Incidental Mutation 'PIT4498001:Dkk3'
ID 556065
Institutional Source Beutler Lab
Gene Symbol Dkk3
Ensembl Gene ENSMUSG00000030772
Gene Name dickkopf WNT signaling pathway inhibitor 3
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # PIT4498001 (G1)
Quality Score 106.008
Status Not validated
Chromosome 7
Chromosomal Location 111715224-111758264 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 111718679 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 236 (V236M)
Ref Sequence ENSEMBL: ENSMUSP00000033036 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033036]
AlphaFold Q9QUN9
Predicted Effect probably benign
Transcript: ENSMUST00000033036
AA Change: V236M

PolyPhen 2 Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000033036
Gene: ENSMUSG00000030772
AA Change: V236M

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
coiled coil region 42 84 N/A INTRINSIC
Pfam:Dickkopf_N 146 196 3e-19 PFAM
Coding Region Coverage
  • 1x: 93.2%
  • 3x: 91.0%
  • 10x: 86.1%
  • 20x: 75.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and euthyroid but exhibit hyperactivity, a slight but significant decrease in the frequency of natural killer cells, and significantly increased IgM, hemoglobin, and hematocrit levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh18a1 T C 19: 40,562,800 (GRCm39) N191S probably benign Het
Cacnb2 T A 2: 14,879,630 (GRCm39) L84* probably null Het
Cdhr2 C T 13: 54,866,052 (GRCm39) T284M possibly damaging Het
Defb45 T C 2: 152,438,394 (GRCm39) probably benign Het
Dscc1 A T 15: 54,945,711 (GRCm39) V328D probably benign Het
Epha3 T C 16: 63,372,889 (GRCm39) Y938C probably damaging Het
Erc1 A T 6: 119,756,452 (GRCm39) F435I possibly damaging Het
Fbxl5 T C 5: 43,908,323 (GRCm39) Y626C possibly damaging Het
Fmn2 A G 1: 174,440,170 (GRCm39) R1196G probably damaging Het
Gabrr1 C T 4: 33,160,225 (GRCm39) S303F probably damaging Het
Ggt1 T C 10: 75,414,689 (GRCm39) V169A possibly damaging Het
Gm10800 CAAGAAAACTGAAAATCAAAGAAAACTGAAAATCA CAAGAAAACTGAAAATCA 2: 98,497,361 (GRCm39) probably null Het
Gm3182 T A 14: 4,481,832 (GRCm38) C9S probably damaging Het
Gpr88 A C 3: 116,046,264 (GRCm39) S16A unknown Het
Kalrn A T 16: 33,851,952 (GRCm39) M2076K possibly damaging Het
Katnip A G 7: 125,412,768 (GRCm39) T371A probably benign Het
Kcnd3 T C 3: 105,566,025 (GRCm39) I402T probably damaging Het
Mink1 A G 11: 70,489,714 (GRCm39) D57G probably benign Het
Ncl T C 1: 86,279,162 (GRCm39) T584A possibly damaging Het
Nfx1 A T 4: 40,977,244 (GRCm39) Q306L probably benign Het
Ogdh A T 11: 6,290,504 (GRCm39) D374V probably benign Het
Or5d39 T A 2: 87,980,259 (GRCm39) T35S probably benign Het
Pak5 T A 2: 135,925,211 (GRCm39) H697L probably damaging Het
Pappa T C 4: 65,234,469 (GRCm39) C1425R probably damaging Het
Pramel26 T C 4: 143,539,406 (GRCm39) E29G possibly damaging Het
Rab3gap2 T A 1: 185,013,882 (GRCm39) I1196N probably damaging Het
Ralyl A T 3: 14,172,299 (GRCm39) D56V probably damaging Het
Scin C T 12: 40,119,446 (GRCm39) probably null Het
Slc25a19 T C 11: 115,514,781 (GRCm39) I69V possibly damaging Het
Slc8a1 G T 17: 81,956,269 (GRCm39) Y256* probably null Het
Smyd1 T C 6: 71,196,272 (GRCm39) H372R probably benign Het
St8sia1 T C 6: 142,859,848 (GRCm39) T94A probably damaging Het
Stard9 T A 2: 120,527,916 (GRCm39) M1391K possibly damaging Het
Tlr9 G A 9: 106,100,721 (GRCm39) R4H probably benign Het
Trim50 A G 5: 135,382,331 (GRCm39) D61G probably damaging Het
Ttn G A 2: 76,597,295 (GRCm39) P19873S probably damaging Het
Vmn1r228 G T 17: 20,996,772 (GRCm39) H249N probably benign Het
Vmn2r108 C T 17: 20,683,279 (GRCm39) G642S probably damaging Het
Wdr27 A G 17: 15,154,831 (GRCm39) S29P probably benign Het
Zan A G 5: 137,415,298 (GRCm39) probably null Het
Other mutations in Dkk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02086:Dkk3 APN 7 111,748,236 (GRCm39) missense probably benign 0.05
IGL02638:Dkk3 APN 7 111,748,234 (GRCm39) missense probably benign 0.35
IGL02934:Dkk3 APN 7 111,749,954 (GRCm39) missense probably damaging 0.99
R0385:Dkk3 UTSW 7 111,757,430 (GRCm39) missense probably damaging 0.99
R0550:Dkk3 UTSW 7 111,757,452 (GRCm39) missense probably damaging 1.00
R4657:Dkk3 UTSW 7 111,748,253 (GRCm39) critical splice acceptor site probably null
R4952:Dkk3 UTSW 7 111,717,558 (GRCm39) missense probably benign 0.01
R5987:Dkk3 UTSW 7 111,749,865 (GRCm39) missense probably benign 0.00
R6221:Dkk3 UTSW 7 111,720,853 (GRCm39) missense probably damaging 1.00
R7680:Dkk3 UTSW 7 111,718,570 (GRCm39) missense probably damaging 0.99
R8282:Dkk3 UTSW 7 111,717,489 (GRCm39) missense probably damaging 1.00
R8430:Dkk3 UTSW 7 111,720,853 (GRCm39) missense probably damaging 1.00
R8838:Dkk3 UTSW 7 111,717,542 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCACTCCCAGATGATAATTTTGGC -3'
(R):5'- AGAGGGTTTAGCATCTTCAGGC -3'

Sequencing Primer
(F):5'- CCAGATGATAATTTTGGCTGCTC -3'
(R):5'- AGGCAGATTCCTGTAACTGC -3'
Posted On 2019-06-07