Mutagenetix > Incidental Mutation

Incidental Mutation 'R7164:Cdk17'

557813

Institutional Source

Beutler Lab

Gene Symbol

Cdk17

Ensembl Gene

ENSMUSG00000020015

Gene Name

cyclin-dependent kinase 17

Synonyms

Pctk2, 6430598J10Rik

MMRRC Submission

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.369) question?

Stock #

R7164 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

93160875-93267071 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 93232481 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 367 (S367A)

Ref Sequence

ENSEMBL: ENSMUSP00000070355 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069965] [ENSMUST00000215286]

AlphaFold

Q8K0D0

Predicted Effect

probably benign
Transcript: ENSMUST00000069965
AA Change: S367A

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000070355
Gene: ENSMUSG00000020015
AA Change: S367A

Domain	Start	End	E-Value	Type
S_TKc	192	473	4.67e-97	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215286
AA Change: S334A

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

100% (59/59)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610037L13Rik	C	A	4: 107,894,890	D155E	not run	Het
4932415D10Rik	G	A	10: 82,286,229	T3649I	probably damaging	Het
Actn2	G	A	13: 12,278,961	H558Y	probably damaging	Het
Akap9	G	C	5: 4,060,364	E3022D	probably damaging	Het
Anapc2	C	T	2: 25,284,999	R710C	probably damaging	Het
Bcl6	G	A	16: 23,966,226	R675*	probably null	Het
Carmil3	A	G	14: 55,501,282	E844G	probably damaging	Het
Cfap206	T	A	4: 34,719,656	M253L	probably benign	Het
Chd3	T	G	11: 69,362,306	K228Q	probably damaging	Het
Cit	T	A	5: 115,985,787	I1503N	possibly damaging	Het
Csn1s1	A	G	5: 87,674,228	N119S	possibly damaging	Het
Degs1	A	G	1: 182,279,125	S226P	probably damaging	Het
Espl1	T	C	15: 102,313,203	W976R	probably damaging	Het
Fbxl4	C	T	4: 22,386,218	P275L	probably benign	Het
Flnb	A	G	14: 7,915,944		probably null	Het
Gm996	T	A	2: 25,578,567	H444L	possibly damaging	Het
Gnptab	T	A	10: 88,434,070	Y878*	probably null	Het
Gpr89	A	T	3: 96,871,398	M453K	probably benign	Het
Igsf5	A	T	16: 96,372,848	Q26L	possibly damaging	Het
Inpp5e	T	A	2: 26,407,983	D202V	possibly damaging	Het
Itga3	C	T	11: 95,052,479	V931M	possibly damaging	Het
Kcnab3	T	C	11: 69,331,358		probably null	Het
Klk4	T	C	7: 43,881,698	I17T	possibly damaging	Het
Lrrc73	T	C	17: 46,256,243	L206P	probably damaging	Het
Manba	A	T	3: 135,542,388	N346I	probably damaging	Het
Map4k4	T	C	1: 39,973,972	Y76H	possibly damaging	Het
Map4k5	T	C	12: 69,830,436	T312A	probably benign	Het
Masp2	A	G	4: 148,610,115		probably null	Het
Mast1	T	C	8: 84,935,304	D63G	possibly damaging	Het
Mtf2	T	A	5: 108,093,369	S254T	possibly damaging	Het
Myo16	A	T	8: 10,569,585	T1379S	unknown	Het
Myo5a	A	G	9: 75,180,153	E1097G	probably benign	Het
Nat1	T	C	8: 67,491,677	V238A	possibly damaging	Het
Nhlrc2	A	G	19: 56,592,499	D493G	probably damaging	Het
Olfr1165-ps	T	C	2: 88,101,832	K52E	probably damaging	Het
Olfr1331	C	T	4: 118,869,725	P315S	probably benign	Het
Olfr1462	A	T	19: 13,190,906	M80L	probably benign	Het
Olfr291	A	G	7: 84,857,043	I227V	possibly damaging	Het
Olfr50	T	C	2: 36,793,697	S154P	probably benign	Het
Olfr919	A	G	9: 38,698,219	I49T	possibly damaging	Het
Pcsk5	C	T	19: 17,451,985	C1543Y	probably damaging	Het
Pde4d	A	G	13: 109,032,688	D88G	probably benign	Het
Pld5	A	T	1: 176,213,621	M1K	probably null	Het
Prmt6	A	G	3: 110,250,364	M203T	probably benign	Het
Prr14l	A	T	5: 32,829,166	V995D	probably damaging	Het
Psg18	T	C	7: 18,350,937	E199G	possibly damaging	Het
Pth1r	A	G	9: 110,723,747	I439T	possibly damaging	Het
Ptprc	T	A	1: 138,117,862	I87F	probably benign	Het
Slc44a1	T	C	4: 53,528,711	S154P	probably benign	Het
Slco1c1	T	A	6: 141,542,129	Y192*	probably null	Het
Spag16	A	G	1: 70,724,866	H615R	possibly damaging	Het
Tas2r114	G	A	6: 131,689,765	A100V	possibly damaging	Het
U2af1l4	T	C	7: 30,565,119	S103P	probably benign	Het
Usp10	T	C	8: 119,942,108	S383P	probably damaging	Het
Vmn2r113	A	G	17: 22,948,163	R505G	probably benign	Het
Vmn2r75	A	C	7: 86,165,384	D300E	probably damaging	Het
Zfp318	T	A	17: 46,397,306		probably null	Het
Zfp318	T	C	17: 46,405,939	V999A	probably damaging	Het
Zfp324	A	T	7: 12,968,883	H58L	probably damaging	Het
Zfp707	A	G	15: 75,975,118	E339G	possibly damaging	Het

Other mutations in Cdk17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Cdk17	APN	10	93226771	missense	probably damaging	1.00
IGL00781:Cdk17	APN	10	93232416	missense	probably damaging	1.00
IGL01622:Cdk17	APN	10	93238962	unclassified	probably benign
IGL01623:Cdk17	APN	10	93238962	unclassified	probably benign
IGL01732:Cdk17	APN	10	93218045	missense	probably benign	0.01
IGL01768:Cdk17	APN	10	93208261	missense	probably damaging	0.99
IGL02942:Cdk17	APN	10	93238968	missense	probably benign
IGL03308:Cdk17	APN	10	93221644	critical splice donor site	probably null
delude	UTSW	10	93217961	splice site	probably null
Imagine	UTSW	10	93232415	missense	probably damaging	1.00
Magician	UTSW	10	93228703	missense	probably damaging	1.00
prestidigitator	UTSW	10	93226117	missense	probably damaging	1.00
R4436_Cdk17_536	UTSW	10	93211896	splice site	probably null
R0039:Cdk17	UTSW	10	93226778	splice site	probably benign
R0398:Cdk17	UTSW	10	93237840	missense	probably benign	0.01
R0432:Cdk17	UTSW	10	93237790	unclassified	probably benign
R0609:Cdk17	UTSW	10	93216472	missense	probably benign
R0781:Cdk17	UTSW	10	93239033	nonsense	probably null
R1110:Cdk17	UTSW	10	93239033	nonsense	probably null
R1604:Cdk17	UTSW	10	93232498	missense	probably damaging	1.00
R1674:Cdk17	UTSW	10	93221630	missense	probably benign	0.21
R1758:Cdk17	UTSW	10	93208250	missense	probably damaging	1.00
R1797:Cdk17	UTSW	10	93208252	missense	possibly damaging	0.76
R1864:Cdk17	UTSW	10	93226105	missense	probably damaging	1.00
R1924:Cdk17	UTSW	10	93226117	missense	probably damaging	1.00
R1929:Cdk17	UTSW	10	93228678	missense	probably damaging	1.00
R2143:Cdk17	UTSW	10	93218019	missense	probably damaging	1.00
R2207:Cdk17	UTSW	10	93228762	missense	probably damaging	1.00
R2261:Cdk17	UTSW	10	93211958	missense	possibly damaging	0.90
R2262:Cdk17	UTSW	10	93211958	missense	possibly damaging	0.90
R3737:Cdk17	UTSW	10	93221644	critical splice donor site	probably null
R3883:Cdk17	UTSW	10	93212077	critical splice donor site	probably null
R4436:Cdk17	UTSW	10	93211896	splice site	probably null
R5372:Cdk17	UTSW	10	93226039	missense	probably benign	0.03
R5444:Cdk17	UTSW	10	93217961	splice site	probably null
R5488:Cdk17	UTSW	10	93232412	missense	probably damaging	1.00
R5489:Cdk17	UTSW	10	93232412	missense	probably damaging	1.00
R5815:Cdk17	UTSW	10	93228697	missense	probably damaging	1.00
R6164:Cdk17	UTSW	10	93235469	missense	probably benign	0.26
R6209:Cdk17	UTSW	10	93208231	missense	probably benign	0.05
R6384:Cdk17	UTSW	10	93211965	missense	probably damaging	0.99
R6627:Cdk17	UTSW	10	93232412	missense	probably damaging	1.00
R6698:Cdk17	UTSW	10	93228678	missense	probably damaging	1.00
R8096:Cdk17	UTSW	10	93216367	missense	probably damaging	0.98
R8118:Cdk17	UTSW	10	93216390	missense	possibly damaging	0.46
R8459:Cdk17	UTSW	10	93232427	missense	probably damaging	0.99
R8670:Cdk17	UTSW	10	93226096	nonsense	probably null
R8722:Cdk17	UTSW	10	93228703	missense	probably damaging	1.00
R8829:Cdk17	UTSW	10	93207058	unclassified	probably benign
R9077:Cdk17	UTSW	10	93232415	missense	probably damaging	1.00
R9488:Cdk17	UTSW	10	93208204	missense	probably damaging	0.98
R9789:Cdk17	UTSW	10	93225029	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GGGCTAAGACCTTCAGCATG -3'
(R):5'- CGGGCTACTAATGTGAATAAGATGG -3'

Sequencing Primer
(F):5'- GGCTAAGACCTTCAGCATGTTAATGG -3'
(R):5'- CTCACTGCTCAAACTCTTTG -3'

Posted On

2019-06-26