Incidental Mutation 'PIT4486001:Cyp3a11'
ID 556099
Institutional Source Beutler Lab
Gene Symbol Cyp3a11
Ensembl Gene ENSMUSG00000056035
Gene Name cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms Cyp3a, Pcn, IIIAm1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # PIT4486001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 145791417-145816664 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 145797302 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 359 (M359K)
Ref Sequence ENSEMBL: ENSMUSP00000037665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035918]
AlphaFold Q64459
Predicted Effect probably damaging
Transcript: ENSMUST00000035918
AA Change: M359K

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000037665
Gene: ENSMUSG00000056035
AA Change: M359K

DomainStartEndE-ValueType
Pfam:p450 38 494 2.4e-136 PFAM
Coding Region Coverage
  • 1x: 93.0%
  • 3x: 90.5%
  • 10x: 84.1%
  • 20x: 70.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T C 5: 144,980,914 (GRCm39) S108P probably damaging Het
Abhd16b A T 2: 181,135,752 (GRCm39) Q218L probably benign Het
Abhd3 T A 18: 10,645,233 (GRCm39) I354F probably benign Het
Abt1 T C 13: 23,607,851 (GRCm39) Y51C possibly damaging Het
Actl9 T A 17: 33,653,172 (GRCm39) Y411N possibly damaging Het
Ano4 A G 10: 88,828,891 (GRCm39) V516A probably damaging Het
Bptf A T 11: 106,945,614 (GRCm39) S2542T probably damaging Het
Card11 C T 5: 140,862,163 (GRCm39) V1045M probably damaging Het
Ccdc121 T A 5: 31,645,087 (GRCm39) I280K probably damaging Het
Cd300ld2 CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG CGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGGCAGAACTGTGGATGTCAGAACTGTGGATGTCAGAACTGTGGATGGCACAACTGTGCATGGCAGAACTGTGGATGGCACAACTGTGGATGGCAGAACTGTGG 11: 114,903,257 (GRCm39) probably benign Het
Cdh3 A G 8: 107,268,122 (GRCm39) K386E possibly damaging Het
Cks1b C A 3: 89,323,621 (GRCm39) Q49H probably damaging Het
Clpb A T 7: 101,313,139 (GRCm39) D41V probably benign Het
Cyp3a13 A T 5: 137,908,228 (GRCm39) I207N probably benign Het
Dennd4c T A 4: 86,717,701 (GRCm39) L566* probably null Het
Dhtkd1 A T 2: 5,904,806 (GRCm39) D859E probably benign Het
Efcab6 T C 15: 83,857,514 (GRCm39) D295G probably benign Het
Fcgbp A G 7: 27,774,698 (GRCm39) T91A possibly damaging Het
Gm11569 GCAGCTGGGCCTGCAGCAGCTGGAAATGCAGCAGCTAGGACGGCAACA GCA 11: 99,689,491 (GRCm39) probably benign Het
Gsdma3 A G 11: 98,528,880 (GRCm39) K454E unknown Het
Herc1 T A 9: 66,279,671 (GRCm39) I193N probably damaging Het
Kdm5b T A 1: 134,556,423 (GRCm39) L1370Q probably damaging Het
Lrrc37 A T 11: 103,509,027 (GRCm39) H980Q unknown Het
Map4 T G 9: 109,901,682 (GRCm39) V965G probably damaging Het
Mkrn2os T C 6: 115,562,444 (GRCm39) D173G probably benign Het
Ndfip2 A G 14: 105,532,300 (GRCm39) D232G probably damaging Het
Nipal2 C T 15: 34,584,875 (GRCm39) G231D probably damaging Het
Notch3 A T 17: 32,373,737 (GRCm39) N490K probably damaging Het
Or5p68 A G 7: 107,945,529 (GRCm39) S220P possibly damaging Het
Or8g50 T A 9: 39,648,535 (GRCm39) C141* probably null Het
Prkar2a T C 9: 108,610,326 (GRCm39) L185S probably damaging Het
Ptpn9 T G 9: 56,968,287 (GRCm39) N542K probably damaging Het
Pus10 G A 11: 23,662,326 (GRCm39) probably null Het
Pyroxd2 A G 19: 42,728,828 (GRCm39) S191P probably benign Het
Rab15 T A 12: 76,848,716 (GRCm39) K122* probably null Het
Rara A G 11: 98,864,321 (GRCm39) N416S possibly damaging Het
Rims2 T C 15: 39,339,916 (GRCm39) V870A possibly damaging Het
Sec16a T C 2: 26,315,785 (GRCm39) T293A Het
Slc26a3 G A 12: 31,520,949 (GRCm39) D718N probably benign Het
Slc44a5 G A 3: 153,964,659 (GRCm39) V520I possibly damaging Het
Spata31e2 G A 1: 26,724,410 (GRCm39) P257S probably damaging Het
Tgfb2 A T 1: 186,422,924 (GRCm39) Y142N probably benign Het
Tgfbi A T 13: 56,777,607 (GRCm39) I364F probably damaging Het
Tmem144 A C 3: 79,734,174 (GRCm39) D176E probably benign Het
Tns4 A T 11: 98,962,161 (GRCm39) L612Q probably damaging Het
Toe1 A G 4: 116,663,692 (GRCm39) L76S probably damaging Het
Trank1 T C 9: 111,219,175 (GRCm39) F1971L probably damaging Het
Tsen54 G T 11: 115,713,422 (GRCm39) V481F probably damaging Het
Uimc1 A G 13: 55,223,381 (GRCm39) L297P probably damaging Het
Wnt8a T C 18: 34,680,636 (GRCm39) Y334H probably damaging Het
Zfp281 A G 1: 136,554,741 (GRCm39) D573G possibly damaging Het
Other mutations in Cyp3a11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Cyp3a11 APN 5 145,799,275 (GRCm39) missense probably damaging 1.00
IGL01316:Cyp3a11 APN 5 145,791,961 (GRCm39) missense possibly damaging 0.78
IGL01348:Cyp3a11 APN 5 145,805,817 (GRCm39) missense possibly damaging 0.80
IGL01591:Cyp3a11 APN 5 145,812,291 (GRCm39) splice site probably benign
IGL01665:Cyp3a11 APN 5 145,805,475 (GRCm39) missense probably benign 0.00
IGL02203:Cyp3a11 APN 5 145,805,976 (GRCm39) missense probably damaging 1.00
IGL02894:Cyp3a11 APN 5 145,805,836 (GRCm39) nonsense probably null
IGL03201:Cyp3a11 APN 5 145,797,189 (GRCm39) missense possibly damaging 0.94
IGL03342:Cyp3a11 APN 5 145,791,927 (GRCm39) missense probably damaging 0.96
R0347:Cyp3a11 UTSW 5 145,802,735 (GRCm39) missense possibly damaging 0.93
R0376:Cyp3a11 UTSW 5 145,799,262 (GRCm39) nonsense probably null
R0378:Cyp3a11 UTSW 5 145,805,417 (GRCm39) missense probably benign 0.43
R0448:Cyp3a11 UTSW 5 145,799,204 (GRCm39) missense probably benign 0.00
R0567:Cyp3a11 UTSW 5 145,805,959 (GRCm39) missense probably damaging 1.00
R0968:Cyp3a11 UTSW 5 145,799,324 (GRCm39) splice site probably benign
R1292:Cyp3a11 UTSW 5 145,802,804 (GRCm39) missense probably benign 0.04
R1400:Cyp3a11 UTSW 5 145,799,299 (GRCm39) missense probably damaging 0.98
R1478:Cyp3a11 UTSW 5 145,795,581 (GRCm39) missense probably benign 0.01
R1520:Cyp3a11 UTSW 5 145,799,263 (GRCm39) missense probably damaging 1.00
R1716:Cyp3a11 UTSW 5 145,805,776 (GRCm39) missense probably benign
R2060:Cyp3a11 UTSW 5 145,791,891 (GRCm39) missense probably benign 0.00
R2076:Cyp3a11 UTSW 5 145,816,576 (GRCm39) missense probably benign
R2227:Cyp3a11 UTSW 5 145,805,357 (GRCm39) missense possibly damaging 0.90
R3725:Cyp3a11 UTSW 5 145,802,810 (GRCm39) missense probably benign 0.02
R4222:Cyp3a11 UTSW 5 145,797,276 (GRCm39) missense probably damaging 0.99
R4256:Cyp3a11 UTSW 5 145,806,005 (GRCm39) missense probably benign 0.04
R4294:Cyp3a11 UTSW 5 145,806,005 (GRCm39) missense probably benign 0.04
R4852:Cyp3a11 UTSW 5 145,797,305 (GRCm39) missense probably damaging 1.00
R5229:Cyp3a11 UTSW 5 145,791,945 (GRCm39) missense probably benign 0.00
R5285:Cyp3a11 UTSW 5 145,791,893 (GRCm39) missense probably benign 0.00
R5590:Cyp3a11 UTSW 5 145,802,787 (GRCm39) missense probably benign 0.00
R5703:Cyp3a11 UTSW 5 145,797,183 (GRCm39) missense probably benign
R5786:Cyp3a11 UTSW 5 145,799,284 (GRCm39) missense possibly damaging 0.47
R6291:Cyp3a11 UTSW 5 145,799,237 (GRCm39) missense possibly damaging 0.89
R6405:Cyp3a11 UTSW 5 145,799,230 (GRCm39) missense probably damaging 0.96
R6892:Cyp3a11 UTSW 5 145,797,258 (GRCm39) missense probably damaging 0.98
R7114:Cyp3a11 UTSW 5 145,795,593 (GRCm39) missense probably benign 0.16
R7243:Cyp3a11 UTSW 5 145,795,613 (GRCm39) missense probably damaging 0.96
R7438:Cyp3a11 UTSW 5 145,802,710 (GRCm39) missense probably benign 0.39
R7611:Cyp3a11 UTSW 5 145,797,191 (GRCm39) missense probably benign 0.25
R8346:Cyp3a11 UTSW 5 145,795,612 (GRCm39) missense probably damaging 1.00
R8371:Cyp3a11 UTSW 5 145,805,438 (GRCm39) missense possibly damaging 0.92
R8895:Cyp3a11 UTSW 5 145,797,330 (GRCm39) missense probably benign
R9043:Cyp3a11 UTSW 5 145,805,995 (GRCm39) missense probably benign 0.02
R9300:Cyp3a11 UTSW 5 145,799,164 (GRCm39) missense possibly damaging 0.60
R9404:Cyp3a11 UTSW 5 145,799,258 (GRCm39) missense probably benign 0.40
Predicted Primers PCR Primer
(F):5'- TTGGAATTCTTCAGGCTCTGACC -3'
(R):5'- GGTGTTTAAATCATCCCACCTCTC -3'

Sequencing Primer
(F):5'- TTCAGGCTCTGACCAGTGCTG -3'
(R):5'- GGATCCATTCATATTGGAGTCCCAG -3'
Posted On 2019-06-07