Incidental Mutation 'PIT4544001:Nudt21'
ID 556415
Institutional Source Beutler Lab
Gene Symbol Nudt21
Ensembl Gene ENSMUSG00000031754
Gene Name nudix hydrolase 21
Synonyms Cpsf5, 3110048P04Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 21, 5730530J16Rik, 25kDa
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # PIT4544001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 94746031-94763667 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 94746225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 158 (F158I)
Ref Sequence ENSEMBL: ENSMUSP00000148485 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034204] [ENSMUST00000212622] [ENSMUST00000212911] [ENSMUST00000212981]
AlphaFold Q9CQF3
Predicted Effect probably benign
Transcript: ENSMUST00000034204
SMART Domains Protein: ENSMUSP00000034204
Gene: ENSMUSG00000031754

DomainStartEndE-ValueType
Pfam:NUDIX_2 35 222 9.9e-85 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000212622
AA Change: F158I
Predicted Effect probably benign
Transcript: ENSMUST00000212911
Predicted Effect probably benign
Transcript: ENSMUST00000212981
Coding Region Coverage
  • 1x: 92.9%
  • 3x: 90.6%
  • 10x: 84.5%
  • 20x: 71.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 A G 16: 14,222,943 (GRCm39) D248G probably damaging Het
Abcc12 A T 8: 87,231,875 (GRCm39) M1358K possibly damaging Het
Adgrl2 C T 3: 148,596,157 (GRCm39) E60K probably damaging Het
Aff3 C T 1: 38,249,443 (GRCm39) A555T probably benign Het
Aspn A T 13: 49,707,458 (GRCm39) K106* probably null Het
Atp8b3 A T 10: 80,366,420 (GRCm39) L281Q probably benign Het
Ccdc54 A T 16: 50,410,343 (GRCm39) C308S possibly damaging Het
Cpa1 T C 6: 30,641,857 (GRCm39) V227A probably benign Het
Dld G A 12: 31,385,556 (GRCm39) Q262* probably null Het
Eif4e3 A T 6: 99,609,314 (GRCm39) W161R probably damaging Het
Epha5 T A 5: 84,479,471 (GRCm39) T178S possibly damaging Het
Erbb2 A T 11: 98,311,865 (GRCm39) T134S probably benign Het
Golga3 A T 5: 110,336,556 (GRCm39) E358D possibly damaging Het
Gon7 A T 12: 102,720,409 (GRCm39) D74E probably benign Het
Hmcn2 A G 2: 31,318,262 (GRCm39) E3869G probably damaging Het
Ifit1bl1 C T 19: 34,571,415 (GRCm39) M347I possibly damaging Het
Ipo5 T A 14: 121,165,949 (GRCm39) D331E probably damaging Het
Mep1a C T 17: 43,793,178 (GRCm39) C355Y probably damaging Het
Nkain1 A G 4: 130,532,098 (GRCm38) S196P probably damaging Het
Padi3 T C 4: 140,518,794 (GRCm39) T443A probably benign Het
Parpbp A G 10: 87,950,411 (GRCm39) V323A possibly damaging Het
Phkb A G 8: 86,738,266 (GRCm39) I520V probably benign Het
Plxna1 A G 6: 89,334,411 (GRCm39) S73P probably benign Het
Rfk T C 19: 17,372,708 (GRCm39) S77P probably damaging Het
Sdk1 A G 5: 141,941,987 (GRCm39) N545S probably benign Het
Setd2 A G 9: 110,380,232 (GRCm39) N1349S probably damaging Het
Slc22a27 T A 19: 7,887,103 (GRCm39) Q262L probably damaging Het
Slc34a3 T C 2: 25,120,607 (GRCm39) D440G probably benign Het
Slc4a4 T C 5: 89,186,402 (GRCm39) L161P probably damaging Het
Stxbp5 A C 10: 9,693,048 (GRCm39) probably null Het
Tekt1 C T 11: 72,245,660 (GRCm39) R165H probably damaging Het
Tmpo T C 10: 90,997,976 (GRCm39) N604D probably benign Het
Trpm1 A T 7: 63,848,998 (GRCm39) probably benign Het
Ubqln3 A C 7: 103,790,550 (GRCm39) H513Q probably damaging Het
Ubr4 A G 4: 139,129,871 (GRCm39) N664D possibly damaging Het
Usp37 G A 1: 74,509,738 (GRCm39) T477I possibly damaging Het
Zbtb11 T G 16: 55,818,556 (GRCm39) L660* probably null Het
Other mutations in Nudt21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02226:Nudt21 APN 8 94,746,329 (GRCm39) nonsense probably null
R1172:Nudt21 UTSW 8 94,757,757 (GRCm39) splice site probably benign
R1576:Nudt21 UTSW 8 94,755,461 (GRCm39) critical splice donor site probably null
R6293:Nudt21 UTSW 8 94,755,506 (GRCm39) missense probably damaging 1.00
R6474:Nudt21 UTSW 8 94,746,282 (GRCm39) missense probably benign 0.02
R6961:Nudt21 UTSW 8 94,755,508 (GRCm39) missense probably benign
R7312:Nudt21 UTSW 8 94,746,227 (GRCm39) missense probably benign 0.00
R7737:Nudt21 UTSW 8 94,749,461 (GRCm39) missense probably damaging 1.00
R7755:Nudt21 UTSW 8 94,749,493 (GRCm39) missense probably benign 0.33
R8539:Nudt21 UTSW 8 94,763,601 (GRCm39) start gained probably benign
R8894:Nudt21 UTSW 8 94,755,498 (GRCm39) missense probably damaging 1.00
R9103:Nudt21 UTSW 8 94,746,321 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGATCCTCGGCTCTAAGACTTTTC -3'
(R):5'- ATGTTTAACATGTCGGAAGGGG -3'

Sequencing Primer
(F):5'- CCAAAAGCTAATGAACACTG -3'
(R):5'- TTTAACATGTCGGAAGGGGAGAGATG -3'
Posted On 2019-06-07