Incidental Mutation 'PIT4151001:Or5m13b'
ID 557000
Institutional Source Beutler Lab
Gene Symbol Or5m13b
Ensembl Gene ENSMUSG00000042863
Gene Name olfactory receptor family 5 subfamily M member 13B
Synonyms Olfr1026, MOR196-4, GA_x6K02T2Q125-47402610-47403533
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # PIT4151001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 85753614-85754537 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85754386 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 258 (M258K)
Ref Sequence ENSEMBL: ENSMUSP00000151927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056718] [ENSMUST00000213474] [ENSMUST00000217615] [ENSMUST00000219615]
AlphaFold Q7TR90
Predicted Effect probably damaging
Transcript: ENSMUST00000056718
AA Change: M258K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000049887
Gene: ENSMUSG00000042863
AA Change: M258K

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-58 PFAM
Pfam:7tm_1 41 290 9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213474
Predicted Effect probably damaging
Transcript: ENSMUST00000217615
AA Change: M258K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000219615
AA Change: M258K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 92.7%
  • 3x: 90.4%
  • 10x: 84.6%
  • 20x: 72.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T C 3: 121,930,670 (GRCm39) L1389P probably damaging Het
Acot10 C T 15: 20,666,684 (GRCm39) G19D probably damaging Het
Adam20 G A 8: 41,248,081 (GRCm39) V64I possibly damaging Het
Ak6 T A 13: 100,791,603 (GRCm39) D15E probably damaging Het
Atp1a2 A G 1: 172,118,288 (GRCm39) Y129H probably damaging Het
Caskin1 C T 17: 24,721,193 (GRCm39) T511I probably damaging Het
Casp9 C T 4: 141,521,259 (GRCm39) R32* probably null Het
Ccdc40 A G 11: 119,133,277 (GRCm39) E445G probably damaging Het
Cct8 T C 16: 87,284,545 (GRCm39) E273G probably damaging Het
Chd5 G A 4: 152,462,986 (GRCm39) V1380I probably damaging Het
Coro2b C T 9: 62,336,286 (GRCm39) G272D probably damaging Het
Cyp4a10 C A 4: 115,382,072 (GRCm39) H251Q probably damaging Het
Dgki A T 6: 37,040,916 (GRCm39) H298Q probably benign Het
Dnmt3b T G 2: 153,526,399 (GRCm39) probably null Het
Dzip1 A G 14: 119,160,200 (GRCm39) F3L probably damaging Het
Egf A G 3: 129,496,198 (GRCm39) S807P probably benign Het
Emc10 C T 7: 44,142,627 (GRCm39) R105H Het
Enthd1 T C 15: 80,336,937 (GRCm39) E499G probably damaging Het
Eps8l1 G A 7: 4,474,414 (GRCm39) S295N probably benign Het
Fer1l5 T A 1: 36,450,728 (GRCm39) M1242K probably benign Het
Gm3415 A G 5: 146,493,079 (GRCm39) R36G probably benign Het
Gm5797 C A 14: 7,330,318 (GRCm38) M114I possibly damaging Het
Gmppa A T 1: 75,418,468 (GRCm39) R284* probably null Het
Homer1 G C 13: 93,485,724 (GRCm39) K118N probably damaging Het
Ivl TTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG TTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG 3: 92,479,608 (GRCm39) probably benign Het
Kcnc4 G A 3: 107,366,019 (GRCm39) A63V probably damaging Het
Kif11 T A 19: 37,373,045 (GRCm39) I88N probably damaging Het
Krba1 T C 6: 48,379,831 (GRCm39) F9S probably damaging Het
Nckap1 A G 2: 80,350,714 (GRCm39) probably null Het
Nox4 A T 7: 86,954,097 (GRCm39) Y134F probably benign Het
Or4a79 T A 2: 89,552,237 (GRCm39) T73S probably benign Het
Or51f23c-ps1 T C 7: 102,431,465 (GRCm39) S261P probably benign Het
Or52e15 A G 7: 104,645,424 (GRCm39) L229P probably damaging Het
Or5m8 T C 2: 85,822,538 (GRCm39) C126R probably damaging Het
Or8k22 G T 2: 86,163,173 (GRCm39) H176N possibly damaging Het
Pcdh17 G T 14: 84,684,798 (GRCm39) V422L probably benign Het
Pcx T A 19: 4,653,157 (GRCm39) V275E probably damaging Het
Pde6h A T 6: 136,938,185 (GRCm39) M53L possibly damaging Het
Phactr3 A T 2: 177,975,861 (GRCm39) E535D probably damaging Het
Pkn3 C A 2: 29,980,539 (GRCm39) T810N probably damaging Het
Pnpla5 T C 15: 84,002,827 (GRCm39) E252G probably damaging Het
Pramel21 T A 4: 143,342,722 (GRCm39) C276* probably null Het
Psg17 A G 7: 18,548,530 (GRCm39) S414P probably benign Het
Pzp T A 6: 128,502,259 (GRCm39) Q30L probably benign Het
Reln A T 5: 22,491,894 (GRCm39) F113I possibly damaging Het
Ret T C 6: 118,141,702 (GRCm39) D975G probably benign Het
Sarnp A G 10: 128,713,235 (GRCm39) I209V probably benign Het
Sorl1 A T 9: 41,879,918 (GRCm39) V2210D probably damaging Het
Stard9 C T 2: 120,533,237 (GRCm39) Q3165* probably null Het
Tmem64 A T 4: 15,283,159 (GRCm39) I319F probably damaging Het
Vmn1r176 A T 7: 23,534,808 (GRCm39) V115D probably damaging Het
Vmn1r2 A G 4: 3,172,623 (GRCm39) T181A probably benign Het
Vmn2r2 T C 3: 64,024,334 (GRCm39) E749G possibly damaging Het
Vps35 G A 8: 86,010,677 (GRCm39) T222I possibly damaging Het
Zfp532 A G 18: 65,757,485 (GRCm39) T473A probably damaging Het
Zfyve16 A G 13: 92,657,712 (GRCm39) V733A probably damaging Het
Zranb1 T A 7: 132,551,723 (GRCm39) S125T probably benign Het
Other mutations in Or5m13b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01701:Or5m13b APN 2 85,754,421 (GRCm39) missense possibly damaging 0.81
R0147:Or5m13b UTSW 2 85,754,362 (GRCm39) missense possibly damaging 0.61
R0601:Or5m13b UTSW 2 85,753,722 (GRCm39) missense probably benign 0.01
R0899:Or5m13b UTSW 2 85,753,731 (GRCm39) missense probably benign
R1728:Or5m13b UTSW 2 85,754,466 (GRCm39) missense possibly damaging 0.48
R2004:Or5m13b UTSW 2 85,753,939 (GRCm39) splice site probably null
R2020:Or5m13b UTSW 2 85,754,087 (GRCm39) missense probably benign
R2396:Or5m13b UTSW 2 85,754,269 (GRCm39) missense probably benign 0.00
R2519:Or5m13b UTSW 2 85,753,951 (GRCm39) missense probably damaging 1.00
R3153:Or5m13b UTSW 2 85,754,074 (GRCm39) missense probably benign
R4696:Or5m13b UTSW 2 85,749,215 (GRCm39) splice site probably null
R5034:Or5m13b UTSW 2 85,753,891 (GRCm39) missense probably damaging 0.99
R5221:Or5m13b UTSW 2 85,754,493 (GRCm39) missense probably damaging 1.00
R5334:Or5m13b UTSW 2 85,754,058 (GRCm39) missense probably damaging 1.00
R6041:Or5m13b UTSW 2 85,753,735 (GRCm39) missense probably damaging 1.00
R7602:Or5m13b UTSW 2 85,754,146 (GRCm39) missense probably damaging 1.00
R8075:Or5m13b UTSW 2 85,754,470 (GRCm39) missense probably benign 0.18
R8697:Or5m13b UTSW 2 85,754,200 (GRCm39) missense possibly damaging 0.77
R8971:Or5m13b UTSW 2 85,754,328 (GRCm39) missense probably damaging 1.00
R9237:Or5m13b UTSW 2 85,754,267 (GRCm39) nonsense probably null
R9347:Or5m13b UTSW 2 85,753,819 (GRCm39) missense probably damaging 1.00
Z1088:Or5m13b UTSW 2 85,754,142 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGGTCCTTGCTTGCTCAGAC -3'
(R):5'- AACATTTTACATACCTGCGACC -3'

Sequencing Primer
(F):5'- AAAAACTGCCATGTTTGTGGTG -3'
(R):5'- ACATTTTACATACCTGCGACCAATTC -3'
Posted On 2019-06-07