Mutagenetix > Incidental Mutation

Incidental Mutation 'PIT4677001:Utrn'

556561

Institutional Source

Beutler Lab

Gene Symbol

Utrn

Ensembl Gene

ENSMUSG00000019820

Gene Name

utrophin

Synonyms

G-utrophin, DRP, Dmdl

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

PIT4677001 (G1)

Quality Score

133.008

Status

Not validated

Chromosome

Chromosomal Location

12382188-12869365 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12666704 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 1846 (I1846F)

Ref Sequence

ENSEMBL: ENSMUSP00000076093 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076817] [ENSMUST00000218635]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000076817
AA Change: I1846F

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000076093
Gene: ENSMUSG00000019820
AA Change: I1846F

Domain	Start	End	E-Value	Type
CH	33	133	1.87e-24	SMART
CH	152	250	4.05e-20	SMART
SPEC	312	416	2.31e-18	SMART
SPEC	421	525	4.18e-16	SMART
SPEC	532	636	3.35e-6	SMART
low complexity region	665	679	N/A	INTRINSIC
SPEC	690	795	1.7e-7	SMART
SPEC	801	901	1e-4	SMART
SPEC	910	1012	8.24e-2	SMART
SPEC	1019	1121	1.32e-4	SMART
SPEC	1128	1229	2.64e-4	SMART
SPEC	1236	1333	4.42e-6	SMART
coiled coil region	1375	1401	N/A	INTRINSIC
SPEC	1438	1540	3.62e-2	SMART
SPEC	1547	1648	7.95e-1	SMART
SPEC	1655	1752	3.56e0	SMART
coiled coil region	1766	1795	N/A	INTRINSIC
SPEC	1870	1972	3.63e0	SMART
SPEC	1979	2080	5.15e-16	SMART
SPEC	2087	2183	3.71e0	SMART
SPEC	2227	2330	4.7e-10	SMART
SPEC	2337	2437	1.02e0	SMART
SPEC	2444	2553	2.35e-10	SMART
SPEC	2560	2685	8.77e-10	SMART
SPEC	2692	2794	4.13e-6	SMART
WW	2811	2843	5.59e-7	SMART
Pfam:EF-hand_2	2844	2962	3.8e-41	PFAM
Pfam:EF-hand_3	2966	3057	1.6e-39	PFAM
ZnF_ZZ	3062	3107	6.33e-17	SMART
coiled coil region	3250	3289	N/A	INTRINSIC
coiled coil region	3310	3354	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000218635
AA Change: I1846F

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)

Coding Region Coverage

1x: 93.3%
3x: 90.8%
10x: 84.5%
20x: 71.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants have reduced density of acetylcholine receptors and reduced number of junctional folds at neuromuscular junctions. Mice homozygous for utrophin and dystrophin knockouts die prematurely with severe, progressive muscular dystrophy. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810024B03Rik	T	A	2: 127,187,013 (GRCm38)	T89S	probably benign	Het
4921517D22Rik	A	T	13: 59,690,491 (GRCm38)	F176I	probably benign	Het
Acsm3	A	G	7: 119,775,117 (GRCm38)	D264G	probably damaging	Het
Adamts12	T	A	15: 11,286,810 (GRCm38)	F834I	probably benign	Het
Arhgap45	A	T	10: 80,020,749 (GRCm38)	M171L	probably benign	Het
Arid5b	A	T	10: 68,098,011 (GRCm38)	M687K	probably damaging	Het
AU040320	A	T	4: 126,792,237 (GRCm38)	Q202L	probably benign	Het
Ccdc47	A	G	11: 106,208,208 (GRCm38)	L219P	probably damaging	Het
Cfhr2	T	G	1: 139,805,379 (GRCm38)	S301R	unknown	Het
Cog2	T	A	8: 124,545,271 (GRCm38)	V508E	probably benign	Het
Cpb2	A	G	14: 75,256,023 (GRCm38)	T47A	probably benign	Het
Ddx60	A	T	8: 61,972,254 (GRCm38)	K692I	possibly damaging	Het
Defb34	A	T	8: 19,126,396 (GRCm38)	R34S	possibly damaging	Het
Fads2	A	T	19: 10,070,330 (GRCm38)	I275N	probably damaging	Het
Fam196b	A	T	11: 34,403,122 (GRCm38)	N388I	probably benign	Het
Fmn2	T	G	1: 174,647,133 (GRCm38)	S1221A	probably damaging	Het
Fndc3a	A	T	14: 72,574,595 (GRCm38)	V302E	probably benign	Het
Galntl6	C	T	8: 57,857,587 (GRCm38)	C360Y	probably damaging	Het
Gm14025	T	C	2: 129,038,716 (GRCm38)	D430G		Het
Gm16519	A	T	17: 70,929,511 (GRCm38)	I152F	probably benign	Het
Hnrnpr	T	A	4: 136,329,439 (GRCm38)	V250D	probably damaging	Het
Hs3st6	A	G	17: 24,758,311 (GRCm38)	D255G	possibly damaging	Het
Ino80	C	T	2: 119,377,545 (GRCm38)	V1422M	probably benign	Het
Kcnu1	A	G	8: 25,905,993 (GRCm38)	I669V	probably benign	Het
Layn	A	T	9: 51,057,411 (GRCm38)	V344E	probably damaging	Het
Mgll	A	T	6: 88,825,681 (GRCm38)	R273W	possibly damaging	Het
Myh2	G	A	11: 67,181,992 (GRCm38)	S636N	probably benign	Het
Nmur2	A	T	11: 56,033,009 (GRCm38)	S240T	probably benign	Het
Pkd1	T	G	17: 24,574,029 (GRCm38)	S1563R	possibly damaging	Het
Ppp4r3b	G	A	11: 29,187,978 (GRCm38)	V109I	probably benign	Het
Prdm2	A	T	4: 143,135,078 (GRCm38)	D547E	probably damaging	Het
Prss46	A	T	9: 110,856,030 (GRCm38)	M241L	probably benign	Het
Ptprf	T	A	4: 118,213,612 (GRCm38)	I1397F	probably damaging	Het
Pus10	A	T	11: 23,720,171 (GRCm38)	T418S	possibly damaging	Het
Qsox2	T	C	2: 26,222,308 (GRCm38)	D74G	probably damaging	Het
Sctr	T	C	1: 120,061,904 (GRCm38)	V383A	probably damaging	Het
Siglec1	T	A	2: 131,072,757 (GRCm38)	N1480Y	probably damaging	Het
Skint2	T	C	4: 112,625,938 (GRCm38)	I180T	probably benign	Het
Snd1	A	G	6: 28,880,296 (GRCm38)	I690V	probably benign	Het
Spire1	T	C	18: 67,491,365 (GRCm38)	T575A	probably damaging	Het
Srbd1	G	A	17: 86,115,212 (GRCm38)	R459*	probably null	Het
Tll2	C	A	19: 41,130,558 (GRCm38)	V244L	probably benign	Het
Tmem60	A	G	5: 20,886,368 (GRCm38)	I44V	probably benign	Het
Ttc30a1	A	G	2: 75,979,769 (GRCm38)	Y657H	possibly damaging	Het
Vps8	T	C	16: 21,500,334 (GRCm38)	F641S	possibly damaging	Het

Other mutations in Utrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Utrn	APN	10	12,671,830 (GRCm38)	missense	probably damaging	1.00
IGL00469:Utrn	APN	10	12,406,529 (GRCm38)	missense	probably damaging	1.00
IGL00518:Utrn	APN	10	12,666,843 (GRCm38)	splice site	probably benign
IGL00560:Utrn	APN	10	12,455,467 (GRCm38)	nonsense	probably null
IGL00589:Utrn	APN	10	12,678,618 (GRCm38)	missense	possibly damaging	0.53
IGL00662:Utrn	APN	10	12,664,961 (GRCm38)	missense	probably damaging	0.99
IGL00754:Utrn	APN	10	12,663,492 (GRCm38)	missense	probably benign	0.05
IGL00772:Utrn	APN	10	12,649,185 (GRCm38)	missense	probably benign
IGL00775:Utrn	APN	10	12,745,230 (GRCm38)	critical splice donor site	probably null
IGL00782:Utrn	APN	10	12,652,811 (GRCm38)	missense	probably benign	0.13
IGL00962:Utrn	APN	10	12,481,334 (GRCm38)	missense	possibly damaging	0.80
IGL01584:Utrn	APN	10	12,726,367 (GRCm38)	missense	probably benign	0.01
IGL01677:Utrn	APN	10	12,744,157 (GRCm38)	missense	probably damaging	1.00
IGL01695:Utrn	APN	10	12,745,342 (GRCm38)	missense	probably benign	0.00
IGL01743:Utrn	APN	10	12,711,557 (GRCm38)	missense	possibly damaging	0.94
IGL01815:Utrn	APN	10	12,652,716 (GRCm38)	missense	probably benign	0.00
IGL01901:Utrn	APN	10	12,640,928 (GRCm38)	missense	probably damaging	1.00
IGL01982:Utrn	APN	10	12,748,029 (GRCm38)	missense	probably damaging	1.00
IGL01983:Utrn	APN	10	12,669,781 (GRCm38)	missense	probably benign	0.18
IGL02031:Utrn	APN	10	12,735,204 (GRCm38)	missense	probably damaging	1.00
IGL02106:Utrn	APN	10	12,413,973 (GRCm38)	missense	possibly damaging	0.92
IGL02134:Utrn	APN	10	12,643,419 (GRCm38)	missense	probably damaging	0.99
IGL02209:Utrn	APN	10	12,683,295 (GRCm38)	missense	probably damaging	0.97
IGL02217:Utrn	APN	10	12,751,559 (GRCm38)	missense	probably damaging	1.00
IGL02250:Utrn	APN	10	12,436,391 (GRCm38)	missense	probably damaging	1.00
IGL02307:Utrn	APN	10	12,750,065 (GRCm38)	nonsense	probably null
IGL02386:Utrn	APN	10	12,421,608 (GRCm38)	missense	possibly damaging	0.91
IGL02494:Utrn	APN	10	12,710,054 (GRCm38)	missense	probably benign
IGL02631:Utrn	APN	10	12,710,063 (GRCm38)	missense	probably benign	0.00
IGL02729:Utrn	APN	10	12,720,810 (GRCm38)	unclassified	probably benign
IGL02736:Utrn	APN	10	12,421,640 (GRCm38)	missense	probably damaging	1.00
IGL02832:Utrn	APN	10	12,738,193 (GRCm38)	missense	possibly damaging	0.82
IGL02926:Utrn	APN	10	12,690,760 (GRCm38)	missense	probably damaging	0.96
IGL03184:Utrn	APN	10	12,710,166 (GRCm38)	missense	probably benign	0.04
IGL03194:Utrn	APN	10	12,406,429 (GRCm38)	splice site	probably benign
IGL03346:Utrn	APN	10	12,525,352 (GRCm38)	missense	probably benign	0.22
retiring	UTSW	10	12,641,020 (GRCm38)	missense	probably damaging	1.00
shrinking_violet	UTSW	10	12,711,585 (GRCm38)	critical splice acceptor site	probably null
Wallflower	UTSW	10	12,747,975 (GRCm38)	missense	probably damaging	1.00
FR4548:Utrn	UTSW	10	12,633,941 (GRCm38)	critical splice donor site	probably benign
I2288:Utrn	UTSW	10	12,421,640 (GRCm38)	missense	probably damaging	1.00
R0022:Utrn	UTSW	10	12,709,956 (GRCm38)	splice site	probably benign
R0024:Utrn	UTSW	10	12,406,011 (GRCm38)	missense	probably benign	0.00
R0024:Utrn	UTSW	10	12,406,011 (GRCm38)	missense	probably benign	0.00
R0026:Utrn	UTSW	10	12,726,196 (GRCm38)	splice site	probably benign
R0026:Utrn	UTSW	10	12,726,196 (GRCm38)	splice site	probably benign
R0091:Utrn	UTSW	10	12,735,204 (GRCm38)	missense	probably damaging	1.00
R0112:Utrn	UTSW	10	12,686,465 (GRCm38)	nonsense	probably null
R0126:Utrn	UTSW	10	12,711,475 (GRCm38)	missense	probably benign	0.02
R0184:Utrn	UTSW	10	12,667,618 (GRCm38)	missense	probably benign
R0219:Utrn	UTSW	10	12,684,451 (GRCm38)	missense	probably damaging	1.00
R0369:Utrn	UTSW	10	12,634,022 (GRCm38)	missense	probably benign	0.37
R0390:Utrn	UTSW	10	12,710,060 (GRCm38)	missense	probably benign	0.05
R0391:Utrn	UTSW	10	12,525,333 (GRCm38)	splice site	probably benign
R0408:Utrn	UTSW	10	12,384,190 (GRCm38)	makesense	probably null
R0409:Utrn	UTSW	10	12,643,601 (GRCm38)	missense	probably benign	0.01
R0441:Utrn	UTSW	10	12,688,294 (GRCm38)	missense	probably null	0.88
R0504:Utrn	UTSW	10	12,402,895 (GRCm38)	missense	probably benign	0.02
R0730:Utrn	UTSW	10	12,698,158 (GRCm38)	splice site	probably benign
R1078:Utrn	UTSW	10	12,455,566 (GRCm38)	critical splice acceptor site	probably null
R1171:Utrn	UTSW	10	12,481,308 (GRCm38)	missense	probably damaging	0.99
R1191:Utrn	UTSW	10	12,634,033 (GRCm38)	missense	probably benign	0.02
R1203:Utrn	UTSW	10	12,486,537 (GRCm38)	missense	probably damaging	1.00
R1401:Utrn	UTSW	10	12,649,153 (GRCm38)	missense	probably benign
R1418:Utrn	UTSW	10	12,713,350 (GRCm38)	missense	probably benign
R1439:Utrn	UTSW	10	12,744,049 (GRCm38)	missense	possibly damaging	0.79
R1441:Utrn	UTSW	10	12,683,295 (GRCm38)	missense	probably damaging	0.97
R1445:Utrn	UTSW	10	12,678,574 (GRCm38)	splice site	probably benign
R1509:Utrn	UTSW	10	12,455,441 (GRCm38)	missense	possibly damaging	0.91
R1546:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R1585:Utrn	UTSW	10	12,436,285 (GRCm38)	missense	possibly damaging	0.62
R1621:Utrn	UTSW	10	12,713,283 (GRCm38)	missense	probably benign	0.24
R1637:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R1703:Utrn	UTSW	10	12,727,729 (GRCm38)	splice site	probably benign
R1725:Utrn	UTSW	10	12,663,519 (GRCm38)	missense	probably damaging	0.99
R1735:Utrn	UTSW	10	12,710,138 (GRCm38)	missense	probably benign
R1770:Utrn	UTSW	10	12,475,296 (GRCm38)	missense	probably damaging	0.98
R1778:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R1783:Utrn	UTSW	10	12,463,339 (GRCm38)	missense	probably damaging	1.00
R1818:Utrn	UTSW	10	12,709,964 (GRCm38)	critical splice donor site	probably null
R1829:Utrn	UTSW	10	12,475,274 (GRCm38)	missense	probably damaging	1.00
R1919:Utrn	UTSW	10	12,455,480 (GRCm38)	missense	probably benign	0.15
R1964:Utrn	UTSW	10	12,684,437 (GRCm38)	missense	probably damaging	1.00
R2080:Utrn	UTSW	10	12,737,082 (GRCm38)	missense	probably benign	0.36
R2092:Utrn	UTSW	10	12,678,698 (GRCm38)	missense	probably benign	0.12
R2107:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R2108:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R2760:Utrn	UTSW	10	12,690,878 (GRCm38)	missense	probably damaging	1.00
R2884:Utrn	UTSW	10	12,739,361 (GRCm38)	splice site	probably null
R2885:Utrn	UTSW	10	12,739,361 (GRCm38)	splice site	probably null
R2886:Utrn	UTSW	10	12,739,361 (GRCm38)	splice site	probably null
R2903:Utrn	UTSW	10	12,643,428 (GRCm38)	missense	probably damaging	1.00
R2944:Utrn	UTSW	10	12,643,419 (GRCm38)	missense	probably damaging	1.00
R2945:Utrn	UTSW	10	12,486,391 (GRCm38)	missense	possibly damaging	0.50
R3438:Utrn	UTSW	10	12,481,318 (GRCm38)	missense	probably damaging	0.98
R3683:Utrn	UTSW	10	12,666,835 (GRCm38)	missense	probably benign	0.10
R3735:Utrn	UTSW	10	12,478,484 (GRCm38)	missense	probably damaging	1.00
R3907:Utrn	UTSW	10	12,710,182 (GRCm38)	splice site	probably benign
R3923:Utrn	UTSW	10	12,739,479 (GRCm38)	missense	probably benign	0.23
R3925:Utrn	UTSW	10	12,698,042 (GRCm38)	missense	probably benign
R3926:Utrn	UTSW	10	12,698,042 (GRCm38)	missense	probably benign
R3938:Utrn	UTSW	10	12,750,030 (GRCm38)	critical splice donor site	probably null
R3941:Utrn	UTSW	10	12,711,585 (GRCm38)	critical splice acceptor site	probably null
R3958:Utrn	UTSW	10	12,750,108 (GRCm38)	missense	probably damaging	1.00
R4091:Utrn	UTSW	10	12,710,171 (GRCm38)	missense	probably benign	0.10
R4454:Utrn	UTSW	10	12,727,840 (GRCm38)	missense	possibly damaging	0.81
R4585:Utrn	UTSW	10	12,688,306 (GRCm38)	missense	probably benign	0.01
R4667:Utrn	UTSW	10	12,698,053 (GRCm38)	missense	probably benign	0.22
R4684:Utrn	UTSW	10	12,745,240 (GRCm38)	missense	probably damaging	1.00
R4782:Utrn	UTSW	10	12,750,069 (GRCm38)	missense	probably damaging	1.00
R4785:Utrn	UTSW	10	12,654,745 (GRCm38)	missense	probably benign	0.39
R4799:Utrn	UTSW	10	12,750,069 (GRCm38)	missense	probably damaging	1.00
R4829:Utrn	UTSW	10	12,663,461 (GRCm38)	missense	probably benign	0.00
R4878:Utrn	UTSW	10	12,727,758 (GRCm38)	missense	probably damaging	1.00
R4955:Utrn	UTSW	10	12,861,567 (GRCm38)	critical splice donor site	probably null
R4967:Utrn	UTSW	10	12,455,420 (GRCm38)	missense	probably damaging	0.99
R5071:Utrn	UTSW	10	12,384,204 (GRCm38)	splice site	probably null
R5072:Utrn	UTSW	10	12,384,204 (GRCm38)	splice site	probably null
R5186:Utrn	UTSW	10	12,728,777 (GRCm38)	missense	probably damaging	1.00
R5213:Utrn	UTSW	10	12,636,760 (GRCm38)	missense	probably damaging	1.00
R5296:Utrn	UTSW	10	12,401,355 (GRCm38)	missense	probably damaging	1.00
R5309:Utrn	UTSW	10	12,727,769 (GRCm38)	missense	probably damaging	1.00
R5312:Utrn	UTSW	10	12,727,769 (GRCm38)	missense	probably damaging	1.00
R5399:Utrn	UTSW	10	12,640,983 (GRCm38)	missense	probably damaging	1.00
R5407:Utrn	UTSW	10	12,680,625 (GRCm38)	missense	probably damaging	1.00
R5411:Utrn	UTSW	10	12,649,185 (GRCm38)	missense	probably benign
R5428:Utrn	UTSW	10	12,693,431 (GRCm38)	missense	probably benign	0.09
R5595:Utrn	UTSW	10	12,682,318 (GRCm38)	missense	possibly damaging	0.89
R5602:Utrn	UTSW	10	12,750,095 (GRCm38)	missense	probably damaging	1.00
R5608:Utrn	UTSW	10	12,671,837 (GRCm38)	missense	probably benign	0.00
R5678:Utrn	UTSW	10	12,442,018 (GRCm38)	missense	probably damaging	1.00
R5726:Utrn	UTSW	10	12,669,806 (GRCm38)	missense	probably benign
R5804:Utrn	UTSW	10	12,421,625 (GRCm38)	missense	probably damaging	1.00
R5916:Utrn	UTSW	10	12,665,051 (GRCm38)	missense	probably damaging	0.97
R5941:Utrn	UTSW	10	12,486,483 (GRCm38)	missense	probably damaging	1.00
R6014:Utrn	UTSW	10	12,690,876 (GRCm38)	missense	probably benign	0.01
R6015:Utrn	UTSW	10	12,478,424 (GRCm38)	missense	possibly damaging	0.85
R6028:Utrn	UTSW	10	12,654,716 (GRCm38)	missense	probably benign	0.00
R6158:Utrn	UTSW	10	12,690,822 (GRCm38)	missense	probably benign	0.04
R6181:Utrn	UTSW	10	12,739,456 (GRCm38)	missense	probably damaging	1.00
R6300:Utrn	UTSW	10	12,501,476 (GRCm38)	missense	probably benign	0.35
R6367:Utrn	UTSW	10	12,747,975 (GRCm38)	missense	probably damaging	1.00
R6377:Utrn	UTSW	10	12,744,083 (GRCm38)	missense	probably damaging	1.00
R6434:Utrn	UTSW	10	12,525,427 (GRCm38)	missense	probably damaging	1.00
R6498:Utrn	UTSW	10	12,442,093 (GRCm38)	missense	probably benign
R6579:Utrn	UTSW	10	12,748,006 (GRCm38)	missense	probably benign	0.05
R6704:Utrn	UTSW	10	12,745,291 (GRCm38)	missense	probably damaging	0.99
R6736:Utrn	UTSW	10	12,621,303 (GRCm38)	missense	probably benign	0.09
R6755:Utrn	UTSW	10	12,699,087 (GRCm38)	missense	probably benign	0.00
R6793:Utrn	UTSW	10	12,699,100 (GRCm38)	missense	possibly damaging	0.69
R6793:Utrn	UTSW	10	12,640,925 (GRCm38)	critical splice donor site	probably null
R6835:Utrn	UTSW	10	12,727,764 (GRCm38)	missense	probably damaging	1.00
R6919:Utrn	UTSW	10	12,693,470 (GRCm38)	nonsense	probably null
R6920:Utrn	UTSW	10	12,750,470 (GRCm38)	missense	probably damaging	0.98
R7037:Utrn	UTSW	10	12,826,770 (GRCm38)	splice site	probably null
R7038:Utrn	UTSW	10	12,682,338 (GRCm38)	missense	probably damaging	1.00
R7055:Utrn	UTSW	10	12,747,921 (GRCm38)	missense	probably benign	0.23
R7072:Utrn	UTSW	10	12,465,213 (GRCm38)	missense	probably damaging	1.00
R7090:Utrn	UTSW	10	12,684,516 (GRCm38)	missense	possibly damaging	0.58
R7211:Utrn	UTSW	10	12,401,335 (GRCm38)	missense	possibly damaging	0.72
R7248:Utrn	UTSW	10	12,728,818 (GRCm38)	missense	possibly damaging	0.51
R7305:Utrn	UTSW	10	12,385,536 (GRCm38)	missense	probably benign
R7334:Utrn	UTSW	10	12,728,009 (GRCm38)	splice site	probably null
R7348:Utrn	UTSW	10	12,748,018 (GRCm38)	missense	probably damaging	1.00
R7375:Utrn	UTSW	10	12,641,020 (GRCm38)	missense	probably damaging	1.00
R7436:Utrn	UTSW	10	12,439,791 (GRCm38)	missense	possibly damaging	0.72
R7476:Utrn	UTSW	10	12,640,951 (GRCm38)	missense	probably benign
R7514:Utrn	UTSW	10	12,698,089 (GRCm38)	missense	probably benign	0.00
R7527:Utrn	UTSW	10	12,401,382 (GRCm38)	missense	possibly damaging	0.81
R7735:Utrn	UTSW	10	12,744,043 (GRCm38)	critical splice donor site	probably null
R7748:Utrn	UTSW	10	12,614,508 (GRCm38)	missense	probably benign	0.01
R7778:Utrn	UTSW	10	12,486,610 (GRCm38)	missense	probably damaging	1.00
R7824:Utrn	UTSW	10	12,486,610 (GRCm38)	missense	probably damaging	1.00
R7826:Utrn	UTSW	10	12,401,306 (GRCm38)	splice site	probably null
R7872:Utrn	UTSW	10	12,698,129 (GRCm38)	missense	probably benign
R7915:Utrn	UTSW	10	12,465,212 (GRCm38)	missense	probably damaging	1.00
R7922:Utrn	UTSW	10	12,667,527 (GRCm38)	missense	possibly damaging	0.68
R8081:Utrn	UTSW	10	12,548,059 (GRCm38)	start gained	probably benign
R8132:Utrn	UTSW	10	12,682,410 (GRCm38)	missense	probably damaging	0.99
R8167:Utrn	UTSW	10	12,671,814 (GRCm38)	nonsense	probably null
R8186:Utrn	UTSW	10	12,698,123 (GRCm38)	missense	probably benign
R8331:Utrn	UTSW	10	12,614,619 (GRCm38)	missense	probably benign	0.00
R8352:Utrn	UTSW	10	12,813,509 (GRCm38)	missense	probably benign	0.34
R8408:Utrn	UTSW	10	12,670,143 (GRCm38)	missense	possibly damaging	0.69
R8452:Utrn	UTSW	10	12,813,509 (GRCm38)	missense	probably benign	0.34
R8478:Utrn	UTSW	10	12,649,148 (GRCm38)	missense	probably benign
R8489:Utrn	UTSW	10	12,711,446 (GRCm38)	missense	probably benign	0.05
R8516:Utrn	UTSW	10	12,486,510 (GRCm38)	missense	probably damaging	0.99
R8520:Utrn	UTSW	10	12,670,186 (GRCm38)	nonsense	probably null
R8550:Utrn	UTSW	10	12,813,585 (GRCm38)	intron	probably benign
R8856:Utrn	UTSW	10	12,667,607 (GRCm38)	missense	probably benign
R8881:Utrn	UTSW	10	12,547,993 (GRCm38)	missense	possibly damaging	0.46
R9180:Utrn	UTSW	10	12,669,719 (GRCm38)	missense	probably damaging	1.00
R9186:Utrn	UTSW	10	12,614,574 (GRCm38)	missense	probably benign
R9216:Utrn	UTSW	10	12,813,485 (GRCm38)	missense	probably benign	0.19
R9251:Utrn	UTSW	10	12,636,787 (GRCm38)	missense	probably benign	0.01
R9273:Utrn	UTSW	10	12,633,963 (GRCm38)	missense	probably damaging	0.97
R9307:Utrn	UTSW	10	12,678,731 (GRCm38)	missense	probably benign	0.02
R9344:Utrn	UTSW	10	12,684,531 (GRCm38)	missense	probably benign	0.17
R9419:Utrn	UTSW	10	12,688,381 (GRCm38)	missense	probably damaging	1.00
R9435:Utrn	UTSW	10	12,643,429 (GRCm38)	missense	probably damaging	1.00
R9623:Utrn	UTSW	10	12,406,481 (GRCm38)	missense	probably damaging	1.00
R9650:Utrn	UTSW	10	12,738,185 (GRCm38)	missense	probably benign	0.00
R9653:Utrn	UTSW	10	12,663,445 (GRCm38)	missense	probably benign	0.41
R9653:Utrn	UTSW	10	12,621,379 (GRCm38)	missense	probably benign	0.17
R9672:Utrn	UTSW	10	12,727,869 (GRCm38)	missense	possibly damaging	0.68
R9678:Utrn	UTSW	10	12,739,415 (GRCm38)	missense	probably benign	0.00
R9741:Utrn	UTSW	10	12,826,820 (GRCm38)	missense	probably benign
R9765:Utrn	UTSW	10	12,735,177 (GRCm38)	missense	probably damaging	0.99
R9799:Utrn	UTSW	10	12,709,992 (GRCm38)	missense	probably benign	0.01
RF009:Utrn	UTSW	10	12,633,945 (GRCm38)	nonsense	probably null
V1662:Utrn	UTSW	10	12,421,640 (GRCm38)	missense	probably damaging	1.00
X0018:Utrn	UTSW	10	12,735,198 (GRCm38)	missense	probably damaging	1.00
Z1176:Utrn	UTSW	10	12,688,429 (GRCm38)	critical splice acceptor site	probably null
Z1176:Utrn	UTSW	10	12,682,360 (GRCm38)	nonsense	probably null
Z1177:Utrn	UTSW	10	12,621,379 (GRCm38)	missense	probably benign	0.17
Z1177:Utrn	UTSW	10	12,525,406 (GRCm38)	nonsense	probably null
Z1186:Utrn	UTSW	10	12,669,747 (GRCm38)	missense	probably damaging	1.00
Z1189:Utrn	UTSW	10	12,669,747 (GRCm38)	missense	probably damaging	1.00
Z1191:Utrn	UTSW	10	12,669,747 (GRCm38)	missense	probably damaging	1.00
Z1192:Utrn	UTSW	10	12,669,747 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TATACACCAGGAATAGGATCCAATC -3'
(R):5'- CAATGGAGAGTACGAAGTTTGTC -3'

Sequencing Primer
(F):5'- CCCTAGGTGATTTGCTTGA -3'
(R):5'- GTACGAAGTTTGTCTGTGTATTTTTG -3'

Posted On

2019-06-07