het
Gm3099 A G 14: 15,346,517 (GRCm39) M128V probably benign Het
Gpaa1 C T 15: 76,218,940 (GRCm39) T594I probably benign Het
Hck C T 2: 152,966,191 (GRCm39) T55M probably damaging Het
Hectd4 T C 5: 121,471,123 (GRCm39) probably null Het
Ica1l C T 1: 60,054,995 (GRCm39) probably null Het
Ilf3 T C 9: 21,314,662 (GRCm39) Y765H unknown Het
Mast4 G A 13: 102,941,226 (GRCm39) T277M probably damaging Het
Mfsd6 T C 1: 52,748,056 (GRCm39) T270A probably benign Het
Mib1 G A 18: 10,775,541 (GRCm39) D498N probably benign Het
Naaladl1 A T 19: 6,164,663 (GRCm39) T576S possibly damaging Het
Ncoa6 A T 2: 155,247,577 (GRCm39) I1909N probably benign Het
Negr1 A G 3: 156,565,235 (GRCm39) D107G probably benign Het
Nlrc4 A G 17: 74,734,114 (GRCm39) M933T probably benign Het
Nmnat3 T G 9: 98,292,306 (GRCm39) F184V probably benign Het
Or4b12 A T 2: 90,096,639 (GRCm39) V45E probably damaging Het
Or5p81 T C 7: 108,266,743 (GRCm39) V40A possibly damaging Het
Or6c76 C T 10: 129,612,142 (GRCm39) R120C probably benign Het
Or7a42 C A 10: 78,791,676 (GRCm39) F212L probably benign Het
Pfkfb4 T C 9: 108,828,222 (GRCm39) Y86H probably benign Het
Pgm5 T G 19: 24,801,693 (GRCm39) Q178H probably damaging Het
Phrf1 C T 7: 140,838,725 (GRCm39) T640M unknown Het
Pramel34 A C 5: 93,784,147 (GRCm39) L439R probably damaging Het
Psg18 T G 7: 18,083,241 (GRCm39) T305P probably benign Het
Skil T A 3: 31,152,381 (GRCm39) V301D probably damaging Het
Slc36a1 C A 11: 55,109,895 (GRCm39) P68T probably damaging Het
Smim6 T C 11: 115,804,371 (GRCm39) F53L probably benign Het
Tpgs2 G A 18: 25,301,652 (GRCm39) T5M possibly damaging Het
Trrap T A 5: 144,765,410 (GRCm39) V2523D probably benign Het
Usp9y A T Y: 1,432,197 (GRCm39) D429E probably damaging Het
Vmn1r125 A G 7: 21,006,818 (GRCm39) T239A probably benign Het
Vmn1r168 T C 7: 23,240,421 (GRCm39) F93L probably damaging Het
Vmn1r88 A G 7: 12,912,403 (GRCm39) N253S possibly damaging Het
Zfp644 C T 5: 106,784,343 (GRCm39) A735T probably damaging Het
Other mutations in Ccdc27
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4472001:Ccdc27 UTSW 4 154,126,184 (GRCm39) missense unknown
R0078:Ccdc27 UTSW 4 154,120,195 (GRCm39) splice site probably benign
R0883:Ccdc27 UTSW 4 154,120,941 (GRCm39) missense unknown
R1389:Ccdc27 UTSW 4 154,126,226 (GRCm39) missense unknown
R1773:Ccdc27 UTSW 4 154,126,222 (GRCm39) missense unknown
R1869:Ccdc27 UTSW 4 154,111,220 (GRCm39) splice site probably null
R2020:Ccdc27 UTSW 4 154,117,770 (GRCm39) missense probably null 0.05
R2070:Ccdc27 UTSW 4 154,126,270 (GRCm39) missense unknown
R2131:Ccdc27 UTSW 4 154,120,763 (GRCm39) small deletion probably benign
R3825:Ccdc27 UTSW 4 154,120,742 (GRCm39) missense unknown
R4183:Ccdc27 UTSW 4 154,120,763 (GRCm39) small deletion probably benign
R4254:Ccdc27 UTSW 4 154,123,976 (GRCm39) missense unknown
R5932:Ccdc27 UTSW 4 154,111,231 (GRCm39) missense probably benign 0.22
R6269:Ccdc27 UTSW 4 154,122,179 (GRCm39) missense unknown
R6324:Ccdc27 UTSW 4 154,120,648 (GRCm39) missense probably benign 0.02
R6761:Ccdc27 UTSW 4 154,122,155 (GRCm39) missense unknown
R7090:Ccdc27 UTSW 4 154,112,523 (GRCm39) missense probably benign 0.03
R7163:Ccdc27 UTSW 4 154,117,282 (GRCm39) missense not run
R7488:Ccdc27 UTSW 4 154,117,424 (GRCm39) missense probably benign 0.22
R7555:Ccdc27 UTSW 4 154,126,274 (GRCm39) missense unknown
R7651:Ccdc27 UTSW 4 154,112,556 (GRCm39) missense probably damaging 1.00
R7826:Ccdc27 UTSW 4 154,123,958 (GRCm39) critical splice donor site probably null
R8250:Ccdc27 UTSW 4 154,126,245 (GRCm39) missense unknown
R8815:Ccdc27 UTSW 4 154,111,205 (GRCm39) missense probably benign 0.02
R8835:Ccdc27 UTSW 4 154,127,023 (GRCm39) missense unknown
R9019:Ccdc27 UTSW 4 154,124,014 (GRCm39) missense unknown
R9224:Ccdc27 UTSW 4 154,122,174 (GRCm39) missense unknown
R9252:Ccdc27 UTSW 4 154,125,507 (GRCm39) missense unknown
R9267:Ccdc27 UTSW 4 154,117,441 (GRCm39) missense probably damaging 1.00
RF016:Ccdc27 UTSW 4 154,120,567 (GRCm39) missense probably benign 0.04
Z1177:Ccdc27 UTSW 4 154,120,928 (GRCm39) missense unknown
Predicted Primers
Posted On 2019-06-07