Incidental Mutation 'B5639:Olfr1155'
ID 557
Institutional Source Beutler Lab
Gene Symbol Olfr1155
Ensembl Gene ENSMUSG00000075145
Gene Name olfactory receptor 1155
Synonyms GA_x6K02T2Q125-49426894-49425950, MOR174-10
Accession Numbers

Genbank: NM_146643; MGI: 3030989

Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock # B5639 of strain 3d
Quality Score
Status Validated
Chromosome 2
Chromosomal Location 87941645-87945137 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 87943598 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Phenylalanine at position 10 (S10F)
Ref Sequence ENSEMBL: ENSMUSP00000149428 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099843] [ENSMUST00000214641] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]
AlphaFold Q8VFR3
Predicted Effect probably benign
Transcript: ENSMUST00000099843
AA Change: S10F

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000097431
Gene: ENSMUSG00000075145
AA Change: S10F

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.7e-44 PFAM
Pfam:7tm_1 43 292 5.3e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214641
AA Change: S10F

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000215903
AA Change: S10F

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000216191
Predicted Effect probably benign
Transcript: ENSMUST00000216726
Meta Mutation Damage Score 0.1056 question?
Coding Region Coverage
  • 1x: 89.7%
  • 3x: 78.3%
Het Detection Efficiency 55.9%
Validation Efficiency 83% (206/248)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Dnmt1 G A 9: 20,907,968 probably benign Het
Eno1 A G 4: 150,245,112 probably benign Het
Ercc8 G A 13: 108,160,723 G56R probably damaging Homo
Gm8773 C T 5: 5,574,060 probably benign Homo
Idh1 A G 1: 65,165,098 probably null Homo
Incenp G A 19: 9,893,818 T149I unknown Het
Olfr181 A T 16: 58,926,526 I15K probably benign Homo
Pdk2 T C 11: 95,032,498 D100G possibly damaging Homo
Prss56 T C 1: 87,187,170 L465P probably benign Homo
Slc10a3 G A X: 74,369,539 P416L probably damaging Homo
Syne2 C A 12: 75,929,790 T1243K probably benign Het
Vwf T C 6: 125,642,984 Y1542H probably damaging Homo
Zc3h13 G A 14: 75,316,039 R302Q probably damaging Het
Zfhx4 G T 3: 5,403,175 G2798W probably damaging Homo
Zfp667 A G 7: 6,290,545 T15A probably damaging Het
Other mutations in Olfr1155
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02507:Olfr1155 APN 2 87942918 nonsense probably null
IGL03245:Olfr1155 APN 2 87942742 missense possibly damaging 0.75
PIT4531001:Olfr1155 UTSW 2 87943227 missense probably damaging 1.00
R0212:Olfr1155 UTSW 2 87943091 missense probably damaging 1.00
R0393:Olfr1155 UTSW 2 87943565 missense possibly damaging 0.62
R1178:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R1180:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R1181:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R1266:Olfr1155 UTSW 2 87943533 missense probably benign 0.01
R1847:Olfr1155 UTSW 2 87942721 splice site probably null
R1998:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R2000:Olfr1155 UTSW 2 87943146 missense probably benign 0.02
R4119:Olfr1155 UTSW 2 87943443 missense probably damaging 1.00
R4213:Olfr1155 UTSW 2 87943121 missense probably benign 0.00
R5157:Olfr1155 UTSW 2 87942888 missense probably benign
R5688:Olfr1155 UTSW 2 87943208 missense probably benign 0.02
R5731:Olfr1155 UTSW 2 87943427 missense possibly damaging 0.89
R6064:Olfr1155 UTSW 2 87943484 missense probably benign 0.00
R6372:Olfr1155 UTSW 2 87942975 missense probably benign 0.00
R6505:Olfr1155 UTSW 2 87943174 nonsense probably null
R6555:Olfr1155 UTSW 2 87943288 missense probably damaging 1.00
R6909:Olfr1155 UTSW 2 87942690 missense probably benign 0.27
R7257:Olfr1155 UTSW 2 87943571 missense probably damaging 1.00
R8037:Olfr1155 UTSW 2 87942975 missense probably benign 0.00
R8367:Olfr1155 UTSW 2 87943097 missense possibly damaging 0.75
R9301:Olfr1155 UTSW 2 87942953 missense probably benign 0.00
Z1088:Olfr1155 UTSW 2 87943448 missense probably damaging 1.00
Z1176:Olfr1155 UTSW 2 87943209 missense possibly damaging 0.57
Z1176:Olfr1155 UTSW 2 87943467 missense probably damaging 1.00
Nature of Mutation

DNA sequencing using the SOLiD technique identified a C to T transition at position 29 of the Olfr1155 transcript.  The mutated nucleotide causes a serine to phenylalanine substitution at amino acid 10 of the encoded protein. The mutation has been confirmed by DNA sequencing using the Sanger method (see trace files for B5639).

Protein Function and Prediction

The Olfr1155 gene encodes the 314 amino acid olfactory receptor 1155. Olfactory receptors are G-protein coupled receptors (GPCRs) and generally seven transmembrane domains, an extracellular N-terminus, and a cytoplasmic C-terminus.

 

The S10F change is predicted to be benign by the PolyPhen program.

Posted On 2010-11-19