Incidental Mutation 'PIT4469001:Naa11'
ID555823
Institutional Source Beutler Lab
Gene Symbol Naa11
Ensembl Gene ENSMUSG00000046000
Gene NameN(alpha)-acetyltransferase 11, NatA catalytic subunit
SynonymsArd1b
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.191) question?
Stock #PIT4469001 (G1)
Quality Score183.009
Status Not validated
Chromosome5
Chromosomal Location97382198-97392379 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 97391626 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000057336 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060265]
Predicted Effect probably null
Transcript: ENSMUST00000060265
SMART Domains Protein: ENSMUSP00000057336
Gene: ENSMUSG00000046000

DomainStartEndE-ValueType
Pfam:Acetyltransf_10 32 125 2.7e-8 PFAM
Pfam:Acetyltransf_7 40 129 1.5e-9 PFAM
Pfam:Acetyltransf_1 46 129 1.4e-18 PFAM
Pfam:FR47 56 137 1.1e-9 PFAM
low complexity region 195 206 N/A INTRINSIC
Coding Region Coverage
  • 1x: 93.3%
  • 3x: 90.7%
  • 10x: 84.4%
  • 20x: 71.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030408B16Rik T C 15: 101,293,271 V6A probably benign Het
A630001G21Rik A G 1: 85,725,199 F83L probably benign Het
Acsm2 T A 7: 119,578,185 C308S possibly damaging Het
Ak3 A G 19: 29,047,757 S25P probably damaging Het
Atp13a2 T A 4: 140,994,127 V176E unknown Het
Bmper A T 9: 23,406,549 H488L probably benign Het
Cacna1c A T 6: 118,595,972 C2084S unknown Het
Ccp110 T A 7: 118,722,377 N418K probably benign Het
Ddx17 C A 15: 79,543,813 G32C probably damaging Het
Dusp16 G A 6: 134,761,152 probably benign Het
Efl1 T G 7: 82,658,165 F90V probably benign Het
Ell2 T A 13: 75,761,892 N252K probably damaging Het
Gdf6 T C 4: 9,859,569 V217A probably damaging Het
Gm6205 T A 5: 94,682,793 V50E probably damaging Het
Hint1 T A 11: 54,870,070 S112T unknown Het
Hist1h1e A T 13: 23,622,379 V40E probably damaging Het
Kif5c T C 2: 49,741,348 V679A probably benign Het
Lrrn3 A T 12: 41,453,018 D433E probably benign Het
Mast4 G A 13: 102,804,718 T277M probably damaging Het
Pcdh18 T A 3: 49,755,069 H599L probably benign Het
Pgc A T 17: 47,728,755 K25* probably null Het
Psd4 G A 2: 24,394,294 D57N probably benign Het
Pxdn G A 12: 30,005,829 R1238Q probably benign Het
Spata32 T C 11: 103,209,827 N38S probably benign Het
St5 G A 7: 109,531,130 A888V probably damaging Het
Tpr A G 1: 150,403,956 T279A probably benign Het
Unc13a C A 8: 71,658,314 E418* probably null Het
Vmn2r97 C A 17: 18,929,616 T422K probably benign Het
Zfp474 A T 18: 52,638,719 Q148L possibly damaging Het
Other mutations in Naa11
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2567:Naa11 UTSW 5 97391759 missense probably benign
R3686:Naa11 UTSW 5 97391789 missense probably benign 0.00
R4004:Naa11 UTSW 5 97391793 missense probably benign
R6268:Naa11 UTSW 5 97392210 missense probably damaging 1.00
R7687:Naa11 UTSW 5 97391789 missense probably benign 0.00
R8310:Naa11 UTSW 5 97391878 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGCATAGTCTATCGTTCAACAC -3'
(R):5'- ACAGATATGTGGTTCTGGGCTC -3'

Sequencing Primer
(F):5'- TCTATCGTTCAACACATCCTATTTTC -3'
(R):5'- TTCTGGGCTCCGAGGAG -3'
Posted On2019-06-07