Incidental Mutation 'R6951:Platr25'
ID 557092
Institutional Source Beutler Lab
Gene Symbol Platr25
Ensembl Gene ENSMUSG00000074863
Gene Name pluripotency associated transcript 25
Synonyms Gm5665, 6720490N10Rik
MMRRC Submission 045063-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # R6951 (G1)
Quality Score 65.0074
Status Validated
Chromosome 13
Chromosomal Location 62819598-62908523 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 62853562 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 77 (D77E)
Ref Sequence ENSEMBL: ENSMUSP00000152470 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000143260] [ENSMUST00000220733] [ENSMUST00000222303] [ENSMUST00000222477] [ENSMUST00000222602] [ENSMUST00000223219] [ENSMUST00000223528]
AlphaFold A0A1Y7VIZ1
Predicted Effect probably benign
Transcript: ENSMUST00000143260
AA Change: D77E

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000220733
Predicted Effect probably benign
Transcript: ENSMUST00000222303
AA Change: D77E

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000222477
Predicted Effect probably benign
Transcript: ENSMUST00000222602
Predicted Effect probably benign
Transcript: ENSMUST00000223219
Predicted Effect probably benign
Transcript: ENSMUST00000223528
AA Change: D77E

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.0%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd34a A G 3: 96,505,738 (GRCm39) N314S possibly damaging Het
Arhgef3 A T 14: 26,865,975 (GRCm39) probably benign Het
Bmp1 T C 14: 70,746,298 (GRCm39) R114G probably benign Het
Cenpf A G 1: 189,385,989 (GRCm39) L2097P probably damaging Het
Cgas A G 9: 78,349,840 (GRCm39) V174A probably damaging Het
Dapk2 C G 9: 66,161,904 (GRCm39) R271G probably benign Het
Dnase2a A T 8: 85,636,254 (GRCm39) N130I possibly damaging Het
Dpp10 C T 1: 123,269,379 (GRCm39) V677M possibly damaging Het
Dsp G A 13: 38,351,622 (GRCm39) C147Y possibly damaging Het
Ecpas A G 4: 58,853,114 (GRCm39) probably null Het
Esyt2 A G 12: 116,287,750 (GRCm39) T223A probably benign Het
Fndc5 G A 4: 129,032,573 (GRCm39) V59I possibly damaging Het
Fsip2 A G 2: 82,812,293 (GRCm39) T2871A possibly damaging Het
H2-Eb1 A T 17: 34,528,831 (GRCm39) R121* probably null Het
Hydin A G 8: 111,124,757 (GRCm39) I589V probably benign Het
Kitl A G 10: 99,887,714 (GRCm39) I48V probably damaging Het
Large1 A G 8: 73,843,047 (GRCm39) S159P probably damaging Het
Lrba T C 3: 86,653,180 (GRCm39) L2570P probably benign Het
Mag G A 7: 30,610,858 (GRCm39) T128I possibly damaging Het
Mkrn3 G T 7: 62,068,881 (GRCm39) D303E possibly damaging Het
Myo9a A G 9: 59,802,051 (GRCm39) D1951G probably damaging Het
Nup85 C T 11: 115,473,781 (GRCm39) T565I possibly damaging Het
Or5l13 T C 2: 87,780,323 (GRCm39) I85V possibly damaging Het
Or8b1d A G 9: 38,558,170 (GRCm39) S217P probably damaging Het
Or8b43 A G 9: 38,360,234 (GRCm39) D22G probably benign Het
Or8k31-ps1 T C 2: 86,355,993 (GRCm39) H176R probably damaging Het
Pdzrn3 A T 6: 101,131,153 (GRCm39) probably null Het
Picalm T A 7: 89,840,583 (GRCm39) N434K probably damaging Het
Prr22 A T 17: 57,079,028 (GRCm39) R394* probably null Het
Psg23 A T 7: 18,348,636 (GRCm39) L57Q probably damaging Het
Rap1gap2 G A 11: 74,375,774 (GRCm39) S44L possibly damaging Het
Rffl A G 11: 82,736,576 (GRCm39) probably null Het
Stox2 G A 8: 47,656,167 (GRCm39) T103I probably damaging Het
Swt1 T C 1: 151,273,019 (GRCm39) N543S possibly damaging Het
Tep1 C T 14: 51,071,370 (GRCm39) probably null Het
Tln2 A G 9: 67,165,767 (GRCm39) Y1023H probably damaging Het
Tssk5 C A 15: 76,257,096 (GRCm39) R262L possibly damaging Het
Ttn C T 2: 76,710,986 (GRCm39) probably benign Het
Ubtfl1 A T 9: 18,320,873 (GRCm39) I134F probably benign Het
Unc80 T C 1: 66,687,670 (GRCm39) F2351S possibly damaging Het
Vps13a A T 19: 16,701,104 (GRCm39) D688E probably benign Het
Other mutations in Platr25
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6272:Platr25 UTSW 13 62,820,811 (GRCm39) missense possibly damaging 0.82
R6379:Platr25 UTSW 13 62,854,051 (GRCm39) missense probably damaging 1.00
R6548:Platr25 UTSW 13 62,821,623 (GRCm39) missense possibly damaging 0.93
R6728:Platr25 UTSW 13 62,848,197 (GRCm39) missense probably damaging 1.00
R7365:Platr25 UTSW 13 62,848,719 (GRCm39) missense probably benign
R7885:Platr25 UTSW 13 62,848,676 (GRCm39) missense possibly damaging 0.91
R8114:Platr25 UTSW 13 62,821,738 (GRCm39) missense possibly damaging 0.66
R8331:Platr25 UTSW 13 62,848,717 (GRCm39) missense probably benign 0.01
R8514:Platr25 UTSW 13 62,848,586 (GRCm39) missense probably damaging 1.00
R8754:Platr25 UTSW 13 62,847,924 (GRCm39) makesense probably null
R8822:Platr25 UTSW 13 62,848,658 (GRCm39) missense probably benign 0.45
R9011:Platr25 UTSW 13 62,848,280 (GRCm39) missense probably damaging 1.00
R9038:Platr25 UTSW 13 62,848,007 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATGGTGGGACTCATGTCT -3'
(R):5'- GCTGGCTTCGATCTCAGAAATC -3'

Sequencing Primer
(F):5'- CTATGCTCCAGTATAGGGGAATGCC -3'
(R):5'- CCTGCCTCTGTCTGGGATTAAAG -3'
Posted On 2019-06-14