Incidental Mutation 'R0585:Lyz3'
ID 55723
Institutional Source Beutler Lab
Gene Symbol Lyz3
Ensembl Gene ENSMUSG00000020177
Gene Name lysozyme 3
Synonyms 9530003J23Rik
MMRRC Submission 038775-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R0585 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 117069658-117074586 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 117074356 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 44 (I44F)
Ref Sequence ENSEMBL: ENSMUSP00000125436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020392] [ENSMUST00000159193]
AlphaFold Q8BM26
Predicted Effect possibly damaging
Transcript: ENSMUST00000020392
AA Change: I44F

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000020392
Gene: ENSMUSG00000020177
AA Change: I44F

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
LYZ1 22 150 4.85e-73 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000159193
AA Change: I44F

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000125436
Gene: ENSMUSG00000020177
AA Change: I44F

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
LYZ1 22 150 4.85e-73 SMART
Meta Mutation Damage Score 0.1371 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.2%
Validation Efficiency 100% (38/38)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Brdt T G 5: 107,504,748 (GRCm39) probably null Het
Ccdc162 C T 10: 41,462,375 (GRCm39) C1474Y probably benign Het
Ces2e T C 8: 105,656,453 (GRCm39) S228P probably damaging Het
Clca3a1 G T 3: 144,738,386 (GRCm39) H41N probably benign Het
Cyp2c39 A T 19: 39,525,203 (GRCm39) I169F probably benign Het
Cyp2c65 A G 19: 39,057,686 (GRCm39) K107R probably benign Het
Cyp2c67 T A 19: 39,627,138 (GRCm39) N231Y possibly damaging Het
Eps8l3 G C 3: 107,788,513 (GRCm39) D33H probably damaging Het
Evi5 T C 5: 107,961,402 (GRCm39) probably benign Het
Fcho1 T C 8: 72,168,369 (GRCm39) Y218C probably damaging Het
Gm3993 T A 12: 20,122,149 (GRCm39) probably null Het
Gtf2ird1 A C 5: 134,405,796 (GRCm39) L28R probably damaging Het
Hsf4 A G 8: 105,997,663 (GRCm39) D75G probably damaging Het
Iqca1l A G 5: 24,755,721 (GRCm39) V267A probably benign Het
Larp4b A G 13: 9,197,529 (GRCm39) T249A probably damaging Het
Larp4b A G 13: 9,220,737 (GRCm39) D578G probably benign Het
Matn3 A T 12: 9,011,103 (GRCm39) probably benign Het
Myo10 T A 15: 25,736,541 (GRCm39) Y428N probably damaging Het
Nf1 T A 11: 79,459,527 (GRCm39) D661E probably damaging Het
Nktr A G 9: 121,583,346 (GRCm39) probably benign Het
Npbwr1 G A 1: 5,986,677 (GRCm39) T279I possibly damaging Het
Or52n3 A C 7: 104,530,706 (GRCm39) H264P probably damaging Het
Osmr T C 15: 6,867,274 (GRCm39) I341V probably benign Het
Pan2 T C 10: 128,146,384 (GRCm39) probably null Het
Pknox2 G A 9: 36,821,056 (GRCm39) probably benign Het
Pla2g2d A C 4: 138,506,704 (GRCm39) D50A probably benign Het
Ptprk C T 10: 28,451,664 (GRCm39) L1051F probably damaging Het
Rap1gds1 G A 3: 138,727,633 (GRCm39) T59M probably benign Het
Rps5 T C 7: 12,659,332 (GRCm39) V41A possibly damaging Het
Ryr1 G T 7: 28,735,501 (GRCm39) D4092E probably damaging Het
Spic T C 10: 88,511,905 (GRCm39) Y117C probably damaging Het
Thrap3 A T 4: 126,072,367 (GRCm39) probably null Het
Tlr9 C T 9: 106,102,275 (GRCm39) T522I probably benign Het
Tspan3 A T 9: 56,053,216 (GRCm39) probably benign Het
Ttn T C 2: 76,703,503 (GRCm39) probably benign Het
Zfp773 T A 7: 7,135,574 (GRCm39) I341L probably benign Het
Zmat3 G A 3: 32,415,254 (GRCm39) P19S probably damaging Het
Other mutations in Lyz3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00543:Lyz3 APN 10 117,074,352 (GRCm39) missense probably benign 0.33
R0610:Lyz3 UTSW 10 117,073,635 (GRCm39) missense probably benign 0.01
R2925:Lyz3 UTSW 10 117,070,336 (GRCm39) missense probably benign 0.02
R6656:Lyz3 UTSW 10 117,071,534 (GRCm39) missense probably benign 0.00
R6934:Lyz3 UTSW 10 117,074,413 (GRCm39) missense probably benign 0.00
R7150:Lyz3 UTSW 10 117,073,647 (GRCm39) missense probably benign 0.01
R7255:Lyz3 UTSW 10 117,070,327 (GRCm39) missense probably benign
R7439:Lyz3 UTSW 10 117,074,602 (GRCm39) unclassified probably benign
R8759:Lyz3 UTSW 10 117,070,340 (GRCm39) missense probably damaging 0.98
R9783:Lyz3 UTSW 10 117,073,653 (GRCm39) missense possibly damaging 0.78
RF014:Lyz3 UTSW 10 117,070,322 (GRCm39) makesense probably null
Z1177:Lyz3 UTSW 10 117,071,546 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GCCCTGGGAGAACGTCTTTGTAATG -3'
(R):5'- GCATGAAGCTCAAAACGTCGAGTC -3'

Sequencing Primer
(F):5'- GGAGAACGTCTTTGTAATGTAAGTC -3'
(R):5'- TAAATACTGGGGCCTGATCGC -3'
Posted On 2013-07-11