Incidental Mutation 'PIT4495001:Or5h26'
ID 555978
Institutional Source Beutler Lab
Gene Symbol Or5h26
Ensembl Gene ENSMUSG00000096695
Gene Name olfactory receptor family 5 subfamily H member 26
Synonyms MOR183-1, Olfr196, GA_x54KRFPKG5P-55389051-55388122
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # PIT4495001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 58987010-58990817 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 58988337 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 56 (H56Q)
Ref Sequence ENSEMBL: ENSMUSP00000145684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077027] [ENSMUST00000205471]
AlphaFold E9PYP4
Predicted Effect possibly damaging
Transcript: ENSMUST00000077027
AA Change: H56Q

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000076285
Gene: ENSMUSG00000096695
AA Change: H56Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.1e-48 PFAM
Pfam:7tm_1 41 290 1.1e-16 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000205471
AA Change: H56Q

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 93.1%
  • 3x: 90.6%
  • 10x: 84.0%
  • 20x: 69.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl2 T A 1: 156,460,755 (GRCm39) V384D probably damaging Het
Adamts7 A G 9: 90,056,675 (GRCm39) E248G probably damaging Het
Aff1 A G 5: 103,997,391 (GRCm39) T1162A probably benign Het
Ank3 C A 10: 69,828,902 (GRCm39) H2524N Het
Aoc1l3 A T 6: 48,964,710 (GRCm39) E239D possibly damaging Het
Cct7 T A 6: 85,436,943 (GRCm39) N60K probably damaging Het
Cfap43 A C 19: 47,885,741 (GRCm39) C291W probably damaging Het
Cobl G A 11: 12,204,596 (GRCm39) T702I probably benign Het
Col5a1 C A 2: 27,914,788 (GRCm39) Q1624K unknown Het
Cubn T A 2: 13,496,561 (GRCm39) T22S probably benign Het
Def8 A C 8: 124,186,292 (GRCm39) M344L probably benign Het
Fzd7 A G 1: 59,523,466 (GRCm39) T450A probably benign Het
Gm11214 G A 4: 63,580,922 (GRCm39) L76F probably benign Het
Gm5797 T C 14: 7,329,530 (GRCm38) T153A probably benign Het
Gsk3a A C 7: 24,935,064 (GRCm39) S129A probably damaging Het
Intu A G 3: 40,652,033 (GRCm39) Q830R probably benign Het
Kcnma1 C T 14: 23,475,665 (GRCm39) V750I probably benign Het
Mlh1 T A 9: 111,076,328 (GRCm39) Y343F probably benign Het
Myb C T 10: 21,028,521 (GRCm39) R114H probably damaging Het
Neb A T 2: 52,102,748 (GRCm39) D4508E probably benign Het
Nell2 T C 15: 95,281,608 (GRCm39) D366G probably benign Het
Or1o3 A C 17: 37,573,721 (GRCm39) V278G possibly damaging Het
Or4d6 A G 19: 12,086,076 (GRCm39) I52T possibly damaging Het
Or5ac25 A C 16: 59,181,871 (GRCm39) F237V probably damaging Het
Or7a38 T C 10: 78,752,821 (GRCm39) V49A probably benign Het
Pcdhgc5 C T 18: 37,954,030 (GRCm39) H435Y possibly damaging Het
Pira12 A T 7: 3,900,457 (GRCm39) C98S probably damaging Het
Pnpla7 T A 2: 24,932,151 (GRCm39) D935E probably damaging Het
Pole A G 5: 110,451,780 (GRCm39) E874G probably damaging Het
Psd3 A C 8: 68,416,565 (GRCm39) I158R probably benign Het
Pzp C A 6: 128,479,192 (GRCm39) V654L probably benign Het
Rabep1 A G 11: 70,808,405 (GRCm39) T454A probably damaging Het
Rad54l2 C A 9: 106,593,343 (GRCm39) S419I probably benign Het
Rin3 A G 12: 102,335,295 (GRCm39) D402G probably benign Het
Ripk4 T C 16: 97,544,370 (GRCm39) H759R probably damaging Het
Rlig1 A T 10: 100,419,812 (GRCm39) F90I probably damaging Het
Sbsn GAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCA GAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCA 7: 30,452,391 (GRCm39) probably benign Het
Sf3a3 C T 4: 124,622,113 (GRCm39) P391L probably damaging Het
Snx9 T A 17: 5,970,401 (GRCm39) I379K possibly damaging Het
Syt5 A C 7: 4,544,077 (GRCm39) probably null Het
Tex47 A G 5: 7,355,011 (GRCm39) D64G probably benign Het
Zbbx C A 3: 74,968,944 (GRCm39) W509L probably damaging Het
Zer1 T C 2: 29,993,555 (GRCm39) K551R probably benign Het
Other mutations in Or5h26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02560:Or5h26 APN 16 58,987,891 (GRCm39) nonsense probably null
R0312:Or5h26 UTSW 16 58,988,202 (GRCm39) missense probably benign 0.00
R0345:Or5h26 UTSW 16 58,988,269 (GRCm39) missense possibly damaging 0.90
R0644:Or5h26 UTSW 16 58,987,979 (GRCm39) missense probably damaging 1.00
R0679:Or5h26 UTSW 16 58,987,979 (GRCm39) missense probably damaging 1.00
R1709:Or5h26 UTSW 16 58,988,264 (GRCm39) missense probably benign 0.03
R1818:Or5h26 UTSW 16 58,988,243 (GRCm39) missense probably benign 0.00
R2090:Or5h26 UTSW 16 58,988,503 (GRCm39) start codon destroyed probably null 0.99
R5327:Or5h26 UTSW 16 58,987,983 (GRCm39) missense possibly damaging 0.96
R5945:Or5h26 UTSW 16 58,988,482 (GRCm39) missense probably benign 0.42
R6093:Or5h26 UTSW 16 58,988,330 (GRCm39) missense probably damaging 1.00
R6268:Or5h26 UTSW 16 58,987,656 (GRCm39) splice site probably null
R6487:Or5h26 UTSW 16 58,988,536 (GRCm39) splice site probably null
R6628:Or5h26 UTSW 16 58,988,344 (GRCm39) missense probably benign 0.00
R6679:Or5h26 UTSW 16 58,988,209 (GRCm39) missense probably benign
R7642:Or5h26 UTSW 16 58,988,080 (GRCm39) missense probably benign 0.01
R8285:Or5h26 UTSW 16 58,988,176 (GRCm39) missense probably benign 0.35
R8336:Or5h26 UTSW 16 58,987,918 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- TAGCGATCATAGGCCATTGC -3'
(R):5'- TGCGTTTCATTTCAGGGACAC -3'

Sequencing Primer
(F):5'- GATCATAGGCCATTGCTGCCAAG -3'
(R):5'- CACCCAGTAAGGACATGGG -3'
Posted On 2019-06-07