Incidental Mutation 'R0604:Pard6g'
ID 55609
Institutional Source Beutler Lab
Gene Symbol Pard6g
Ensembl Gene ENSMUSG00000056214
Gene Name par-6 family cell polarity regulator gamma
Synonyms 2410049N21Rik
MMRRC Submission 038793-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.377) question?
Stock # R0604 (G1)
Quality Score 182
Status Not validated
Chromosome 18
Chromosomal Location 80090105-80162854 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 80160423 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 179 (S179G)
Ref Sequence ENSEMBL: ENSMUSP00000069182 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070219]
AlphaFold Q9JK84
Predicted Effect probably damaging
Transcript: ENSMUST00000070219
AA Change: S179G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069182
Gene: ENSMUSG00000056214
AA Change: S179G

DomainStartEndE-ValueType
PB1 18 98 1.16e-16 SMART
PDZ 168 251 8.6e-14 SMART
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap1 T C 11: 69,775,451 (GRCm39) E302G probably benign Het
Acsbg3 T A 17: 57,192,169 (GRCm39) Y577* probably null Het
Adrb2 G A 18: 62,311,586 (GRCm39) T413I possibly damaging Het
Aqr T C 2: 113,961,085 (GRCm39) K725R probably benign Het
Braf A G 6: 39,600,631 (GRCm39) I662T probably damaging Het
Ccdc178 A G 18: 22,200,500 (GRCm39) S435P probably benign Het
Chd9 A G 8: 91,763,170 (GRCm39) M2332V possibly damaging Het
Clgn T C 8: 84,150,823 (GRCm39) V496A probably benign Het
Dnah17 A C 11: 118,012,297 (GRCm39) S193R probably benign Het
Dntt A G 19: 41,041,588 (GRCm39) E424G probably benign Het
Fam149a A G 8: 45,798,045 (GRCm39) L492P probably damaging Het
Fetub T C 16: 22,754,410 (GRCm39) Y126H possibly damaging Het
Fgfr3 A T 5: 33,890,126 (GRCm39) Y96F probably damaging Het
Gm4952 A G 19: 12,602,036 (GRCm39) E148G probably benign Het
Gucy2g T A 19: 55,191,519 (GRCm39) L977F probably benign Het
Il1r1 T C 1: 40,321,406 (GRCm39) V6A probably benign Het
Itsn2 C A 12: 4,708,189 (GRCm39) Q832K probably benign Het
Lats1 T A 10: 7,588,425 (GRCm39) F1014Y probably damaging Het
Mcc G A 18: 44,606,823 (GRCm39) A536V probably damaging Het
Mtrf1 T C 14: 79,653,327 (GRCm39) V334A possibly damaging Het
Or1j21 T A 2: 36,684,119 (GRCm39) Y290* probably null Het
Or2t46 T A 11: 58,472,174 (GRCm39) M168K probably damaging Het
Or2z8 C T 8: 72,812,244 (GRCm39) T240M probably damaging Het
Or4p18 T C 2: 88,232,727 (GRCm39) T184A probably benign Het
Pierce1 C A 2: 28,356,103 (GRCm39) R60L possibly damaging Het
Polr3a G A 14: 24,534,232 (GRCm39) P91L probably damaging Het
Psg27 A T 7: 18,290,997 (GRCm39) V402D probably damaging Het
Rttn A G 18: 88,995,882 (GRCm39) I222V probably damaging Het
Sp9 T A 2: 73,103,982 (GRCm39) S179T probably benign Het
Tbc1d8 T A 1: 39,444,407 (GRCm39) H184L probably damaging Het
Vmn1r69 A G 7: 10,314,581 (GRCm39) V50A probably benign Het
Vmn2r58 A G 7: 41,510,000 (GRCm39) F526L possibly damaging Het
Other mutations in Pard6g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Pard6g APN 18 80,123,037 (GRCm39) splice site probably benign
IGL01514:Pard6g APN 18 80,160,661 (GRCm39) missense probably damaging 1.00
IGL01519:Pard6g APN 18 80,123,071 (GRCm39) missense probably benign 0.34
IGL02305:Pard6g APN 18 80,160,985 (GRCm39) missense probably damaging 1.00
IGL03115:Pard6g APN 18 80,123,068 (GRCm39) missense probably damaging 1.00
R0411:Pard6g UTSW 18 80,160,337 (GRCm39) missense probably damaging 1.00
R0938:Pard6g UTSW 18 80,123,259 (GRCm39) nonsense probably null
R1730:Pard6g UTSW 18 80,123,040 (GRCm39) missense probably damaging 0.97
R1783:Pard6g UTSW 18 80,123,040 (GRCm39) missense probably damaging 0.97
R1785:Pard6g UTSW 18 80,160,523 (GRCm39) missense probably damaging 0.96
R1786:Pard6g UTSW 18 80,160,523 (GRCm39) missense probably damaging 0.96
R1851:Pard6g UTSW 18 80,160,357 (GRCm39) missense probably damaging 1.00
R2070:Pard6g UTSW 18 80,160,940 (GRCm39) missense probably benign 0.00
R2132:Pard6g UTSW 18 80,160,523 (GRCm39) missense probably damaging 0.96
R2133:Pard6g UTSW 18 80,160,523 (GRCm39) missense probably damaging 0.96
R3778:Pard6g UTSW 18 80,123,038 (GRCm39) critical splice acceptor site probably null
R5282:Pard6g UTSW 18 80,123,116 (GRCm39) missense probably benign 0.01
R6084:Pard6g UTSW 18 80,160,420 (GRCm39) missense possibly damaging 0.73
R6913:Pard6g UTSW 18 80,160,534 (GRCm39) missense possibly damaging 0.94
R7124:Pard6g UTSW 18 80,160,340 (GRCm39) missense possibly damaging 0.70
R8109:Pard6g UTSW 18 80,160,658 (GRCm39) missense possibly damaging 0.65
R8469:Pard6g UTSW 18 80,090,347 (GRCm39) missense possibly damaging 0.81
R8903:Pard6g UTSW 18 80,160,411 (GRCm39) nonsense probably null
R8915:Pard6g UTSW 18 80,160,957 (GRCm39) missense probably damaging 0.99
R9077:Pard6g UTSW 18 80,160,772 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTCAGACTTGCGGTGGCAGATG -3'
(R):5'- GCGGACCACATTGTTCCTTTGGTTG -3'

Sequencing Primer
(F):5'- TTCTTGGCATCACAGGGAC -3'
(R):5'- CCGGCTTGACAGTGACAATG -3'
Posted On 2013-07-11