Incidental Mutation 'R7165:Rasgrp1'
| ID |
557846 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rasgrp1
|
| Ensembl Gene |
ENSMUSG00000027347 |
| Gene Name |
RAS guanyl releasing protein 1 |
| Synonyms |
|
| MMRRC Submission |
045262-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.264)
|
| Stock # |
R7165 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
117110464-117173358 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 117168885 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 31
(T31I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136423
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102534]
[ENSMUST00000172901]
[ENSMUST00000173252]
[ENSMUST00000173541]
[ENSMUST00000174770]
[ENSMUST00000178884]
|
| AlphaFold |
Q9Z1S3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102534
AA Change: T31I
PolyPhen 2
Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000099593
Gene: ENSMUSG00000027347
AA Change: T31I
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
474 |
499 |
3.2e-6 |
PFAM |
|
Pfam:EF-hand_6
|
474 |
502 |
5e-6 |
PFAM |
|
C1
|
542 |
591 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
740 |
791 |
2e-23 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172901
AA Change: T31I
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000133449
Gene: ENSMUSG00000027347
AA Change: T31I
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_6
|
442 |
467 |
1.2e-5 |
PFAM |
|
C1
|
507 |
556 |
5.77e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173252
AA Change: T31I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000134592
Gene: ENSMUSG00000027347
AA Change: T31I
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_6
|
442 |
467 |
1.1e-5 |
PFAM |
|
Pfam:C1_1
|
507 |
539 |
3.4e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173541
AA Change: T31I
PolyPhen 2
Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000134027
Gene: ENSMUSG00000027347
AA Change: T31I
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
441 |
464 |
1.6e-5 |
PFAM |
|
Pfam:EF-hand_6
|
442 |
467 |
1.6e-5 |
PFAM |
|
C1
|
507 |
556 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
705 |
756 |
2e-23 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174770
AA Change: T31I
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000134167
Gene: ENSMUSG00000027347
AA Change: T31I
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178884
AA Change: T31I
PolyPhen 2
Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000136423
Gene: ENSMUSG00000027347
AA Change: T31I
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
474 |
499 |
3.2e-6 |
PFAM |
|
C1
|
542 |
591 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
740 |
791 |
2e-23 |
PDB |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
98% (79/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acoxl |
C |
A |
2: 127,965,028 (GRCm39) |
A624E |
probably benign |
Het |
| Adnp |
A |
G |
2: 168,024,287 (GRCm39) |
S1003P |
probably benign |
Het |
| Akap8l |
T |
C |
17: 32,557,386 (GRCm39) |
D75G |
probably damaging |
Het |
| Ap4e1 |
A |
T |
2: 126,905,238 (GRCm39) |
T970S |
possibly damaging |
Het |
| Asb3 |
T |
A |
11: 30,979,029 (GRCm39) |
N106K |
probably damaging |
Het |
| Atp1a3 |
T |
C |
7: 24,678,390 (GRCm39) |
I988V |
probably benign |
Het |
| Camta1 |
A |
G |
4: 151,169,157 (GRCm39) |
L198S |
possibly damaging |
Het |
| Ccdc77 |
A |
G |
6: 120,327,193 (GRCm39) |
L84P |
probably damaging |
Het |
| Ccne1 |
C |
T |
7: 37,798,726 (GRCm39) |
A298T |
probably damaging |
Het |
| Cdc42bpb |
T |
A |
12: 111,287,951 (GRCm39) |
E532V |
probably damaging |
Het |
| Clasp2 |
G |
A |
9: 113,615,467 (GRCm39) |
|
probably null |
Het |
| Cntnap5b |
C |
A |
1: 100,003,887 (GRCm39) |
T289N |
possibly damaging |
Het |
| Dcun1d4 |
A |
G |
5: 73,648,538 (GRCm39) |
|
probably null |
Het |
| Dnah14 |
A |
G |
1: 181,532,100 (GRCm39) |
T2296A |
probably benign |
Het |
| Dnaja4 |
A |
T |
9: 54,616,516 (GRCm39) |
Q173L |
probably damaging |
Het |
| Dync2h1 |
G |
A |
9: 7,050,479 (GRCm39) |
A3190V |
probably benign |
Het |
| Frrs1 |
T |
A |
3: 116,671,920 (GRCm39) |
I6N |
probably benign |
Het |
| Fscn1 |
T |
C |
5: 142,957,801 (GRCm39) |
V477A |
probably benign |
Het |
| Fsip2 |
G |
A |
2: 82,811,541 (GRCm39) |
G2620E |
possibly damaging |
Het |
| Glp1r |
C |
T |
17: 31,128,297 (GRCm39) |
A92V |
probably benign |
Het |
| Gpr137b |
A |
T |
13: 13,542,205 (GRCm39) |
M204K |
probably damaging |
Het |
| Gstm1 |
A |
G |
3: 107,923,693 (GRCm39) |
V104A |
probably benign |
Het |
| Gtf2e1 |
A |
T |
16: 37,356,228 (GRCm39) |
N101K |
probably damaging |
Het |
| Igsf9b |
T |
C |
9: 27,245,536 (GRCm39) |
F1168L |
probably benign |
Het |
| Itpr2 |
A |
T |
6: 146,195,589 (GRCm39) |
V1629E |
probably damaging |
Het |
| Kat14 |
A |
G |
2: 144,235,918 (GRCm39) |
T428A |
probably benign |
Het |
| Kif21b |
T |
C |
1: 136,077,186 (GRCm39) |
Y403H |
probably damaging |
Het |
| Lpcat1 |
G |
C |
13: 73,662,649 (GRCm39) |
A533P |
probably benign |
Het |
| Lrp2 |
A |
T |
2: 69,336,917 (GRCm39) |
I1285N |
probably damaging |
Het |
| Mboat1 |
A |
T |
13: 30,408,398 (GRCm39) |
Y187F |
probably damaging |
Het |
| Mkx |
T |
C |
18: 7,002,525 (GRCm39) |
N7S |
probably damaging |
Het |
| Mrps27 |
A |
T |
13: 99,551,307 (GRCm39) |
T357S |
possibly damaging |
Het |
| Muc21 |
A |
G |
17: 35,932,870 (GRCm39) |
S439P |
unknown |
Het |
| Naa35 |
A |
G |
13: 59,733,997 (GRCm39) |
D9G |
probably benign |
Het |
| Ncoa4 |
T |
A |
14: 31,897,940 (GRCm39) |
N253K |
probably damaging |
Het |
| Neb |
A |
G |
2: 52,160,318 (GRCm39) |
Y2232H |
probably damaging |
Het |
| Nlk |
G |
A |
11: 78,481,793 (GRCm39) |
Q223* |
probably null |
Het |
| Npas2 |
T |
A |
1: 39,331,798 (GRCm39) |
I71N |
possibly damaging |
Het |
| Nup107 |
T |
A |
10: 117,609,267 (GRCm39) |
Q364L |
probably damaging |
Het |
| Or8g17 |
T |
A |
9: 38,934,566 (GRCm39) |
|
probably benign |
Het |
| Otof |
C |
T |
5: 30,532,964 (GRCm39) |
G1593S |
probably damaging |
Het |
| Panx3 |
G |
T |
9: 37,575,381 (GRCm39) |
H160Q |
probably damaging |
Het |
| Pappa |
T |
A |
4: 65,180,110 (GRCm39) |
H990Q |
probably damaging |
Het |
| Pax4 |
G |
A |
6: 28,446,136 (GRCm39) |
P119L |
probably damaging |
Het |
| Pcdhb20 |
T |
A |
18: 37,638,123 (GRCm39) |
D216E |
probably damaging |
Het |
| Pcdhgb8 |
T |
A |
18: 37,896,231 (GRCm39) |
S434T |
possibly damaging |
Het |
| Pf4 |
T |
C |
5: 90,920,448 (GRCm39) |
V3A |
probably benign |
Het |
| Phf24 |
T |
C |
4: 42,938,325 (GRCm39) |
S229P |
probably benign |
Het |
| Plcd3 |
A |
G |
11: 102,970,439 (GRCm39) |
F200S |
probably damaging |
Het |
| Ppp1r16a |
A |
G |
15: 76,575,104 (GRCm39) |
H4R |
probably damaging |
Het |
| Pramel15 |
A |
G |
4: 144,099,389 (GRCm39) |
C459R |
probably damaging |
Het |
| Prdm10 |
A |
G |
9: 31,227,738 (GRCm39) |
|
probably null |
Het |
| Prim2 |
A |
G |
1: 33,667,474 (GRCm39) |
|
probably null |
Het |
| Prkg1 |
T |
A |
19: 30,562,599 (GRCm39) |
H550L |
probably damaging |
Het |
| Prrc2c |
G |
T |
1: 162,501,086 (GRCm39) |
T2809N |
possibly damaging |
Het |
| Ptx3 |
A |
G |
3: 66,132,391 (GRCm39) |
E304G |
probably benign |
Het |
| Ralgps2 |
A |
G |
1: 156,655,818 (GRCm39) |
F369L |
probably benign |
Het |
| Rbsn |
A |
T |
6: 92,168,315 (GRCm39) |
M373K |
probably benign |
Het |
| Rnf168 |
C |
G |
16: 32,101,179 (GRCm39) |
R120G |
probably benign |
Het |
| Rp1 |
A |
G |
1: 4,420,140 (GRCm39) |
I324T |
probably damaging |
Het |
| Samd11 |
T |
C |
4: 156,336,747 (GRCm39) |
S31G |
probably benign |
Het |
| Sart3 |
A |
T |
5: 113,884,056 (GRCm39) |
L652Q |
probably benign |
Het |
| Scrn2 |
A |
G |
11: 96,924,634 (GRCm39) |
E421G |
probably benign |
Het |
| Sik2 |
A |
T |
9: 50,828,397 (GRCm39) |
L215Q |
probably damaging |
Het |
| Speer4a3 |
AACT |
A |
5: 26,155,849 (GRCm39) |
|
probably benign |
Het |
| Stard9 |
A |
T |
2: 120,534,639 (GRCm39) |
K3632M |
probably damaging |
Het |
| Swt1 |
A |
T |
1: 151,264,428 (GRCm39) |
D695E |
probably damaging |
Het |
| Tead3 |
T |
A |
17: 28,552,228 (GRCm39) |
M357L |
probably benign |
Het |
| Tgfbi |
A |
T |
13: 56,775,829 (GRCm39) |
T292S |
probably damaging |
Het |
| Tmc7 |
T |
C |
7: 118,155,157 (GRCm39) |
H247R |
probably benign |
Het |
| Trmt10b |
T |
A |
4: 45,308,549 (GRCm39) |
D236E |
probably damaging |
Het |
| Tshz1 |
C |
A |
18: 84,034,052 (GRCm39) |
V119L |
probably damaging |
Het |
| Ttn |
A |
C |
2: 76,658,258 (GRCm39) |
V12374G |
unknown |
Het |
| Tubgcp2 |
A |
G |
7: 139,585,274 (GRCm39) |
Y484H |
probably damaging |
Het |
| Ubr4 |
G |
C |
4: 139,177,824 (GRCm39) |
A1947P |
|
Het |
| Uggt1 |
A |
C |
1: 36,194,188 (GRCm39) |
V1350G |
probably benign |
Het |
| Vmn1r173 |
A |
T |
7: 23,402,076 (GRCm39) |
M104L |
probably benign |
Het |
| Xirp1 |
A |
T |
9: 119,848,113 (GRCm39) |
C257S |
probably damaging |
Het |
| Zfyve26 |
A |
G |
12: 79,327,179 (GRCm39) |
S724P |
probably damaging |
Het |
| Zmpste24 |
A |
T |
4: 120,940,091 (GRCm39) |
L185Q |
probably null |
Het |
| Zpld1 |
G |
A |
16: 55,052,594 (GRCm39) |
A340V |
probably benign |
Het |
|
| Other mutations in Rasgrp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00504:Rasgrp1
|
APN |
2 |
117,136,272 (GRCm39) |
nonsense |
probably null |
|
|
IGL00901:Rasgrp1
|
APN |
2 |
117,115,611 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01083:Rasgrp1
|
APN |
2 |
117,115,549 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01325:Rasgrp1
|
APN |
2 |
117,129,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01520:Rasgrp1
|
APN |
2 |
117,119,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01776:Rasgrp1
|
APN |
2 |
117,117,321 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01780:Rasgrp1
|
APN |
2 |
117,115,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01859:Rasgrp1
|
APN |
2 |
117,119,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01892:Rasgrp1
|
APN |
2 |
117,124,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02068:Rasgrp1
|
APN |
2 |
117,131,059 (GRCm39) |
splice site |
probably benign |
|
|
IGL02684:Rasgrp1
|
APN |
2 |
117,113,057 (GRCm39) |
missense |
probably benign |
0.03 |
|
bukhansan
|
UTSW |
2 |
117,122,178 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Commendatore
|
UTSW |
2 |
117,113,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
dragged
|
UTSW |
2 |
117,129,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
grouper
|
UTSW |
2 |
117,132,485 (GRCm39) |
nonsense |
probably null |
|
|
Gyeryandsan
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Haddock
|
UTSW |
2 |
117,122,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
jovial
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
mercurial
|
UTSW |
2 |
117,118,314 (GRCm39) |
nonsense |
probably null |
|
|
naejangsan
|
UTSW |
2 |
117,122,273 (GRCm39) |
nonsense |
probably null |
|
|
sea_bass
|
UTSW |
2 |
117,113,135 (GRCm39) |
missense |
probably benign |
0.02 |
|
venutian
|
UTSW |
2 |
117,115,410 (GRCm39) |
nonsense |
probably null |
|
|
R0067:Rasgrp1
|
UTSW |
2 |
117,125,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0067:Rasgrp1
|
UTSW |
2 |
117,125,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Rasgrp1
|
UTSW |
2 |
117,115,428 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0786:Rasgrp1
|
UTSW |
2 |
117,130,980 (GRCm39) |
missense |
probably benign |
|
|
R1068:Rasgrp1
|
UTSW |
2 |
117,113,057 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1165:Rasgrp1
|
UTSW |
2 |
117,115,420 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1491:Rasgrp1
|
UTSW |
2 |
117,113,100 (GRCm39) |
nonsense |
probably null |
|
|
R1707:Rasgrp1
|
UTSW |
2 |
117,129,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Rasgrp1
|
UTSW |
2 |
117,120,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2214:Rasgrp1
|
UTSW |
2 |
117,115,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2425:Rasgrp1
|
UTSW |
2 |
117,119,931 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3236:Rasgrp1
|
UTSW |
2 |
117,122,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3915:Rasgrp1
|
UTSW |
2 |
117,119,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Rasgrp1
|
UTSW |
2 |
117,115,510 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4163:Rasgrp1
|
UTSW |
2 |
117,113,135 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4781:Rasgrp1
|
UTSW |
2 |
117,122,190 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4782:Rasgrp1
|
UTSW |
2 |
117,115,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5028:Rasgrp1
|
UTSW |
2 |
117,132,485 (GRCm39) |
nonsense |
probably null |
|
|
R6019:Rasgrp1
|
UTSW |
2 |
117,122,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6220:Rasgrp1
|
UTSW |
2 |
117,115,410 (GRCm39) |
nonsense |
probably null |
|
|
R6294:Rasgrp1
|
UTSW |
2 |
117,122,273 (GRCm39) |
nonsense |
probably null |
|
|
R6335:Rasgrp1
|
UTSW |
2 |
117,124,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6948:Rasgrp1
|
UTSW |
2 |
117,129,085 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7246:Rasgrp1
|
UTSW |
2 |
117,168,835 (GRCm39) |
nonsense |
probably null |
|
|
R7372:Rasgrp1
|
UTSW |
2 |
117,115,635 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7400:Rasgrp1
|
UTSW |
2 |
117,129,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Rasgrp1
|
UTSW |
2 |
117,122,178 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7448:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7449:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7475:Rasgrp1
|
UTSW |
2 |
117,116,589 (GRCm39) |
missense |
probably benign |
|
|
R7487:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7573:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7672:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8016:Rasgrp1
|
UTSW |
2 |
117,118,314 (GRCm39) |
nonsense |
probably null |
|
|
R8199:Rasgrp1
|
UTSW |
2 |
117,124,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8527:Rasgrp1
|
UTSW |
2 |
117,168,785 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8692:Rasgrp1
|
UTSW |
2 |
117,115,353 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8725:Rasgrp1
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8727:Rasgrp1
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8880:Rasgrp1
|
UTSW |
2 |
117,115,425 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9280:Rasgrp1
|
UTSW |
2 |
117,113,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9675:Rasgrp1
|
UTSW |
2 |
117,173,190 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R9792:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9793:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9795:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1176:Rasgrp1
|
UTSW |
2 |
117,132,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCAAAATACAATCTAGGTTGCTC -3'
(R):5'- AGCTTCAGAGACTCACTGTCC -3'
Sequencing Primer
(F):5'- TCTAGGTTGCTCTTGTATAAGACAC -3'
(R):5'- AGAGACTCACTGTCCTATCTCC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation