Mutagenetix > Incidental Mutation

Incidental Mutation 'PIT4651001:Dnah6'

556659

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

PIT4651001 (G1)

Quality Score

201.009

Status

Not validated

Chromosome

Chromosomal Location

73017606-73221651 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 73060260 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 3333 (N3333S)

Ref Sequence

ENSEMBL: ENSMUSP00000068758 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000064948
AA Change: N3333S

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: N3333S

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114040
AA Change: N3281S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: N3281S

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204053
AA Change: N3333S

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: N3333S

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Coding Region Coverage

1x: 93.1%
3x: 90.7%
10x: 84.4%
20x: 70.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	A	T	13: 77,259,895 (GRCm38)	I428L	probably benign	Het
Aass	T	C	6: 23,118,751 (GRCm38)	I131V	probably benign	Het
Alcam	T	A	16: 52,295,187 (GRCm38)	K189N	probably benign	Het
Ankrd50	C	A	3: 38,455,810 (GRCm38)	E803*	probably null	Het
Ankrd53	A	G	6: 83,765,733 (GRCm38)	D236G	probably damaging	Het
Bard1	A	G	1: 71,074,928 (GRCm38)	V298A	probably benign	Het
Cacna1d	C	T	14: 30,178,645 (GRCm38)	G361D	probably damaging	Het
Camkk1	A	G	11: 73,025,821 (GRCm38)	S82G	probably benign	Het
Ccr4	A	T	9: 114,492,193 (GRCm38)	V268E	probably benign	Het
Cdh6	G	A	15: 13,044,719 (GRCm38)	S439L	possibly damaging	Het
Ces1e	G	T	8: 93,215,083 (GRCm38)	A254E	probably benign	Het
Cfap46	T	C	7: 139,645,551 (GRCm38)	T1078A		Het
Cyp46a1	A	G	12: 108,353,108 (GRCm38)	D288G	probably benign	Het
Dzip3	A	G	16: 48,944,878 (GRCm38)	V491A	probably benign	Het
Egr1	G	T	18: 34,863,187 (GRCm38)	E341*	probably null	Het
Enpp1	G	A	10: 24,653,950 (GRCm38)	P597S	probably benign	Het
Ercc3	A	T	18: 32,240,312 (GRCm38)		probably benign	Het
Fbn1	T	C	2: 125,363,989 (GRCm38)		probably null	Het
Fbxw11	T	C	11: 32,711,999 (GRCm38)		probably null	Het
Fhip1a	C	T	3: 85,683,641 (GRCm38)	A389T	probably damaging	Het
Gbf1	A	G	19: 46,163,543 (GRCm38)	N5S	probably benign	Het
Gbp4	T	A	5: 105,118,423 (GRCm38)	H584L	probably benign	Het
Gcgr	G	T	11: 120,538,142 (GRCm38)	C402F	probably damaging	Het
Grm7	T	A	6: 110,646,089 (GRCm38)	N74K	probably benign	Het
H1f9	A	G	11: 94,968,316 (GRCm38)	S146G	probably benign	Het
Hoxa10	T	G	6: 52,234,897 (GRCm38)	N13T	possibly damaging	Het
Ice1	A	T	13: 70,623,921 (GRCm38)		probably null	Het
Il22	C	A	10: 118,205,590 (GRCm38)	N69K	probably damaging	Het
Il9r	A	T	11: 32,191,798 (GRCm38)	H319Q	probably benign	Het
Itgax	A	G	7: 128,149,110 (GRCm38)	T1104A	probably benign	Het
Jag1	C	T	2: 137,101,697 (GRCm38)	G193D	probably damaging	Het
Krt13	T	A	11: 100,120,036 (GRCm38)	D164V	probably damaging	Het
Lepr	T	C	4: 101,791,997 (GRCm38)	M865T	probably damaging	Het
Lmf2	G	A	15: 89,352,069 (GRCm38)	H576Y	possibly damaging	Het
Lrrc8c	C	T	5: 105,608,323 (GRCm38)	H655Y	probably benign	Het
Mapk6	A	T	9: 75,397,587 (GRCm38)	S183T	possibly damaging	Het
Mcrs1	A	T	15: 99,246,951 (GRCm38)	Y261N	probably damaging	Het
Mon1b	G	A	8: 113,638,622 (GRCm38)	G194D	probably benign	Het
Myo18b	C	T	5: 112,834,435 (GRCm38)	R1144Q	probably benign	Het
Myo9b	T	A	8: 71,342,812 (GRCm38)	H808Q	possibly damaging	Het
Ngdn	T	C	14: 55,016,200 (GRCm38)	I15T	probably benign	Het
Nhsl1	T	G	10: 18,408,435 (GRCm38)	S41R	probably damaging	Het
Numa1	A	T	7: 102,013,934 (GRCm38)	K2089M	probably damaging	Het
Obscn	A	G	11: 59,041,681 (GRCm38)	L4900P	probably damaging	Het
Olfm4	T	A	14: 80,021,485 (GRCm38)	L391Q	probably benign	Het
Or10g9b	A	T	9: 40,006,230 (GRCm38)	C240S	probably damaging	Het
Or2ag1	A	G	7: 106,873,523 (GRCm38)	C241R	probably damaging	Het
Or5b106	T	A	19: 13,146,627 (GRCm38)	I11F	probably benign	Het
Or5b111	A	G	19: 13,314,192 (GRCm38)	I31T	probably benign	Het
Or5m9	T	C	2: 86,046,518 (GRCm38)	L12P	probably damaging	Het
Parn	T	A	16: 13,631,567 (GRCm38)	N302Y	probably benign	Het
Pi4k2b	T	G	5: 52,748,470 (GRCm38)	S118A	possibly damaging	Het
Piwil4	C	T	9: 14,708,899 (GRCm38)	V704I	possibly damaging	Het
Pm20d2	G	A	4: 33,181,715 (GRCm38)	T296M	probably damaging	Het
Pmpcb	C	T	5: 21,746,050 (GRCm38)	A270V	probably benign	Het
Pnpt1	T	C	11: 29,156,945 (GRCm38)		probably null	Het
Prkn	T	A	17: 11,067,243 (GRCm38)	L41Q	probably damaging	Het
Rc3h1	C	A	1: 160,963,540 (GRCm38)	N931K	probably benign	Het
Rlf	A	G	4: 121,150,313 (GRCm38)	V600A	probably damaging	Het
Rnf219	T	A	14: 104,506,256 (GRCm38)	D129V	probably damaging	Het
Rpl27rt	A	T	18: 34,737,839 (GRCm38)	Q142L	unknown	Het
Sall1	T	G	8: 89,031,103 (GRCm38)	Q791P	probably damaging	Het
Sema3c	T	A	5: 17,694,733 (GRCm38)	Y408N	probably benign	Het
Serpinb13	C	T	1: 106,982,844 (GRCm38)	S66L	probably damaging	Het
Tmem181a	A	T	17: 6,300,895 (GRCm38)	M319L	probably benign	Het
Trim24	T	C	6: 37,900,732 (GRCm38)		probably null	Het
Ttn	T	A	2: 76,888,934 (GRCm38)	T7234S	unknown	Het
Unc13c	T	A	9: 73,483,739 (GRCm38)	M2076L	possibly damaging	Het
Uroc1	C	T	6: 90,363,113 (GRCm38)	R667*	probably null	Het
Uvrag	A	G	7: 98,906,520 (GRCm38)	F456L	probably benign	Het
Vmn1r215	T	C	13: 23,076,360 (GRCm38)	V190A	probably damaging	Het
Vmn2r50	T	A	7: 10,037,732 (GRCm38)	T681S	probably benign	Het
Vmn2r65	T	A	7: 84,946,253 (GRCm38)	T408S	probably benign	Het
Vps33b	A	G	7: 80,290,007 (GRCm38)	D502G	probably damaging	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,195,737 (GRCm38)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,086,207 (GRCm38)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,195,761 (GRCm38)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,212,434 (GRCm38)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,123,771 (GRCm38)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,156,350 (GRCm38)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,033,526 (GRCm38)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,083,157 (GRCm38)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,173,390 (GRCm38)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,074,781 (GRCm38)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,065,725 (GRCm38)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,173,456 (GRCm38)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,092,178 (GRCm38)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,074,748 (GRCm38)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,024,252 (GRCm38)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,075,802 (GRCm38)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,076,660 (GRCm38)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,188,377 (GRCm38)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,065,776 (GRCm38)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,135,801 (GRCm38)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,032,569 (GRCm38)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,060,143 (GRCm38)	missense	probably benign
IGL02126:Dnah6	APN	6	73,103,166 (GRCm38)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	73,017,797 (GRCm38)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,133,650 (GRCm38)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,168,911 (GRCm38)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,101,898 (GRCm38)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,076,640 (GRCm38)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,027,448 (GRCm38)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	73,021,227 (GRCm38)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,095,104 (GRCm38)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,121,823 (GRCm38)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,208,599 (GRCm38)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,138,715 (GRCm38)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,032,587 (GRCm38)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,149,140 (GRCm38)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,145,004 (GRCm38)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,041,054 (GRCm38)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,144,700 (GRCm38)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,053,647 (GRCm38)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,083,085 (GRCm38)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,075,850 (GRCm38)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,163,504 (GRCm38)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,065,755 (GRCm38)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,208,641 (GRCm38)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,101,880 (GRCm38)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,114,582 (GRCm38)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,038,734 (GRCm38)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,188,535 (GRCm38)	splice site	probably benign
R0165:Dnah6	UTSW	6	73,021,323 (GRCm38)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,082,923 (GRCm38)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,159,115 (GRCm38)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,173,558 (GRCm38)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,069,399 (GRCm38)	splice site	probably benign
R0345:Dnah6	UTSW	6	73,021,257 (GRCm38)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,188,359 (GRCm38)	missense	probably benign
R0362:Dnah6	UTSW	6	73,208,609 (GRCm38)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,083,124 (GRCm38)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,044,774 (GRCm38)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	73,022,412 (GRCm38)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,123,811 (GRCm38)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,129,474 (GRCm38)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,212,622 (GRCm38)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,087,602 (GRCm38)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,035,293 (GRCm38)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,124,757 (GRCm38)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,159,193 (GRCm38)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,144,965 (GRCm38)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,159,135 (GRCm38)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,124,709 (GRCm38)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,208,545 (GRCm38)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,191,619 (GRCm38)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,027,442 (GRCm38)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,049,048 (GRCm38)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,151,553 (GRCm38)	missense	probably benign
R1557:Dnah6	UTSW	6	73,049,131 (GRCm38)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,076,600 (GRCm38)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,067,469 (GRCm38)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,144,963 (GRCm38)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,100,112 (GRCm38)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,044,752 (GRCm38)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,155,296 (GRCm38)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,205,732 (GRCm38)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,129,540 (GRCm38)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,044,761 (GRCm38)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,160,982 (GRCm38)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,024,958 (GRCm38)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,181,797 (GRCm38)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,100,088 (GRCm38)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,181,762 (GRCm38)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,084,721 (GRCm38)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,121,970 (GRCm38)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,095,044 (GRCm38)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,092,192 (GRCm38)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,067,466 (GRCm38)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,173,419 (GRCm38)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,027,422 (GRCm38)	missense	probably benign
R2041:Dnah6	UTSW	6	73,073,439 (GRCm38)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	73,021,182 (GRCm38)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,144,035 (GRCm38)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,049,166 (GRCm38)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,089,746 (GRCm38)	splice site	probably null
R2193:Dnah6	UTSW	6	73,138,640 (GRCm38)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,100,085 (GRCm38)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,113,581 (GRCm38)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	73,021,109 (GRCm38)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,156,421 (GRCm38)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,091,967 (GRCm38)	splice site	probably null
R2436:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,173,350 (GRCm38)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,032,633 (GRCm38)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,191,498 (GRCm38)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,127,927 (GRCm38)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,089,592 (GRCm38)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,129,448 (GRCm38)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,149,484 (GRCm38)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,118,026 (GRCm38)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,129,291 (GRCm38)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,191,479 (GRCm38)	missense	probably benign
R4486:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,178,416 (GRCm38)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,192,405 (GRCm38)	missense	probably benign
R4573:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,152,712 (GRCm38)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,129,660 (GRCm38)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,070,597 (GRCm38)	missense	probably benign
R4653:Dnah6	UTSW	6	73,073,457 (GRCm38)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,037,688 (GRCm38)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,192,422 (GRCm38)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,025,012 (GRCm38)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,129,530 (GRCm38)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,095,074 (GRCm38)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,089,668 (GRCm38)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	73,022,424 (GRCm38)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,044,762 (GRCm38)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,121,788 (GRCm38)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,192,676 (GRCm38)	intron	probably benign
R4948:Dnah6	UTSW	6	73,053,689 (GRCm38)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,188,383 (GRCm38)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,144,815 (GRCm38)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,044,691 (GRCm38)	missense	probably benign
R5044:Dnah6	UTSW	6	73,037,622 (GRCm38)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,181,761 (GRCm38)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,195,634 (GRCm38)	missense	probably benign
R5186:Dnah6	UTSW	6	73,067,427 (GRCm38)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,195,732 (GRCm38)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,113,488 (GRCm38)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,127,861 (GRCm38)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,212,620 (GRCm38)	missense	probably benign
R5343:Dnah6	UTSW	6	73,212,616 (GRCm38)	missense	probably benign
R5375:Dnah6	UTSW	6	73,123,855 (GRCm38)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,037,615 (GRCm38)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,060,138 (GRCm38)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,075,734 (GRCm38)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,086,185 (GRCm38)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,092,157 (GRCm38)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,092,116 (GRCm38)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,190,419 (GRCm38)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,159,229 (GRCm38)	missense	probably benign
R5541:Dnah6	UTSW	6	73,192,988 (GRCm38)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,151,689 (GRCm38)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,149,525 (GRCm38)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	73,021,227 (GRCm38)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,060,279 (GRCm38)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,181,722 (GRCm38)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,086,166 (GRCm38)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,114,697 (GRCm38)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,188,494 (GRCm38)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,086,217 (GRCm38)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,191,605 (GRCm38)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,155,418 (GRCm38)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,074,586 (GRCm38)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,074,704 (GRCm38)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,044,732 (GRCm38)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,173,533 (GRCm38)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,053,695 (GRCm38)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,035,280 (GRCm38)	splice site	probably null
R6640:Dnah6	UTSW	6	73,024,293 (GRCm38)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,138,760 (GRCm38)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,037,549 (GRCm38)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,133,608 (GRCm38)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,133,542 (GRCm38)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,212,522 (GRCm38)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,181,755 (GRCm38)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,044,773 (GRCm38)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	73,021,178 (GRCm38)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,087,562 (GRCm38)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,135,680 (GRCm38)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,181,705 (GRCm38)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,173,545 (GRCm38)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,084,760 (GRCm38)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,144,722 (GRCm38)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,212,612 (GRCm38)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,192,317 (GRCm38)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,212,492 (GRCm38)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,127,904 (GRCm38)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,118,099 (GRCm38)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,027,440 (GRCm38)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,149,430 (GRCm38)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,092,168 (GRCm38)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,095,206 (GRCm38)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,124,759 (GRCm38)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,169,080 (GRCm38)	splice site	probably null
R7735:Dnah6	UTSW	6	73,069,429 (GRCm38)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,025,720 (GRCm38)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,127,919 (GRCm38)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,135,467 (GRCm38)	splice site	probably null
R8034:Dnah6	UTSW	6	73,129,225 (GRCm38)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,160,913 (GRCm38)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,025,786 (GRCm38)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,060,225 (GRCm38)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,037,566 (GRCm38)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,044,728 (GRCm38)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,168,827 (GRCm38)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,195,681 (GRCm38)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,076,599 (GRCm38)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,025,000 (GRCm38)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,074,651 (GRCm38)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,138,774 (GRCm38)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,178,457 (GRCm38)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,095,188 (GRCm38)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,168,867 (GRCm38)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,075,890 (GRCm38)	intron	probably benign
R8737:Dnah6	UTSW	6	73,067,445 (GRCm38)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,179,828 (GRCm38)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,065,773 (GRCm38)	missense	probably benign
R8809:Dnah6	UTSW	6	73,032,563 (GRCm38)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,127,954 (GRCm38)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,144,173 (GRCm38)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	73,021,148 (GRCm38)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,178,498 (GRCm38)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,144,751 (GRCm38)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,142,292 (GRCm38)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,084,657 (GRCm38)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,144,046 (GRCm38)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,067,486 (GRCm38)	missense	probably benign
R9106:Dnah6	UTSW	6	73,144,769 (GRCm38)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,060,203 (GRCm38)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,121,899 (GRCm38)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,144,941 (GRCm38)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,144,705 (GRCm38)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,027,514 (GRCm38)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,083,057 (GRCm38)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	73,021,278 (GRCm38)	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73,212,530 (GRCm38)	missense	probably benign
R9439:Dnah6	UTSW	6	73,035,347 (GRCm38)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,142,316 (GRCm38)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,138,767 (GRCm38)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,191,606 (GRCm38)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,101,889 (GRCm38)	missense	probably benign
RF020:Dnah6	UTSW	6	73,118,057 (GRCm38)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,178,518 (GRCm38)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,191,500 (GRCm38)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,037,673 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,133,559 (GRCm38)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,087,783 (GRCm38)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,032,526 (GRCm38)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	73,021,237 (GRCm38)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,155,272 (GRCm38)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,041,138 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGAAGAAATTCCACTCGGCC -3'
(R):5'- TGCCGAATTCCGTGTTATGAGC -3'

Sequencing Primer
(F):5'- GCCTCCGTTAGCTGCTCATG -3'
(R):5'- ATCTCACACACTGCGTTGAGATCTAG -3'

Posted On

2019-06-07