Incidental Mutation 'PIT4677001:4921517D22Rik'
ID |
556570 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
4921517D22Rik
|
Ensembl Gene |
ENSMUSG00000049902 |
Gene Name |
RIKEN cDNA 4921517D22 gene |
Synonyms |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.073)
|
Stock # |
PIT4677001 (G1)
|
Quality Score |
174.009 |
Status
|
Not validated
|
Chromosome |
13 |
Chromosomal Location |
59835216-59841917 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 59838305 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Isoleucine
at position 176
(F176I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000061773
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061597]
[ENSMUST00000225373]
|
AlphaFold |
Q8CET0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000061597
AA Change: F176I
PolyPhen 2
Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
|
Predicted Effect |
probably null
Transcript: ENSMUST00000225373
AA Change: C119*
|
Coding Region Coverage |
- 1x: 93.3%
- 3x: 90.8%
- 10x: 84.5%
- 20x: 71.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 45 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1810024B03Rik |
T |
A |
2: 127,028,933 (GRCm39) |
T89S |
probably benign |
Het |
Acsm3 |
A |
G |
7: 119,374,340 (GRCm39) |
D264G |
probably damaging |
Het |
Adamts12 |
T |
A |
15: 11,286,896 (GRCm39) |
F834I |
probably benign |
Het |
Arhgap45 |
A |
T |
10: 79,856,583 (GRCm39) |
M171L |
probably benign |
Het |
Arid5b |
A |
T |
10: 67,933,841 (GRCm39) |
M687K |
probably damaging |
Het |
AU040320 |
A |
T |
4: 126,686,030 (GRCm39) |
Q202L |
probably benign |
Het |
Ccdc47 |
A |
G |
11: 106,099,034 (GRCm39) |
L219P |
probably damaging |
Het |
Cfhr2 |
T |
G |
1: 139,733,117 (GRCm39) |
S301R |
unknown |
Het |
Cog2 |
T |
A |
8: 125,272,010 (GRCm39) |
V508E |
probably benign |
Het |
Cpb2 |
A |
G |
14: 75,493,463 (GRCm39) |
T47A |
probably benign |
Het |
Ddx60 |
A |
T |
8: 62,425,288 (GRCm39) |
K692I |
possibly damaging |
Het |
Defb34 |
A |
T |
8: 19,176,412 (GRCm39) |
R34S |
possibly damaging |
Het |
Fads2 |
A |
T |
19: 10,047,694 (GRCm39) |
I275N |
probably damaging |
Het |
Fmn2 |
T |
G |
1: 174,474,699 (GRCm39) |
S1221A |
probably damaging |
Het |
Fndc3a |
A |
T |
14: 72,812,035 (GRCm39) |
V302E |
probably benign |
Het |
Galntl6 |
C |
T |
8: 58,310,621 (GRCm39) |
C360Y |
probably damaging |
Het |
Gm16519 |
A |
T |
17: 71,236,506 (GRCm39) |
I152F |
probably benign |
Het |
Hnrnpr |
T |
A |
4: 136,056,750 (GRCm39) |
V250D |
probably damaging |
Het |
Hs3st6 |
A |
G |
17: 24,977,285 (GRCm39) |
D255G |
possibly damaging |
Het |
Ift70a1 |
A |
G |
2: 75,810,113 (GRCm39) |
Y657H |
possibly damaging |
Het |
Ino80 |
C |
T |
2: 119,208,026 (GRCm39) |
V1422M |
probably benign |
Het |
Insyn2b |
A |
T |
11: 34,353,122 (GRCm39) |
N388I |
probably benign |
Het |
Kcnu1 |
A |
G |
8: 26,396,021 (GRCm39) |
I669V |
probably benign |
Het |
Layn |
A |
T |
9: 50,968,711 (GRCm39) |
V344E |
probably damaging |
Het |
Mgll |
A |
T |
6: 88,802,663 (GRCm39) |
R273W |
possibly damaging |
Het |
Myh2 |
G |
A |
11: 67,072,818 (GRCm39) |
S636N |
probably benign |
Het |
Nmur2 |
A |
T |
11: 55,923,835 (GRCm39) |
S240T |
probably benign |
Het |
Pkd1 |
T |
G |
17: 24,793,003 (GRCm39) |
S1563R |
possibly damaging |
Het |
Ppp4r3b |
G |
A |
11: 29,137,978 (GRCm39) |
V109I |
probably benign |
Het |
Prdm2 |
A |
T |
4: 142,861,648 (GRCm39) |
D547E |
probably damaging |
Het |
Prss46 |
A |
T |
9: 110,685,098 (GRCm39) |
M241L |
probably benign |
Het |
Ptprf |
T |
A |
4: 118,070,809 (GRCm39) |
I1397F |
probably damaging |
Het |
Pus10 |
A |
T |
11: 23,670,171 (GRCm39) |
T418S |
possibly damaging |
Het |
Qsox2 |
T |
C |
2: 26,112,320 (GRCm39) |
D74G |
probably damaging |
Het |
Sctr |
T |
C |
1: 119,989,634 (GRCm39) |
V383A |
probably damaging |
Het |
Siglec1 |
T |
A |
2: 130,914,677 (GRCm39) |
N1480Y |
probably damaging |
Het |
Skint2 |
T |
C |
4: 112,483,135 (GRCm39) |
I180T |
probably benign |
Het |
Snd1 |
A |
G |
6: 28,880,295 (GRCm39) |
I690V |
probably benign |
Het |
Spire1 |
T |
C |
18: 67,624,435 (GRCm39) |
T575A |
probably damaging |
Het |
Srbd1 |
G |
A |
17: 86,422,640 (GRCm39) |
R459* |
probably null |
Het |
Tll2 |
C |
A |
19: 41,118,997 (GRCm39) |
V244L |
probably benign |
Het |
Tmem60 |
A |
G |
5: 21,091,366 (GRCm39) |
I44V |
probably benign |
Het |
Utrn |
T |
A |
10: 12,542,448 (GRCm39) |
I1846F |
probably benign |
Het |
Vinac1 |
T |
C |
2: 128,880,636 (GRCm39) |
D430G |
|
Het |
Vps8 |
T |
C |
16: 21,319,084 (GRCm39) |
F641S |
possibly damaging |
Het |
|
Other mutations in 4921517D22Rik |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00827:4921517D22Rik
|
APN |
13 |
59,837,290 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01516:4921517D22Rik
|
APN |
13 |
59,838,548 (GRCm39) |
missense |
probably benign |
0.00 |
R0395:4921517D22Rik
|
UTSW |
13 |
59,837,470 (GRCm39) |
missense |
possibly damaging |
0.94 |
R0579:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0664:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0757:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0758:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0777:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0779:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0814:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0870:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0872:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R0873:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1062:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1064:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1149:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1149:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1151:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1152:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1207:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1207:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1285:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1339:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1358:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1359:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1360:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1361:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R1679:4921517D22Rik
|
UTSW |
13 |
59,839,412 (GRCm39) |
frame shift |
probably null |
|
R4703:4921517D22Rik
|
UTSW |
13 |
59,837,342 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4785:4921517D22Rik
|
UTSW |
13 |
59,839,406 (GRCm39) |
missense |
probably benign |
|
R4823:4921517D22Rik
|
UTSW |
13 |
59,838,718 (GRCm39) |
missense |
probably damaging |
0.99 |
R5054:4921517D22Rik
|
UTSW |
13 |
59,837,315 (GRCm39) |
missense |
probably damaging |
0.97 |
R6144:4921517D22Rik
|
UTSW |
13 |
59,837,347 (GRCm39) |
missense |
probably damaging |
0.99 |
R6977:4921517D22Rik
|
UTSW |
13 |
59,839,394 (GRCm39) |
missense |
possibly damaging |
0.66 |
R7009:4921517D22Rik
|
UTSW |
13 |
59,838,624 (GRCm39) |
missense |
possibly damaging |
0.89 |
R7791:4921517D22Rik
|
UTSW |
13 |
59,838,508 (GRCm39) |
missense |
probably benign |
|
R8319:4921517D22Rik
|
UTSW |
13 |
59,838,486 (GRCm39) |
missense |
probably benign |
|
R8422:4921517D22Rik
|
UTSW |
13 |
59,839,443 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
R8520:4921517D22Rik
|
UTSW |
13 |
59,838,423 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
Predicted Primers |
PCR Primer
(F):5'- TAGCTGCAAACCCTAGACCG -3'
(R):5'- GTCAGATCTACTTCACCAAAGTCTG -3'
Sequencing Primer
(F):5'- GCAAACCCTAGACCGTGCTTC -3'
(R):5'- GCTCCATTGGATCAGGTATACAGC -3'
|
Posted On |
2019-06-07 |