Incidental Mutation 'PIT4812001:Atrnl1'
ID 556949
Institutional Source Beutler Lab
Gene Symbol Atrnl1
Ensembl Gene ENSMUSG00000054843
Gene Name attractin like 1
Synonyms Alp
Accession Numbers
Essential gene? Probably non essential (E-score: 0.210) question?
Stock # PIT4812001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 57611034-58133338 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57731623 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 1082 (I1082V)
Ref Sequence ENSEMBL: ENSMUSP00000076514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077282]
AlphaFold Q6A051
Predicted Effect probably benign
Transcript: ENSMUST00000077282
AA Change: I1082V

PolyPhen 2 Score 0.078 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000076514
Gene: ENSMUSG00000054843
AA Change: I1082V

DomainStartEndE-ValueType
low complexity region 25 32 N/A INTRINSIC
EGF 61 90 5.71e-1 SMART
CUB 92 208 1.43e-11 SMART
EGF 209 244 1.95e1 SMART
Pfam:EGF_2 248 279 5.8e-7 PFAM
Pfam:Kelch_5 350 391 2.1e-9 PFAM
Pfam:Kelch_6 354 401 5.8e-8 PFAM
Pfam:Kelch_4 465 517 4.3e-7 PFAM
Pfam:Kelch_1 519 573 2.7e-6 PFAM
PSI 613 656 3.38e-1 SMART
PSI 665 708 2e-3 SMART
PSI 714 759 1.72e-2 SMART
CLECT 747 872 2.86e-20 SMART
PSI 888 938 6.26e-5 SMART
PSI 941 1011 1.73e-7 SMART
EGF_Lam 1013 1056 1.07e-5 SMART
low complexity region 1157 1173 N/A INTRINSIC
transmembrane domain 1229 1251 N/A INTRINSIC
low complexity region 1261 1272 N/A INTRINSIC
low complexity region 1326 1339 N/A INTRINSIC
Coding Region Coverage
  • 1x: 93.8%
  • 3x: 91.0%
  • 10x: 85.3%
  • 20x: 73.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit normal coat coloring and normal brain morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T C 18: 6,630,053 S252P possibly damaging Het
4933409G03Rik G A 2: 68,588,948 V14I probably benign Het
Adgrf5 T G 17: 43,450,369 V985G probably damaging Het
Ankrd44 A T 1: 54,723,038 Y542* probably null Het
Atp13a3 T C 16: 30,362,578 T75A probably damaging Het
Atr T C 9: 95,910,649 F1675L probably benign Het
C87977 A G 4: 144,209,516 I56T probably benign Het
Clip1 T A 5: 123,630,675 R620S probably benign Het
Cped1 T C 6: 22,122,294 F391S probably benign Het
Cracr2a T C 6: 127,625,870 L230P probably damaging Het
Dctn1 T A 6: 83,199,762 V1266E possibly damaging Het
Dlg1 T A 16: 31,846,885 F687I probably benign Het
Dnah8 C A 17: 30,708,445 D1358E probably benign Het
Dnajc11 A G 4: 151,952,889 R84G probably benign Het
Dnajc14 C A 10: 128,806,683 T158N probably damaging Het
Dscc1 A G 15: 55,082,261 L346P probably damaging Het
Efcab3 A G 11: 105,099,979 I71V probably null Het
Erbb3 T A 10: 128,574,379 Q670L possibly damaging Het
Ercc4 G A 16: 13,144,447 E652K probably benign Het
Ercc6l2 T A 13: 63,858,257 V591D possibly damaging Het
Fam126b T G 1: 58,548,703 D117A possibly damaging Het
Fam3c C T 6: 22,321,370 G134E probably damaging Het
Frmd5 A G 2: 121,586,446 V70A probably benign Het
Gjc1 A T 11: 102,800,981 Y65* probably null Het
Gm3033 A C 14: 3,848,891 L137F Het
Gria4 C A 9: 4,427,128 A771S probably damaging Het
Hc A G 2: 35,029,452 L674P probably benign Het
Hjurp CTCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCT C 1: 88,266,277 probably benign Het
Inpp5f A T 7: 128,692,308 Y696F probably benign Het
Itga11 C A 9: 62,732,193 Q157K probably damaging Het
Itgb5 G T 16: 33,919,987 C489F probably damaging Het
Klhl38 C T 15: 58,322,542 G264S probably benign Het
Krt78 C T 15: 101,948,069 V436M probably damaging Het
Mia2 A T 12: 59,101,579 D75V possibly damaging Het
Mphosph6 T A 8: 117,799,149 Q20L probably damaging Het
Ogfr C T 2: 180,595,511 P630S possibly damaging Het
Olfr1206 G A 2: 88,864,970 V122M probably benign Het
Olfr1431 T G 19: 12,210,253 I229S probably damaging Het
Olfr15 A T 16: 3,839,530 K186* probably null Het
Pbx3 T C 2: 34,224,619 E101G probably damaging Het
Pcca T A 14: 122,790,382 N587K probably benign Het
Pdia3 G T 2: 121,433,530 A287S probably damaging Het
Pfas T A 11: 68,990,036 D209V Het
Pter A T 2: 12,980,368 I170F probably damaging Het
Ptprq A T 10: 107,666,567 V830E probably damaging Het
Rab11fip5 T C 6: 85,341,558 D783G probably benign Het
Rbm19 T C 5: 120,128,250 V446A possibly damaging Het
Selp A G 1: 164,132,263 N363D probably benign Het
Six2 C A 17: 85,685,301 S258I possibly damaging Het
Smc1b A G 15: 85,069,651 V1139A possibly damaging Het
Sp1 A G 15: 102,408,408 T121A possibly damaging Het
Sucla2 A T 14: 73,579,449 I210L possibly damaging Het
Trank1 T C 9: 111,347,912 L339P probably damaging Het
Ttll5 T A 12: 85,926,861 D794E probably benign Het
Usp32 C T 11: 85,010,074 V1107I probably damaging Het
Vmn1r195 T C 13: 22,278,863 Y168H probably benign Het
Vmn1r223 A G 13: 23,249,890 N218S probably damaging Het
Vmn2r25 T A 6: 123,823,488 S632C probably damaging Het
Vwa3a A T 7: 120,776,133 K390I probably damaging Het
Zfp442 A T 2: 150,409,741 C80* probably null Het
Zic1 A T 9: 91,364,341 I226N probably damaging Het
Other mutations in Atrnl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Atrnl1 APN 19 57,691,817 (GRCm38) missense probably benign 0.02
IGL00707:Atrnl1 APN 19 57,673,265 (GRCm38) missense probably damaging 0.96
IGL00921:Atrnl1 APN 19 57,702,153 (GRCm38) missense probably damaging 1.00
IGL01410:Atrnl1 APN 19 58,131,104 (GRCm38) missense probably damaging 1.00
IGL01468:Atrnl1 APN 19 57,699,712 (GRCm38) missense probably benign 0.02
IGL01756:Atrnl1 APN 19 57,652,948 (GRCm38) missense probably benign
IGL01971:Atrnl1 APN 19 57,753,283 (GRCm38) missense probably damaging 1.00
IGL02019:Atrnl1 APN 19 57,691,763 (GRCm38) splice site probably benign
IGL02580:Atrnl1 APN 19 57,714,576 (GRCm38) splice site probably benign
IGL02649:Atrnl1 APN 19 57,650,441 (GRCm38) splice site probably benign
IGL02676:Atrnl1 APN 19 57,691,884 (GRCm38) missense probably damaging 1.00
IGL03276:Atrnl1 APN 19 57,652,927 (GRCm38) missense probably damaging 0.99
IGL03379:Atrnl1 APN 19 57,642,541 (GRCm38) missense probably benign 0.02
Magnetogorsk UTSW 19 57,630,306 (GRCm38) missense probably damaging 1.00
polar UTSW 19 57,652,950 (GRCm38) missense probably benign 0.00
R0109:Atrnl1 UTSW 19 57,755,517 (GRCm38) missense possibly damaging 0.78
R0308:Atrnl1 UTSW 19 57,753,288 (GRCm38) missense probably benign 0.04
R0394:Atrnl1 UTSW 19 57,673,176 (GRCm38) missense probably benign 0.10
R0734:Atrnl1 UTSW 19 57,654,861 (GRCm38) missense probably damaging 1.00
R0811:Atrnl1 UTSW 19 57,673,141 (GRCm38) missense probably benign 0.07
R0812:Atrnl1 UTSW 19 57,673,141 (GRCm38) missense probably benign 0.07
R1183:Atrnl1 UTSW 19 57,650,293 (GRCm38) missense probably damaging 0.97
R1213:Atrnl1 UTSW 19 57,638,462 (GRCm38) missense probably benign 0.25
R1344:Atrnl1 UTSW 19 57,935,705 (GRCm38) critical splice donor site probably null
R1418:Atrnl1 UTSW 19 57,935,705 (GRCm38) critical splice donor site probably null
R1707:Atrnl1 UTSW 19 57,686,737 (GRCm38) missense probably benign 0.00
R1748:Atrnl1 UTSW 19 57,714,702 (GRCm38) missense probably damaging 0.99
R2051:Atrnl1 UTSW 19 57,691,849 (GRCm38) missense probably benign 0.01
R2113:Atrnl1 UTSW 19 57,755,616 (GRCm38) nonsense probably null
R2130:Atrnl1 UTSW 19 57,654,994 (GRCm38) missense probably damaging 1.00
R3710:Atrnl1 UTSW 19 57,657,114 (GRCm38) missense probably damaging 1.00
R3916:Atrnl1 UTSW 19 57,935,652 (GRCm38) missense possibly damaging 0.82
R4524:Atrnl1 UTSW 19 57,630,306 (GRCm38) missense probably damaging 1.00
R4707:Atrnl1 UTSW 19 57,629,158 (GRCm38) missense probably damaging 0.97
R4712:Atrnl1 UTSW 19 57,652,950 (GRCm38) missense probably benign 0.00
R4784:Atrnl1 UTSW 19 57,629,158 (GRCm38) missense probably damaging 0.97
R4785:Atrnl1 UTSW 19 57,629,158 (GRCm38) missense probably damaging 0.97
R4798:Atrnl1 UTSW 19 58,042,361 (GRCm38) missense probably benign
R5172:Atrnl1 UTSW 19 57,685,513 (GRCm38) nonsense probably null
R5226:Atrnl1 UTSW 19 57,650,335 (GRCm38) missense probably benign
R5289:Atrnl1 UTSW 19 57,657,082 (GRCm38) missense probably damaging 1.00
R5372:Atrnl1 UTSW 19 57,755,536 (GRCm38) missense probably benign
R5737:Atrnl1 UTSW 19 57,777,888 (GRCm38) missense possibly damaging 0.84
R5782:Atrnl1 UTSW 19 57,753,286 (GRCm38) missense possibly damaging 0.95
R5826:Atrnl1 UTSW 19 57,630,292 (GRCm38) nonsense probably null
R6169:Atrnl1 UTSW 19 57,642,463 (GRCm38) missense probably benign 0.00
R6242:Atrnl1 UTSW 19 57,642,478 (GRCm38) missense probably benign 0.02
R6342:Atrnl1 UTSW 19 57,638,510 (GRCm38) missense probably damaging 1.00
R6372:Atrnl1 UTSW 19 57,650,332 (GRCm38) missense probably benign 0.01
R6811:Atrnl1 UTSW 19 57,654,961 (GRCm38) missense probably damaging 0.98
R6897:Atrnl1 UTSW 19 58,042,368 (GRCm38) missense probably benign 0.01
R7024:Atrnl1 UTSW 19 57,638,450 (GRCm38) critical splice acceptor site probably null
R7085:Atrnl1 UTSW 19 57,691,857 (GRCm38) missense probably damaging 1.00
R7144:Atrnl1 UTSW 19 58,042,352 (GRCm38) missense probably damaging 1.00
R7259:Atrnl1 UTSW 19 57,935,606 (GRCm38) nonsense probably null
R7289:Atrnl1 UTSW 19 57,650,414 (GRCm38) missense probably benign 0.13
R7310:Atrnl1 UTSW 19 57,642,424 (GRCm38) missense possibly damaging 0.69
R7372:Atrnl1 UTSW 19 57,935,646 (GRCm38) missense possibly damaging 0.47
R7432:Atrnl1 UTSW 19 57,755,524 (GRCm38) missense probably damaging 1.00
R7478:Atrnl1 UTSW 19 57,696,312 (GRCm38) missense possibly damaging 0.89
R7556:Atrnl1 UTSW 19 57,654,846 (GRCm38) missense probably benign
R7567:Atrnl1 UTSW 19 57,699,523 (GRCm38) missense probably damaging 0.98
R7608:Atrnl1 UTSW 19 57,714,687 (GRCm38) missense probably damaging 1.00
R7632:Atrnl1 UTSW 19 57,630,306 (GRCm38) missense probably damaging 1.00
R7655:Atrnl1 UTSW 19 57,611,379 (GRCm38) nonsense probably null
R7656:Atrnl1 UTSW 19 57,611,379 (GRCm38) nonsense probably null
R7718:Atrnl1 UTSW 19 57,740,183 (GRCm38) nonsense probably null
R7721:Atrnl1 UTSW 19 57,696,331 (GRCm38) missense probably benign 0.00
R7726:Atrnl1 UTSW 19 57,702,072 (GRCm38) missense probably damaging 1.00
R7733:Atrnl1 UTSW 19 57,701,988 (GRCm38) missense probably benign 0.00
R7774:Atrnl1 UTSW 19 57,699,671 (GRCm38) missense probably damaging 1.00
R8010:Atrnl1 UTSW 19 57,682,446 (GRCm38) missense probably benign 0.14
R8119:Atrnl1 UTSW 19 57,642,463 (GRCm38) missense probably benign 0.00
R9242:Atrnl1 UTSW 19 57,657,228 (GRCm38) missense probably benign 0.07
R9265:Atrnl1 UTSW 19 57,777,927 (GRCm38) missense probably benign 0.11
R9272:Atrnl1 UTSW 19 57,654,988 (GRCm38) missense probably benign 0.00
R9480:Atrnl1 UTSW 19 57,701,988 (GRCm38) missense possibly damaging 0.61
R9526:Atrnl1 UTSW 19 57,629,119 (GRCm38) missense probably damaging 0.99
R9672:Atrnl1 UTSW 19 57,630,263 (GRCm38) missense possibly damaging 0.87
R9673:Atrnl1 UTSW 19 57,611,354 (GRCm38) start codon destroyed probably null 0.04
RF021:Atrnl1 UTSW 19 57,642,473 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTTAGGTACATGATAGACAGAGGACAC -3'
(R):5'- AGCCTCTGTAACTGCCATCG -3'

Sequencing Primer
(F):5'- AGTTTTGCAAAGTCATATAGGTGAC -3'
(R):5'- GCCTCTGTAACTGCCATCGTTAAAC -3'
Posted On 2019-06-07