Incidental Mutation 'PIT4486001:Zfp281'
ID 556085
Institutional Source Beutler Lab
Gene Symbol Zfp281
Ensembl Gene ENSMUSG00000041483
Gene Name zinc finger protein 281
Synonyms
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # PIT4486001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 136552639-136557791 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 136554741 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 573 (D573G)
Ref Sequence ENSEMBL: ENSMUSP00000039003 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047734] [ENSMUST00000112046]
AlphaFold Q99LI5
Predicted Effect possibly damaging
Transcript: ENSMUST00000047734
AA Change: D573G

PolyPhen 2 Score 0.482 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000039003
Gene: ENSMUSG00000041483
AA Change: D573G

DomainStartEndE-ValueType
low complexity region 4 36 N/A INTRINSIC
low complexity region 83 95 N/A INTRINSIC
low complexity region 161 171 N/A INTRINSIC
low complexity region 180 191 N/A INTRINSIC
low complexity region 230 241 N/A INTRINSIC
ZnF_C2H2 258 280 3.34e-2 SMART
ZnF_C2H2 286 308 6.78e-3 SMART
ZnF_C2H2 314 336 1.43e-1 SMART
ZnF_C2H2 342 362 2.97e1 SMART
low complexity region 397 407 N/A INTRINSIC
low complexity region 488 501 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000112046
AA Change: D573G

PolyPhen 2 Score 0.482 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000107677
Gene: ENSMUSG00000041483
AA Change: D573G

DomainStartEndE-ValueType
low complexity region 4 36 N/A INTRINSIC
low complexity region 83 95 N/A INTRINSIC
low complexity region 161 171 N/A INTRINSIC
low complexity region 180 191 N/A INTRINSIC
low complexity region 230 241 N/A INTRINSIC
ZnF_C2H2 258 280 3.34e-2 SMART
ZnF_C2H2 286 308 6.78e-3 SMART
ZnF_C2H2 314 336 1.43e-1 SMART
ZnF_C2H2 342 362 2.97e1 SMART
low complexity region 397 407 N/A INTRINSIC
low complexity region 488 501 N/A INTRINSIC
Coding Region Coverage
  • 1x: 93.0%
  • 3x: 90.5%
  • 10x: 84.1%
  • 20x: 70.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality between E7.5 and E8.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T C 5: 144,980,914 (GRCm39) S108P probably damaging Het
Abhd16b A T 2: 181,135,752 (GRCm39) Q218L probably benign Het
Abhd3 T A 18: 10,645,233 (GRCm39) I354F probably benign Het
Abt1 T C 13: 23,607,851 (GRCm39) Y51C possibly damaging Het
Actl9 T A 17: 33,653,172 (GRCm39) Y411N possibly damaging Het
Ano4 A G 10: 88,828,891 (GRCm39) V516A probably damaging Het
Bptf A T 11: 106,945,614 (GRCm39) S2542T probably damaging Het
Card11 C T 5: 140,862,163 (GRCm39) V1045M probably damaging Het
Ccdc121 T A 5: 31,645,087 (GRCm39) I280K probably damaging Het
Cd300ld2 CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG 11: 114,903,257 (GRCm39) probably benign Het
Cdh3 A G 8: 107,268,122 (GRCm39) K386E possibly damaging Het
Cks1b C A 3: 89,323,621 (GRCm39) Q49H probably damaging Het
Clpb A T 7: 101,313,139 (GRCm39) D41V probably benign Het
Cyp3a11 A T 5: 145,797,302 (GRCm39) M359K probably damaging Het
Cyp3a13 A T 5: 137,908,228 (GRCm39) I207N probably benign Het
Dennd4c T A 4: 86,717,701 (GRCm39) L566* probably null Het
Dhtkd1 A T 2: 5,904,806 (GRCm39) D859E probably benign Het
Efcab6 T C 15: 83,857,514 (GRCm39) D295G probably benign Het
Fcgbp A G 7: 27,774,698 (GRCm39) T91A possibly damaging Het
Gm11569 GCAGCTGGGCCTGCAGCAGCTGGAAATGCAGCAGCTAGGACGGCAACA GCA 11: 99,689,491 (GRCm39) probably benign Het
Gsdma3 A G 11: 98,528,880 (GRCm39) K454E unknown Het
Herc1 T A 9: 66,279,671 (GRCm39) I193N probably damaging Het
Kdm5b T A 1: 134,556,423 (GRCm39) L1370Q probably damaging Het
Lrrc37 A T 11: 103,509,027 (GRCm39) H980Q unknown Het
Map4 T G 9: 109,901,682 (GRCm39) V965G probably damaging Het
Mkrn2os T C 6: 115,562,444 (GRCm39) D173G probably benign Het
Ndfip2 A G 14: 105,532,300 (GRCm39) D232G probably damaging Het
Nipal2 C T 15: 34,584,875 (GRCm39) G231D probably damaging Het
Notch3 A T 17: 32,373,737 (GRCm39) N490K probably damaging Het
Or5p68 A G 7: 107,945,529 (GRCm39) S220P possibly damaging Het
Or8g50 T A 9: 39,648,535 (GRCm39) C141* probably null Het
Prkar2a T C 9: 108,610,326 (GRCm39) L185S probably damaging Het
Ptpn9 T G 9: 56,968,287 (GRCm39) N542K probably damaging Het
Pus10 G A 11: 23,662,326 (GRCm39) probably null Het
Pyroxd2 A G 19: 42,728,828 (GRCm39) S191P probably benign Het
Rab15 T A 12: 76,848,716 (GRCm39) K122* probably null Het
Rara A G 11: 98,864,321 (GRCm39) N416S possibly damaging Het
Rims2 T C 15: 39,339,916 (GRCm39) V870A possibly damaging Het
Sec16a T C 2: 26,315,785 (GRCm39) T293A Het
Slc26a3 G A 12: 31,520,949 (GRCm39) D718N probably benign Het
Slc44a5 G A 3: 153,964,659 (GRCm39) V520I possibly damaging Het
Spata31e2 G A 1: 26,724,410 (GRCm39) P257S probably damaging Het
Tgfb2 A T 1: 186,422,924 (GRCm39) Y142N probably benign Het
Tgfbi A T 13: 56,777,607 (GRCm39) I364F probably damaging Het
Tmem144 A C 3: 79,734,174 (GRCm39) D176E probably benign Het
Tns4 A T 11: 98,962,161 (GRCm39) L612Q probably damaging Het
Toe1 A G 4: 116,663,692 (GRCm39) L76S probably damaging Het
Trank1 T C 9: 111,219,175 (GRCm39) F1971L probably damaging Het
Tsen54 G T 11: 115,713,422 (GRCm39) V481F probably damaging Het
Uimc1 A G 13: 55,223,381 (GRCm39) L297P probably damaging Het
Wnt8a T C 18: 34,680,636 (GRCm39) Y334H probably damaging Het
Other mutations in Zfp281
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00531:Zfp281 APN 1 136,555,648 (GRCm39) missense probably damaging 1.00
IGL01408:Zfp281 APN 1 136,553,853 (GRCm39) missense probably damaging 1.00
IGL02037:Zfp281 APN 1 136,555,185 (GRCm39) missense possibly damaging 0.64
IGL03233:Zfp281 APN 1 136,554,567 (GRCm39) missense possibly damaging 0.82
R1514:Zfp281 UTSW 1 136,554,435 (GRCm39) missense probably benign 0.00
R1784:Zfp281 UTSW 1 136,553,091 (GRCm39) small insertion probably benign
R1785:Zfp281 UTSW 1 136,553,091 (GRCm39) small insertion probably benign
R2049:Zfp281 UTSW 1 136,553,091 (GRCm39) small insertion probably benign
R2142:Zfp281 UTSW 1 136,553,091 (GRCm39) small insertion probably benign
R4086:Zfp281 UTSW 1 136,553,859 (GRCm39) missense probably damaging 1.00
R4087:Zfp281 UTSW 1 136,553,859 (GRCm39) missense probably damaging 1.00
R4088:Zfp281 UTSW 1 136,553,859 (GRCm39) missense probably damaging 1.00
R4090:Zfp281 UTSW 1 136,553,859 (GRCm39) missense probably damaging 1.00
R4819:Zfp281 UTSW 1 136,553,448 (GRCm39) missense probably benign
R5380:Zfp281 UTSW 1 136,553,676 (GRCm39) missense possibly damaging 0.93
R6033:Zfp281 UTSW 1 136,554,464 (GRCm39) missense probably benign 0.14
R6033:Zfp281 UTSW 1 136,554,464 (GRCm39) missense probably benign 0.14
R6056:Zfp281 UTSW 1 136,553,178 (GRCm39) missense possibly damaging 0.93
R6213:Zfp281 UTSW 1 136,553,250 (GRCm39) missense probably benign 0.01
R7402:Zfp281 UTSW 1 136,553,190 (GRCm39) missense probably damaging 0.99
R7503:Zfp281 UTSW 1 136,554,678 (GRCm39) missense possibly damaging 0.67
R7969:Zfp281 UTSW 1 136,553,772 (GRCm39) missense probably benign 0.06
R8343:Zfp281 UTSW 1 136,555,620 (GRCm39) missense probably damaging 1.00
R8722:Zfp281 UTSW 1 136,553,334 (GRCm39) missense probably benign 0.00
R9199:Zfp281 UTSW 1 136,553,643 (GRCm39) missense probably benign
R9461:Zfp281 UTSW 1 136,554,500 (GRCm39) missense probably benign 0.28
R9487:Zfp281 UTSW 1 136,555,143 (GRCm39) missense probably damaging 0.96
R9532:Zfp281 UTSW 1 136,554,894 (GRCm39) missense probably benign
R9541:Zfp281 UTSW 1 136,555,303 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTCACTTGGCATCGTATC -3'
(R):5'- AGGTGTGTAAATCCACTCGTG -3'

Sequencing Primer
(F):5'- GTCTTCTCCAAAGTACAAGTGGC -3'
(R):5'- CCACTCGTGGTTCTGTTAAATTG -3'
Posted On 2019-06-07