Incidental Mutation 'R0604:Or4p18'
ID 55581
Institutional Source Beutler Lab
Gene Symbol Or4p18
Ensembl Gene ENSMUSG00000075127
Gene Name olfactory receptor family 4 subfamily P member 18
Synonyms MOR225-2, GA_x6K02T2Q125-49890854-49889931, Olfr1179
MMRRC Submission 038793-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R0604 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88232353-88233276 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88232727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 184 (T184A)
Ref Sequence ENSEMBL: ENSMUSP00000151174 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099825] [ENSMUST00000213157] [ENSMUST00000214040]
AlphaFold A2AUS6
Predicted Effect probably benign
Transcript: ENSMUST00000099825
AA Change: T184A

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000097413
Gene: ENSMUSG00000075127
AA Change: T184A

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.1e-47 PFAM
Pfam:7tm_1 39 285 3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213157
AA Change: T184A

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000214040
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217346
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219086
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap1 T C 11: 69,775,451 (GRCm39) E302G probably benign Het
Acsbg3 T A 17: 57,192,169 (GRCm39) Y577* probably null Het
Adrb2 G A 18: 62,311,586 (GRCm39) T413I possibly damaging Het
Aqr T C 2: 113,961,085 (GRCm39) K725R probably benign Het
Braf A G 6: 39,600,631 (GRCm39) I662T probably damaging Het
Ccdc178 A G 18: 22,200,500 (GRCm39) S435P probably benign Het
Chd9 A G 8: 91,763,170 (GRCm39) M2332V possibly damaging Het
Clgn T C 8: 84,150,823 (GRCm39) V496A probably benign Het
Dnah17 A C 11: 118,012,297 (GRCm39) S193R probably benign Het
Dntt A G 19: 41,041,588 (GRCm39) E424G probably benign Het
Fam149a A G 8: 45,798,045 (GRCm39) L492P probably damaging Het
Fetub T C 16: 22,754,410 (GRCm39) Y126H possibly damaging Het
Fgfr3 A T 5: 33,890,126 (GRCm39) Y96F probably damaging Het
Gm4952 A G 19: 12,602,036 (GRCm39) E148G probably benign Het
Gucy2g T A 19: 55,191,519 (GRCm39) L977F probably benign Het
Il1r1 T C 1: 40,321,406 (GRCm39) V6A probably benign Het
Itsn2 C A 12: 4,708,189 (GRCm39) Q832K probably benign Het
Lats1 T A 10: 7,588,425 (GRCm39) F1014Y probably damaging Het
Mcc G A 18: 44,606,823 (GRCm39) A536V probably damaging Het
Mtrf1 T C 14: 79,653,327 (GRCm39) V334A possibly damaging Het
Or1j21 T A 2: 36,684,119 (GRCm39) Y290* probably null Het
Or2t46 T A 11: 58,472,174 (GRCm39) M168K probably damaging Het
Or2z8 C T 8: 72,812,244 (GRCm39) T240M probably damaging Het
Pard6g A G 18: 80,160,423 (GRCm39) S179G probably damaging Het
Pierce1 C A 2: 28,356,103 (GRCm39) R60L possibly damaging Het
Polr3a G A 14: 24,534,232 (GRCm39) P91L probably damaging Het
Psg27 A T 7: 18,290,997 (GRCm39) V402D probably damaging Het
Rttn A G 18: 88,995,882 (GRCm39) I222V probably damaging Het
Sp9 T A 2: 73,103,982 (GRCm39) S179T probably benign Het
Tbc1d8 T A 1: 39,444,407 (GRCm39) H184L probably damaging Het
Vmn1r69 A G 7: 10,314,581 (GRCm39) V50A probably benign Het
Vmn2r58 A G 7: 41,510,000 (GRCm39) F526L possibly damaging Het
Other mutations in Or4p18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:Or4p18 APN 2 88,232,421 (GRCm39) missense possibly damaging 0.95
IGL02445:Or4p18 APN 2 88,232,456 (GRCm39) missense possibly damaging 0.60
R0127:Or4p18 UTSW 2 88,232,699 (GRCm39) missense probably benign 0.05
R1526:Or4p18 UTSW 2 88,232,777 (GRCm39) missense probably damaging 1.00
R1816:Or4p18 UTSW 2 88,232,943 (GRCm39) missense possibly damaging 0.65
R2041:Or4p18 UTSW 2 88,232,568 (GRCm39) missense probably damaging 1.00
R3694:Or4p18 UTSW 2 88,232,540 (GRCm39) missense possibly damaging 0.80
R4229:Or4p18 UTSW 2 88,233,227 (GRCm39) missense possibly damaging 0.67
R4735:Or4p18 UTSW 2 88,233,267 (GRCm39) missense probably benign 0.02
R4974:Or4p18 UTSW 2 88,232,756 (GRCm39) missense probably damaging 1.00
R5173:Or4p18 UTSW 2 88,233,266 (GRCm39) missense probably benign 0.00
R5909:Or4p18 UTSW 2 88,232,535 (GRCm39) missense probably damaging 0.98
R6931:Or4p18 UTSW 2 88,232,408 (GRCm39) missense probably benign 0.01
R6990:Or4p18 UTSW 2 88,232,639 (GRCm39) missense probably benign 0.13
R7167:Or4p18 UTSW 2 88,232,552 (GRCm39) missense possibly damaging 0.46
R8121:Or4p18 UTSW 2 88,233,040 (GRCm39) missense probably benign
R8140:Or4p18 UTSW 2 88,232,457 (GRCm39) missense possibly damaging 0.74
R8269:Or4p18 UTSW 2 88,232,381 (GRCm39) missense probably damaging 0.98
R8832:Or4p18 UTSW 2 88,233,137 (GRCm39) missense probably damaging 0.98
R9269:Or4p18 UTSW 2 88,232,586 (GRCm39) missense probably benign 0.06
Z1176:Or4p18 UTSW 2 88,232,466 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGGCACCAAACTTTTCTCAAGGC -3'
(R):5'- GTGACACCCAAGTTTCTCACTGACC -3'

Sequencing Primer
(F):5'- AACACTTTATCTTCTGGGTAAGTGG -3'
(R):5'- TCACAGTGATGGCCTATGAC -3'
Posted On 2013-07-11