Incidental Mutation 'R0586:Parp14'
ID 55787
Institutional Source Beutler Lab
Gene Symbol Parp14
Ensembl Gene ENSMUSG00000034422
Gene Name poly (ADP-ribose) polymerase family, member 14
Synonyms CoaSt6, collaborator of Stat6, 1600029O10Rik
MMRRC Submission 038776-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.493) question?
Stock # R0586 (G1)
Quality Score 140
Status Validated
Chromosome 16
Chromosomal Location 35653244-35691914 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 35661382 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 1522 (K1522R)
Ref Sequence ENSEMBL: ENSMUSP00000037657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042665]
AlphaFold Q2EMV9
PDB Structure Solution structure of WWE domain in Parp14 protein [SOLUTION NMR]
Predicted Effect probably benign
Transcript: ENSMUST00000042665
AA Change: K1522R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000037657
Gene: ENSMUSG00000034422
AA Change: K1522R

DomainStartEndE-ValueType
low complexity region 38 49 N/A INTRINSIC
low complexity region 93 115 N/A INTRINSIC
RRM 228 297 4.71e-2 SMART
coiled coil region 443 468 N/A INTRINSIC
Blast:A1pp 693 746 6e-6 BLAST
low complexity region 771 795 N/A INTRINSIC
A1pp 814 948 7.62e-41 SMART
A1pp 1026 1160 5.88e-24 SMART
A1pp 1239 1358 6.82e-20 SMART
PDB:1X4R|A 1532 1619 9e-53 PDB
Pfam:PARP 1632 1817 2.5e-29 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.5%
  • 20x: 94.4%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit altered B cell subsets and inability to respond to the apoptosis protective affects of IL4. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A T 4: 53,092,860 (GRCm39) V308E probably benign Het
Amy1 A G 3: 113,356,418 (GRCm39) probably benign Het
Astn2 C T 4: 66,103,379 (GRCm39) V345M unknown Het
Brwd1 T C 16: 95,844,286 (GRCm39) E756G probably damaging Het
Ccpg1 C T 9: 72,909,103 (GRCm39) L135F probably benign Het
Cecr2 C T 6: 120,734,845 (GRCm39) H694Y probably damaging Het
Cfh G A 1: 140,110,920 (GRCm39) T14I probably damaging Het
Cfhr2 G A 1: 139,741,172 (GRCm39) R268* probably null Het
Clca3a1 T A 3: 144,738,350 (GRCm39) I53L probably benign Het
Clcn6 A G 4: 148,123,206 (GRCm39) probably benign Het
Cnfn C T 7: 25,067,256 (GRCm39) V98I probably benign Het
Cntnap1 C T 11: 101,077,840 (GRCm39) R1122W probably damaging Het
Cpne9 A T 6: 113,272,024 (GRCm39) E384V probably damaging Het
Ctr9 T C 7: 110,648,705 (GRCm39) probably benign Het
Ctsj T A 13: 61,151,515 (GRCm39) probably benign Het
Cyp2c39 A C 19: 39,501,934 (GRCm39) probably benign Het
Dock5 A C 14: 68,046,481 (GRCm39) I767S probably damaging Het
Eftud2 T C 11: 102,737,446 (GRCm39) T552A probably damaging Het
Epdr1 A G 13: 19,778,715 (GRCm39) I25T probably damaging Het
Fcgbp A T 7: 27,789,138 (GRCm39) D568V probably damaging Het
Fcgbpl1 T A 7: 27,836,516 (GRCm39) V145D probably damaging Het
Fhip1b T C 7: 105,038,654 (GRCm39) E195G probably damaging Het
Frem2 T A 3: 53,555,342 (GRCm39) T1732S probably damaging Het
Fuz T C 7: 44,547,982 (GRCm39) V183A possibly damaging Het
Grb7 T C 11: 98,344,046 (GRCm39) S284P probably damaging Het
Hoxb4 G T 11: 96,209,713 (GRCm39) G40C probably damaging Het
Kcnn1 T C 8: 71,316,513 (GRCm39) probably benign Het
Kmt2d C A 15: 98,733,088 (GRCm39) probably benign Het
L3mbtl3 A G 10: 26,203,732 (GRCm39) V366A unknown Het
Ldlr G A 9: 21,651,040 (GRCm39) R486H probably benign Het
Lnpep A T 17: 17,795,658 (GRCm39) probably benign Het
Mical3 A T 6: 121,006,602 (GRCm39) probably benign Het
Myh15 T C 16: 48,992,250 (GRCm39) probably benign Het
Nup155 T A 15: 8,159,716 (GRCm39) H542Q probably benign Het
Opn4 A G 14: 34,320,930 (GRCm39) probably benign Het
Or13a20 T C 7: 140,231,976 (GRCm39) F28S probably benign Het
Or4a68 T A 2: 89,269,698 (GRCm39) R308S possibly damaging Het
Or6c68 A G 10: 129,157,916 (GRCm39) I141M probably benign Het
Or8g4 A T 9: 39,662,414 (GRCm39) H244L probably damaging Het
Or8h10 T C 2: 86,809,126 (GRCm39) N5D probably damaging Het
Pak3 TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC X: 142,526,889 (GRCm39) probably benign Het
Pkhd1 A T 1: 20,594,335 (GRCm39) D1259E probably benign Het
Pogz C T 3: 94,786,664 (GRCm39) A1084V probably damaging Het
Popdc3 G A 10: 45,191,359 (GRCm39) V157M probably benign Het
Prrt4 T C 6: 29,171,183 (GRCm39) Y423C probably damaging Het
Qrich1 C T 9: 108,411,719 (GRCm39) H415Y probably damaging Het
Rabgap1 A G 2: 37,433,235 (GRCm39) N801D probably benign Het
Rb1 A G 14: 73,525,124 (GRCm39) probably benign Het
Rp1 A T 1: 4,418,060 (GRCm39) N1017K possibly damaging Het
Ryr2 T C 13: 11,650,445 (GRCm39) D356G probably null Het
Skint8 C G 4: 111,794,126 (GRCm39) P172R probably damaging Het
Slc12a8 T G 16: 33,478,600 (GRCm39) M643R possibly damaging Het
Sult1c2 A T 17: 54,271,113 (GRCm39) probably benign Het
Tasor2 A G 13: 3,640,321 (GRCm39) L272P probably damaging Het
Tcaf1 T A 6: 42,650,473 (GRCm39) M869L probably damaging Het
Tecpr1 T C 5: 144,154,219 (GRCm39) N78S probably damaging Het
Tectb A T 19: 55,170,356 (GRCm39) Y69F probably damaging Het
Them4 A T 3: 94,237,101 (GRCm39) N187I possibly damaging Het
Tm9sf3 A G 19: 41,244,582 (GRCm39) probably null Het
Tnik G T 3: 28,631,510 (GRCm39) probably benign Het
Tns2 G T 15: 102,018,020 (GRCm39) probably benign Het
Tnxb A G 17: 34,891,118 (GRCm39) D487G probably damaging Het
Trim33 T A 3: 103,217,660 (GRCm39) C202S probably damaging Het
Trpm2 T A 10: 77,759,350 (GRCm39) I1145F probably damaging Het
Trpv2 A G 11: 62,483,596 (GRCm39) T478A probably benign Het
Ube2e3 T C 2: 78,750,334 (GRCm39) Y187H probably benign Het
Ubxn11 A G 4: 133,836,963 (GRCm39) R64G possibly damaging Het
Wwtr1 T C 3: 57,366,487 (GRCm39) T407A probably damaging Het
Zfyve26 A T 12: 79,315,502 (GRCm39) S1325T possibly damaging Het
Other mutations in Parp14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Parp14 APN 16 35,661,445 (GRCm39) missense probably benign 0.00
IGL00497:Parp14 APN 16 35,655,206 (GRCm39) missense probably damaging 1.00
IGL00754:Parp14 APN 16 35,659,741 (GRCm39) missense probably benign 0.15
IGL00960:Parp14 APN 16 35,661,589 (GRCm39) missense probably benign 0.20
IGL01321:Parp14 APN 16 35,676,929 (GRCm39) missense probably benign
IGL01397:Parp14 APN 16 35,679,098 (GRCm39) missense probably benign 0.19
IGL01591:Parp14 APN 16 35,678,877 (GRCm39) missense possibly damaging 0.71
IGL01728:Parp14 APN 16 35,677,805 (GRCm39) missense probably damaging 1.00
IGL01734:Parp14 APN 16 35,678,970 (GRCm39) missense probably benign 0.00
IGL02156:Parp14 APN 16 35,678,967 (GRCm39) missense probably benign 0.13
IGL02951:Parp14 APN 16 35,678,903 (GRCm39) missense probably benign 0.06
IGL03067:Parp14 APN 16 35,676,878 (GRCm39) missense probably benign 0.10
IGL03135:Parp14 APN 16 35,678,381 (GRCm39) missense probably damaging 1.00
IGL03141:Parp14 APN 16 35,659,663 (GRCm39) missense probably benign 0.00
IGL03146:Parp14 APN 16 35,678,823 (GRCm39) nonsense probably null
IGL03333:Parp14 APN 16 35,661,800 (GRCm39) missense probably benign 0.08
IGL03391:Parp14 APN 16 35,678,640 (GRCm39) missense probably benign
thurston UTSW 16 35,664,785 (GRCm39) splice site probably benign
PIT4585001:Parp14 UTSW 16 35,678,975 (GRCm39) missense probably benign 0.03
R0306:Parp14 UTSW 16 35,676,944 (GRCm39) missense probably benign
R0506:Parp14 UTSW 16 35,661,779 (GRCm39) missense possibly damaging 0.70
R0606:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R0612:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R0699:Parp14 UTSW 16 35,680,955 (GRCm39) missense probably damaging 1.00
R0786:Parp14 UTSW 16 35,661,172 (GRCm39) missense possibly damaging 0.86
R0883:Parp14 UTSW 16 35,678,888 (GRCm39) missense probably benign 0.03
R0900:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1087:Parp14 UTSW 16 35,678,658 (GRCm39) missense probably damaging 1.00
R1104:Parp14 UTSW 16 35,664,785 (GRCm39) splice site probably benign
R1120:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1134:Parp14 UTSW 16 35,655,272 (GRCm39) missense probably damaging 1.00
R1153:Parp14 UTSW 16 35,678,041 (GRCm39) missense possibly damaging 0.49
R1159:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1160:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1237:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1238:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1239:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1423:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1511:Parp14 UTSW 16 35,677,594 (GRCm39) missense probably benign 0.00
R1518:Parp14 UTSW 16 35,677,008 (GRCm39) missense possibly damaging 0.79
R1619:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1707:Parp14 UTSW 16 35,678,219 (GRCm39) missense probably damaging 1.00
R1792:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1831:Parp14 UTSW 16 35,678,958 (GRCm39) missense possibly damaging 0.77
R1840:Parp14 UTSW 16 35,683,819 (GRCm39) missense probably damaging 1.00
R1889:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1902:Parp14 UTSW 16 35,673,888 (GRCm39) critical splice donor site probably null
R1943:Parp14 UTSW 16 35,656,499 (GRCm39) missense probably damaging 1.00
R1954:Parp14 UTSW 16 35,678,671 (GRCm39) missense probably benign 0.08
R2115:Parp14 UTSW 16 35,678,904 (GRCm39) missense probably benign 0.16
R2216:Parp14 UTSW 16 35,677,575 (GRCm39) missense probably benign 0.00
R2519:Parp14 UTSW 16 35,678,573 (GRCm39) missense possibly damaging 0.95
R3851:Parp14 UTSW 16 35,674,118 (GRCm39) missense possibly damaging 0.92
R4052:Parp14 UTSW 16 35,678,771 (GRCm39) missense probably benign 0.05
R4671:Parp14 UTSW 16 35,678,691 (GRCm39) missense probably benign 0.00
R4867:Parp14 UTSW 16 35,677,697 (GRCm39) missense probably benign 0.01
R4941:Parp14 UTSW 16 35,666,403 (GRCm39) missense probably benign
R4992:Parp14 UTSW 16 35,661,512 (GRCm39) missense probably benign 0.05
R5055:Parp14 UTSW 16 35,664,733 (GRCm39) missense probably benign 0.00
R5073:Parp14 UTSW 16 35,655,077 (GRCm39) missense probably damaging 0.99
R5170:Parp14 UTSW 16 35,677,649 (GRCm39) missense probably benign 0.21
R5422:Parp14 UTSW 16 35,686,545 (GRCm39) missense probably benign 0.01
R5543:Parp14 UTSW 16 35,655,137 (GRCm39) missense probably benign 0.00
R5549:Parp14 UTSW 16 35,661,505 (GRCm39) missense probably benign 0.00
R5553:Parp14 UTSW 16 35,677,306 (GRCm39) missense probably benign 0.01
R5691:Parp14 UTSW 16 35,683,909 (GRCm39) missense probably benign 0.12
R5774:Parp14 UTSW 16 35,678,780 (GRCm39) missense probably damaging 1.00
R5855:Parp14 UTSW 16 35,661,297 (GRCm39) nonsense probably null
R5942:Parp14 UTSW 16 35,659,737 (GRCm39) missense probably damaging 0.98
R5990:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R5991:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6018:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6022:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6075:Parp14 UTSW 16 35,677,389 (GRCm39) missense probably damaging 0.99
R6395:Parp14 UTSW 16 35,676,918 (GRCm39) missense probably benign 0.00
R6525:Parp14 UTSW 16 35,680,811 (GRCm39) missense probably benign 0.05
R6683:Parp14 UTSW 16 35,655,047 (GRCm39) missense probably damaging 1.00
R7525:Parp14 UTSW 16 35,677,861 (GRCm39) missense probably benign 0.00
R8011:Parp14 UTSW 16 35,677,004 (GRCm39) missense probably benign 0.00
R8192:Parp14 UTSW 16 35,691,584 (GRCm39) missense probably benign 0.01
R8367:Parp14 UTSW 16 35,678,124 (GRCm39) missense probably benign 0.36
R8526:Parp14 UTSW 16 35,661,307 (GRCm39) missense possibly damaging 0.87
R8751:Parp14 UTSW 16 35,677,181 (GRCm39) missense probably benign 0.32
R8962:Parp14 UTSW 16 35,677,187 (GRCm39) missense probably damaging 1.00
R9231:Parp14 UTSW 16 35,661,583 (GRCm39) missense probably damaging 0.98
R9363:Parp14 UTSW 16 35,678,586 (GRCm39) missense possibly damaging 0.90
R9366:Parp14 UTSW 16 35,659,630 (GRCm39) critical splice donor site probably null
R9379:Parp14 UTSW 16 35,680,853 (GRCm39) missense probably benign 0.08
R9562:Parp14 UTSW 16 35,677,775 (GRCm39) missense probably benign 0.16
R9565:Parp14 UTSW 16 35,677,775 (GRCm39) missense probably benign 0.16
R9696:Parp14 UTSW 16 35,661,252 (GRCm39) missense probably damaging 0.96
R9696:Parp14 UTSW 16 35,661,251 (GRCm39) missense possibly damaging 0.67
X0026:Parp14 UTSW 16 35,677,527 (GRCm39) nonsense probably null
X0060:Parp14 UTSW 16 35,655,077 (GRCm39) missense probably damaging 0.99
Z1088:Parp14 UTSW 16 35,661,956 (GRCm39) missense probably damaging 1.00
Z1177:Parp14 UTSW 16 35,665,708 (GRCm39) missense probably damaging 1.00
Z1177:Parp14 UTSW 16 35,691,573 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- TACCTTCAGCTTTGACGAGGCG -3'
(R):5'- AGAGCAGCTTTCCTACACCAATGAC -3'

Sequencing Primer
(F):5'- AGTCCACCGTGAAATCCTGATTG -3'
(R):5'- TTCCTACACCAATGACGATGAGTG -3'
Posted On 2013-07-11