Mutagenetix > Incidental Mutation

Incidental Mutation 'R7165:Or8g17'

557879

Institutional Source

Beutler Lab

Gene Symbol

Or8g17

Ensembl Gene

ENSMUSG00000058820

Gene Name

olfactory receptor family 8 subfamily G member 17

Synonyms

MOR171-10, M15, Olfr146, GA_x6K02T2PVTD-32715386-32714466

MMRRC Submission

045262-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R7165 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

38929915-38930835 bp(-) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

T to A at 38934566 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151064 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073671] [ENSMUST00000214369] [ENSMUST00000214410] [ENSMUST00000215383]

AlphaFold

Q60884

Predicted Effect

probably benign
Transcript: ENSMUST00000073671

SMART Domains

Protein: ENSMUSP00000073352
Gene: ENSMUSG00000058820

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	7.6e-54	PFAM
Pfam:7tm_1	41	290	8.1e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214369

Predicted Effect

probably benign
Transcript: ENSMUST00000214410

Predicted Effect

probably benign
Transcript: ENSMUST00000215383

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.8%

Validation Efficiency

98% (79/81)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acoxl	C	A	2: 127,965,028 (GRCm39)	A624E	probably benign	Het
Adnp	A	G	2: 168,024,287 (GRCm39)	S1003P	probably benign	Het
Akap8l	T	C	17: 32,557,386 (GRCm39)	D75G	probably damaging	Het
Ap4e1	A	T	2: 126,905,238 (GRCm39)	T970S	possibly damaging	Het
Asb3	T	A	11: 30,979,029 (GRCm39)	N106K	probably damaging	Het
Atp1a3	T	C	7: 24,678,390 (GRCm39)	I988V	probably benign	Het
Camta1	A	G	4: 151,169,157 (GRCm39)	L198S	possibly damaging	Het
Ccdc77	A	G	6: 120,327,193 (GRCm39)	L84P	probably damaging	Het
Ccne1	C	T	7: 37,798,726 (GRCm39)	A298T	probably damaging	Het
Cdc42bpb	T	A	12: 111,287,951 (GRCm39)	E532V	probably damaging	Het
Clasp2	G	A	9: 113,615,467 (GRCm39)		probably null	Het
Cntnap5b	C	A	1: 100,003,887 (GRCm39)	T289N	possibly damaging	Het
Dcun1d4	A	G	5: 73,648,538 (GRCm39)		probably null	Het
Dnah14	A	G	1: 181,532,100 (GRCm39)	T2296A	probably benign	Het
Dnaja4	A	T	9: 54,616,516 (GRCm39)	Q173L	probably damaging	Het
Dync2h1	G	A	9: 7,050,479 (GRCm39)	A3190V	probably benign	Het
Frrs1	T	A	3: 116,671,920 (GRCm39)	I6N	probably benign	Het
Fscn1	T	C	5: 142,957,801 (GRCm39)	V477A	probably benign	Het
Fsip2	G	A	2: 82,811,541 (GRCm39)	G2620E	possibly damaging	Het
Glp1r	C	T	17: 31,128,297 (GRCm39)	A92V	probably benign	Het
Gpr137b	A	T	13: 13,542,205 (GRCm39)	M204K	probably damaging	Het
Gstm1	A	G	3: 107,923,693 (GRCm39)	V104A	probably benign	Het
Gtf2e1	A	T	16: 37,356,228 (GRCm39)	N101K	probably damaging	Het
Igsf9b	T	C	9: 27,245,536 (GRCm39)	F1168L	probably benign	Het
Itpr2	A	T	6: 146,195,589 (GRCm39)	V1629E	probably damaging	Het
Kat14	A	G	2: 144,235,918 (GRCm39)	T428A	probably benign	Het
Kif21b	T	C	1: 136,077,186 (GRCm39)	Y403H	probably damaging	Het
Lpcat1	G	C	13: 73,662,649 (GRCm39)	A533P	probably benign	Het
Lrp2	A	T	2: 69,336,917 (GRCm39)	I1285N	probably damaging	Het
Mboat1	A	T	13: 30,408,398 (GRCm39)	Y187F	probably damaging	Het
Mkx	T	C	18: 7,002,525 (GRCm39)	N7S	probably damaging	Het
Mrps27	A	T	13: 99,551,307 (GRCm39)	T357S	possibly damaging	Het
Muc21	A	G	17: 35,932,870 (GRCm39)	S439P	unknown	Het
Naa35	A	G	13: 59,733,997 (GRCm39)	D9G	probably benign	Het
Ncoa4	T	A	14: 31,897,940 (GRCm39)	N253K	probably damaging	Het
Neb	A	G	2: 52,160,318 (GRCm39)	Y2232H	probably damaging	Het
Nlk	G	A	11: 78,481,793 (GRCm39)	Q223*	probably null	Het
Npas2	T	A	1: 39,331,798 (GRCm39)	I71N	possibly damaging	Het
Nup107	T	A	10: 117,609,267 (GRCm39)	Q364L	probably damaging	Het
Otof	C	T	5: 30,532,964 (GRCm39)	G1593S	probably damaging	Het
Panx3	G	T	9: 37,575,381 (GRCm39)	H160Q	probably damaging	Het
Pappa	T	A	4: 65,180,110 (GRCm39)	H990Q	probably damaging	Het
Pax4	G	A	6: 28,446,136 (GRCm39)	P119L	probably damaging	Het
Pcdhb20	T	A	18: 37,638,123 (GRCm39)	D216E	probably damaging	Het
Pcdhgb8	T	A	18: 37,896,231 (GRCm39)	S434T	possibly damaging	Het
Pf4	T	C	5: 90,920,448 (GRCm39)	V3A	probably benign	Het
Phf24	T	C	4: 42,938,325 (GRCm39)	S229P	probably benign	Het
Plcd3	A	G	11: 102,970,439 (GRCm39)	F200S	probably damaging	Het
Ppp1r16a	A	G	15: 76,575,104 (GRCm39)	H4R	probably damaging	Het
Pramel15	A	G	4: 144,099,389 (GRCm39)	C459R	probably damaging	Het
Prdm10	A	G	9: 31,227,738 (GRCm39)		probably null	Het
Prim2	A	G	1: 33,667,474 (GRCm39)		probably null	Het
Prkg1	T	A	19: 30,562,599 (GRCm39)	H550L	probably damaging	Het
Prrc2c	G	T	1: 162,501,086 (GRCm39)	T2809N	possibly damaging	Het
Ptx3	A	G	3: 66,132,391 (GRCm39)	E304G	probably benign	Het
Ralgps2	A	G	1: 156,655,818 (GRCm39)	F369L	probably benign	Het
Rasgrp1	G	A	2: 117,168,885 (GRCm39)	T31I	probably benign	Het
Rbsn	A	T	6: 92,168,315 (GRCm39)	M373K	probably benign	Het
Rnf168	C	G	16: 32,101,179 (GRCm39)	R120G	probably benign	Het
Rp1	A	G	1: 4,420,140 (GRCm39)	I324T	probably damaging	Het
Samd11	T	C	4: 156,336,747 (GRCm39)	S31G	probably benign	Het
Sart3	A	T	5: 113,884,056 (GRCm39)	L652Q	probably benign	Het
Scrn2	A	G	11: 96,924,634 (GRCm39)	E421G	probably benign	Het
Sik2	A	T	9: 50,828,397 (GRCm39)	L215Q	probably damaging	Het
Speer4a3	AACT	A	5: 26,155,849 (GRCm39)		probably benign	Het
Stard9	A	T	2: 120,534,639 (GRCm39)	K3632M	probably damaging	Het
Swt1	A	T	1: 151,264,428 (GRCm39)	D695E	probably damaging	Het
Tead3	T	A	17: 28,552,228 (GRCm39)	M357L	probably benign	Het
Tgfbi	A	T	13: 56,775,829 (GRCm39)	T292S	probably damaging	Het
Tmc7	T	C	7: 118,155,157 (GRCm39)	H247R	probably benign	Het
Trmt10b	T	A	4: 45,308,549 (GRCm39)	D236E	probably damaging	Het
Tshz1	C	A	18: 84,034,052 (GRCm39)	V119L	probably damaging	Het
Ttn	A	C	2: 76,658,258 (GRCm39)	V12374G	unknown	Het
Tubgcp2	A	G	7: 139,585,274 (GRCm39)	Y484H	probably damaging	Het
Ubr4	G	C	4: 139,177,824 (GRCm39)	A1947P		Het
Uggt1	A	C	1: 36,194,188 (GRCm39)	V1350G	probably benign	Het
Vmn1r173	A	T	7: 23,402,076 (GRCm39)	M104L	probably benign	Het
Xirp1	A	T	9: 119,848,113 (GRCm39)	C257S	probably damaging	Het
Zfyve26	A	G	12: 79,327,179 (GRCm39)	S724P	probably damaging	Het
Zmpste24	A	T	4: 120,940,091 (GRCm39)	L185Q	probably null	Het
Zpld1	G	A	16: 55,052,594 (GRCm39)	A340V	probably benign	Het

Other mutations in Or8g17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01533:Or8g17	APN	9	38,930,097 (GRCm39)	missense	probably damaging	0.98
IGL01655:Or8g17	APN	9	38,930,214 (GRCm39)	missense	probably benign	0.00
IGL01804:Or8g17	APN	9	38,930,697 (GRCm39)	missense	probably benign	0.13
IGL02098:Or8g17	APN	9	38,930,187 (GRCm39)	missense	probably damaging	1.00
IGL02719:Or8g17	APN	9	38,930,312 (GRCm39)	missense	probably benign	0.11
R0531:Or8g17	UTSW	9	38,930,472 (GRCm39)	missense	probably damaging	0.97
R1270:Or8g17	UTSW	9	38,930,543 (GRCm39)	missense	possibly damaging	0.90
R1511:Or8g17	UTSW	9	38,930,321 (GRCm39)	missense	probably benign	0.03
R1590:Or8g17	UTSW	9	38,930,253 (GRCm39)	missense	probably benign	0.09
R1649:Or8g17	UTSW	9	38,930,776 (GRCm39)	missense	probably benign	0.03
R3419:Or8g17	UTSW	9	38,930,372 (GRCm39)	missense	probably benign	0.03
R4669:Or8g17	UTSW	9	38,930,675 (GRCm39)	missense	probably benign	0.10
R4788:Or8g17	UTSW	9	38,930,217 (GRCm39)	missense	probably benign	0.07
R5184:Or8g17	UTSW	9	38,929,998 (GRCm39)	missense	probably damaging	0.98
R5581:Or8g17	UTSW	9	38,929,998 (GRCm39)	missense	probably damaging	0.98
R6032:Or8g17	UTSW	9	38,930,261 (GRCm39)	missense	probably benign	0.00
R6032:Or8g17	UTSW	9	38,930,261 (GRCm39)	missense	probably benign	0.00
R6319:Or8g17	UTSW	9	38,930,810 (GRCm39)	missense	probably damaging	1.00
R6626:Or8g17	UTSW	9	38,930,402 (GRCm39)	missense	possibly damaging	0.63
R6693:Or8g17	UTSW	9	38,930,097 (GRCm39)	missense	probably damaging	0.98
R7947:Or8g17	UTSW	9	38,930,747 (GRCm39)	missense	probably damaging	0.99
R7957:Or8g17	UTSW	9	38,930,349 (GRCm39)	missense	probably benign
R8052:Or8g17	UTSW	9	38,930,783 (GRCm39)	missense	probably damaging	0.99
R8162:Or8g17	UTSW	9	38,930,249 (GRCm39)	missense	probably benign	0.01
R9004:Or8g17	UTSW	9	38,930,580 (GRCm39)	missense	probably benign	0.01
R9083:Or8g17	UTSW	9	38,930,016 (GRCm39)	missense	probably damaging	1.00
R9584:Or8g17	UTSW	9	38,930,462 (GRCm39)	missense	probably damaging	1.00
Z1088:Or8g17	UTSW	9	38,930,085 (GRCm39)	missense	probably damaging	1.00
Z1191:Or8g17	UTSW	9	38,930,229 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TAAGTTAGTTCTCTATGGCTGAGCTC -3'
(R):5'- AGCTTAAGTCTAATTGGGCCC -3'

Sequencing Primer
(F):5'- TATGGCTGAGCTCTCCCAG -3'
(R):5'- GACTAAATCATGAAAATCTCCAAGGG -3'

Posted On

2019-06-26