Incidental Mutation 'R7164:Tas2r114'
ID 557796
Institutional Source Beutler Lab
Gene Symbol Tas2r114
Ensembl Gene ENSMUSG00000063478
Gene Name taste receptor, type 2, member 114
Synonyms mt2r46, mGR14, T2R14, Tas2r14
MMRRC Submission 045331-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R7164 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 131666097-131667026 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 131666728 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 100 (A100V)
Ref Sequence ENSEMBL: ENSMUSP00000079453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053652] [ENSMUST00000072404] [ENSMUST00000080619]
AlphaFold Q7M722
Predicted Effect probably benign
Transcript: ENSMUST00000053652
SMART Domains Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 9.4e-109 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000072404
SMART Domains Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.3e-102 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000080619
AA Change: A100V

PolyPhen 2 Score 0.742 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478
AA Change: A100V

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.1e-104 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn2 G A 13: 12,293,847 (GRCm39) H558Y probably damaging Het
Ajm1 T A 2: 25,468,579 (GRCm39) H444L possibly damaging Het
Akap9 G C 5: 4,110,364 (GRCm39) E3022D probably damaging Het
Anapc2 C T 2: 25,175,011 (GRCm39) R710C probably damaging Het
Bcl6 G A 16: 23,784,976 (GRCm39) R675* probably null Het
Carmil3 A G 14: 55,738,739 (GRCm39) E844G probably damaging Het
Cdk17 T G 10: 93,068,343 (GRCm39) S367A probably benign Het
Cfap206 T A 4: 34,719,656 (GRCm39) M253L probably benign Het
Chd3 T G 11: 69,253,132 (GRCm39) K228Q probably damaging Het
Cit T A 5: 116,123,846 (GRCm39) I1503N possibly damaging Het
Csn1s1 A G 5: 87,822,087 (GRCm39) N119S possibly damaging Het
Czib C A 4: 107,752,087 (GRCm39) D155E not run Het
Degs1 A G 1: 182,106,690 (GRCm39) S226P probably damaging Het
Espl1 T C 15: 102,221,638 (GRCm39) W976R probably damaging Het
Fbxl4 C T 4: 22,386,218 (GRCm39) P275L probably benign Het
Flnb A G 14: 7,915,944 (GRCm38) probably null Het
Gnptab T A 10: 88,269,932 (GRCm39) Y878* probably null Het
Gpr89 A T 3: 96,778,714 (GRCm39) M453K probably benign Het
Igsf5 A T 16: 96,174,048 (GRCm39) Q26L possibly damaging Het
Inpp5e T A 2: 26,297,995 (GRCm39) D202V possibly damaging Het
Itga3 C T 11: 94,943,305 (GRCm39) V931M possibly damaging Het
Kcnab3 T C 11: 69,222,184 (GRCm39) probably null Het
Klk4 T C 7: 43,531,122 (GRCm39) I17T possibly damaging Het
Lrrc73 T C 17: 46,567,169 (GRCm39) L206P probably damaging Het
Manba A T 3: 135,248,149 (GRCm39) N346I probably damaging Het
Map4k4 T C 1: 40,013,132 (GRCm39) Y76H possibly damaging Het
Map4k5 T C 12: 69,877,210 (GRCm39) T312A probably benign Het
Masp2 A G 4: 148,694,572 (GRCm39) probably null Het
Mast1 T C 8: 85,661,933 (GRCm39) D63G possibly damaging Het
Mtf2 T A 5: 108,241,235 (GRCm39) S254T possibly damaging Het
Myo16 A T 8: 10,619,585 (GRCm39) T1379S unknown Het
Myo5a A G 9: 75,087,435 (GRCm39) E1097G probably benign Het
Nat1 T C 8: 67,944,329 (GRCm39) V238A possibly damaging Het
Nhlrc2 A G 19: 56,580,931 (GRCm39) D493G probably damaging Het
Or10ak9 C T 4: 118,726,922 (GRCm39) P315S probably benign Het
Or1j21 T C 2: 36,683,709 (GRCm39) S154P probably benign Het
Or5ae2 A G 7: 84,506,251 (GRCm39) I227V possibly damaging Het
Or5b108 A T 19: 13,168,270 (GRCm39) M80L probably benign Het
Or5d20-ps1 T C 2: 87,932,176 (GRCm39) K52E probably damaging Het
Or8g51 A G 9: 38,609,515 (GRCm39) I49T possibly damaging Het
Pcsk5 C T 19: 17,429,349 (GRCm39) C1543Y probably damaging Het
Pde4d A G 13: 109,169,222 (GRCm39) D88G probably benign Het
Pld5 A T 1: 176,041,187 (GRCm39) M1K probably null Het
Prmt6 A G 3: 110,157,680 (GRCm39) M203T probably benign Het
Prr14l A T 5: 32,986,510 (GRCm39) V995D probably damaging Het
Psg18 T C 7: 18,084,862 (GRCm39) E199G possibly damaging Het
Pth1r A G 9: 110,552,815 (GRCm39) I439T possibly damaging Het
Ptprc T A 1: 138,045,600 (GRCm39) I87F probably benign Het
Slc44a1 T C 4: 53,528,711 (GRCm39) S154P probably benign Het
Slco1c1 T A 6: 141,487,855 (GRCm39) Y192* probably null Het
Spag16 A G 1: 70,764,025 (GRCm39) H615R possibly damaging Het
Spata31h1 G A 10: 82,122,063 (GRCm39) T3649I probably damaging Het
U2af1l4 T C 7: 30,264,544 (GRCm39) S103P probably benign Het
Usp10 T C 8: 120,668,847 (GRCm39) S383P probably damaging Het
Vmn2r113 A G 17: 23,167,137 (GRCm39) R505G probably benign Het
Vmn2r75 A C 7: 85,814,592 (GRCm39) D300E probably damaging Het
Zfp318 T A 17: 46,708,232 (GRCm39) probably null Het
Zfp318 T C 17: 46,716,865 (GRCm39) V999A probably damaging Het
Zfp324 A T 7: 12,702,810 (GRCm39) H58L probably damaging Het
Zfp707 A G 15: 75,846,967 (GRCm39) E339G possibly damaging Het
Other mutations in Tas2r114
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01777:Tas2r114 APN 6 131,666,664 (GRCm39) nonsense probably null
IGL02971:Tas2r114 APN 6 131,666,243 (GRCm39) missense probably benign 0.00
R0561:Tas2r114 UTSW 6 131,666,758 (GRCm39) missense probably benign 0.30
R3034:Tas2r114 UTSW 6 131,666,611 (GRCm39) missense probably benign 0.15
R3687:Tas2r114 UTSW 6 131,666,231 (GRCm39) missense probably benign 0.25
R4411:Tas2r114 UTSW 6 131,666,585 (GRCm39) missense probably benign 0.06
R4826:Tas2r114 UTSW 6 131,666,800 (GRCm39) missense probably damaging 0.99
R4889:Tas2r114 UTSW 6 131,666,758 (GRCm39) missense probably damaging 0.96
R5084:Tas2r114 UTSW 6 131,666,251 (GRCm39) nonsense probably null
R5258:Tas2r114 UTSW 6 131,666,504 (GRCm39) missense probably benign 0.03
R6038:Tas2r114 UTSW 6 131,666,444 (GRCm39) missense possibly damaging 0.89
R6038:Tas2r114 UTSW 6 131,666,444 (GRCm39) missense possibly damaging 0.89
R6499:Tas2r114 UTSW 6 131,666,099 (GRCm39) makesense probably null
R7276:Tas2r114 UTSW 6 131,666,310 (GRCm39) missense probably damaging 0.96
R7745:Tas2r114 UTSW 6 131,666,401 (GRCm39) missense probably damaging 1.00
R7851:Tas2r114 UTSW 6 131,666,888 (GRCm39) missense probably damaging 1.00
R8002:Tas2r114 UTSW 6 131,666,102 (GRCm39) missense probably damaging 1.00
R8901:Tas2r114 UTSW 6 131,666,914 (GRCm39) missense probably damaging 0.99
R9297:Tas2r114 UTSW 6 131,666,287 (GRCm39) missense probably damaging 0.96
R9380:Tas2r114 UTSW 6 131,666,381 (GRCm39) missense probably benign 0.00
R9402:Tas2r114 UTSW 6 131,666,894 (GRCm39) missense possibly damaging 0.49
R9473:Tas2r114 UTSW 6 131,666,104 (GRCm39) missense probably benign
R9513:Tas2r114 UTSW 6 131,666,746 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGCCAAGATGTGTTTATATACAGC -3'
(R):5'- CTGGGCATTGTAGGGAACAC -3'

Sequencing Primer
(F):5'- AGCACCCTATCAGGAAGA -3'
(R):5'- GGGAACACATTCATTGCACTTG -3'
Posted On 2019-06-26