Incidental Mutation 'PIT4585001:Clasp1'
ID |
556582 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Clasp1
|
Ensembl Gene |
ENSMUSG00000064302 |
Gene Name |
CLIP associating protein 1 |
Synonyms |
CLASP1alpha, 1700030C23Rik, 5730583A19Rik, CLASP1, B130045P17Rik, mCLASP1 |
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.953)
|
Stock # |
PIT4585001 (G1)
|
Quality Score |
185.009 |
Status
|
Not validated
|
Chromosome |
1 |
Chromosomal Location |
118314976-118537192 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 118390285 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Lysine
at position 156
(N156K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000140019
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049404]
[ENSMUST00000070989]
[ENSMUST00000165223]
[ENSMUST00000178710]
[ENSMUST00000185405]
[ENSMUST00000186349]
[ENSMUST00000190571]
[ENSMUST00000187713]
[ENSMUST00000188710]
[ENSMUST00000189262]
[ENSMUST00000189570]
[ENSMUST00000189738]
[ENSMUST00000190733]
[ENSMUST00000191445]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000049404
AA Change: N156K
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000042266 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
7.31e-51 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
1.14e-11 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
low complexity region
|
751 |
763 |
N/A |
INTRINSIC |
low complexity region
|
821 |
831 |
N/A |
INTRINSIC |
TOG
|
847 |
1085 |
3.23e-1 |
SMART |
low complexity region
|
1096 |
1113 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1147 |
N/A |
INTRINSIC |
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
TOG
|
1287 |
1525 |
4.96e-30 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000070989
AA Change: N156K
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000067858 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
7.31e-51 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
1.14e-11 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
low complexity region
|
751 |
763 |
N/A |
INTRINSIC |
low complexity region
|
850 |
860 |
N/A |
INTRINSIC |
TOG
|
876 |
1114 |
3.23e-1 |
SMART |
low complexity region
|
1125 |
1142 |
N/A |
INTRINSIC |
low complexity region
|
1215 |
1226 |
N/A |
INTRINSIC |
TOG
|
1277 |
1515 |
4.96e-30 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000165223
AA Change: N156K
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000128089 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
7.31e-51 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
1.14e-11 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
684 |
714 |
N/A |
INTRINSIC |
low complexity region
|
792 |
802 |
N/A |
INTRINSIC |
TOG
|
818 |
1056 |
3.23e-1 |
SMART |
low complexity region
|
1067 |
1084 |
N/A |
INTRINSIC |
low complexity region
|
1157 |
1168 |
N/A |
INTRINSIC |
TOG
|
1219 |
1457 |
4.96e-30 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000178710
AA Change: N156K
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000137137 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
7.31e-51 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
1.14e-11 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
668 |
698 |
N/A |
INTRINSIC |
low complexity region
|
752 |
766 |
N/A |
INTRINSIC |
low complexity region
|
784 |
794 |
N/A |
INTRINSIC |
TOG
|
810 |
1047 |
6.55e-2 |
SMART |
low complexity region
|
1058 |
1075 |
N/A |
INTRINSIC |
low complexity region
|
1148 |
1159 |
N/A |
INTRINSIC |
TOG
|
1210 |
1448 |
4.96e-30 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000185405
AA Change: N156K
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000139619 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
3.4e-55 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
5.5e-16 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
682 |
715 |
N/A |
INTRINSIC |
low complexity region
|
769 |
783 |
N/A |
INTRINSIC |
low complexity region
|
801 |
811 |
N/A |
INTRINSIC |
TOG
|
827 |
1065 |
1.6e-5 |
SMART |
low complexity region
|
1076 |
1093 |
N/A |
INTRINSIC |
low complexity region
|
1166 |
1177 |
N/A |
INTRINSIC |
TOG
|
1228 |
1466 |
2.3e-34 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000186349
AA Change: N156K
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000141105 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
7.31e-51 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
1.14e-11 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
low complexity region
|
751 |
763 |
N/A |
INTRINSIC |
low complexity region
|
821 |
831 |
N/A |
INTRINSIC |
TOG
|
847 |
1085 |
3.23e-1 |
SMART |
low complexity region
|
1096 |
1113 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1147 |
N/A |
INTRINSIC |
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
TOG
|
1287 |
1525 |
4.96e-30 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000190571
AA Change: N156K
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000140019 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
3.4e-55 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
5.5e-16 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
682 |
715 |
N/A |
INTRINSIC |
low complexity region
|
759 |
771 |
N/A |
INTRINSIC |
low complexity region
|
805 |
819 |
N/A |
INTRINSIC |
low complexity region
|
837 |
847 |
N/A |
INTRINSIC |
TOG
|
863 |
1101 |
1.6e-5 |
SMART |
low complexity region
|
1112 |
1129 |
N/A |
INTRINSIC |
low complexity region
|
1150 |
1163 |
N/A |
INTRINSIC |
low complexity region
|
1241 |
1252 |
N/A |
INTRINSIC |
TOG
|
1303 |
1541 |
2.3e-34 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000187713
AA Change: N156K
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000139526 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
3.4e-55 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
5.5e-16 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
684 |
714 |
N/A |
INTRINSIC |
low complexity region
|
768 |
782 |
N/A |
INTRINSIC |
low complexity region
|
800 |
810 |
N/A |
INTRINSIC |
TOG
|
826 |
1064 |
1.6e-5 |
SMART |
low complexity region
|
1075 |
1092 |
N/A |
INTRINSIC |
low complexity region
|
1165 |
1176 |
N/A |
INTRINSIC |
TOG
|
1227 |
1465 |
2.3e-34 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000188710
AA Change: N156K
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000140593 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
3.4e-55 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
5.5e-16 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
low complexity region
|
751 |
763 |
N/A |
INTRINSIC |
low complexity region
|
818 |
832 |
N/A |
INTRINSIC |
low complexity region
|
850 |
860 |
N/A |
INTRINSIC |
TOG
|
876 |
1114 |
1.6e-5 |
SMART |
low complexity region
|
1125 |
1142 |
N/A |
INTRINSIC |
low complexity region
|
1215 |
1226 |
N/A |
INTRINSIC |
TOG
|
1277 |
1515 |
2.3e-34 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000189262
AA Change: N156K
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000140860 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
3.4e-55 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
5.5e-16 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
668 |
698 |
N/A |
INTRINSIC |
low complexity region
|
776 |
786 |
N/A |
INTRINSIC |
TOG
|
802 |
1040 |
1.6e-5 |
SMART |
low complexity region
|
1051 |
1068 |
N/A |
INTRINSIC |
low complexity region
|
1141 |
1152 |
N/A |
INTRINSIC |
TOG
|
1203 |
1441 |
2.3e-34 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000189570
AA Change: N156K
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000140167 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
3.4e-55 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
5.5e-16 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
684 |
714 |
N/A |
INTRINSIC |
low complexity region
|
792 |
802 |
N/A |
INTRINSIC |
TOG
|
818 |
1055 |
3.2e-6 |
SMART |
low complexity region
|
1066 |
1083 |
N/A |
INTRINSIC |
low complexity region
|
1156 |
1167 |
N/A |
INTRINSIC |
TOG
|
1218 |
1456 |
2.3e-34 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000189738
AA Change: N156K
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000140665 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
7.31e-51 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
1.14e-11 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
668 |
698 |
N/A |
INTRINSIC |
low complexity region
|
752 |
766 |
N/A |
INTRINSIC |
low complexity region
|
784 |
794 |
N/A |
INTRINSIC |
TOG
|
810 |
1048 |
3.23e-1 |
SMART |
low complexity region
|
1059 |
1076 |
N/A |
INTRINSIC |
low complexity region
|
1149 |
1160 |
N/A |
INTRINSIC |
TOG
|
1211 |
1449 |
4.96e-30 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000190733
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000191445
AA Change: N156K
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000140095 Gene: ENSMUSG00000064302 AA Change: N156K
Domain | Start | End | E-Value | Type |
TOG
|
1 |
232 |
3.4e-55 |
SMART |
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
low complexity region
|
280 |
296 |
N/A |
INTRINSIC |
TOG
|
319 |
551 |
5.5e-16 |
SMART |
low complexity region
|
579 |
594 |
N/A |
INTRINSIC |
low complexity region
|
606 |
633 |
N/A |
INTRINSIC |
low complexity region
|
674 |
707 |
N/A |
INTRINSIC |
low complexity region
|
761 |
775 |
N/A |
INTRINSIC |
low complexity region
|
793 |
803 |
N/A |
INTRINSIC |
TOG
|
819 |
1056 |
3.2e-6 |
SMART |
low complexity region
|
1067 |
1084 |
N/A |
INTRINSIC |
low complexity region
|
1157 |
1168 |
N/A |
INTRINSIC |
TOG
|
1219 |
1457 |
2.3e-34 |
SMART |
|
Coding Region Coverage |
- 1x: 93.6%
- 3x: 91.2%
- 10x: 86.5%
- 20x: 76.8%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 55 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aurka |
T |
C |
2: 172,199,117 (GRCm39) |
M318V |
probably benign |
Het |
Cacna2d1 |
T |
A |
5: 16,531,342 (GRCm39) |
D560E |
probably damaging |
Het |
Ccdc148 |
T |
A |
2: 58,872,988 (GRCm39) |
T202S |
probably benign |
Het |
Cdc42bpb |
T |
C |
12: 111,271,412 (GRCm39) |
D1149G |
probably damaging |
Het |
Cox18 |
G |
A |
5: 90,365,434 (GRCm39) |
T255I |
possibly damaging |
Het |
Cse1l |
A |
G |
2: 166,783,394 (GRCm39) |
T783A |
probably damaging |
Het |
Dnajc16 |
T |
C |
4: 141,491,996 (GRCm39) |
Y609C |
probably damaging |
Het |
Doc2g |
A |
G |
19: 4,056,630 (GRCm39) |
T339A |
probably benign |
Het |
Eif5a |
T |
C |
11: 69,808,896 (GRCm39) |
|
probably benign |
Het |
Epha3 |
A |
G |
16: 63,386,940 (GRCm39) |
|
probably null |
Het |
Esco1 |
A |
T |
18: 10,594,355 (GRCm39) |
C310* |
probably null |
Het |
Fam222a |
A |
G |
5: 114,749,101 (GRCm39) |
Y99C |
probably damaging |
Het |
Fzd2 |
T |
C |
11: 102,496,573 (GRCm39) |
L339P |
probably damaging |
Het |
Gfral |
A |
T |
9: 76,104,576 (GRCm39) |
N145K |
probably damaging |
Het |
Gga1 |
T |
A |
15: 78,777,990 (GRCm39) |
N618K |
probably benign |
Het |
Gpatch3 |
T |
A |
4: 133,310,397 (GRCm39) |
H447Q |
probably damaging |
Het |
Gpn1 |
A |
T |
5: 31,666,747 (GRCm39) |
R346* |
probably null |
Het |
Gsg1 |
T |
C |
6: 135,214,558 (GRCm39) |
E317G |
probably benign |
Het |
Gsk3b |
A |
G |
16: 38,004,816 (GRCm39) |
N129S |
probably damaging |
Het |
Hmg20b |
G |
T |
10: 81,184,789 (GRCm39) |
D94E |
possibly damaging |
Het |
Kash5 |
C |
T |
7: 44,849,695 (GRCm39) |
G76D |
probably benign |
Het |
Klhdc9 |
T |
A |
1: 171,187,386 (GRCm39) |
H204L |
possibly damaging |
Het |
Klhl24 |
A |
G |
16: 19,925,638 (GRCm39) |
I55M |
probably benign |
Het |
Kmt2c |
T |
C |
5: 25,520,104 (GRCm39) |
D2002G |
probably benign |
Het |
Lama4 |
A |
G |
10: 38,950,742 (GRCm39) |
N1015S |
probably damaging |
Het |
Lpp |
T |
C |
16: 24,580,697 (GRCm39) |
C263R |
probably benign |
Het |
Lrp1b |
T |
C |
2: 41,159,216 (GRCm39) |
I1689V |
|
Het |
Mipep |
C |
A |
14: 61,022,284 (GRCm39) |
Q50K |
probably benign |
Het |
Mx1 |
T |
C |
16: 97,257,454 (GRCm39) |
D101G |
probably benign |
Het |
Nabp2 |
C |
G |
10: 128,244,676 (GRCm39) |
E37Q |
possibly damaging |
Het |
Nme6 |
A |
G |
9: 109,671,104 (GRCm39) |
I115V |
possibly damaging |
Het |
Nup93 |
A |
T |
8: 94,970,355 (GRCm39) |
T85S |
probably benign |
Het |
Oit3 |
T |
A |
10: 59,266,835 (GRCm39) |
I224F |
possibly damaging |
Het |
Parp14 |
T |
C |
16: 35,678,975 (GRCm39) |
K331R |
probably benign |
Het |
Pls1 |
T |
A |
9: 95,643,443 (GRCm39) |
T519S |
probably benign |
Het |
Rcn3 |
A |
G |
7: 44,736,118 (GRCm39) |
F197L |
probably benign |
Het |
Rnf213 |
C |
T |
11: 119,349,218 (GRCm39) |
T3773I |
|
Het |
Rprd1b |
A |
T |
2: 157,889,877 (GRCm39) |
I153L |
probably benign |
Het |
Scel |
A |
G |
14: 103,829,804 (GRCm39) |
D462G |
possibly damaging |
Het |
Sh3bp1 |
C |
T |
15: 78,794,276 (GRCm39) |
S548L |
possibly damaging |
Het |
Sim1 |
T |
A |
10: 50,860,284 (GRCm39) |
Y715* |
probably null |
Het |
Slc18a2 |
A |
T |
19: 59,282,293 (GRCm39) |
Q500L |
possibly damaging |
Het |
Slc5a8 |
T |
G |
10: 88,722,365 (GRCm39) |
M66R |
probably damaging |
Het |
Slco1a6 |
T |
C |
6: 142,055,246 (GRCm39) |
T233A |
probably damaging |
Het |
Smu1 |
T |
C |
4: 40,739,623 (GRCm39) |
T396A |
probably benign |
Het |
Tas2r104 |
T |
C |
6: 131,662,521 (GRCm39) |
T63A |
possibly damaging |
Het |
Tasor2 |
G |
A |
13: 3,624,979 (GRCm39) |
A1657V |
possibly damaging |
Het |
Top2a |
C |
T |
11: 98,892,199 (GRCm39) |
A1088T |
probably benign |
Het |
Ucp1 |
T |
C |
8: 84,020,577 (GRCm39) |
F129S |
probably damaging |
Het |
Unc13b |
T |
A |
4: 43,091,298 (GRCm39) |
D41E |
probably benign |
Het |
Usp10 |
T |
G |
8: 120,681,631 (GRCm39) |
V696G |
probably benign |
Het |
Xylt2 |
C |
T |
11: 94,557,066 (GRCm39) |
V745M |
probably damaging |
Het |
Zbtb49 |
A |
T |
5: 38,373,820 (GRCm39) |
N41K |
probably damaging |
Het |
Zfp109 |
T |
A |
7: 23,928,779 (GRCm39) |
D218V |
probably benign |
Het |
Zfp420 |
G |
A |
7: 29,575,430 (GRCm39) |
R550Q |
probably benign |
Het |
|
Other mutations in Clasp1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01785:Clasp1
|
APN |
1 |
118,425,466 (GRCm39) |
missense |
possibly damaging |
0.74 |
IGL01786:Clasp1
|
APN |
1 |
118,425,466 (GRCm39) |
missense |
possibly damaging |
0.74 |
IGL01871:Clasp1
|
APN |
1 |
118,498,619 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02066:Clasp1
|
APN |
1 |
118,492,990 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02602:Clasp1
|
APN |
1 |
118,399,515 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02683:Clasp1
|
APN |
1 |
118,466,996 (GRCm39) |
missense |
probably benign |
0.33 |
IGL02728:Clasp1
|
APN |
1 |
118,530,107 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02820:Clasp1
|
APN |
1 |
118,478,834 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL02874:Clasp1
|
APN |
1 |
118,479,773 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL02975:Clasp1
|
APN |
1 |
118,390,277 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03100:Clasp1
|
APN |
1 |
118,395,626 (GRCm39) |
missense |
possibly damaging |
0.79 |
IGL03115:Clasp1
|
APN |
1 |
118,429,053 (GRCm39) |
nonsense |
probably null |
|
IGL03122:Clasp1
|
APN |
1 |
118,438,007 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03180:Clasp1
|
APN |
1 |
118,433,255 (GRCm39) |
missense |
probably benign |
0.33 |
IGL03248:Clasp1
|
APN |
1 |
118,530,206 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03388:Clasp1
|
APN |
1 |
118,433,233 (GRCm39) |
missense |
possibly damaging |
0.95 |
F5770:Clasp1
|
UTSW |
1 |
118,509,078 (GRCm39) |
missense |
probably damaging |
1.00 |
I2288:Clasp1
|
UTSW |
1 |
118,492,959 (GRCm39) |
missense |
probably benign |
0.09 |
R0079:Clasp1
|
UTSW |
1 |
118,471,034 (GRCm39) |
missense |
probably damaging |
1.00 |
R0395:Clasp1
|
UTSW |
1 |
118,467,061 (GRCm39) |
missense |
possibly damaging |
0.48 |
R0960:Clasp1
|
UTSW |
1 |
118,479,756 (GRCm39) |
missense |
probably benign |
0.39 |
R1448:Clasp1
|
UTSW |
1 |
118,436,646 (GRCm39) |
missense |
probably benign |
0.01 |
R1497:Clasp1
|
UTSW |
1 |
118,479,788 (GRCm39) |
missense |
probably benign |
0.42 |
R1607:Clasp1
|
UTSW |
1 |
118,432,689 (GRCm39) |
missense |
probably damaging |
0.98 |
R1722:Clasp1
|
UTSW |
1 |
118,518,194 (GRCm39) |
missense |
probably damaging |
1.00 |
R1758:Clasp1
|
UTSW |
1 |
118,475,755 (GRCm39) |
missense |
probably damaging |
1.00 |
R1765:Clasp1
|
UTSW |
1 |
118,433,261 (GRCm39) |
missense |
probably damaging |
0.99 |
R1855:Clasp1
|
UTSW |
1 |
118,436,624 (GRCm39) |
missense |
probably damaging |
1.00 |
R1861:Clasp1
|
UTSW |
1 |
118,498,661 (GRCm39) |
missense |
possibly damaging |
0.93 |
R1874:Clasp1
|
UTSW |
1 |
118,528,315 (GRCm39) |
critical splice donor site |
probably null |
|
R1942:Clasp1
|
UTSW |
1 |
118,429,078 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2025:Clasp1
|
UTSW |
1 |
118,432,629 (GRCm39) |
missense |
probably damaging |
1.00 |
R2174:Clasp1
|
UTSW |
1 |
118,487,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R2280:Clasp1
|
UTSW |
1 |
118,492,913 (GRCm39) |
missense |
probably benign |
0.05 |
R2288:Clasp1
|
UTSW |
1 |
118,506,608 (GRCm39) |
missense |
probably benign |
|
R2895:Clasp1
|
UTSW |
1 |
118,387,568 (GRCm39) |
missense |
probably damaging |
1.00 |
R3958:Clasp1
|
UTSW |
1 |
118,395,611 (GRCm39) |
missense |
probably damaging |
0.99 |
R4073:Clasp1
|
UTSW |
1 |
118,431,578 (GRCm39) |
missense |
probably damaging |
1.00 |
R4206:Clasp1
|
UTSW |
1 |
118,506,636 (GRCm39) |
missense |
probably damaging |
1.00 |
R4465:Clasp1
|
UTSW |
1 |
118,488,808 (GRCm39) |
missense |
probably damaging |
1.00 |
R4609:Clasp1
|
UTSW |
1 |
118,430,765 (GRCm39) |
intron |
probably benign |
|
R4679:Clasp1
|
UTSW |
1 |
118,471,001 (GRCm39) |
missense |
probably damaging |
0.99 |
R4707:Clasp1
|
UTSW |
1 |
118,470,927 (GRCm39) |
nonsense |
probably null |
|
R4809:Clasp1
|
UTSW |
1 |
118,388,980 (GRCm39) |
missense |
probably benign |
0.00 |
R4906:Clasp1
|
UTSW |
1 |
118,436,640 (GRCm39) |
nonsense |
probably null |
|
R5048:Clasp1
|
UTSW |
1 |
118,475,340 (GRCm39) |
intron |
probably benign |
|
R5298:Clasp1
|
UTSW |
1 |
118,475,650 (GRCm39) |
missense |
possibly damaging |
0.71 |
R5485:Clasp1
|
UTSW |
1 |
118,395,643 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5516:Clasp1
|
UTSW |
1 |
118,425,451 (GRCm39) |
missense |
probably damaging |
1.00 |
R5821:Clasp1
|
UTSW |
1 |
118,518,214 (GRCm39) |
missense |
probably damaging |
1.00 |
R5911:Clasp1
|
UTSW |
1 |
118,434,638 (GRCm39) |
unclassified |
probably benign |
|
R6092:Clasp1
|
UTSW |
1 |
118,438,028 (GRCm39) |
missense |
probably damaging |
0.97 |
R6181:Clasp1
|
UTSW |
1 |
118,347,547 (GRCm39) |
missense |
probably benign |
0.18 |
R6478:Clasp1
|
UTSW |
1 |
118,439,910 (GRCm39) |
nonsense |
probably null |
|
R7090:Clasp1
|
UTSW |
1 |
118,409,816 (GRCm39) |
missense |
probably benign |
0.45 |
R7216:Clasp1
|
UTSW |
1 |
118,475,648 (GRCm39) |
missense |
probably benign |
0.00 |
R7508:Clasp1
|
UTSW |
1 |
118,473,164 (GRCm39) |
missense |
probably benign |
0.30 |
R7541:Clasp1
|
UTSW |
1 |
118,470,727 (GRCm39) |
splice site |
probably null |
|
R7644:Clasp1
|
UTSW |
1 |
118,440,480 (GRCm39) |
splice site |
probably null |
|
R7825:Clasp1
|
UTSW |
1 |
118,473,123 (GRCm39) |
missense |
probably benign |
0.00 |
R7910:Clasp1
|
UTSW |
1 |
118,530,144 (GRCm39) |
nonsense |
probably null |
|
R7971:Clasp1
|
UTSW |
1 |
118,449,559 (GRCm39) |
missense |
probably damaging |
0.99 |
R8074:Clasp1
|
UTSW |
1 |
118,390,213 (GRCm39) |
missense |
probably benign |
|
R8344:Clasp1
|
UTSW |
1 |
118,431,629 (GRCm39) |
missense |
probably damaging |
1.00 |
R8847:Clasp1
|
UTSW |
1 |
118,506,705 (GRCm39) |
missense |
probably damaging |
1.00 |
R9035:Clasp1
|
UTSW |
1 |
118,431,583 (GRCm39) |
missense |
probably damaging |
1.00 |
R9073:Clasp1
|
UTSW |
1 |
118,390,193 (GRCm39) |
splice site |
probably null |
|
R9161:Clasp1
|
UTSW |
1 |
118,474,651 (GRCm39) |
missense |
probably damaging |
0.98 |
R9184:Clasp1
|
UTSW |
1 |
118,470,908 (GRCm39) |
missense |
probably benign |
0.17 |
R9379:Clasp1
|
UTSW |
1 |
118,509,168 (GRCm39) |
utr 3 prime |
probably benign |
|
R9379:Clasp1
|
UTSW |
1 |
118,509,157 (GRCm39) |
utr 3 prime |
probably benign |
|
R9422:Clasp1
|
UTSW |
1 |
118,390,257 (GRCm39) |
missense |
possibly damaging |
0.46 |
R9516:Clasp1
|
UTSW |
1 |
118,431,560 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9566:Clasp1
|
UTSW |
1 |
118,479,801 (GRCm39) |
missense |
probably benign |
0.01 |
R9776:Clasp1
|
UTSW |
1 |
118,509,108 (GRCm39) |
missense |
possibly damaging |
0.89 |
V7581:Clasp1
|
UTSW |
1 |
118,509,078 (GRCm39) |
missense |
probably damaging |
1.00 |
X0028:Clasp1
|
UTSW |
1 |
118,478,855 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Predicted Primers |
PCR Primer
(F):5'- AGAGCTCTTGTTTTGATGACTCCTG -3'
(R):5'- CCAAGGGGCTAGAAATGTGATTC -3'
Sequencing Primer
(F):5'- ATGACTCCTGTCTTACTGTGAAGAG -3'
(R):5'- GCCAGTAATCTCAGCTGTTAAGG -3'
|
Posted On |
2019-06-07 |