Incidental Mutation 'PIT4802001:Or14a256'
ID 556731
Institutional Source Beutler Lab
Gene Symbol Or14a256
Ensembl Gene ENSMUSG00000062042
Gene Name olfactory receptor family 14 subfamily A member 256
Synonyms Olfr294, MOR219-5, GA_x6K02T2NHDJ-9504525-9505532
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # PIT4802001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 86264844-86265851 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86265763 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 30 (L30Q)
Ref Sequence ENSEMBL: ENSMUSP00000077662 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078588]
AlphaFold F7CWV4
Predicted Effect probably null
Transcript: ENSMUST00000078588
AA Change: L30Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077662
Gene: ENSMUSG00000062042
AA Change: L30Q

DomainStartEndE-ValueType
Pfam:7tm_4 29 309 1.2e-38 PFAM
Pfam:7tm_1 39 288 1.8e-22 PFAM
Coding Region Coverage
  • 1x: 93.6%
  • 3x: 91.0%
  • 10x: 85.4%
  • 20x: 73.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A T 11: 119,902,172 (GRCm39) D741E probably benign Het
Abca16 A G 7: 120,139,351 (GRCm39) D1461G probably benign Het
Adam6a G T 12: 113,509,078 (GRCm39) D484Y probably damaging Het
Akap5 T C 12: 76,376,706 (GRCm39) Y713H probably damaging Het
AW554918 A G 18: 25,473,132 (GRCm39) E312G possibly damaging Het
Car4 G A 11: 84,855,231 (GRCm39) A157T probably damaging Het
Chst9 A T 18: 15,585,849 (GRCm39) M238K probably benign Het
Ctbp2 G A 7: 132,589,974 (GRCm39) H397Y possibly damaging Het
Cyp3a59 A G 5: 146,039,611 (GRCm39) M295V probably benign Het
Daglb T C 5: 143,488,803 (GRCm39) Y586H probably benign Het
Ehbp1l1 G T 19: 5,769,603 (GRCm39) P567T possibly damaging Het
Emilin2 A G 17: 71,580,464 (GRCm39) I754T probably damaging Het
Esyt2 G A 12: 116,329,457 (GRCm39) A672T probably benign Het
Evx1 G T 6: 52,291,175 (GRCm39) E116* probably null Het
Exph5 T C 9: 53,286,278 (GRCm39) S1120P probably damaging Het
Fam184a A T 10: 53,560,450 (GRCm39) L515* probably null Het
Flt4 T A 11: 49,523,996 (GRCm39) D525E probably benign Het
Galt T C 4: 41,756,764 (GRCm39) W135R probably damaging Het
Ifitm6 A T 7: 140,596,648 (GRCm39) C42S probably damaging Het
Ift172 A G 5: 31,442,610 (GRCm39) S186P probably benign Het
Kcnk3 A G 5: 30,779,712 (GRCm39) E254G probably damaging Het
Kmt2b A G 7: 30,278,996 (GRCm39) S1509P probably damaging Het
Ky T A 9: 102,414,972 (GRCm39) S295T probably benign Het
Lrba T A 3: 86,571,801 (GRCm39) Y2368* probably null Het
Mtmr4 T A 11: 87,501,953 (GRCm39) V669E probably benign Het
Myh10 C T 11: 68,655,918 (GRCm39) R471C probably damaging Het
Nav1 G A 1: 135,380,671 (GRCm39) T1416I unknown Het
Nrip1 A C 16: 76,090,157 (GRCm39) S467A probably damaging Het
Ntrk1 T A 3: 87,695,941 (GRCm39) N190Y probably damaging Het
Or5h25 A C 16: 58,930,964 (GRCm39) M3R probably benign Het
Pdxp A G 15: 78,802,611 (GRCm39) S282G probably damaging Het
Phtf2 A T 5: 21,006,904 (GRCm39) S220T probably damaging Het
Piezo2 A T 18: 63,157,540 (GRCm39) V2390E probably damaging Het
Pop1 T G 15: 34,529,229 (GRCm39) L783R probably benign Het
Prf1 G A 10: 61,135,972 (GRCm39) A83T probably benign Het
Rab4b A G 7: 26,875,267 (GRCm39) V50A probably benign Het
Rtn1 T A 12: 72,351,100 (GRCm39) T370S probably benign Het
Sdr16c5 T A 4: 4,012,423 (GRCm39) I123F probably damaging Het
Smg6 T A 11: 75,046,991 (GRCm39) V1228D probably damaging Het
Smim19 A G 8: 22,963,539 (GRCm39) V23A probably benign Het
Sox13 A T 1: 133,313,996 (GRCm39) I346N probably damaging Het
Tap1 T A 17: 34,412,165 (GRCm39) Y457N probably damaging Het
Tbck C T 3: 132,458,427 (GRCm39) P686S probably damaging Het
Tcof1 A G 18: 60,965,010 (GRCm39) S570P unknown Het
Tmc5 A T 7: 118,271,449 (GRCm39) M921L probably benign Het
Ttc6 A G 12: 57,772,462 (GRCm39) Y1594C possibly damaging Het
Virma T A 4: 11,546,008 (GRCm39) H1615Q probably damaging Het
Vmn1r19 T A 6: 57,382,037 (GRCm39) Y197N probably damaging Het
Vps13c T C 9: 67,845,068 (GRCm39) F2051L probably damaging Het
Wdr6 C T 9: 108,451,765 (GRCm39) C706Y probably damaging Het
Zfand4 A G 6: 116,261,736 (GRCm39) N100D probably damaging Het
Other mutations in Or14a256
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01365:Or14a256 APN 7 86,265,205 (GRCm39) missense probably damaging 1.00
IGL02617:Or14a256 APN 7 86,264,872 (GRCm39) missense probably benign 0.14
IGL02694:Or14a256 APN 7 86,265,518 (GRCm39) missense probably benign 0.00
IGL02828:Or14a256 APN 7 86,265,277 (GRCm39) missense possibly damaging 0.67
IGL03229:Or14a256 APN 7 86,265,286 (GRCm39) missense probably benign 0.00
IGL03351:Or14a256 APN 7 86,264,885 (GRCm39) missense possibly damaging 0.68
R0848:Or14a256 UTSW 7 86,264,848 (GRCm39) missense probably damaging 0.96
R1448:Or14a256 UTSW 7 86,265,569 (GRCm39) missense probably damaging 1.00
R1720:Or14a256 UTSW 7 86,265,664 (GRCm39) missense probably damaging 1.00
R1734:Or14a256 UTSW 7 86,265,425 (GRCm39) missense probably benign 0.07
R1959:Or14a256 UTSW 7 86,265,639 (GRCm39) missense probably benign 0.00
R2116:Or14a256 UTSW 7 86,265,286 (GRCm39) missense probably benign 0.00
R2518:Or14a256 UTSW 7 86,265,395 (GRCm39) missense probably benign 0.03
R3034:Or14a256 UTSW 7 86,264,970 (GRCm39) missense possibly damaging 0.50
R3110:Or14a256 UTSW 7 86,264,884 (GRCm39) missense probably benign
R3112:Or14a256 UTSW 7 86,264,884 (GRCm39) missense probably benign
R3690:Or14a256 UTSW 7 86,265,686 (GRCm39) missense probably damaging 1.00
R4612:Or14a256 UTSW 7 86,264,944 (GRCm39) missense probably benign 0.00
R6476:Or14a256 UTSW 7 86,265,218 (GRCm39) missense probably benign 0.04
R6895:Or14a256 UTSW 7 86,265,323 (GRCm39) missense probably damaging 1.00
R7102:Or14a256 UTSW 7 86,265,475 (GRCm39) missense probably benign 0.25
R7104:Or14a256 UTSW 7 86,264,900 (GRCm39) missense probably null 0.07
R7179:Or14a256 UTSW 7 86,265,574 (GRCm39) missense possibly damaging 0.76
R7256:Or14a256 UTSW 7 86,264,873 (GRCm39) missense probably benign 0.03
R7624:Or14a256 UTSW 7 86,265,769 (GRCm39) missense possibly damaging 0.47
R8422:Or14a256 UTSW 7 86,265,466 (GRCm39) missense probably benign 0.13
R9432:Or14a256 UTSW 7 86,265,065 (GRCm39) missense possibly damaging 0.66
R9700:Or14a256 UTSW 7 86,265,618 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AACAATTGGAGGGCACAACC -3'
(R):5'- GGGCAGTATCTAGGTAGTGTCC -3'

Sequencing Primer
(F):5'- GGCACAACCCAGAATAGAAATTG -3'
(R):5'- CTGGGTCCATTTCCACTGAG -3'
Posted On 2019-06-07