Incidental Mutation 'R0604:Vmn1r69'
| ID |
55586 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r69
|
| Ensembl Gene |
ENSMUSG00000091662 |
| Gene Name |
vomeronasal 1 receptor 69 |
| Synonyms |
V1re9 |
| MMRRC Submission |
038793-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
R0604 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
10313683-10315414 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 10314581 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 50
(V50A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154076
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163658]
[ENSMUST00000176284]
[ENSMUST00000176707]
[ENSMUST00000226160]
[ENSMUST00000226190]
[ENSMUST00000226228]
[ENSMUST00000228478]
[ENSMUST00000227853]
[ENSMUST00000228296]
[ENSMUST00000228638]
|
| AlphaFold |
Q8VIC1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163658
AA Change: V50A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000129646
Gene: ENSMUSG00000091662
AA Change: V50A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
50 |
307 |
3.3e-32 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176284
AA Change: V50A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176707
AA Change: V50A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226160
AA Change: V50A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226190
AA Change: V50A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226228
AA Change: V50A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226990
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228478
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227853
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228296
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228638
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.4%
- 20x: 94.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acap1 |
T |
C |
11: 69,775,451 (GRCm39) |
E302G |
probably benign |
Het |
| Acsbg3 |
T |
A |
17: 57,192,169 (GRCm39) |
Y577* |
probably null |
Het |
| Adrb2 |
G |
A |
18: 62,311,586 (GRCm39) |
T413I |
possibly damaging |
Het |
| Aqr |
T |
C |
2: 113,961,085 (GRCm39) |
K725R |
probably benign |
Het |
| Braf |
A |
G |
6: 39,600,631 (GRCm39) |
I662T |
probably damaging |
Het |
| Ccdc178 |
A |
G |
18: 22,200,500 (GRCm39) |
S435P |
probably benign |
Het |
| Chd9 |
A |
G |
8: 91,763,170 (GRCm39) |
M2332V |
possibly damaging |
Het |
| Clgn |
T |
C |
8: 84,150,823 (GRCm39) |
V496A |
probably benign |
Het |
| Dnah17 |
A |
C |
11: 118,012,297 (GRCm39) |
S193R |
probably benign |
Het |
| Dntt |
A |
G |
19: 41,041,588 (GRCm39) |
E424G |
probably benign |
Het |
| Fam149a |
A |
G |
8: 45,798,045 (GRCm39) |
L492P |
probably damaging |
Het |
| Fetub |
T |
C |
16: 22,754,410 (GRCm39) |
Y126H |
possibly damaging |
Het |
| Fgfr3 |
A |
T |
5: 33,890,126 (GRCm39) |
Y96F |
probably damaging |
Het |
| Gm4952 |
A |
G |
19: 12,602,036 (GRCm39) |
E148G |
probably benign |
Het |
| Gucy2g |
T |
A |
19: 55,191,519 (GRCm39) |
L977F |
probably benign |
Het |
| Il1r1 |
T |
C |
1: 40,321,406 (GRCm39) |
V6A |
probably benign |
Het |
| Itsn2 |
C |
A |
12: 4,708,189 (GRCm39) |
Q832K |
probably benign |
Het |
| Lats1 |
T |
A |
10: 7,588,425 (GRCm39) |
F1014Y |
probably damaging |
Het |
| Mcc |
G |
A |
18: 44,606,823 (GRCm39) |
A536V |
probably damaging |
Het |
| Mtrf1 |
T |
C |
14: 79,653,327 (GRCm39) |
V334A |
possibly damaging |
Het |
| Or1j21 |
T |
A |
2: 36,684,119 (GRCm39) |
Y290* |
probably null |
Het |
| Or2t46 |
T |
A |
11: 58,472,174 (GRCm39) |
M168K |
probably damaging |
Het |
| Or2z8 |
C |
T |
8: 72,812,244 (GRCm39) |
T240M |
probably damaging |
Het |
| Or4p18 |
T |
C |
2: 88,232,727 (GRCm39) |
T184A |
probably benign |
Het |
| Pard6g |
A |
G |
18: 80,160,423 (GRCm39) |
S179G |
probably damaging |
Het |
| Pierce1 |
C |
A |
2: 28,356,103 (GRCm39) |
R60L |
possibly damaging |
Het |
| Polr3a |
G |
A |
14: 24,534,232 (GRCm39) |
P91L |
probably damaging |
Het |
| Psg27 |
A |
T |
7: 18,290,997 (GRCm39) |
V402D |
probably damaging |
Het |
| Rttn |
A |
G |
18: 88,995,882 (GRCm39) |
I222V |
probably damaging |
Het |
| Sp9 |
T |
A |
2: 73,103,982 (GRCm39) |
S179T |
probably benign |
Het |
| Tbc1d8 |
T |
A |
1: 39,444,407 (GRCm39) |
H184L |
probably damaging |
Het |
| Vmn2r58 |
A |
G |
7: 41,510,000 (GRCm39) |
F526L |
possibly damaging |
Het |
|
| Other mutations in Vmn1r69 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00155:Vmn1r69
|
APN |
7 |
10,313,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01972:Vmn1r69
|
APN |
7 |
10,314,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL02339:Vmn1r69
|
APN |
7 |
10,314,645 (GRCm39) |
nonsense |
probably null |
|
|
IGL02424:Vmn1r69
|
APN |
7 |
10,314,585 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02602:Vmn1r69
|
APN |
7 |
10,313,901 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL03271:Vmn1r69
|
APN |
7 |
10,314,596 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0034:Vmn1r69
|
UTSW |
7 |
10,314,738 (GRCm39) |
intron |
probably benign |
|
|
R0052:Vmn1r69
|
UTSW |
7 |
10,314,327 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0096:Vmn1r69
|
UTSW |
7 |
10,313,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Vmn1r69
|
UTSW |
7 |
10,314,874 (GRCm39) |
splice site |
probably benign |
|
|
R1681:Vmn1r69
|
UTSW |
7 |
10,314,179 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1884:Vmn1r69
|
UTSW |
7 |
10,314,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3741:Vmn1r69
|
UTSW |
7 |
10,314,069 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4655:Vmn1r69
|
UTSW |
7 |
10,314,026 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4735:Vmn1r69
|
UTSW |
7 |
10,314,926 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4758:Vmn1r69
|
UTSW |
7 |
10,314,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5582:Vmn1r69
|
UTSW |
7 |
10,314,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Vmn1r69
|
UTSW |
7 |
10,314,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5977:Vmn1r69
|
UTSW |
7 |
10,314,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6458:Vmn1r69
|
UTSW |
7 |
10,314,365 (GRCm39) |
missense |
probably benign |
|
|
R6987:Vmn1r69
|
UTSW |
7 |
10,314,491 (GRCm39) |
start codon destroyed |
probably null |
0.99 |
|
R7133:Vmn1r69
|
UTSW |
7 |
10,314,995 (GRCm39) |
intron |
probably benign |
|
|
R7532:Vmn1r69
|
UTSW |
7 |
10,314,281 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7878:Vmn1r69
|
UTSW |
7 |
10,314,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9100:Vmn1r69
|
UTSW |
7 |
10,314,064 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9558:Vmn1r69
|
UTSW |
7 |
10,314,185 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn1r69
|
UTSW |
7 |
10,314,023 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCAATGGATATACTCCGGCCAAC -3'
(R):5'- TGGAACCATCTGATTTAGCCAATGAGG -3'
Sequencing Primer
(F):5'- CCGGCCAACTCTTTGAATG -3'
(R):5'- TAGCCAATGAGGAACTCTTCAG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation